Antibody News

The Hypoxia Inducible Factors (HIFs) are a family of mammalian transcription factors which are expressed in response to low cellular oxygen concentrations (hypoxia). Three human hypoxia inducible factors have been identified, HIF-1, HIF-2 and HIF-3, each having an alpha and a beta subunit. Our antibody catalog at Novus Biologicals includes a full range of HIF products, including  useful HIF-1 alpha antibody packs containing multiple different samples. The Hypoxia Inducible Factor antibody catalog is widely used in disease research, as hypoxia is a contributing factor in the pathogenesis of many diseases, including kidney disease. Hypoxia is also a common complication following renal allograft, or transplant surgery, resulting in necrosis and...

Hypoxia-Inducible Factor-1 (HIF-1) is a highly conserved heterodimeric transcription factor. Novus' antibody catalogue contains an extensive range of both HIF-1 alpha and HIF-1 beta, useful for hypoxia, angiogenesis, cancer and many other areas of research.

The Hypoxia-inducible factors play an essential role in homeostasis, responding to changes in the available oxygen content of the cell. Specifically, they respond to hypoxic, or low oxygen conditions. There are three main members of the human HIF family, each comprising an alpha and beta subunit, encoded by a separate gene. All these proteins are represented in our antibody catalog, which has a particularly extensive range of top quality HIF-1 alpha antibody products...

The ABC (ATP-binding cassette) transporters are a superfamily of transmembrane proteins which play an essential role in membrane transport in both prokaryotes and eukaryotes. In humans, ABC transporters have been implicated in many conditions. For example, ABCA1 antibody research has shown mutations in the ABCA1 gene can cause Tangier disease, while the ABCB family causes multiple drug resistance. We at Novus Biologicals have a large antibody database of ABC transporters and related proteins, for a variety of species and applications.

ABC transporters use energy harnessed from ATP hydrolysis, to carry out a range of functions, including the translocation of lipids, drugs and metabolic substrates across intracellular and extracellular membranes. However, research has also shown that some proteins do not have a membrane transport...

We at Novus Biologicals have a large catalogue of protein, peptide and antibody products to choose from. To make life easier for researchers, our catalog includes products like the actin antibody pack, which contains two actin antibody vials mapped to the N-termini of human beta and gamma actin.

Antibody packs contain multiple vials of similarly targeted immunoglobulins, which researchers can test to find the best product for their assay. Buying them in kit form saves the tedium of hunting through the catalog to match up likely products (of which there are over 500 for the actin antibody alone). However, the process can be improved even further with the Precipitor^TM Affinity Magnetic Precipitation System.

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The high prevalence of atherosclerosis in developed nations is not breaking news; it has been well established that heart disease is the leading cause of death in the United States, and it presents a major socioeconomic burden. Investigators across the globe have been laboring for decades to unravel the molecular mechanisms that contribute to atherosclerosis, and while some of the major players in these pathways have been identified, unanswered questions persist.  Over the past ten years, an enormous amount of work has been done to establish the role of ATP-binding cassette (ABC) transporters in lipid trafficking, and their subsequent influence on the development of atherosclerosis.  Two rare diseases have been identified as models for studying the effects of ABC transporter mutations on the progression of atherosclerosis: Tangier disease, which is caused by a mutation in ABCA1, and sitosterolemia, which occurs as a result of mutations in either...

Profilin-1, or Pfn-1, is a small actin-binding protein which plays an essential role controlling the growth of microfilaments. Profilin 1 and Profilin 2 have similar biochemical properties but are expressed in different tissues. The Profilin 1 antibody targets the more common form of the protein, which is expressed everywhere but the skeletal muscle. We at Novus Biologicals have an extensive range of Profilin I and Profilin II antibody products in our antibody catalog.

Profilin regulates the spatial and temporal growth of actin microfilaments, thus aiding cellular migration, changes in cellular morphology, and processes such as organ development and wound healing to take place. Profilin mainly binds to actin, but has over 50 binding partners in total. Profilin I antibody studies have shown that the protein may have other functions apart from actin regulation.

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Tumor necrosis factor alpha, or TNF alpha antibody products are widely used in cytokine and immunology research. TNF alpha is a pleiotropic ligand which plays an essential role in apoptosis, immune system development and the inflammatory response. We at Novus Biologicals have a number of TNF alpha antibody products in our catalog, which was recently enhanced by the addition of a new neutralizing TNF alpha antibody (NBP1-43235) . It is reactive against mouse, rat and rabbit tumour TNF-a, but not the human form of the antigen.

In nature, neutralizing antibodies defend cells from attack by antigens by neutralizing their biological effects. Normally, antibody binding flags antigens, which signal for their destruction – a response which may be...

We at Novus Biologicals are one of the leading antibody suppliers for cancer research. In a recent Notch antibody study, the Notch ligand Jagged 2 was found to promote the growth of metastatic lung cancer cells by inhibiting miR-200, which blocks epithelial-to-mesenchymal transition (EMT) – an early stage in metastasis which, if blocked, can prevent secondary tumour growth.

The Notch proteins are large single-pass transmembrane receptors, important to embryonic development cell signalling. It comprises an intracellular and extracellular domain, the latter being composed of EGF-like repeats and cysteine-rich Notch/Lin-12 repeats. Notch signalling is initiated following Delta or Jagged1/2 ligand binding. Antibody studies have shown this results in cleavage of the extracellular domain, initiating translocation of the intracellular fragment to the nucleus, triggering transcription...

Adiponectin (also called ADIPOQ) is a cytokine expressed exclusively in adipose tissue. It has a number of functions, regulating lipid metabolism, gluconeogenesis and the inflammatory response. Adiponectin antibody products are widely used in diabetes, obesity and lipid metabolism research. Obesity and Type 2 Diabetes are linked to an increased risk of breast cancer in women. New adiponectin antibodies recently proved important in this area of research.

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The V5 tag antibody identifies the V5 epitope tag, enabling proteins of interest to be analyzed and studied via ELISA, Western blot and other immunochemical methods. We at Novus Biologicals are one of the leading suppliers of epitope tag reagents, with an extensive range of V5 tag antibody products on our antibody database.

An epitope tag is a short peptide sequence, which is bioengineered onto the N- or C- terminus of a protein so it can be recognized by the equivalent antibody, or antibody paratope (i.e. the area of the immunoglobulin receptive to that tag).

Epitope tags are created using recombinant DNA technology, which allows the fusion of a short sequence of...

Novus is launching a new Travel Grant offer for researchers who provide feedback on our antibodies.

For each complete product review that you submit, you will be entered into a drawing for a $500 travel grant! We will select a winner every 3 months - giving you 4 chances for you to win each year!  The winner will receive a $200 airline voucher and $300 towards registration for a scientific conference of your choice.

Complete reviews will require a descriptive summary of the experiment and results, regardless of whether they are positive or negative, and a high quality image. However, researchers may also submit reviews for previously untested species and applications that are being tested under the Innovators Reward Program. Therefore, you could earn Innovators Rewards, Novus points toward a future discount, and be entered to win the Travel Voucher, all by submitting one review...

Sorting Nexin Family Member 27 (SNX27) binds the cell membrane to regulate endocytic vesicular and protein trafficking. SNX27 has also been shown to play a key role in the endocytic recycling pathway, whereby internalized membrane proteins and lipids are degraded and recycled into the cell, in T lymphocytes. In their groundbreaking work on endocytic recycling pathways, Dr. F Maxfield and Dr. T McGraw showed that these pathways are essential for proper organelle maintenance and homeostatic regulation of molecules.

Although it contains the characteristic internal endosome binding PZ domain,...