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VEGFR2/KDR/Flk-1 Antibody (89106) [Allophycocyanin]

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HUVEC human umbilical vein endothelial cells were stained with Mouse Anti-Human VEGF R2/KDR/Flk-1 APC-conjugated Mono-clonal Antibody (Catalog # FAB357A, filled histogram) or isotype control antibody (Catalog # IC002A, ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
89106
Clonality
Monoclonal
Host
Mouse
Conjugate
Allophycocyanin

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VEGFR2/KDR/Flk-1 Antibody (89106) [Allophycocyanin] Summary

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human VEGF R2/KDR/Flk-1
Ala20-Glu764
Accession # P35968
Specificity
Detects human VEGF R2/KDR/Flk-1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) VEGF R1, rhVEGF R3 or recombinant mouse VEGF R2 is observed.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
KDR
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 10 uL/10^6 cells
Publications
Read Publications using
FAB357A in the following applications:

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for VEGFR2/KDR/Flk-1 Antibody (89106) [Allophycocyanin]

  • CD309 antigen
  • CD309
  • EC 2.7.10
  • EC 2.7.10.1
  • Fetal liver kinase 1
  • fetal liver kinase-1
  • Flk1
  • Flk-1
  • FLK1tyrosine kinase growth factor receptor
  • KDR
  • kinase insert domain receptor (a type III receptor tyrosine kinase)
  • Kinase insert domain receptor
  • KRD1
  • Ly73
  • Protein-tyrosine kinase receptor flk-1
  • soluble VEGFR2
  • vascular endothelial growth factor receptor 2
  • VEGF R2
  • VEGFR
  • VEGFR2
  • VEGFR-2

Background

VEGF R2 (KDR/Flk-1), VEGF R1 (Flt-1) and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domains and kinase insert domains in their intracellular regions. The expression of VEGF R1, 2, and 3 is almost exclusively restricted to the endothelial cells. These receptors are likely to play essential roles in vasculogenesis and angiogenesis. Mature VEGF R2 is composed of a 745 aa extracellular domain, a 25 aa transmembrane domain and a 567 aa cytoplasmic domain. In contrast to VEGF R1 which binds both PlGF and VEGF with high affinity, VEGF R2 binds VEGF but not PlGF with high affinity. The recombinant soluble VEGF R2/Fc chimera binds VEGF with high affinity and is a potent VEGF antagonist.

  1. Ferra, N. and R. Davis-Smyth (1997) Endocrine Reviews 18:4.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for VEGFR2/KDR/Flk-1 Antibody (FAB357A)(28)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: Flow Cytometry, Functional Assay, ICC.


Filter By Application
Flow Cytometry
(23)
Functional Assay
(1)
ICC
(2)
All Applications
Filter By Species
Human
(25)
All Species
Showing Publications 1 - 10 of 28. Show All 28 Publications.
Publications using FAB357A Applications Species
Chen, C;Lin, LY;Chen, JW;Chang, TT; CXCL5 suppression recovers neovascularization and accelerates wound healing in diabetes mellitus Cardiovascular diabetology 2023-07-07 [PMID: 37420254] (Flow Cytometry, Human) Flow Cytometry Human
X Wang, W Chen, W Lao, Y Chen Upregulation of PCED1B-AS1 in proliferative diabetic retinopathy and its involvement in retinal vascular endothelial cell proliferation BMC ophthalmology, 2022-11-23;22(1):450. 2022-11-23 [PMID: 36418980] (Flow Cytometry, Human) Flow Cytometry Human
CS Kuo, CY Chen, HL Huang, HY Tsai, RH Chou, JH Wei, PH Huang, SJ Lin Melatonin Improves Ischemia-Induced Circulation Recovery Impairment in Mice with Streptozotocin-Induced Diabetes by Improving the Endothelial Progenitor Cells Functioning International Journal of Molecular Sciences, 2022-08-30;23(17):. 2022-08-30 [PMID: 36077238] (ICC, Human) ICC Human
AC Ponsen, R Proust, S Soave, F Mercier-No, I Garcin, L Combettes, JJ Lataillade, G Uzan A new hemostatic agent composed of Zn2+-enriched Ca2+ alginate activates vascular endothelial cells in vitro and promotes tissue repair in vivo Bioactive materials, 2022-02-12;18(0):368-382. 2022-02-12 [PMID: 35415309] (Flow Cytometry, Human) Flow Cytometry Human
S Di Franco, P Bianca, DS Sardina, A Turdo, M Gaggianesi, V Veschi, A Nicotra, LR Mangiapane, M Lo Iacono, I Pillitteri, S van Hooff, F Martorana, G Motta, E Gulotta, VL Lentini, E Martorana, ME Fiori, S Vieni, MR Bongiorno, G Giannone, D Giuffrida, L Memeo, L Colarossi, M Mare, P Vigneri, M Todaro, R De Maria, JP Medema, G Stassi Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery Nature Communications, 2021-08-18;12(1):5006. 2021-08-18 [PMID: 34408135] (Flow Cytometry, Human) Flow Cytometry Human
L Zilberman, A Zalik, I Fugenfirov, S Shimoni, J George, S Goland Residual alterations of cardiac and endothelial function in patients who recovered from Takotsubo cardiomyopathy Clinical cardiology, 2021-05-06;0(0):. 2021-05-06 [PMID: 33955558] (Flow Cytometry, Human) Flow Cytometry Human
T Toya, I Ozcan, MT Corban, JD Sara, EV Marietta, A Ahmad, IE Horwath, DL Loeffler, JA Murray, LO Lerman, A Lerman Compositional change of gut microbiome and osteocalcin expressing endothelial progenitor cells in patients with coronary artery disease PLoS ONE, 2021-03-25;16(3):e0249187. 2021-03-25 [PMID: 33765061] (Flow Cytometry, Human) Flow Cytometry Human
F Lopes-Coel, F Silva, S Gouveia-Fe, C Martins, N Lopes, G Domingues, C Brito, AM Almeida, SA Pereira, J Serpa Monocytes as Endothelial Progenitor Cells (EPCs), Another Brick in the Wall to Disentangle Tumor Angiogenesis Cells, 2020-01-01;9(1):. 2020-01-01 [PMID: 31906296] (Flow Cytometry, Human) Flow Cytometry Human
HX Sun, GJ Li, ZH Du, Z Bing, ZX Ji, G Luo, SL Pan The relationship between endothelial progenitor cells and pulmonary arterial hypertension in children with congenital heart disease BMC Pediatr, 2019-12-17;19(1):502. 2019-12-17 [PMID: 31847901] (Flow Cytometry, Human) Flow Cytometry Human
TC Wu, JS Chen, CH Wang, PH Huang, FY Lin, LY Lin, SJ Lin, JW Chen Activation of heme oxygenase-1 by Ginkgo biloba extract differentially modulates endothelial and smooth muscle-like progenitor cells for vascular repair Sci Rep, 2019-11-21;9(1):17316. 2019-11-21 [PMID: 31754254] (ICC, Human) ICC Human
Show All 28 Publications.

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Bioinformatics

Gene Symbol KDR
Uniprot