Lipase A Products

Description

Lipase A, also known as LIPA or Lysosomal acid lipase/cholesteryl ester hydrolase, has a 399 amino acid long isoform that is 45 kDa and a short 343 amino acid isoform that is 39 kDa; lysosome located; is very important for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles, and also in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation. This protein is currently being studied for involvement in the following diseases and disorders: cholesteryl ester storage disease, wolman disease, cholesterol, cholesterol ester storage disease, lysosomal storage disease, coronary heart disease, hepatitis c, splenomegaly, hepatitis b, hepatitis, hyperlipidemia, hypercholesterolemia, tuberculosis, obesity atherosclerosis, alzheimer's disease, neisseria meningitides, lipid storage disease, lipodystrophy, pandas, wolman disease, and blepharitis. The LIPA protein has been shown to interact with HIST1H4A, HIST1H4B, HIST1H4C, SOAT1, and HIST1H4E in cholesterol and sphingolipids transport / distribution to the intracellular membrane compartments (normal and CF), steroid biosynthesis, and lysosome pathways.

Bioinformatics

Entrez	16889 Mouse 3988 Human
Uniprot	AAH12287 Human AAH12287.1 Human NM_000235 Human NP_001121077 Human P38571 Human Q9Z0M5 Mouse
Product By Gene ID	3988
Alternate Names	Acid cholesteryl ester hydrolase Cholesteryl esterase EC 3.1.1 EC 3.1.1.13 LALCESDcholesterol ester hydrolase Lipase A lipase A, lysosomal acid, cholesterol esterase lysosomal acid lipase lysosomal acid lipase/cholesteryl ester hydrolase Sterol esterase

Research Areas for Lipase A

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Lipid and Metabolism

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How do Lipase A and the CD36 Antibody Relate to Each Other Obesity, diabetes and metabolic disorders are dramatically on the increase, linked to disorders such as heart disease, stroke and cancer. To combat this, research groups are studying metabolism at both a cellular and a systemic level. Although we at N...    Read more.

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