Total BDNF Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

BDNF (Brain-Derived Neurotrophic Factor) is a secreted protein that regulates many aspects of neuronal development and function in the nervous system. It is produced as proBDNF in response to neuronal activity or inflammatory stimulation and is then cleaved before associating into a homodimer. It is expressed throughout the nervous system as well as by fibroblasts, megakaryocytes/platelets, and smooth muscle cells. BDNF regulates neural stem cell survival and differentiation, axon/dendrite differentiation, synapse formation and maturation, and refinement of developing circuits. It is also a key regulator of synaptic plasticity and late-phase long-term potentiation. BDNF signals through the TrkB and NGF R/TNFRSF16 receptors. Secreted proBDNF can bind to NGF R/TNFRSF16 and induce long-term depression and cell apoptosis.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

Showing Publications 1 - 10 of 46. Show All 46 Publications. Collapse Publications.

Publications using DBNT00	Applications	Species
Rabelo, TK;Campos, ACP;Almeida Souza, TH;Mahmud, F;Popovic, MR;Covolan, L;Betta, VC;DaCosta, L;Lipsman, N;Diwan, M;Hamani, C; Deep brain stimulation mitigates memory deficits in a rodent model of traumatic brain injury Brain stimulation 2024-10-15 [PMID: 39419474] (Rat)		Rat
Salamanca-Fernández, E;Espín-Moreno, L;Olivas-Martínez, A;Pérez-Cantero, A;Martín-Rodríguez, JL;Poyatos, RM;Barbone, F;Rosolen, V;Mariuz, M;Ronfani, L;Palkovi?ová Murínová, ?;Fábelová, L;Szigeti, T;Kakucs, R;Sakhi, AK;Haug, LS;Lindeman, B;Snoj Tratnik, J;Kosjek, T;Jacobs, G;Voorspoels, S;Jurdáková, H;Górová, R;Petrovi?ová, I;Kolena, B;Esteban, M;Pedraza-Díaz, S;Kolossa-Gehring, M;Remy, S;Govarts, E;Schoeters, G;Fernández, MF;Mustieles, V; Associations between Urinary Phthalate Metabolites with BDNF and Behavioral Function among European Children from Five HBM4EU Aligned Studies Toxics 2024-08-31 [PMID: 39330570] (Human)		Human
Liang, CL;Yen, CY;Wang, HK;Tsai, YD;Chye, CL;Wang, KW; Intramuscular Pulsed Radiofrequency Upregulates BNDF-TrKB Expression in the Spinal Cord in Rats as an Alternative Treatment for Complicated Pain International journal of molecular sciences 2024-06-29 [PMID: 39000303] (Rat)		Rat
Kang, D;Koh, S;Kim, T;Bressel, E;Kim, D; Circuit Training Improves the Levels of ?-Amyloid and Brain-Derived Neurotrophic Factor Related to Cognitive Impairment Risk Factors in Obese Elderly Korean Women Journal of clinical medicine 2024-01-30 [PMID: 38337492] (Human)		Human
Driskill, CM;Childs, JE;Phensy, AJ;Rodriguez, SR;O'Brien, JT;Lindquist, KL;Naderi, A;Bordieanu, B;McGinty, JF;Kroener, S; Vagus nerve stimulation (VNS) modulates synaptic plasticity in the rat infralimbic cortex via Trk-B receptor activation to reduce drug-seeking bioRxiv : the preprint server for biology 2024-01-26 [PMID: 38328140] (Rat)		Rat
Lin, TC;Tsai, YC;Chen, YA;Young, TH;Wu, CC;Chiang, YH;Kao, CH;Huang, AP;Hsu, YH;Chen, KY;Tsai, LK; Brain-derived neurotrophic factor contributes to neurogenesis after intracerebral hemorrhage: a rodent model and human study Frontiers in cellular neuroscience 2023-05-11 [PMID: 37252187] (Rat, Human)		Rat, Human
Y Moon, E Lee, S Lee, GI Son, H Byeon, HR Shin, B Bolortsets Changes in cortisol awakening responses (CAR) in menopausal women through short-term marine healing retreat program with specific factors affecting each CAR index PLoS ONE, 2023-04-19;18(4):e0284627. 2023-04-19 [PMID: 37075032] (Human)		Human
Y Moon, E Lee, S Lee, GI Son, H Byeon, HR Shin, B Bolortsets Changes in cortisol awakening responses (CAR) in menopausal women through short-term marine healing retreat program with specific factors affecting each CAR index PLoS ONE, 2023;18(4):e0284627. 2023 [PMID: 37075032] (Human)		Human
M Chroboczek, S Kujach, M ?uszczyk, H Soya, R Laskowski Exercise-Induced Elevated BDNF Concentration Seems to Prevent Cognitive Impairment after Acute Exposure to Moderate Normobaric Hypoxia among Young Men International Journal of Environmental Research and Public Health, 2023-02-18;20(4):. 2023-02-18 [PMID: 36834322] (Human)		Human
DA Formolo, TH Lee, J Yu, K Lin, G Chen, GS Kranz, SY Yau Increasing Adiponectin Signaling by Sub-Chronic AdipoRon Treatment Elicits Antidepressant- and Anxiolytic-Like Effects Independent of Changes in Hippocampal Plasticity Biomedicines, 2023-01-18;11(2):. 2023-01-18 [PMID: 36830788] (Mouse)		Mouse
AJ Al Omran, S Watanabe, EC Hong, SG Skinner, M Zhang, J Zhang, XM Shao, J Liang Dihydromyricetin ameliorates social isolation-induced anxiety by modulating mitochondrial function, antioxidant enzymes, and BDNF Neurobiology of stress, 2022-10-30;21(0):100499. 2022-10-30 [PMID: 36532369] (Mouse)		Mouse
S Takamiya, M Kawabori, K Yamazaki, S Yamaguchi, A Tanimori, K Yamamoto, S Ohnishi, T Seki, K Konno, KK Tha, D Hashimoto, M Watanabe, K Houkin, M Fujimura Intravenous transplantation of amnion-derived mesenchymal stem cells promotes functional recovery and alleviates intestinal dysfunction after spinal cord injury PLoS ONE, 2022-07-08;17(7):e0270606. 2022-07-08 [PMID: 35802703] (Rat)		Rat
JL Wu, SL Yang, YC Ho, CH Chen, BR Tasi, MC Lee, BY Chen The Functional Vision Restorative Effect of Crocin via the BDNF-TrkB Pathway: An In Vivo Study Nutrients, 2022-04-20;14(9):. 2022-04-20 [PMID: 35565684] (Mouse)		Mouse
SY Jung, YE Kim, WS Park, SY Ahn, DK Sung, SI Sung, KM Joo, SG Kim, YS Chang Thrombin Preconditioning Improves the Therapeutic Efficacy of Mesenchymal Stem Cells in Severe Intraventricular Hemorrhage Induced Neonatal Rats International Journal of Molecular Sciences, 2022-04-18;23(8):. 2022-04-18 [PMID: 35457266] (Rat)		Rat
A Rodríguez-, V Mustieles, SC D'Cruz, L Legoff, F Gil, P Olmedo, I Reina-Pére, A Mundo, M Molina, F Smagulova, A David, C Freire, MF Fernández Exploring the relationship between metal exposure, BDNF, and behavior in adolescent males Oncogene, 2021-10-28;239(0):113877. 2021-10-28 [PMID: 34757248] (Human)		Human
KM Crombie, A Sartin-Tar, K Sellnow, R Ahrenholtz, S Lee, M Matalamaki, NE Almassi, CJ Hillard, KF Koltyn, TG Adams, JM Cisler Exercise-induced increases in Anandamide and BDNF during extinction consolidation contribute to reduced threat following reinstatement: Preliminary evidence from a randomized controlled trial Psychoneuroendocrinology, 2021-07-09;132(0):105355. 2021-07-09 [PMID: 34280820] (Human)		Human
R Li, C Ma, Y Xiong, H Zhao, Y Yang, L Xue, B Wang, T Xiao, J Chen, X Lei, B Ma, J Zhang An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced Depression through the Hypothalamic-Pituitary-Ovarian Axis Biomolecules, 2021-06-09;11(6):. 2021-06-09 [PMID: 34207497] (Mouse)		Mouse
N Sultan, LE Amin, AR Zaher, ME Grawish, BA Scheven Dental pulp stem cells stimulate neuronal differentiation of PC12 cells Neural regeneration research, 2021-09-01;16(9):1821-1828. 2021-09-01 [PMID: 33510089] (Rat)		Rat
GR Chai, S Liu, HW Yang, XL Chen Quercetin protects against diabetic retinopathy in rats by inducing heme oxygenase-1 expression Neural regeneration research, 2021-07-01;16(7):1344-1350. 2021-07-01 [PMID: 33318415] (Rat)		Rat
R Zilkha-Fal, T Rachutin-Z, L Cleaver, M Gurevich, A Achiron RAM-589.555 favors neuroprotective and anti-inflammatory profile of CNS-resident glial cells in acute relapse EAE affected mice J Neuroinflammation, 2020-10-21;17(1):313. 2020-10-21 [PMID: 33081798] (Mouse)		Mouse
JP Sanabria-M, J Montero-Ma, A Feliu-Sole, V Gasión, M Navarro-Gi, H Morillo-Sa, A Colomer-Ca, X Borràs, M Tops, JV Luciano, J García-Cam Mindfulness-Based Program Plus Amygdala and Insula Retraining (MAIR) for the Treatment of Women with Fibromyalgia: A Pilot Randomized Controlled Trial J Clin Med, 2020-10-11;9(10):. 2020-10-11 [PMID: 33050630] (Human)		Human
MD Pinazo-Dur, JJ García-Med, JM Bolarín, SM Sanz-Gonzá, M Valero-Vel, J Abellán-Ab, V Zanón-More, J Moreno-Mon Computational Analysis of Clinical and Molecular Markers and New Theranostic Possibilities in Primary Open-Angle Glaucoma Journal of Clinical Medicine, 2020-09-21;9(9):. 2020-09-21 [PMID: 32967086] (Human)		Human
RA Williams, SB Cooper, KJ Dring, L Hatch, JG Morris, C Sunderland, ME Nevill Effect of football activity and physical fitness on information processing, inhibitory control and working memory in adolescents BMC Public Health, 2020-09-14;20(1):1398. 2020-09-14 [PMID: 32928161] (Human)		Human
W Stevenson, Y Hase, E Wilson, A Hollins, M Hase, A Ennaceur, L Craggs, M Ihara, K Horsburgh, RN Kalaria Long-term effects of experimental carotid stenosis on hippocampal infarct pathology, neurons and glia and amelioration by environmental enrichment Brain Res. Bull., 2020-07-21;163(0):72-83. 2020-07-21 [PMID: 32707262] (Mouse)		Mouse
TW Kim, SS Park, JY Park, HS Park Infusion of Plasma from Exercised Mice Ameliorates Cognitive Dysfunction by Increasing Hippocampal Neuroplasticity and Mitochondrial Functions in 3xTg-AD Mice Int J Mol Sci, 2020-05-06;21(9):. 2020-05-06 [PMID: 32384696] (Mouse)		Mouse
Y Geng, Y Chen, W Sun, Y Gu, Y Zhang, M Li, J Xie, X Tian Electroacupuncture Ameliorates Cerebral I/R-Induced Inflammation through DOR-BDNF/TrkB Pathway Evid Based Complement Alternat Med, 2020-03-16;2020(0):3495836. 2020-03-16 [PMID: 32256638] (Rat)		Rat
JH Kim, BK Jeong, SJ Jang, JW Yun, MH Jung, KM Kang, TG Kim, SH Woo Alpha-Lipoic Acid Ameliorates Radiation-Induced Salivary Gland Injury by Preserving Parasympathetic Innervation in Rats Int J Mol Sci, 2020-03-25;21(7):. 2020-03-25 [PMID: 32218158] (Rat)		Rat
L Guéniot, V Lepere, GF De Medeiro, A Danckaert, P Flamant, M Le Dudal, O Langeron, PL Goossens, F Chrétien, G Jouvion Muscle Injury Induces Postoperative Cognitive Dysfunction Sci Rep, 2020-02-17;10(1):2768. 2020-02-17 [PMID: 32066806] (Mouse)		Mouse
J Kubica, J Szymura, A Domagalik, S Golda, M Wiecek, M Fafrowicz, T Marek, J Pera Systematic Balance Exercises Influence Cortical Activation and Serum BDNF Levels in Older Adults J Clin Med, 2019-11-07;8(11):. 2019-11-07 [PMID: 31703409] (Human)		Human
B Tian, C Yang, J Wang, X Hou, S Zhao, Y Li, P Yang Peripheral blood brain-derived neurotrophic factor level and tyrosine kinase B expression on T lymphocytes in systemic lupus erythematosus: Implications for systemic involvement Cytokine, 2019-06-27;123(0):154764. 2019-06-27 [PMID: 31255912] (Human)		Human
Y Martín-Mar, L Fernández-, MH Sanchez-Re, N Marí-Buyé, FJ Rojo, J Pérez-Rigu, M Ramos, GV Guinea, F Panetsos, D González-N Evaluation of Neurosecretome from Mesenchymal Stem Cells Encapsulated in Silk Fibroin Hydrogels Sci Rep, 2019-06-19;9(1):8801. 2019-06-19 [PMID: 31217546] (Mouse)		Mouse
P Bortoluzzi, D Casagrande, N Dos Santos, K Ugioni Sim, C Mendes, ME Anastácio, PC Lock Silve, A Pastoris M Insulin treatment protects the brain against neuroinflammation by reducing cerebral cytokines and modulating mitochondrial function Brain Res. Bull., 2019-04-16;0(0):. 2019-04-16 [PMID: 31002914] (Rat)		Rat
C Danesi, VS Achuta, P Corcoran, UK Peteri, G Turconi, N Matsui, I Albayrak, V Rezov, A Isaksson, ML Castrén Increased Calcium Influx through L-type Calcium Channels in Human and Mouse Neural Progenitors Lacking Fragile X Mental Retardation Protein Stem Cell Reports, 2018-11-29;0(0):. 2018-11-29 [PMID: 30503263] (Human)		Human
K Kin, T Yasuhara, M Kameda, Y Tomita, M Umakoshi, K Kuwahara, I Kin, N Kidani, J Morimoto, M Okazaki, T Sasaki, N Tajiri, CV Borlongan, I Date Cell encapsulation enhances antidepressant effect of the mesenchymal stem cells and counteracts depressive-like behavior of treatment-resistant depressed rats Mol. Psychiatry, 2018-08-14;0(0):. 2018-08-14 [PMID: 30108315] (Rat)		Rat
K Saitoh, R Furihata, Y Kaneko, M Suzuki, S Takahashi, M Uchiyama Association of serum BDNF levels and the BDNF Val66Met polymorphism with the sleep pattern in healthy young adults PLoS ONE, 2018-06-26;13(6):e0199765. 2018-06-26 [PMID: 29944703] (Human)		Human
YS Tao, SG Piao, YS Jin, JZ Jin, HL Zheng, HY Zhao, SW Lim, CW Yang, C Li Expression of brain-derived neurotrophic factor in kidneys from normal and cyclosporine-treated rats BMC Nephrol, 2018-03-14;19(1):63. 2018-03-14 [PMID: 29540150] (Rat)		Rat
N Brondino, L Fusar-Poli, M Rocchetti, F Bertoglio, N Bloise, L Visai, P Politi BDNF levels are associated with autistic traits in the general population Psychoneuroendocrinology, 2018-01-09;89(0):131-133. 2018-01-09 [PMID: 29414026] (Human)		Human
JH Kim, DY Kim Aquarobic exercises improve the serum blood irisin and brain-derived neurotrophic factor levels in elderly women Exp. Gerontol., 2018-02-06;104(0):60-65. 2018-02-06 [PMID: 29408452] (Human)		Human
Byiers B, Barney C, Ehrhardt M, Panoskaltsis-Mortari A, Feyma T, Beisang A, Symons F Initial Observations of Salivary Brain-Derived Neurotrophic Factor Levels in Rett Syndrome. Pediatr Neurol, 2017-12-08;80(0):88-89. 2017-12-08 [PMID: 29373156] (Human)		Human
C Yin, X Qi Pregnancy promotes pituitary tumors by increasing the rate of the cell cycle Oncol Lett, 2017-08-16;14(4):4873-4877. 2017-08-16 [PMID: 29085495] (Mouse)		Mouse
T Nomura, TF Musial, JJ Marshall, Y Zhu, CL Remmers, J Xu, DA Nicholson, A Contractor Delayed Maturation of Fast-Spiking Interneurons is Rectified by Activation of the TrkB Receptor in the Mouse Model of Fragile X Syndrome J. Neurosci., 2017-10-16;0(0):. 2017-10-16 [PMID: 29038238] (Mouse)		Mouse
MA Stefani, R Modkovski, G Hansel, ER Zimmer, A Kopczynski, AP Muller, NR Strogulski, MS Rodolphi, RK Carteri, AP Schmidt, JP Oses, DH Smith, LV Portela Elevated glutamate and lactate predict brain death after severe head trauma Ann Clin Transl Neurol, 2017-05-04;4(6):392-402. 2017-05-04 [PMID: 28589166] (Human)		Human
AÖ Sungur, MCE Jochner, H Harb, A K?l?ç, H Garn, RKW Schwarting, M Wöhr Aberrant cognitive phenotypes and altered hippocampal BDNF expression related to epigenetic modifications in mice lacking the post-synaptic scaffolding protein SHANK1: Implications for autism spectrum disorder Hippocampus, 2017-05-29;0(0):. 2017-05-29 [PMID: 28500650] (Mouse)		Mouse
G Marwarha, K Claycombe-, J Schommer, O Ghribi Maternal low-protein diet decreases brain-derived neurotrophic factor expression in the brains of the neonatal rat offspring J. Nutr. Biochem., 2017-04-06;45(0):54-66. 2017-04-06 [PMID: 28432877] (Rat)		Rat
SW Saliba, EL Vieira, RP Santos, E Candelario, BL Fiebich, LB Vieira, AL Teixeira, AC de Oliveir Neuroprotective effects of intrastriatal injection of rapamycin in a mouse model of excitotoxicity induced by quinolinic acid J Neuroinflammation, 2017-01-31;14(1):25. 2017-01-31 [PMID: 28143498] (Mouse)		Mouse
Xiao-Su Yang Involvement of BDNF/TrkB and ERK/CREB axes in nitroglycerin-induced rat migraine and effects of estrogen on these signals in the migraine Biol Open, 2017-01-15;0(0):. 2017-01-15 [PMID: 27875242] (Rat)		Rat
Show All 46 Publications. Collapse Publications.

Array DBNT00

• BDNF Antibodies
• BDNF ELISA Kits
• BDNF Lysates
• BDNF Proteins
• BDNF ELISAs
• BDNF Proteins and Enzymes