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VEGFR3/Flt-4 Antibody [Unconjugated]

Name: VEGFR3/Flt-4 Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF743
Rating: 4 (3 reviews)

(140 Publications)

(3 Reviews)

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bEnd.3 cells, a mouse endothelioma cell line, was stained with Goat Anti-Mouse VEGFR3/Flt‑4 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF743, filled histogram) or isotype control antibody (Catalog # ...read more

Cells with BLEC molecular markers are present within the mouse leptomeninges. a Coronal brain section of adult zebrafish brain indicating the imaging area in the dorsal optic tectum (TeO). b A 14 month old ...read more

Mouse LLECs take up A beta 1-40. a Schematic showing the site of dye and A beta 1-40 perfusion into the CSF via the cisterna magna (arrow) of a 2-month old mouse. The dotted line indicates the plane of section. A ...read more

Cells of human meninges co-express LLEC markers. a–c DAB-IHC with single antibodies detects VEGFR3 (a), LYVE1 (b), and MRC1 (c) in the meninges of human post mortem brain showing no signs of neuropathology. These ...read more

Endothelial changes after pericyte depletion. a–f Maximum intensity projection of confocal images from control and DTRiPC P6 retinas stained for IB4 (red) in combination with VEGF-A a, VEGFR2 b, VEGFR3 c, Tie2 d, Esm1 ...read more

Cultured murine LECs express VDR.To check lymphatic origin of mouse LECs, we used three different well-established markers expressed by LECs. (a) Lymphatic origin of murine LECs was confirmed by IHC for Prox-1, VEGFR3 ...read more

Vascular alterations after intraocular VEGF-A injection. a Morphology of IB4-stained P6 wild-type retinal vessels at 4 h after administration of human VEGF-A165 (0.5 µl at a concentration of 5 μg μl−1). ...read more

Kinase activity of EphB4 is required for lymphatic valve development.(a) Visualization of mesenteric lymphatic vessels and valves (arrows) by staining for Prox-1 and VEGFR3 2 days following treatment of P3 neonatal mice ...read more

YAP and TAZ are required for the maintenance of LVs. The lymphatic vessels in the dorsal skin of E16.5 and E18.5 control and Lyve1-Cre;Yapf/f;Tazf/f embryos were analyzed by whole-mount immunohistochemistry. (A,B) LVs ...read more

Product Details

Summary

Reactivity	MuSpecies Glossary
Applications	WB, Flow, CyTOF-ready
Clonality	Polyclonal
Host	Goat
Conjugate	Unconjugated
Concentration	LYOPH

Order Details

View Available Conjugates

Catalog# & Conjugate	Size	Price
Alexa Fluor 488 FAB743G

Allophycocyanin FAB743A

Biotin BAF743

Phycoerythrin FAB743P

View Available Formulations

Catalog# & Formulation	Size	Price
Carrier Free FAB743A

Carrier Free FAB743G

Carrier Free FAB743P

Carrier Free AF743-SP

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Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 488	FAB743G
Allophycocyanin	FAB743A
Biotin	BAF743
Phycoerythrin	FAB743P

VEGFR3/Flt-4 Antibody [Unconjugated] Summary

Immunogen	S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse VEGFR3/Flt-4 Tyr25-Asp770 Accession # P35917
Specificity	Detects mouse VEGFR3/Flt-4 in direct ELISAs and Western blots. In direct ELISAs, approximately 30% cross-reactivity with recombinant human (rh) VEGFR3 is observed and less than 5% cross-reactivity with recombinant mouse VEGFR2 is observed.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Goat
Gene	FLT4
Purity Statement	Antigen Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Applications/Dilutions

Dilutions

CyTOF-ready
Flow Cytometry 0.25 ug/10^6 cells
Western Blot 0.1 ug/mL

Reviewed Applications

Read 3 Reviews rated 4

using
AF743 in the following applications:

Western Blot
Immunohistochemistry-Frozen
Immunofluorescence

Publications

Read Publications using
AF743 in the following applications:

ELISA Development
1 publication
Flow Cytometry
1 publication
ICC
5 publications
IHC
50 publications
IHC-Fr
12 publications
IHC-P
8 publications
Immunohistochemistry
4 publications
Immunoprecipitation
2 publications
Western Blot
6 publications

Packaging, Storage & Formulations

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for VEGFR3/Flt-4 Antibody [Unconjugated]

EC 2.7.10
EC 2.7.10.1
FLT4
Flt-4
fms-related tyrosine kinase 4
LMPH1A
PCLFLT41
soluble VEGFR3 variant 1
soluble VEGFR3 variant 2
soluble VEGFR3 variant 3
Tyrosine-protein kinase receptor FLT4
vascular endothelial growth factor receptor 3
VEGF R3
VEGFR3
VEGFR-3
VEGFR3Fms-like tyrosine kinase 4

Background

VEGFR3 (Flt-4), together with VEGFR1 (Flt-1) and VEGFR2 (KDR/Flk-1), belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domains and kinase insert domains in their intracellular regions. The expression of these receptors is almost exclusively restricted to the endothelial cells. These receptors are likely to play essential roles in vasculogenesis and angiogenesis.

In adults, VEGFR3 expression is restricted to the endothelial cells of the lymphatic vessels. Mouse VEGFR3 cDNA encodes a 1363 amino acid (aa) residue precursor protein with a 24 aa residue signal peptide. Mature VEGFR3 has a 751 aa residue extracellular domain, a 22 aa residue hydrophobic transmembrane domain and a 565 aa residue cytoplasmic domain. The polypeptide sequences of murine Flt-4 is 88% identical to the human homologue. VEGFR3 has been reported to serve as the receptors for VEGF-C and VEGF-D.

Finnerty, H. et al. (1993) Oncogene 8:2293.
Joukov, V. et al. (1996) EMBO J. 15:290.
Achen, M. et al. (1998) Proc. Natl. Acad. Sci. USA 95:548.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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VEGFR3/Flt-4
Antibody [Unconjugate

AF743

Species: Mu

Applications: WB, Flow, CyTOF-ready

Publications for VEGFR3/Flt-4 Antibody (AF743)(140)

We have publications tested in 3 confirmed species: Mouse, Equine, Transgenic Mouse.

We have publications tested in 9 applications: ELISA Development, Flow Cytometry, ICC, IHC, IHC-Fr, IHC-P, Immunohistochemistry, Immunoprecipitation, Western Blot.

Showing Publications 1 - 10 of 140. Show All 140 Publications.

Publications using AF743	Applications	Species
Crossey, E;Carty, S;Shao, F;Henao-Vasquez, J;Ysasi, AB;Zeng, M;Hinds, A;Lo, M;Tilston-Lunel, A;Varelas, X;Jones, MR;Fine, A; Influenza induces lung lymphangiogenesis independent of YAP/TAZ activity in lymphatic endothelial cells. Scientific reports 2024-09-12 [PMID: 39266641] (Immunohistochemistry, Mouse)	Immunohistochemistry	Mouse
Tai, Y;Chow, A;Han, S;Coker, C;Ma, W;Gu, Y;Estrada Navarro, V;Kandpal, M;Hibshoosh, H;Kalinsky, K;Manova-Todorova, K;Safonov, A;Walsh, EM;Robson, M;Norton, L;Baer, R;Merghoub, T;Biswas, AK;Acharyya, S; FLT1 activation in cancer cells promotes PARP-inhibitor resistance in breast cancer EMBO molecular medicine 2024-07-02 [PMID: 38956205] (Immunohistochemistry, Mouse)	Immunohistochemistry	Mouse
Guo, T;Pei, F;Zhang, M;Yamada, T;Feng, J;Jing, J;Ho, TV;Chai, Y; Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor Cell stem cell 2024-04-30 [PMID: 38703771] (Immunohistochemistry, Transgenic Mouse)	Immunohistochemistry	Transgenic Mouse
Crossey, E;Carty, S;Shao, F;Henao-Vasquez, J;Ysasi, AB;Zeng, M;Hinds, A;Lo, M;Tilston-Lunel, A;Varelas, X;Jones, MR;Fine, A; Influenza Induces Lung Lymphangiogenesis Independent of YAP/TAZ Activity in Lymphatic Endothelial Cells Research square 2024-02-27 [PMID: 38463972] (Immunohistochemistry, Mouse)	Immunohistochemistry	Mouse
Iga, T;Kobayashi, H;Kusumoto, D;Sanosaka, T;Fujita, N;Tai-Nagara, I;Ando, T;Takahashi, T;Matsuo, K;Hozumi, K;Ito, K;Ema, M;Miyamoto, T;Matsumoto, M;Nakamura, M;Okano, H;Shibata, S;Kohyama, J;Kim, KK;Takubo, K;Kubota, Y; Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis Nature cell biology 2023-10-05 [PMID: 37798545] (IHC, Mouse)	IHC	Mouse
Uçar, MC;Hannezo, E;Tiilikainen, E;Liaqat, I;Jakobsson, E;Nurmi, H;Vaahtomeri, K; Self-organized and directed branching results in optimal coverage in developing dermal lymphatic networks Nature communications 2023-09-21 [PMID: 37735168] (IHC, Mouse)	IHC	Mouse
Jannaway, M;Iyer, D;Mastrogiacomo, DM;Li, K;Sung, DC;Yang, Y;Kahn, ML;Scallan, JP; VEGFR3 is required for button junction formation in lymphatic vessels Cell reports 2023-07-15 [PMID: 37454290] (IHC, Mouse)	IHC	Mouse
Freise, L;Behncke, RY;Allerkamp, HH;Sandermann, TH;Chu, NH;Funk, EM;Hondrich, LJ;Riedel, A;Witzel, C;Hansmeier, NR;Danyel, M;Gellhaus, A;Dechend, R;Hägerling, R; Three-Dimensional Histological Characterization of the Placental Vasculature Using Light Sheet Microscopy Biomolecules 2023-06-17 [PMID: 37371590] (IHC, Mouse)	IHC	Mouse
Ryoko Sato-Nishiuchi, Masamichi Doiguchi, Nanami Morooka, Kiyotoshi Sekiguchi Polydom/SVEP1 binds to Tie1 and promotes migration of lymphatic endothelial cells Journal of Cell Biology 9/4/2023 [PMID: 37338522]
Qi, L;Li, X;Zhang, F;Zhu, X;Zhao, Q;Yang, D;Hao, S;Li, T;Li, X;Tian, T;Feng, J;Sun, X;Wang, X;Gao, S;Wang, H;Ye, J;Cao, S;He, Y;Wang, H;Wei, B; VEGFR-3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection Cell reports 2023-05-10 [PMID: 37167063] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Nithyapriya Shankar, Shyam Thapa, Amrit Kumar Shrestha, Poonam Sarkar, M. Waleed Gaber, Roberto Barrios et al. Hyperoxia Disrupts Lung Lymphatic Homeostasis in Neonatal Mice Antioxidants (Basel) 3/2/2023 [PMID: 36978868]
J Kazenwadel, P Venugopal, A Oszmiana, J Toubia, L Arriola-Ma, V Panara, SG Piltz, C Brown, W Ma, AW Schreiber, K Koltowska, S Taoudi, PQ Thomas, HS Scott, NL Harvey A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature Nature, 2023-01-25;614(7947):343-348. 2023-01-25 [PMID: 36697821] (IHC, Mouse)	IHC	Mouse
Kazuaki Maruyama, Sachiko Miyagawa-Tomita, Yuka Haneda, Mayuko Kida, Fumio Matsuzaki, Kyoko Imanaka-Yoshida et al. The cardiopharyngeal mesoderm contributes to lymphatic vessel development in mouse eLife 10/5/2022 [PMID: 36196867]
K Takahashi, K Abe, SI Kubota, N Fukatsu, Y Morishita, Y Yoshimatsu, S Hirakawa, Y Kubota, T Watabe, S Ehata, HR Ueda, T Shimamura, K Miyazono An analysis modality for vascular structures combining tissue-clearing technology and topological data analysis Nature Communications, 2022-09-12;13(1):5239. 2022-09-12 [PMID: 36097010] (IHC, Mouse)	IHC	Mouse
Ziwen Li, Emmanouil G Solomonidis, Bronwyn Berkeley, Michelle Nga Huen Tang, Katherine Ross Stewart, Daniel Perez-Vicencio et al. Multi-species meta-analysis identifies transcriptional signatures associated with cardiac endothelial responses in the ischaemic heart Cardiovascular Research 3/17/2023 [PMID: 36082978]
Raghu P. Kataru, Hyeung Ju Park, Jinyeon Shin, Jung Eun Baik, Ananta Sarker, Stav Brown et al. Structural and Functional Changes in Aged Skin Lymphatic Vessels Frontiers in Aging 4/4/2022 [PMID: 35821848]
Hao Hu, Yiwen Cui, Jing Yang, Ying Cao Loss of the Sympathetic Signal Produces Sterile Inflammation of the Prostate Frontiers in Molecular Neuroscience 5/10/2022 [PMID: 35620446]
X Li, L Qi, D Yang, S Hao, F Zhang, X Zhu, Y Sun, C Chen, J Ye, J Yang, L Zhao, DM Altmann, S Cao, H Wang, B Wei Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system Nature Neuroscience, 2022-05-06;25(5):577-587. 2022-05-06 [PMID: 35524140] (IHC, Mouse)	IHC	Mouse
Kelly M. Cautivo, Peri R. Matatia, Carlos O. Lizama, Nicholas M. Mroz, Madelene W. Dahlgren, Xiaofei Yu et al. Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation Immunity 2/1/2022 [PMID: 35139352]
Peter Baluk, Donald M. McDonald Imaging Blood Vessels and Lymphatics in Mouse Trachea Wholemounts Methods in Molecular Biology 9/6/2022 [PMID: 35099733]
Sinem Karaman, Satu Paavonsalo, Krista Heinolainen, Madeleine H. Lackman, Amanda Ranta, Karthik A. Hemanthakumar et al. Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance Journal of Experimental Medicine 3/7/2022 [PMID: 35050301]
D Olmeda, D Cerezo-Wal, C Mucientes, TG Calvo, E Cañón, D Alonso-Cur, N Ibarz, J Muñoz, JL Rodriguez-, P Ortiz-Rome, S Ortega, MS Soengas Live imaging of neolymphangiogenesis identifies acute antimetastatic roles of dsRNA mimics Embo Molecular Medicine, 2021-11-11;0(0):e12924. 2021-11-11 [PMID: 34762341] (IHC, Mouse)	IHC	Mouse
E Redder, N Kirschnick, S Bobe, R Hägerling, NR Hansmeier, F Kiefer Vegfr3-tdTomato, a reporter mouse for microscopic visualization of lymphatic vessel by multiple modalities PLoS ONE, 2021-09-20;16(9):e0249256. 2021-09-20 [PMID: 34543279] (IHC, Mouse)	IHC	Mouse
A Chakrabort, R Upadhya, TA Usman, AK Shetty, JM Rutkowski Chronic VEGFR-3 signaling preserves dendritic arborization and sensitization under stress Brain, Behavior, and Immunity, 2021-08-11;0(0):. 2021-08-11 [PMID: 34389489] (IHC, Mouse)	IHC	Mouse
L Cordero-Es, AM Dowbaj, TN Kohler, B Strauss, O Sarlidou, G Belenguer, C Pacini, NP Martins, R Dobie, JR Wilson-Kan, R Butler, N Prior, P Serup, F Jug, NC Henderson, F Hollfelder, M Huch Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation Cell Stem Cell, 2021-08-02;0(0):. 2021-08-02 [PMID: 34343491] (IHC, Mouse)	IHC	Mouse
D Zhang, J Huang, X Sun, H Chen, S Huang, J Yang, X Du, Q Tan, F Luo, R Zhang, S Zhou, W Jiang, Z Ni, Z Wang, M Jin, M Xu, F Li, L Chen, M Liu, N Su, X Luo, L Yin, Y Zhu, JQ Feng, D Chen, H Qi, L Chen, Y Xie Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway Nature Communications, 2021-07-19;12(1):4391. 2021-07-19 [PMID: 34282140] (IHC, Mouse)	IHC	Mouse
Wanshu Ma, Hyea Jin Gil, Xiaolei Liu, Lauren P. Diebold, Marc A. Morgan, Michael J. Oxendine-Burns et al. Mitochondrial respiration controls the Prox1-Vegfr3 feedback loop during lymphatic endothelial cell fate specification and maintenance Science Advances 4/30/2021 [PMID: 33931446]
Yue Sun, Qi Wang, Yi Wang, Wenran Ren, Ying Cao, Jiali Li et al. Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon Protein & Cell 8/1/2021 [PMID: 33871822]
KP Yeo, HY Lim, CH Thiam, SH Azhar, C Tan, Y Tang, WQ See, XH Koh, MH Zhao, ML Phua, A Balachande, Y Tan, SY Lim, HS Chew, LG Ng, V Angeli Efficient aortic lymphatic drainage is necessary for atherosclerosis regression induced by ezetimibe Science Advances, 2020-12-11;6(50):. 2020-12-11 [PMID: 33310846] (IHC, Mouse)	IHC	Mouse
I Tai-Nagara, Y Hasumi, D Kusumoto, H Hasumi, K Okabe, T Ando, F Matsuzaki, F Itoh, H Saya, C Liu, W Li, YS Mukouyama, W Marston Li, X Liu, M Hirashima, Y Suzuki, S Funasaki, Y Satou, M Furuya, M Baba, Y Kubota Blood and lymphatic systems are segregated by the FLCN tumor suppressor Nature Communications, 2020-12-09;11(1):6314. 2020-12-09 [PMID: 33298956] (IHC, Mouse)	IHC	Mouse
Boksik Cha, Yen-Chun Ho, Xin Geng, Md. Riaj Mahamud, Lijuan Chen, Yeunhee Kim et al. YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling Development 12/1/2020 [PMID: 33060128]
SP Hong, MJ Yang, H Cho, I Park, H Bae, K Choe, SH Suh, RH Adams, K Alitalo, D Lim, GY Koh Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi Nat Commun, 2020-08-14;11(1):4102. 2020-08-14 [PMID: 32796823] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
Yifan Wu, Young Jin Seong, Kin Li, Dongwon Choi, Eunkyung Park, George H. Daghlian et al. Organogenesis and distribution of the ocular lymphatic vessels in the anterior eye JCI Insight 7/9/2020 [PMID: 32641580]
X Geng, K Yanagida, RG Akwii, D Choi, L Chen, Y Ho, B Cha, MR Mahamud, K Berman de, H Ichise, H Chen, J Wythe, CM Mikelis, T Hla, RS Srinivasan S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling JCI Insight, 2020-07-23;0(0):. 2020-07-23 [PMID: 32544090] (IHC, Transgenic Mouse)	IHC	Transgenic Mouse
I Martinez-C, Y Zhang, M Petkova, H Ortsäter, S Sjöberg, SD Castillo, P Brouillard, L Libbrecht, D Saur, M Graupera, K Alitalo, L Boon, M Vikkula, T Mäkinen Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation Nat Commun, 2020-06-08;11(1):2869. 2020-06-08 [PMID: 32513927] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
Pieter R Norden, Amélie Sabine, Ying Wang, Cansaran Saygili Demir, Ting Liu, Tatiana V Petrova et al. Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation eLife 6/8/2020 [PMID: 32510325]
Xiaowei Wang, Nanhong Lou, Allison Eberhardt, Yujia Yang, Peter Kusk, Qiwu Xu et al. An ocular glymphatic clearance system removes beta -amyloid from the rodent eye Science Translational Medicine 3/25/2020 [PMID: 32213628]
Kitti Szoták-Ajtay, Dániel Szõke, Gábor Kovács, Judit Andréka, Gábor B. Brenner, Zoltán Giricz et al. Reduced Prenatal Pulmonary Lymphatic Function Is Observed in Clp1 K/K Embryos With Impaired Motor Functions Including Fetal Breathing Movements in Preparation of the Developing Lung for Inflation at Birth Frontiers in Bioengineering and Biotechnology 3/6/2020 [PMID: 32211389]
KL Betterman, DL Sutton, GA Secker, J Kazenwadel, A Oszmiana, L Lim, N Miura, L Sorokin, BM Hogan, ML Kahn, H McNeill, NL Harvey Atypical cadherin Fat4 orchestrates lymphatic endothelial cell polarity in response to flow J. Clin. Invest., 2020-06-01;0(0):. 2020-06-01 [PMID: 32182215] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
Eric Engelbrecht, Michel V Levesque, Liqun He, Michael Vanlandewijck, Anja Nitzsche, Hira Niazi et al. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta eLife 2/24/2020 [PMID: 32091396]
Sivaraj KK, Dharmalingam B, Mohanakrishnan V et al. YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells Elife 1/20/2020 [PMID: 31958058]
Daniyal J Jafree, Dale Moulding, Maria Kolatsi-Joannou, Nuria Perretta Tejedor, Karen L Price, Natalie J Milmoe et al. Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease eLife 12/6/2019 [PMID: 31808745]
Shibata-Germanos S, Goodman JR, Grieg A et al. Structural and functional conservation of non-lumenized lymphatic endothelial cells in the mammalian leptomeninges Acta Neuropathol. 11/6/2019 [PMID: 31696318]
Hasina Outtz Outtz Reed, Liqing Wang, Mark L. Kahn, Wayne W. Hancock Donor-host Lymphatic Anastomosis After Murine Lung Transplantation Transplantation 3/1/2020 [PMID: 31688808]
Md. Riaj Mahamud, Xin Geng, Yen-Chun Ho, Boksik Cha, Yuenhee Kim, Jing Ma et al. GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126 Development 11/1/2019 [PMID: 31582413]
TA Norman, AC Gower, F Chen, A Fine Transcriptional landscape of pulmonary lymphatic endothelial cells during fetal gestation PLoS ONE, 2019-05-13;14(5):e0216795. 2019-05-13 [PMID: 31083674] (IHC-P, Mouse)	IHC-P	Mouse
A Zarjou, LM Black, S Bolisetty, AM Traylor, SA Bowhay, MZ Zhang, RC Harris, A Agarwal Dynamic signature of lymphangiogenesis during acute kidney injury and chronic kidney disease Lab. Invest., 2019-04-24;0(0):. 2019-04-24 [PMID: 31019289] (IHC-P, Western Blot, Mouse)	IHC-P, Western Blot	Mouse
HO Reed, L Wang, J Sonett, M Chen, J Yang, L Li, P Aradi, Z Jakus, J D'Armiento, WW Hancock, ML Kahn Lymphatic impairment leads to pulmonary tertiary lymphoid organ formation and alveolar damage J. Clin. Invest., 2019-04-04;129(6):2514-2526. 2019-04-04 [PMID: 30946031] (IHC-P, Mouse)	IHC-P	Mouse
M Hsu, A Rayasam, JA Kijak, YH Choi, JS Harding, SA Marcus, WJ Karpus, M Sandor, Z Fabry Neuroinflammation-induced lymphangiogenesis near the cribriform plate contributes to drainage of CNS-derived antigens and immune cells Nat Commun, 2019-01-16;10(1):229. 1/16/2019 [PMID: 30651548]
Sofia Urner, Lara Planas‐Paz, Laura Sophie Hilger, Carina Henning, Anna Branopolski, Molly Kelly‐Goss et al. Identification of ILK as a critical regulator of VEGFR 3 signalling and lymphatic vascular growth The EMBO Journal 1/15/2019 [PMID: 30518533]
Gregory Farber, Matthew M. Parks, Nicole Lustgarten Guahmich, Yi Zhang, Sébastien Monette, Scott C. Blanchard et al. ADAM10 controls the differentiation of the coronary arterial endothelium Angiogenesis 5/1/2019 [PMID: 30446855]
DJ Crona, AD Skol, VM Leppänen, DM Glubb, AS Etheridge, E Hilliard, CE Peña, YK Peterson, N Klauber-De, KK Alitalo, F Innocenti Genetic variants of VEGFA and FLT4 are determinants of survival in renal cell carcinoma patients treated with sorafenib Cancer Res., 2018-11-01;0(0):. 11/1/2018 [PMID: 30385613]
B Cha, X Geng, MR Mahamud, JY Zhang, L Chen, W Kim, EH Jho, Y Kim, D Choi, JB Dixon, H Chen, YK Hong, L Olson, TH Kim, BJ Merrill, MJ Davis, RS Srinivasan Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/?-Catenin Signaling Cell Rep, 2018-10-16;25(3):571-584.e5. 2018-10-16 [PMID: 30332639] (IHC, Mouse)	IHC	Mouse
René Hägerling, Esther Hoppe, Cathrin Dierkes, Martin Stehling, Taija Makinen, Stefan Butz et al. Distinct roles of VE ‐cadherin for development and maintenance of specific lymph vessel beds The EMBO Journal 11/15/2018 [PMID: 30297530]
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Le Bras B, Barallobre MJ, Homman-Ludiye J, Ny A, Wyns S, Tammela T, Haiko P, Karkkainen MJ, Yuan L, Muriel MP, Chatzopoulou E, Breant C, Zalc B, Carmeliet P, Alitalo K, Eichmann A, Thomas JL VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nat. Neurosci., 2006-02-05;9(3):340-8. 2006-02-05 [PMID: 16462734] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Fedele C, Berens D, Rautenfeld V, Pabst R Desmoplakin and Plakoglobin--specific markers of lymphatic vessels in the skin? Anat Histol Embryol, 2004-06-01;33(3):168-71. 2004-06-01 [PMID: 15144286] (IHC, Equine)	IHC	Equine
Ruddell A, Mezquita P, Brandvold KA, Farr A, Iritani BM B lymphocyte-specific c-Myc expression stimulates early and functional expansion of the vasculature and lymphatics during lymphomagenesis. Am. J. Pathol., 2003-12-01;163(6):2233-45. 2003-12-01 [PMID: 14633598] (ICC, Mouse)	ICC	Mouse
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Reviews for VEGFR3/Flt-4 Antibody (AF743) (3) 43

Average Rating: 4

(Based on 3 reviews)

We have 3 reviews tested in 1 species: Mouse.

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reviewed by:
Verified Customer

Mouse

01/09/2015

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Application	Western Blot
Sample Tested	See PMID 19901262
Species	Mouse

reviewed by:
Verified Customer

IHC-Fr

Mouse

01/09/2015

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Application	Immunohistochemistry-Frozen
Sample Tested	See PMID 23878309
Species	Mouse

reviewed by:
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Mouse

01/09/2015

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Application	Immunofluorescence
Sample Tested	See PMID 19901262
Species	Mouse

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SH-SY5Y human neuroblastoma cell line was stained with Goat Anti-Human/Mouse/RatEphrin-B2 Antigen Affinity-purified Polyclonal Antibody (Catalog #AF496,filled histogram) or Normal Goat IgG Isotype Control Antibody(Catalog # AB-108-C, open histogram), followed by Phycoerythrin-conjugatedAnti-Goat IgG Secondary Antibody (Catalog #F0107).

Goat IgG Isotype Control [Unconjugated]
AB-108-C

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	Verified Customer 01/09/2015
Application:	WB
Species:	Mouse

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	Verified Customer 01/09/2015
Application:	IHC-Fr
Species:	Mouse

read this review

	Verified Customer 01/09/2015
Application:	IF
Species:	Mouse

read this review

Bioinformatics

Gene Symbol	FLT4
Uniprot	P35917()

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

VEGFR3/Flt-4 Antibody [Unconjugated]

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Publications for VEGFR3/Flt-4 Antibody (AF743)(140)

Reviews for VEGFR3/Flt-4 Antibody (AF743) (3) 43

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