Mouse Sonic Hedgehog/Shh N-Terminus Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Shh (Sonic Hedgehog) is expressed in embryonic tissues that are critical for the patterning of the developing central nervous system, somite, and limb. It is also involved in whisker, hair, foregut, tooth, and bone development. Shh regulates neural and hematopoietic stem cell fate and is important for thymocyte differentiation and proliferation. In adult tissue Shh is associated with cancer development and tissue remodeling following injury. Palmitoylation and cholesterol addition of Shh contribute to its membrane tethering and assembly into multimers. Lipid modification and multimerization greatly increase Shh signaling potency. Shh can be released from the plasma membrane by the cooperative action of DISP1, SCUBE2, and TACE/ADAM17. Canonical signaling of Shh is mediated by a receptor complex that includes Patched (PTCH1, PTCH2) and Smoothened (SMO).

We have publications tested in 1 confirmed species: Mouse.

Showing Publications 1 - 4 of 4.

Publications using MSHH00	Applications	Species
Wofford, W;Kim, J;Kim, D;Janneh, AH;Lee, HG;Atilgan, FC;Oleinik, N;Kassir, MF;Saatci, O;Chakraborty, P;Tokat, UM;Gencer, S;Howley, B;Howe, P;Mehrotra, S;Sahin, O;Ogretmen, B; Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response Cell reports 2024-07-23 [PMID: 39046874] (Mouse)		Mouse
B ?wierczek-, D Dudka, D Bauer, T Czajkowski, K Ilach, W Streminska, A Kominek, K Piwocka, MA Ciemerych, K Archacka Comparison of Differentiation Pattern and WNT/SHH Signaling in Pluripotent Stem Cells Cultured under Different Conditions Cells, 2021-10-14;10(10):. 2021-10-14 [PMID: 34685722] (Mouse)		Mouse
ME Coulter, CM Dorobantu, GA Lodewijk, F Delalande, S Cianferani, VS Ganesh, RS Smith, ET Lim, CS Xu, S Pang, ET Wong, HGW Lidov, ML Calicchio, E Yang, DM Gonzalez, TM Schlaeger, GH Mochida, H Hess, WA Lee, MK Lehtinen, T Kirchhause, D Haussler, FMJ Jacobs, R Gaudin, CA Walsh The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles Cell Rep, 2018-07-24;24(4):973-986.e8. 2018-07-24 [PMID: 30044992] (Mouse)		Mouse
Lun M, Johnson M, Broadbelt K, Watanabe M, Kang Y, Chau K, Springel M, Malesz A, Sousa A, Pletikos M, Adelita T, Calicchio M, Zhang Y, Holtzman M, Lidov H, Sestan N, Steen H, Monuki E, Lehtinen M Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. J Neurosci, 2015-03-25;35(12):4903-16. 2015-03-25 [PMID: 25810521] (Mouse)		Mouse

Array MSHH00

• Sonic Hedgehog/Shh Antibodies
• Sonic Hedgehog/Shh ELISA Kits
• Sonic Hedgehog/Shh Lysate
• Sonic Hedgehog/Shh Proteins
• Sonic Hedgehog/Shh Proteins and Enzymes
• Sonic Hedgehog/Shh ELISAs