Sonic Hedgehog/Shh Products

Description

Sonic Hedgehog Protein (SHH, VHH-1) belongs to hedgehog protein family which includes Indian Hh, and Desert Hh. Hh family is involved in the cell fate and patterning during embryonic development, homeostasis, and adult tissue renewal (1). Similar to other member in the family, SHH binds to the patched (PTC) cell surface receptor, releasing the signal transducer Smoothened (Smo) to transmit the Hh signal into the cell and activate transcription of the target gene (2). Precursor SHH is autocatlytically cleaved into two subunits, N-terminal and C-terminal products. Soluble N-terminal product is involved in the signaling activity, while C-product displays an autoproteolysis activity on the precursor and a cholesterol transferase activity on the N-terminal product. C-terminal product attaches a cholesterol moiety to the N-terminal product, preventing N-terminal product diffusion within the developing embryo (3). A defect in SHH has been linked in holoprosencephaly type 3 (HPE3), in which developing forebrain fails to separate into right and left hemispheres, and ocular coloboma (4).

Bioinformatics

Entrez	20423 Mouse 29499 Rat 6469 Human
Uniprot	AB018076 Human NM_000193 Human NP_000184 Human Q15465 Human Q62226 Mouse
Product By Gene ID	6469
Alternate Names	HHG1 HHG-1 HLP3 HPE3 MCOPCB5sonic hedgehog (Drosophila) homolog SMMCIsonic hedgehog homolog (Drosophila) sonic hedgehog homolog sonic hedgehog protein sonic hedgehog TPT TPTPS

Research Areas for Sonic Hedgehog/Shh

Find related products by research area and learn more about each of the different research areas below.

Neuroscience
Sensory Systems
Stem Cell Signaling Pathway
Vision