Name: VEGFR2/KDR/Flk-1 Antibody (89106) [Unconjugated]
Brand: Novus Biologicals
SKU: MAB3572
Price: 459 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	Flow, B/N, CyTOF-ready
Clone	89106
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated

Catalog# & Conjugate	Size	Price
Alexa Fluor 350 FAB3572U-100UG

Alexa Fluor 405 FAB3572V-100UG

Alexa Fluor 488 FAB3572G-100UG

Alexa Fluor 532 FAB3572X

Alexa Fluor 594 FAB3572T-100UG

Alexa Fluor 647 FAB3572R-100UG

Alexa Fluor 700 FAB357N-100

Alexa Fluor 700 FAB357N-025

Alexa Fluor 750 FAB3572S-100UG

Allophycocyanin FAB357A-025

Allophycocyanin FAB357A-100

Allophycocyanin/Cy7 FAB3572APCCY7

Biotin FAB3572B

DyLight 350 FAB3572D

DyLight 405 FAB3572E

DyLight 488 FAB3572K

DyLight 550 FAB3572L

DyLight 594 FAB3572M

DyLight 650 FAB3572W

DyLight 680 FAB3572Y

DyLight 755 FAB3572Z

Fluorescein FAB357F-025

Fluorescein FAB357F-100

HRP FAB3572H

Janelia Fluor 549 FAB3572I

Janelia Fluor 646 FAB3572J

PE/Atto594 FAB3572PEATT594

PE/Cy5.5 FAB3572PECY55

PE/Cy7 FAB3572PECY7

PerCP (Peridinin-chlorophyll Protein Complex) FAB357C-100

PerCP (Peridinin-chlorophyll Protein Complex) FAB357C-025

Phycoerythrin FAB357P-025

Phycoerythrin FAB357P-100

mFluor Violet 450 SE FAB3572MFV450

mFluor Violet 500 SE FAB3572MFV500

mFluor Violet 610 SE FAB3572MFV610

Catalog# & Formulation	Size	Price
Carrier Free FAB357P-025

Carrier Free FAB3572R-100UG

Carrier Free FAB3572S-100UG

Carrier Free FAB3572T-100UG

Carrier Free FAB3572U-100UG

Carrier Free FAB3572V-100UG

Carrier Free MAB3572-500

Carrier Free FAB357P-100

Carrier Free MAB3572-SP

Carrier Free FAB357A-025

Carrier Free FAB357A-100

Carrier Free FAB357N-025

Carrier Free FAB357N-100

Carrier Free FAB357F-025

Carrier Free FAB357F-100

Carrier Free FAB357C-025

Carrier Free FAB357C-100

Carrier Free FAB3572G-100UG

Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 350	FAB3572U-100UG
Alexa Fluor 405	FAB3572V-100UG
Alexa Fluor 488	FAB3572G-100UG
Alexa Fluor 532	FAB3572X
Alexa Fluor 594	FAB3572T-100UG
Alexa Fluor 647	FAB3572R-100UG
Alexa Fluor 700	FAB357N-100
Alexa Fluor 700	FAB357N-025
Alexa Fluor 750	FAB3572S-100UG
Allophycocyanin	FAB357A-025
Allophycocyanin	FAB357A-100
Allophycocyanin/Cy7	FAB3572APCCY7
Biotin	FAB3572B
DyLight 350	FAB3572D
DyLight 405	FAB3572E
DyLight 488	FAB3572K
DyLight 550	FAB3572L
DyLight 594	FAB3572M
DyLight 650	FAB3572W
DyLight 680	FAB3572Y
DyLight 755	FAB3572Z
Fluorescein	FAB357F-025
Fluorescein	FAB357F-100
HRP	FAB3572H
Janelia Fluor 549	FAB3572I
Janelia Fluor 646	FAB3572J
PE/Atto594	FAB3572PEATT594
PE/Cy5.5	FAB3572PECY55
PE/Cy7	FAB3572PECY7
PerCP (Peridinin-chlorophyll Protein Complex)	FAB357C-100
PerCP (Peridinin-chlorophyll Protein Complex)	FAB357C-025
Phycoerythrin	FAB357P-025
Phycoerythrin	FAB357P-100
mFluor Violet 450 SE	FAB3572MFV450
mFluor Violet 500 SE	FAB3572MFV500
mFluor Violet 610 SE	FAB3572MFV610

VEGFR2/KDR/Flk-1 Antibody (89106) [Unconjugated]

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VEGFR2/KDR/Flk-1 Antibody (89106) [Unconjugated] Summary

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Alternate Names for VEGFR2/KDR/Flk-1 Antibody (89106) [Unconjugated]

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Publications for VEGFR2/KDR/Flk-1 Antibody (MAB3572)(35)

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Bioinformatics

Immunogen	S. frugiperda insect ovarian cell line Sf 21-derived recombinant human VEGFR2/KDR/Flk-1 Ala20-Glu764 Accession # P35968
Specificity	Detects human VEGFR2/KDR/Flk-1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) VEGFR1, rhVEGFR3 or recombinant mouse VEGFR2 is observed.
Source	N/A
Isotype	IgG1
Clonality	Monoclonal
Host	Mouse
Gene	KDR
Purity Statement	Protein A or G purified from hybridoma culture supernatant
Endotoxin Note	<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Reconstitution Instructions	Reconstitute at 0.5 mg/mL in sterile PBS.

Publications using MAB3572	Applications	Species
Ghersi, JJ;Baldissera, G;Hintzen, J;Luff, SA;Cheng, S;Xia, IF;Sturgeon, CM;Nicoli, S; Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium Nature cell biology 2023-07-17 [PMID: 37460694] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
O Doppelt-Fl, A Younis, T Tamari, O Ginesin, T Shentzer-K, D Nikomarov, G Bar-Sela, BR Coyac, YG Assaraf, H Zigdon-Gil Endothelial Progenitor Cells Promote Osteosarcoma Progression and Invasiveness via AKT/PI3K Signaling Cancers, 2023-03-17;15(6):. 2023-03-17 [PMID: 36980704] (Flow Cytometry, Human)	Flow Cytometry	Human
SA Luff, JP Creamer, S Valsoni, C Dege, R Scarfò, A Dacunto, S Cascione, LN Randolph, E Cavalca, I Merelli, SA Morris, A Ditadi, CM Sturgeon Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells Nature Cell Biology, 2022-04-28;0(0):. 2022-04-28 [PMID: 35484246] (Flow Cytometry, Human)	Flow Cytometry	Human
BK Gage, S Merlin, C Olgasi, A Follenzi, GM Keller Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors Cell Reports, 2022-04-05;39(1):110621. 2022-04-05 [PMID: 35385743] (Flow Cytometry, Human)	Flow Cytometry	Human
Shogo Tamura, Masato Mukaide, Yumi Katsuragi, Wataru Fujii, Koya Odaira, Nobuaki Suzuki et al. Periosteum-derived podoplanin-expressing stromal cells regulate nascent vascularization during epiphyseal marrow development Journal of Biological Chemistry 2022-05-01 [PMID: 35304101]
D Dong, Y Fu, F Chen, J Zhang, H Jia, J Li, H Wang, J Wen Hyperoxia sensitizes hypoxic HeLa cells to ionizing radiation by downregulating HIF?1&alpha and VEGF expression Mol Med Rep, 2020-11-20;23(1):. 2020-11-20 [PMID: 33215223] (Neutralization, Human)	Neutralization	Human
E Gambini, I Martinelli, I Stadiotti, MC Vinci, A Scopece, L Eramo, E Sommariva, J Resta, S Benaouadi, E Cogliati, A Paolin, A Parini, G Pompilio, F Savagner Differences in Mitochondrial Membrane Potential Identify Distinct Populations of Human Cardiac Mesenchymal Progenitor Cells Int J Mol Sci, 2020-10-10;21(20):. 2020-10-10 [PMID: 33050449] (Flow Cytometry, Human)	Flow Cytometry	Human
T Tamari, R Kawar-Jara, O Doppelt, B Giladi, N Sabbah, H Zigdon-Gil The Paracrine Role of Endothelial Cells in Bone Formation via CXCR4/SDF-1 Pathway Cells, 2020-05-26;9(6):. 2020-05-26 [PMID: 32466427] (Flow Cytometry, Human)	Flow Cytometry	Human
L Koehler, G Ruiz-Gómez, K Balamuruga, S Rother, J Freyse, S Möller, M Schnabelra, S Köhling, S Djordjevic, D Scharnwebe, J Rademann, MT Pisabarro, V Hintze Dual Action of Sulfated Hyaluronan on Angiogenic Processes in Relation to Vascular Endothelial Growth Factor-A Sci Rep, 2019-12-02;9(1):18143. 2019-12-02 [PMID: 31792253] (Neutralization, Human)	Neutralization	Human
Song Yi Ko, WonJae Lee, Hilary A. Kenny, Long H. Dang, Lee M. Ellis, Eric Jonasch et al. Cancer-derived small extracellular vesicles promote angiogenesis by heparin-bound, bevacizumab-insensitive VEGF, independent of vesicle uptake Communications Biology 2019-10-18 [PMID: 31646189]
N Toledo-Pon, G Noell, A Jahn, A Iglesias, MA Duran, J Iglesias, A Rios, S Scrimini, R Faner, O Gigirey, A Agustí, BG Cosío Bone marrow characterization in COPD: a multi-level network analysis Respir. Res., 2018-06-15;19(1):118. 2018-06-15 [PMID: 29903047] (Flow Cytometry, Human)	Flow Cytometry	Human
L Chen, E Okeke, D Ayalew, D Wang, L Shahid, AO Dokun Modulation of miR29a improves impaired post-ischemic angiogenesis in hyperglycemia Exp. Biol. Med. (Maywood), 2017-06-21;0(0):1535370217716. 6/21/2017 [PMID: 28637396]
Ira Indrakusuma, Tania Romacho, Jürgen Eckel Protease-Activated Receptor 2 Promotes Pro-Atherogenic Effects through Transactivation of the VEGF Receptor 2 in Human Vascular Smooth Muscle Cells Frontiers in Pharmacology 2017-01-04 [PMID: 28101054]
Gabriela Odent Grig Synergic effects of VEGF-A and SDF-1 on the angiogenic properties of endothelial progenitor cells J Tissue Eng Regen Med, 2016-12-12;0(0):. 2016-12-12 [PMID: 27943613] (Flow Cytometry, Human)	Flow Cytometry	Human
Goodwin G Jinesh, Ashish M Kamat Endocytosis and serpentine filopodia drive blebbishield-mediated resurrection of apoptotic cancer stem cells Cell Death Discovery 2016-05-27 [PMID: 27226900]
Clare Arnott, Gaya Punnia-Moorthy, Joanne Tan, Sara Sadeghipour, Christina Bursill, Sanjay Patel The Vascular Endothelial Growth Factor Inhibitors Ranibizumab and Aflibercept Markedly Increase Expression of Atherosclerosis-Associated Inflammatory Mediators on Vascular Endothelial Cells PLOS ONE 2016-03-09 [PMID: 26959822]
IP Silva, A Salhi, KM Giles, M Vogelsang, SW Han, N Ismaili, KP Lui, EM Robinson, MA Wilson, RL Shapiro, A Pavlick, J Zhong, T Kirchhoff, I Osman Identification of a Novel Pathogenic Germline KDR Variant in Melanoma Clin. Cancer Res., 2015-12-02;22(10):2377-85. 2015-12-02 [PMID: 26631613] (Neutralization, Human)	Neutralization	Human
Jee Yeon Kim, Junha Hwang, Seo Hyun Lee, Hyo Jin Lee, Jaroslav Jelinek, Hyeseon Jeong et al. Decreased efficacy of drugs targeting the vascular endothelial growth factor pathway by the epigenetic silencing of FLT1 in renal cancer cells Clinical Epigenetics 2015-12-01 [PMID: 26380584]
Fleetwood F, Klint S, Hanze M, Gunneriusson E, Frejd F, Stahl S, Lofblom J Simultaneous targeting of two ligand-binding sites on VEGFR2 using biparatopic Affibody molecules results in dramatically improved affinity. Sci Rep, 2014-12-17;4(0):7518. 2014-12-17 [PMID: 25515662] (Flow Cytometry, Human)	Flow Cytometry	Human
Jarajapu Y, Hazra S, Segal M, Li Calzi S, Jadhao C, Qian K, Mitter S, Raizada M, Boulton M, Grant M Vasoreparative dysfunction of CD34+ cells in diabetic individuals involves hypoxic desensitization and impaired autocrine/paracrine mechanisms. PLoS ONE, 2014-04-08;9(4):e93965. 2014-04-08 [PMID: 24713821] (Flow Cytometry, Human)	Flow Cytometry	Human
Sarita Saraswati, Pawan K Kanaujia, Shakti Kumar, Ranjeet Kumar, Abdulqader A Alhaider Tylophorine, a phenanthraindolizidine alkaloid isolated from Tylophora indica exerts antiangiogenic and antitumor activity by targeting vascular endothelial growth factor receptor 2–mediated angiogenesis Molecular Cancer 2013-07-29 [PMID: 23895055]
Goretti E, Rolland-Turner M, Leonard F, Zhang L, Wagner D, Devaux Y MicroRNA-16 affects key functions of human endothelial progenitor cells. J Leukoc Biol, 2013-01-16;93(5):645-55. 2013-01-16 [PMID: 23325924] (Flow Cytometry, Human)	Flow Cytometry	Human
Facciabene A, Peng X, Hagemann IS, Balint K, Barchetti A, Wang LP, Gimotty PA, Gilks CB, Lal P, Zhang L, Coukos G Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature, 2011-07-13;475(7355):226-30. 2011-07-13 [PMID: 21753853] (Neutralization, Human)	Neutralization	Human
Yoon-Jin Lee, Daniel L. Karl, Ugwuji N. Maduekwe, Courtney Rothrock, Sandra Ryeom, Patricia A. D'Amore et al. Differential Effects of VEGFR-1 and VEGFR-2 Inhibition on Tumor Metastases Based on Host Organ Environment Cancer Research 2010-11-01 [PMID: 20978198]
Bougatef F, Menashi S, Khayati F et al. EMMPRIN promotes melanoma cells malignant properties through a HIF-2alpha mediated up-regulation of VEGF-receptor-2 PLoS One 8/31/2010 [PMID: 20824203]
Byeon SH, Lee SC, Choi SH, Lee HK, Lee JH, Chu YK, Kwon OW Vascular endothelial growth factor as an autocrine survival factor for retinal pigment epithelial cells under oxidative stress via the VEGF-R2/PI3K/Akt. Invest. Ophthalmol. Vis. Sci., 2009-10-15;51(2):1190-7. 2009-10-15 [PMID: 19834034] (Neutralization, Human)	Neutralization	Human
Zhizhong Yin, David Noren, C Joanne Wang, Rob Hang, Andre Levchenko Analysis of pairwise cell interactions using an integrated dielectrophoretic‐microfluidic system Molecular Systems Biology 2008-12-16 [PMID: 19096359]
Riccioni R, Senese M, Diverio D, Riti V, Mariani G, Boe A, LoCoco F, Foa R, Peschle C, Sporn M, Testa U Resistance of acute myeloid leukemic cells to the triterpenoid CDDO-Imidazolide is associated with low caspase-8 and FADD levels. Leuk. Res., 2008-03-04;32(8):1244-58. 2008-03-04 [PMID: 18304628] (Flow Cytometry, Human)	Flow Cytometry	Human
Ohsaka A, Hirota-Komatsu S, Shibata M, Ezaki J, Shinohara F, Yoshida T Specific association of increased vascular endothelial growth factor expression and its receptors with macrophage differentiation of HL-60 leukemia cells. Biochem. Biophys. Res. Commun., 2008-02-07;368(3):543-9. 2008-02-07 [PMID: 18261985] (Neutralization, Human)	Neutralization	Human
Lin YL, Liang YC, Chiang BL Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells. J. Leukoc. Biol., 2007-08-30;82(6):1473-80. 2007-08-30 [PMID: 17761954] (Neutralization, Human)	Neutralization	Human
Ball SG, Shuttleworth CA, Kielty CM Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. J. Cell Biol., 2007-04-30;177(3):489-500. 2007-04-30 [PMID: 17470632] (Flow Cytometry, Neutralization, Human)	Flow Cytometry, Neutralization	Human
Riccioni R, Diverio D, Mariani G, Buffolino S, Riti V, Saulle E, Petrucci E, Cedrone M, Lo-Coco F, Foa R, Peschle C, Testa U Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blasts. Stem Cells, 2007-04-19;25(8):1862-71. 2007-04-19 [PMID: 17446561] (Flow Cytometry, Human)	Flow Cytometry	Human
Rajesh</LastName><ForeNam D</Initial, Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin I, Thomson JA, Shaaban AF Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells. Stem Cells, 2007-02-01;25(2):490-9. 2007-02-01 [PMID: 17284653] (Flow Cytometry, Human, Primate - Macaca mulatta (Rhesus Macaque))	Flow Cytometry	Human, Primate - Macaca mulatta (Rhesus Macaque)
Caldas H, Fangusaro JR, Boue DR, Holloway MP, Altura RA Dissecting the role of endothelial SURVIVIN DeltaEx3 in angiogenesis. Blood, 2006-10-12;109(4):1479-89. 2006-10-12 [PMID: 17038538] (Neutralization, Human)	Neutralization	Human
Sreekumar PG, Kannan R, de Silva AT, Burton R, Ryan SJ, Hinton DR Thiol regulation of vascular endothelial growth factor-A and its receptors in human retinal pigment epithelial cells. Biochem. Biophys. Res. Commun., 2006-06-12;346(4):1200-6. 2006-06-12 [PMID: 16793007] (Flow Cytometry, Human)	Flow Cytometry	Human
Show All 35 Publications. Collapse Publications.

Gene Symbol	KDR
Uniprot	P35968()