Syntaxin-BP1 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

STXBP1 (Syntaxin-binding protein 1; also p67, Munc18-1, N-Sec1 and Unc18A) is a 67 kDa member of the SNARE-interacting Sec1/Unc18/STXBP family of proteins. It is expressed in a variety of cells, presumably in those that exhibit granule exocytosis, and likely participates in (synaptic) granule release. Ligands for STXBP1 include STX1A, 2 and 3, and it is possible that STXBP1 both suppresses STX activity, and serves as an anchor for STX-mediated vesicle fusion. Human STXBP1 is 594 amino acids (aa) in length. It contains one SEC1 domain (aa 41‑575). Phosphorylation at Ser313 may stimulate granule release. There is one splice variant that shows a 28 aa substitution for aa 576‑594. This is restricted to neural tissue. Over aa 80‑226, human and mouse STXBP1 are absolutely identical in amino acid sequence.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array AF5675

• Syntaxin-BP1 Antibodies
• Syntaxin-BP1 Lysate
• Syntaxin-BP1 Proteins