GLI-2 Products

Description

Gli2 belongs to the C2H2 type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors that bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. Gli2 is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes Greig cephalopolysyndactyly syndrome, Pallister Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.

Bioinformatics

Entrez	14633 Mouse 2736 Human 304729 Rat
Uniprot	NP_005261 Human NP_005261.2 Human P10070 Human Q0VGT2 Mouse
Product By Gene ID	2736
Alternate Names	GLI family zinc finger 2 GLI-Kruppel family member GLI2 glioma-associated oncogene family zinc finger 2 HPE9tax helper protein 1 oncogene GLI2 tax helper protein 2 Tax helper protein tax-responsive element-2 holding protein tax-responsive element-25-bp sequence binding protein THP THP1 THP2 zinc finger protein GLI2

Research Areas for GLI-2

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
Cancer
Cell Cycle and Replication
Neuroscience
Stem Cell Signaling Pathway