Recombinant Human GDNF Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Glial Cell Line-derived Neurotrophic Factor (GDNF) is a neurotrophic factor that has been shown to promote the survival of various neuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of their development. Neuronal subpopulations that have been shown to be affected by GDNF include motoneurons, midbrain dopaminergic neurons, Purkinje cells and sympathetic neurons.

Native GDNF, a disulfide-linked homodimeric glycoprotein, is a novel member of the TGF-beta  superfamily. Human GDNF cDNA encodes a 211 amino acid residue prepropeptide that is processed to yield a dimeric protein. Mature human GDNF was predicted to contain two 134 amino acid residue subunits. NS0 expressed mature human GDNF lacks 31 residues from the amino-terminus of the predicted sequence. This glycosylated recombinant mature human GDNF still contains the seven conserved Cys residues found in all members of the TGF-beta superfamily and is biologically active. The GDNF sequence contains two potential glycosylation sites and insect cell‑expressed recombinant rat GDNF proteins are glycosylated. Mature rat and human GDNF exhibit approximately 93% amino acid sequence identity and show considerable species cross-reactivity. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells.

We have publications tested in 15 confirmed species: Human, Mouse, Rat, Bacteria, Canine, Chicken, Goat, Guinea Pig, N/A, Porcine, Primate, Primate - Macaca mulatta (Rhesus Macaque), Rabbit, Synthetic, Transgenic Mouse.

We have publications tested in 7 applications: Bioassay, Cell Culture, Differentiation, ELISA (Capture), In Vivo, In vitro, Surface Plasmon Resonance.

Showing Publications 1 - 10 of 218. Show All 218 Publications. Collapse Publications.

Publications using 212-GD	Applications	Species
Souza, LRQ;Pedrosa, CGDS;Puig-Pijuan, T;da Silva Dos Santos, C;Vitória, G;Delou, JMA;Setti-Perdigão, P;Higa, LM;Tanuri, A;Rehen, SK;Guimarães, MZP; Saxitoxin potentiates human neuronal cell death induced by Zika virus while sparing neural progenitors and astrocytes Scientific reports 2024-10-01 [PMID: 39354036] (Bioassay, Human)	Bioassay	Human
Pokharel, PV;Newchurch, AM;Overby, SC;Spease, CA;Darzi, LG;Kraemer, BR; LM11a-31 Inhibits p75 Neurotrophin Receptor (p75 NTR ) Cleavage and is Neuroprotective in a Cell Culture Model of Parkinson's Disease bioRxiv : the preprint server for biology 2024-09-13 [PMID: 39314373] (Bioassay, Human)	Bioassay	Human
Fernandez Garcia, M;Retallick-Townsley, K;Pruitt, A;Davidson, E;Dai, Y;Fitzpatrick, SE;Sen, A;Cohen, S;Livoti, O;Khan, S;Dossou, G;Cheung, J;Deans, PJM;Wang, Z;Huckins, L;Hoffman, E;Brennand, K; Dynamic convergence of autism disorder risk genes across neurodevelopment bioRxiv : the preprint server for biology 2024-08-24 [PMID: 39229156] (Bioassay, Human)	Bioassay	Human
Costa, MFD;Rösler, TW;Höglinger, GU; Exploring the neuroprotective potential of Nrf2-pathway activators against annonacin toxicity Scientific reports 2024-08-29 [PMID: 39209951] (Bioassay, Human)	Bioassay	Human
Khampang, S;Lorthongpanich, C;Laowtammathron, C;Klaihmon, P;Meesa, S;Suksomboon, W;Jiamvoraphong, N;Kheolamai, P;Luanpitpong, S;Easley, CA;Mahyari, E;Issaragrisil, S; The dynamic expression of YAP is essential for the development of male germ cells derived from human embryonic stem cells Scientific reports 2024-07-08 [PMID: 38977826] (Bioassay, Human)	Bioassay	Human
Werren, EA;Peirent, ER;Jantti, H;Guxholli, A;Srivastava, KR;Orenstein, N;Narayanan, V;Wiszniewski, W;Dawidziuk, M;Gawlinski, P;Umair, M;Khan, A;Khan, SN;Geneviève, D;Lehalle, D;van Gassen, KLI;Giltay, JC;Oegema, R;van Jaarsveld, RH;Rafiullah, R;Rappold, GA;Rabin, R;Pappas, JG;Wheeler, MM;Bamshad, MJ;Tsan, YC;Johnson, MB;Keegan, CE;Srivastava, A;Bielas, SL; Biallelic variants in CSMD1 are implicated in a neurodevelopmental disorder with intellectual disability and variable cortical malformations Cell death & disease 2024-05-30 [PMID: 38816421] (Bioassay, Human)	Bioassay	Human
Renner, N;Schöb, F;Pape, R;Suciu, I;Spreng, AS;Ückert, AK;Cöllen, E;Bovio, F;Chilian, B;Bauer, J;Röpcke, S;Bergemann, J;Leist, M;Schildknecht, S; Modeling ferroptosis in human dopaminergic neurons: Pitfalls and opportunities for neurodegeneration research Redox biology 2024-04-24 [PMID: 38688061] (Bioassay, Human)	Bioassay	Human
Martin, EJ;Santacruz, C;Mitevska, A;Jones, IE;Krishnan, G;Gao, FB;Finan, JD;Kiskinis, E; Traumatic injury causes selective degeneration and TDP-43 mislocalization in human iPSC-derived C9orf72 -associated ALS/FTD motor neurons bioRxiv : the preprint server for biology 2024-03-26 [PMID: 38585915] (Bioassay, Human)	Bioassay	Human
Wang, M;Zhang, L;Novak, SW;Yu, J;Gallina, IS;Xu, LL;Lim, CK;Fernandes, S;Shokhirev, MN;Williams, AE;Saxena, MD;Coorapati, S;Parylak, SL;Quintero, C;Molina, E;Andrade, LR;Manor, U;Gage, FH; Morphological diversification and functional maturation of human astrocytes in glia-enriched cortical organoid transplanted in mouse brain Nature biotechnology 2024-02-28 [PMID: 38418648] (Bioassay, Human)	Bioassay	Human
Liu, J;Prahl, LS;Huang, A;Hughes, AJ; Measurement of adhesion and traction of cells at high yield (MATCHY) reveals an energetic ratchet driving nephron condensation bioRxiv : the preprint server for biology 2024-02-08 [PMID: 38370771] (Bioassay, Canine)	Bioassay	Canine
Zeng, Y;Lovchykova, A;Akiyama, T;Liu, C;Guo, C;Jawahar, VM;Sianto, O;Calliari, A;Prudencio, M;Dickson, DW;Petrucelli, L;Gitler, AD; TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes bioRxiv : the preprint server for biology 2024-01-22 [PMID: 38328059] (Bioassay, Human)	Bioassay	Human
Song, Y;Zhang, X;Desmarais, JA;Nagano, M; Postnatal development of mouse spermatogonial stem cells as determined by immunophenotype, regenerative capacity, and long-term culture-initiating ability: a model for practical applications Scientific reports 2024-01-27 [PMID: 38280889] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
Zholudeva, LV;Fortino, T;Agrawal, A;Vila, OF;Williams, M;McDevitt, T;Lane, MA;Srivastava, D; Human spinal interneurons repair the injured spinal cord through synaptic integration bioRxiv : the preprint server for biology 2024-01-12 [PMID: 38260390] (Bioassay, Human)	Bioassay	Human
Kojima, R;Paslawski, W;Lyu, G;Arenas, E;Zhang, X;Svenningsson, P; Secretome Analyses Identify FKBP4 as a GBA1-Associated Protein in CSF and iPS Cells from Parkinson's Disease Patients with GBA1 Mutations International journal of molecular sciences 2024-01-04 [PMID: 38203854] (Bioassay, Human)	Bioassay	Human
Maimaitili, M;Chen, M;Febbraro, F;Ucuncu, E;Kelly, R;Niclis, JC;Christiansen, JR;Mermet-Joret, N;Niculescu, D;Lauritsen, J;Iannielli, A;Klæstrup, IH;Jensen, UB;Qvist, P;Nabavi, S;Broccoli, V;Nykjær, A;Romero-Ramos, M;Denham, M; Enhanced production of mesencephalic dopaminergic neurons from lineage-restricted human undifferentiated stem cells Nature communications 2023-12-05 [PMID: 38052784] (Bioassay, Human)	Bioassay	Human
Marmolejo-Garza, A;Krabbendam, IE;Luu, MDA;Brouwer, F;Trombetta-Lima, M;Unal, O;O'Connor, SJ;Majerníková, N;Elzinga, CRS;Mammucari, C;Schmidt, M;Madesh, M;Boddeke, E;Dolga, AM; Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis Cell death & disease 2023-11-25 [PMID: 38007529] (Bioassay, Human)	Bioassay	Human
Kovács, T;Halasy, V;Peth?, C;Sz?cs, E;Soós, Á;Dóra, D;de Santa Barbara, P;Faure, S;Stavely, R;Goldstein, AM;Nagy, N; Essential Role of BMP4 Signaling in the Avian Ceca in Colorectal Enteric Nervous System Development International journal of molecular sciences 2023-10-27 [PMID: 37958648] (Bioassay, Chicken)	Bioassay	Chicken
Ortega, JA;Sasselli, IR;Boccitto, M;Fleming, AC;Fortuna, TR;Li, Y;Sato, K;Clemons, TD;Mckenna, ED;Nguyen, TP;Anderson, EN;Asin, J;Ichida, JK;Pandey, UB;Wolin, SL;Stupp, SI;Kiskinis, E; CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiology Science advances 2023-11-10 [PMID: 37948524] (Bioassay, Human)	Bioassay	Human
Ückert, AK;Rütschlin, S;Gutbier, S;Wörz, NC;Miah, MR;Martins, AC;Hauer, I;Holzer, AK;Meyburg, B;Mix, AK;Hauck, C;Aschner, M;Böttcher, T;Leist, M; Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration Environment international 2023-10-01 [PMID: 37797477] (Bioassay, Human)	Bioassay	Human
Tsioras, K;Smith, KC;Edassery, SL;Garjani, M;Li, Y;Williams, C;McKenna, ED;Guo, W;Wilen, AP;Hark, TJ;Marklund, SL;Ostrow, LW;Gilthorpe, JD;Ichida, JK;Kalb, RG;Savas, JN;Kiskinis, E; Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis Cell reports 2023-09-25 [PMID: 37776851] (Cell Culture, Human)	Cell Culture	Human
Lim, CM;González Díaz, A;Fuxreiter, M;Pun, FW;Zhavoronkov, A;Vendruscolo, M; Multiomic prediction of therapeutic targets for human diseases associated with protein phase separation Proceedings of the National Academy of Sciences of the United States of America 2023-10-03 [PMID: 37774095] (Bioassay, Human)	Bioassay	Human
Pan, AL;Audrain, M;Sakakibara, E;Joshi, R;Zhu, X;Wang, Q;Wang, M;Beckmann, ND;Schadt, EE;Gandy, S;Zhang, B;Ehrlich, ME;Salton, SR; Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice bioRxiv : the preprint server for biology 2023-08-25 [PMID: 37662269] (Bioassay, Human)	Bioassay	Human
Mann, JR;McKenna, ED;Mawrie, D;Papakis, V;Alessandrini, F;Anderson, EN;Mayers, R;Ball, HE;Kaspi, E;Lubinski, K;Baron, DM;Tellez, L;Landers, JE;Pandey, UB;Kiskinis, E; Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import Science advances 2023-08-18 [PMID: 37585529] (Bioassay, Human)	Bioassay	Human
Clayton, BLL;Barbar, L;Sapar, M;Rusielewicz, T;Kalpana, K;Migliori, B;NYSCF Global Stem Cell Array® Team, ;Paull, D;Brenner, K;Moroziewicz, D;Sand, IK;Casaccia, P;Tesar, PJ;Fossati, V; Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis bioRxiv : the preprint server for biology 2023-08-02 [PMID: 37577713] (Bioassay, Human)	Bioassay	Human
Jourdon, A;Wu, F;Mariani, J;Capauto, D;Norton, S;Tomasini, L;Amiri, A;Suvakov, M;Schreiner, JD;Jang, Y;Panda, A;Nguyen, CK;Cummings, EM;Han, G;Powell, K;Szekely, A;McPartland, JC;Pelphrey, K;Chawarska, K;Ventola, P;Abyzov, A;Vaccarino, FM; Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis Nature neuroscience 2023-08-10 [PMID: 37563294] (Bioassay, Human)	Bioassay	Human
Glass, MR;Waxman, EA;Yamashita, S;Lafferty, M;Beltran, A;Farah, T;Patel, NK;Matoba, N;Ahmed, S;Srivastava, M;Drake, E;Davis, LT;Yeturi, M;Sun, K;Love, MI;Hashimoto-Torii, K;French, DL;Stein, JL; Cross-site reproducibility of human cortical organoids reveals consistent cell type composition and architecture bioRxiv : the preprint server for biology 2023-07-29 [PMID: 37546772] (Bioassay, Human)	Bioassay	Human
Jin, C;Wang, Z;Li, P;Tang, J;Jiao, T;Li, Y;Ou, J;Zou, D;Li, M;Mang, X;Liu, J;Ma, Y;Wu, X;Shi, J;Chen, S;He, M;Lu, Y;Zhang, N;Miao, S;Sun, F;Wang, L;Li, K;Yu, J;Song, W; Decoding the spermatogonial stem cell niche under physiological and recovery conditions in adult mice and humans Science advances 2023-08-04 [PMID: 37540753] (Bioassay, Human)	Bioassay	Human
Oiwa, K;Watanabe, S;Onodera, K;Iguchi, Y;Kinoshita, Y;Komine, O;Sobue, A;Okada, Y;Katsuno, M;Yamanaka, K; Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis Science advances 2023-08-04 [PMID: 37540751] (Bioassay, Human)	Bioassay	Human
Sinclair, P;Hakeem, J;Kumar, SG;Loser, D;Dixit, K;Leist, M;Kraushaar, U;Kabbani, N; Proteomic responses in the human dopaminergic LUHMES cell line to imidacloprid and its metabolites imidacloprid-olefin and desnitro-imidacloprid Pesticide biochemistry and physiology 2023-08-01 [PMID: 37532312] (Bioassay, Human)	Bioassay	Human
Onda-Ohto, A;Hasegawa-Ogawa, M;Matsuno, H;Shiraishi, T;Bono, K;Hiraki, H;Kanegae, Y;Iguchi, Y;Okano, HJ; Specific vulnerability of iPSC-derived motor neurons with TDP-43 gene mutation to oxidative stress Molecular brain 2023-07-26 [PMID: 37496071] (Bioassay, Human)	Bioassay	Human
Rajachandran, S;Zhang, X;Cao, Q;Caldeira-Brant, AL;Zhang, X;Song, Y;Evans, M;Bukulmez, O;Grow, EJ;Nagano, M;Orwig, KE;Chen, H; Dissecting the spermatogonial stem cell niche using spatial transcriptomics Cell reports 2023-07-01 [PMID: 37393620] (Cell Culture, Mouse)	Cell Culture	Mouse
Mubariz, F;Saadin, A;Lingenfelter, N;Sarkar, C;Banerjee, A;Lipinski, MM;Awad, O; Deregulation of mTORC1-TFEB axis in human iPSC model of GBA1-associated Parkinson's disease Frontiers in neuroscience 2023-06-02 [PMID: 37332877] (Bioassay, Human)	Bioassay	Human
Tam, KW;Wong, CY;Wu, KL;Lam, G;Liang, X;Wong, WT;Li, MT;Liu, WY;Cai, S;Shea, GK;Shum, DK;Chan, YS; IPSC-Derived Sensory Neurons Directing Fate Commitment of Human BMSC-Derived Schwann Cells: Applications in Traumatic Neural Injuries Cells 2023-05-25 [PMID: 37296600] (Bioassay, Human)	Bioassay	Human
Hartmann, J;Henschel, N;Bartmann, K;D�nmez, A;Brockerhoff, G;Koch, K;Fritsche, E; Molecular and Functional Characterization of Different BrainSphere Models for Use in Neurotoxicity Testing on Microelectrode Arrays Cells 2023-04-27 [PMID: 37174670] (Bioassay, Human)	Bioassay	Human
MH Berryer, G Rizki, A Nathanson, JA Klein, D Trendafilo, SG Susco, D Lam, A Messana, KM Holton, KW Karhohs, BA Cimini, K Pfaff, AE Carpenter, LL Rubin, LE Barrett High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly Elife, 2023-04-21;12(0):. 2023-04-21 [PMID: 37083703] (Bioassay, Human)	Bioassay	Human
C Li, Z Yao, L Ma, X Song, W Wang, C Wan, S Ren, D Chen, Y Zheng, YT Zhu, G Chang, S Wu, K Miao, F Luo, XY Zhao Lovastatin promotes the self-renewal of murine and primate spermatogonial stem cells Stem Cell Reports, 2023-04-11;18(4):969-984. 2023-04-11 [PMID: 37044069] (Bioassay, Human)	Bioassay	Human
SD Sharma, BK Reddy, R Pal, TE Ritakari, JD Cooper, BT Selvaraj, PC Kind, S Chandran, DJA Wyllie, S Chattarji Astrocytes mediate cell non-autonomous correction of aberrant firing in human FXS neurons Cell Reports, 2023-04-04;42(4):112344. 2023-04-04 [PMID: 37018073] (Bioassay, Human)	Bioassay	Human
YW Jun, S Lee, BK Ban, JA Lee, FB Gao Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis Autophagy, 2023-02-27;0(0):1-17. 2023-02-27 [PMID: 36849436] (Bioassay, Human)	Bioassay	Human
HW Ong, Y Liang, W Richardson, ER Lowry, CI Wells, X Chen, M Silvestre, K Dempster, JA Silvaroli, JL Smith, H Wichterle, NS Pabla, SK Ultanir, AN Bullock, DH Drewry, AD Axtman A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective bioRxiv : the preprint server for biology, 2023-02-10;0(0):. 2023-02-10 [PMID: 36798313] (Bioassay, Human)	Bioassay	Human
GR Linares, Y Li, WH Chang, J Rubin-Sigl, S Mendonca, S Hong, Y Eoh, W Guo, YH Huang, J Chang, S Tu, N Dorjsuren, M Santana, ST Hung, J Yu, J Perez, M Chickering, TY Cheng, CC Huang, SJ Lee, HJ Deng, KT Bach, K Gray, V Subramanya, J Rosenfeld, SV Alworth, H Goodarzi, JK Ichida SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS Cell Stem Cell, 2023-02-02;30(2):171-187.e14. 2023-02-02 [PMID: 36736291] (Bioassay, Human)	Bioassay	Human
O Pietiläine, A Trehan, D Meyer, J Mitchell, M Tegtmeyer, V Valakh, H Gebre, T Chen, E Vartiainen, SL Farhi, K Eggan, SA McCarroll, R Nehme Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons Cell Reports, 2023-01-12;42(1):111988. 2023-01-12 [PMID: 36640364] (Bioassay, Human)	Bioassay	Human
Z Álvarez, JA Ortega, K Sato, IR Sasselli, AN Kolberg-Ed, R Qiu, KA Marshall, TP Nguyen, CS Smith, KA Quinlan, V Papakis, Z Syrgiannis, NA Sather, C Musumeci, E Engel, SI Stupp, E Kiskinis Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons Cell Stem Cell, 2023-01-12;0(0):. 2023-01-12 [PMID: 36638801] (Bioassay, Human)	Bioassay	Human
CB Pantazis, A Yang, E Lara, JA McDonough, C Blauwendra, L Peng, H Oguro, J Kanaujiya, J Zou, D Sebesta, G Pratt, E Cross, J Blockwick, P Buxton, L Kinner-Bib, C Medura, C Tompkins, S Hughes, M Santiana, F Faghri, MA Nalls, D Vitale, S Ballard, YA Qi, DM Ramos, KM Anderson, J Stadler, P Narayan, J Papademetr, L Reilly, MP Nelson, S Aggarwal, LU Rosen, P Kirwan, V Pisupati, SL Coon, SW Scholz, T Priebe, M Öttl, J Dong, M Meijer, LJM Janssen, VS Lourenco, R van der Ka, D Crusius, D Paquet, AC Raulin, G Bu, A Held, BJ Wainger, RMC Gabriele, JM Casey, S Wray, D Abu-Bonsra, CL Parish, MS Beccari, DW Cleveland, E Li, IVL Rose, M Kampmann, C Calatayud, P Verstreken, L Heinrich, MY Chen, B Schüle, D Dou, ELF Holzbaur, MC Zanellati, R Basundra, M Deshmukh, S Cohen, R Khanna, M Raman, ZS Nevin, M Matia, J Van Lent, V Timmerman, BR Conklin, K Johnson Ch, K Zhang, S Funes, DA Bosco, L Erlebach, M Welzer, D Kronenberg, G Lyu, E Arenas, E Coccia, L Sarrafha, T Ahfeldt, JC Marioni, WC Skarnes, MR Cookson, ME Ward, FT Merkle A reference human induced pluripotent stem cell line for large-scale collaborative studies Cell Stem Cell, 2022-12-01;29(12):1685-1702.e22. 2022-12-01 [PMID: 36459969] (Bioassay, Human)	Bioassay	Human
JR Herdy, L Traxler, RK Agarwal, L Karbacher, JCM Schlachetz, L Boehnke, D Zangwill, D Galasko, CK Glass, J Mertens, FH Gage Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer's disease Cell Stem Cell, 2022-12-01;29(12):1637-1652.e6. 2022-12-01 [PMID: 36459967] (Bioassay, Human)	Bioassay	Human
M Jones, A Cunningham, N Frank, D Sethi The monoculture of cord-blood-derived CD34+ cells by an automated, membrane-based dynamic perfusion system with a novel cytokine cocktail Stem Cell Reports, 2022-11-03;0(0):. 2022-11-03 [PMID: 36332632] (Bioassay, Human)	Bioassay	Human
G Kim, L Nakayama, JA Blum, T Akiyama, S Boeynaems, M Chakrabort, J Couthouis, E Tassoni-Ts, CM Rodriguez, MC Bassik, AD Gitler Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2 Cell Reports, 2022-10-25;41(4):111508. 2022-10-25 [PMID: 36288714] (Bioassay, Human)	Bioassay	Human
C Seah, MS Breen, T Rusielewic, HN Bader, C Xu, CJ Hunter, B McCarthy, PJM Deans, M Chattopadh, J Goldberg, F Desarnaud, I Makotkine, JD Flory, LM Bierer, M Staniskyte, NYSCF Glob, SA Noggle, LM Huckins, D Paull, KJ Brennand, R Yehuda Modeling gene � environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression Nature Neuroscience, 2022-10-20;25(11):1434-1445. 2022-10-20 [PMID: 36266471] (Bioassay, Human)	Bioassay	Human
T Patel, J Hammelman, S Aziz, S Jang, M Closser, TL Michaels, JA Blum, DK Gifford, H Wichterle Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro Nature Communications, 2022-09-15;13(1):5427. 2022-09-15 [PMID: 36109497] (Cell Culture, Mouse)	Cell Culture	Mouse
L Mahoney-Sa, H Bouchaoui, I Boussaad, A Jonneaux, K Timmerman, O Berdeaux, S Ayton, R Krüger, JA Duce, D Devos, JC Devedjian Alpha synuclein determines ferroptosis sensitivity in dopaminergic neurons via modulation of ether-phospholipid membrane composition Cell Reports, 2022-08-23;40(8):111231. 2022-08-23 [PMID: 36001957] (Bioassay, Human)	Bioassay	Human
R Lieberman, LK Cortes, G Gao, H Park, B Wang, PL Jones, RB Hunter, JP Leonard, RH Barker Human iPSC-derived astrocytes generated from donors with globoid cell leukodystrophy display phenotypes associated with disease PLoS ONE, 2022-08-03;17(8):e0271360. 2022-08-03 [PMID: 35921286] (Bioassay, Human)	Bioassay	Human
K ?uczkowska, O Taryma-Le?, J Bi?kowski, KE Soko?owska, D Strapagiel, J Jarczak, E Paczkowska, B Machali?sk, TK Wojdacz Long-Term Treatment with Bortezomib Induces Specific Methylation Changes in Differentiated Neuronal Cells Cancers, 2022-07-13;14(14):. 2022-07-13 [PMID: 35884461] (Bioassay, Human)	Bioassay	Human
M Sawamura, K Imamura, R Hikawa, T Enami, A Nagahashi, H Yamakado, H Ichijo, T Fujisawa, H Yamashita, S Minamiyama, M Kaido, H Wada, M Urushitani, H Inoue, N Egawa, R Takahashi Cellular analysis of SOD1 protein-aggregation propensity and toxicity: a case of ALS with slow progression harboring homozygous SOD1-D92G mutation Scientific Reports, 2022-07-25;12(1):12636. 2022-07-25 [PMID: 35879519] (Bioassay, Human)	Bioassay	Human
Y Chen, Q Yin, XY Cheng, JR Zhang, H Jin, K Li, CJ Mao, F Wang, HZ Bei, CF Liu G2019S LRRK2 Mutation Enhances MPP+-Induced Inflammation of Human Induced Pluripotent Stem Cells-Differentiated Dopaminergic Neurons Frontiers in Neuroscience, 2022-07-06;16(0):947927. 2022-07-06 [PMID: 35873822] (Bioassay, Human)	Bioassay	Human
MA Hossain, M Hasegawa-O, Y Manome, M Igarashi, C Wu, K Suzuki, J Igarashi, T Iwamoto, HJ Okano, Y Eto Generation and characterization of motor neuron progenitors and motor neurons using metachromatic leukodystrophy-induced pluripotent stem cells Oncogene, 2022-02-21;31(0):100852. 2022-02-21 [PMID: 35782608] (Bioassay, Human)	Bioassay	Human
MK Eltahir, M Nakamori, S Hattori, T Kimura, H Mochizuki, S Nagano Pharmacotherapy alleviates pathological changes in human direct reprogrammed neuronal cell model of myotonic dystrophy type 1 PLoS ONE, 2022-07-01;17(7):e0269683. 2022-07-01 [PMID: 35776705] (Bioassay, Human)	Bioassay	Human
FC Yang, JL Vivian, C Traxler, SM Shapiro, JA Stanford MGE-Like Neural Progenitor Cell Survival and Expression of Parvalbumin and Proenkephalin in a Jaundiced Rat Model of Kernicterus Cell Transplantation, 2022-01-01;31(0):9636897221101. 2022-01-01 [PMID: 35596532] (Bioassay, Human)	Bioassay	Human
AK Holzer, I Suciu, C Karreman, T Goj, M Leist Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro International Journal of Molecular Sciences, 2022-03-29;23(7):. 2022-03-29 [PMID: 35409095] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
Salokas K, Liu X, Ohman T, Chowdhury I, Gawriyski L, Keskitalo S, Varjosalo M Physical and functional interactome atlas of human receptor tyrosine kinases. EMBO Rep, 2022-04-05;23(6):e54041. 2022-04-05 [PMID: 35384245] (Bioassay, Human)	Bioassay	Human
JM Suárez-Riv, CJ Pastor-Mal, A Romero-Gon, D Gómez-Fern, S Povea-Cabe, M Álvarez-Có, I Villalón-G, M Talaverón-, A Suárez-Car, M Munuera-Ca, JA Sánchez-Al Pterostilbene in Combination With Mitochondrial Cofactors Improve Mitochondrial Function in Cellular Models of Mitochondrial Diseases Frontiers in Pharmacology, 2022-03-18;13(0):862085. 2022-03-18 [PMID: 35370630] (Bioassay, Human)	Bioassay	Human
M Häkli, S Jäntti, T Joki, L Sukki, K Tornberg, K Aalto-Setä, P Kallio, M Pekkanen-M, S Narkilahti Human Neurons Form Axon-Mediated Functional Connections with Human Cardiomyocytes in Compartmentalized Microfluidic Chip International Journal of Molecular Sciences, 2022-03-15;23(6):. 2022-03-15 [PMID: 35328569] (Bioassay, Human)	Bioassay	Human
L Torres-Gar, JM P Domingue, E Brandi, C Haikal, JM Mudannayak, IC Brás, E Gerhardt, W Li, A Svanbergss, TF Outeiro, GK Gouras, JY Li Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation Scientific Reports, 2022-02-22;12(1):2987. 2022-02-22 [PMID: 35194057] (Bioassay, Human)	Bioassay	Human
N Moriarty, CW Gantner, CPJ Hunt, CM Ermine, S Frausin, S Viventi, DA Ovchinniko, D Kirik, CL Parish, LH Thompson A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells Cell Stem Cell, 2022-02-17;29(3):434-448.e5. 2022-02-17 [PMID: 35180398] (Bioassay, Human)	Bioassay	Human
WM Seo, J Yoon, JH Lee, Y Lee, H Lee, D Geum, W Sun, MR Song Modeling axonal regeneration by changing cytoskeletal dynamics in stem cell-derived motor nerve organoids Scientific Reports, 2022-02-08;12(1):2082. 2022-02-08 [PMID: 35136073] (Bioassay, Human)	Bioassay	Human
R Mzezewa, J Lotila, H Kiiski, A Vinogradov, FE Kapucu, J Peltola, S Hagman, S Narkilahti A kainic acid-induced seizure model in human pluripotent stem cell-derived cortical neurons for studying the role of IL-6 in the functional activity Stem Cell Research, 2022-01-17;60(0):102665. 2022-01-17 [PMID: 35091307] (Bioassay, Human)	Bioassay	Human
P Nouri, A Zimmer, S Brüggemann, R Friedrich, R Kühn, N Prakash Generation of a NES-mScarlet Red Fluorescent Reporter Human iPSC Line for Live Cell Imaging and Flow Cytometric Analysis and Sorting Using CRISPR-Cas9-Mediated Gene Editing Cells, 2022-01-13;11(2):. 2022-01-13 [PMID: 35053384] (Bioassay, Human)	Bioassay	Human
A Bruzelius, S Kidnapilla, J Drouin-Oue, T Stoker, RA Barker, D Rylander O Reprogramming Human Adult Fibroblasts into GABAergic Interneurons Cells, 2021-12-08;10(12):. 2021-12-08 [PMID: 34943958] (Bioassay, Human)	Bioassay	Human
D Segelcke, HK Fischer, M Hütte, S Dennerlein, F Benseler, N Brose, EM Pogatzki-Z, M Schmidt Tmem160 contributes to the establishment of discrete nerve injury-induced pain behaviors in male mice Cell Reports, 2021-12-21;37(12):110152. 2021-12-21 [PMID: 34936870] (Bioassay, Mouse)	Bioassay	Mouse
C Vajhøj, B Schmid, A Alik, R Melki, K Fog, B Holst, TC Stummann Establishment of a human induced pluripotent stem cell neuronal model for identification of modulators of A53T alpha-synuclein levels and aggregation PLoS ONE, 2021-12-21;16(12):e0261536. 2021-12-21 [PMID: 34932569] (Bioassay, Human)	Bioassay	Human
AM Earley, LF Burbulla, D Krainc, R Awatramani Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons Scientific Reports, 2021-11-15;11(1):22257. 2021-11-15 [PMID: 34782629] (Bioassay, Human)	Bioassay	Human
P Sabatier, CM Beusch, AA Saei, M Aoun, N Moruzzi, A Coelho, N Leijten, M Nordenskjö, P Micke, D Maltseva, AG Tonevitsky, V Millischer, J Carlos Vil, S Kadekar, M Gaetani, K Altynbekov, A Kel, PO Berggren, O Simonson, KH Grinnemo, R Holmdahl, S Rodin, RA Zubarev An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation Nature Communications, 2021-11-12;12(1):6558. 2021-11-12 [PMID: 34772928] (Bioassay, Human)	Bioassay	Human
Y Sonobe, J Aburas, G Krishnan, AC Fleming, G Ghadge, P Islam, EC Warren, Y Gu, MW Kankel, AEX Brown, E Kiskinis, TF Gendron, FB Gao, RP Roos, P Kratsios A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation Nature Communications, 2021-10-15;12(1):6025. 2021-10-15 [PMID: 34654821] (Bioassay, Human)	Bioassay	Human
X Reed, MM Cobb, G Skinbinski, D Roosen, A Kaganovich, J Ding, S Finkbeiner, MR Cookson Transcriptional signatures in iPSC-derived neurons are reproducible across labs when differentiation protocols are closely matched Stem Cell Research, 2021-10-03;56(0):102558. 2021-10-03 [PMID: 34626895] (Cell Culture, Human)	Cell Culture	Human
M Shibata, K Pattabiram, B Lorente-Ga, D Andrijevic, SK Kim, N Kaur, SK Muchnik, X Xing, G Santpere, AMM Sousa, N Sestan Regulation of prefrontal patterning and connectivity by retinoic acid Nature, 2021-10-01;0(0):. 2021-10-01 [PMID: 34599305] (Cell Culture, Human, Primate)	Cell Culture	Human, Primate
Q Tang, P Gao, T Arzberger, M Höllerhage, J Herms, G Höglinger, T Koeglsperg Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion Cell Death & Disease, 2021-09-17;12(10):854. 2021-09-17 [PMID: 34535638] (Bioassay, Human)	Bioassay	Human
N Gustavsson, E Savchenko, O Klementiev, L Roybon The intracellular milieu of Parkinson's disease patient brain cells modulates alpha-synuclein protein aggregation Acta neuropathologica communications, 2021-09-16;9(1):153. 2021-09-16 [PMID: 34530929] (Bioassay, Human)	Bioassay	Human
K Tan, HW Song, MF Wilkinson RHOX10 drives mouse spermatogonial stem cell establishment through a transcription factor signaling cascade Cell Reports, 2021-07-20;36(3):109423. 2021-07-20 [PMID: 34289349] (Bioassay, Human)	Bioassay	Human
B Calamini, N Geyer, N Huss-Braun, A Bernhardt, V Harsany, P Rival, M Cindhuchao, D Hoffmann, S Gratzer Development of a physiologically relevant and easily scalable LUHMES cell-based model of G2019S LRRK2-driven Parkinson's disease Disease Models & Mechanisms, 2021-06-11;14(6):. 2021-06-11 [PMID: 34114604] (Bioassay, Human)	Bioassay	Human
IR de Luzy, KCL Law, N Moriarty, CPJ Hunt, JC Durnall, LH Thompson, A Nagy, CL Parish Human stem cells harboring a suicide gene improve the�safety and standardisation of neural transplants in Parkinsonian rats Nature Communications, 2021-05-27;12(1):3275. 2021-05-27 [PMID: 34045451] (Bioassay, Human)	Bioassay	Human
ZT Olmsted, JL Paluh Co-development of central and peripheral neurons with trunk mesendoderm in human elongating multi-lineage organized gastruloids Nature Communications, 2021-05-21;12(1):3020. 2021-05-21 [PMID: 34021144] (Bioassay, Human)	Bioassay	Human
A Boyer, X Zhang, A Levasseur, N Abou Nader, G St-Jean, MC Nagano, D Boerboom Constitutive activation of CTNNB1 results in a loss of spermatogonial stem cell activity in mice PLoS ONE, 2021-05-20;16(5):e0251911. 2021-05-20 [PMID: 34015032] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
G Pintacuda, FH Lassen, YH Hsu, A Kim, JM Martín, E Malolepsza, JK Lim, N Fornelos, KC Eggan, K Lage Genoppi is an open-source software for robust and standardized integration of proteomic and genetic data Nature Communications, 2021-05-10;12(1):2580. 2021-05-10 [PMID: 33972534] (Bioassay, Human)	Bioassay	Human
B Calamini, N Geyer, N Huss-Braun, A Bernhardt, V Harsany, P Rival, M Cindhuchao, D Hoffmann, S Gratzer Development of a physiologically relevant and easily scalable LUHMES cell-based model of G2019S LRRK2 driven parkinson's disease Disease Models & Mechanisms, 2021-01-01;0(0):. 2021-01-01 [PMID: 33955449] (Bioassay, Human)	Bioassay	Human
J Mertens, JR Herdy, L Traxler, ST Schafer, JCM Schlachetz, L Böhnke, DA Reid, H Lee, D Zangwill, DP Fernandes, RK Agarwal, R Lucciola, L Zhou-Yang, L Karbacher, F Edenhofer, S Stern, S Horvath, ACM Paquola, CK Glass, SH Yuan, M Ku, A Szücs, LSB Goldstein, D Galasko, FH Gage Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients Cell Stem Cell, 2021-04-27;0(0):. 2021-04-27 [PMID: 33910058] (Bioassay, Human)	Bioassay	Human
X Dong, L Yang, K Liu, X Ji, C Tang, W Li, L Ma, Y Mei, T Peng, B Feng, Z Wu, Q Tang, Y Gao, K Yan, W Zhou, M Xiong Transcriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment Cell Reports, 2021-03-02;34(9):108802. 2021-03-02 [PMID: 33657377] (Bioassay, Human)	Bioassay	Human
B Sun, X Yang, F Hou, X Yu, Q Wang, HS Oh, P Raja, JM Pesola, EAH Vanni, S McCarron, J Morris-Lov, AHM Ng, GM Church, DM Knipe, DM Coen, D Pan Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency Nature Microbiology, 2021-02-08;0(0):. 2021-02-08 [PMID: 33558653] (Bioassay, Mouse)	Bioassay	Mouse
TY Feng, Q Li, F Ren, HM Xi, DL Lv, Y Li, JH Hu Melatonin Protects Goat Spermatogonial Stem Cells against Oxidative Damage during Cryopreservation by Improving Antioxidant Capacity and Inhibiting Mitochondrial Apoptosis Pathway Oxidative Medicine and Cellular Longevity, 2020-12-31;2020(0):5954635. 2020-12-31 [PMID: 33488926] (Bioassay, Goat)	Bioassay	Goat
A Merlevede, EM Legault, V Drugge, RA Barker, J Drouin-Oue, V Olariu A quantitative model of cellular decision making in direct neuronal reprogramming Scientific Reports, 2021-01-15;11(1):1514. 2021-01-15 [PMID: 33452356] (Bioassay, Human)	Bioassay	Human
SE Howden, SB Wilson, E Groenewege, L Starks, TA Forbes, KS Tan, JM Vanslambro, EM Holloway, YH Chen, S Jain, JR Spence, MH Little Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk Cell Stem Cell, 2020-12-29;0(0):. 2020-12-29 [PMID: 33378647] (Bioassay, Human)	Bioassay	Human
L Honkamäki, T Joki, NA Grigoryev, K Levon, L Ylä-Outine, S Narkilahti Novel method to produce a layered 3D scaffold for human pluripotent stem cell-derived neuronal cells Journal of neuroscience methods, 2020-12-17;350(0):109043. 2020-12-17 [PMID: 33345946] (Bioassay, Human)	Bioassay	Human
K Uchimura, H Wu, Y Yoshimura, BD Humphreys Human Pluripotent Stem Cell-Derived Kidney Organoids with Improved Collecting Duct Maturation and Injury Modeling Cell Reports, 2020-12-15;33(11):108514. 2020-12-15 [PMID: 33326782] (Bioassay, Human)	Bioassay	Human
D Jutzi, S Campagne, R Schmidt, S Reber, J Mechtershe, F Gypas, C Schweingru, M Colombo, C von Schroe, FE Loughlin, A Devoy, E Hedlund, M Zavolan, FH Allain, MD Ruepp Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis Nature Communications, 2020-12-11;11(1):6341. 2020-12-11 [PMID: 33311468] (Bioassay, Human)	Bioassay	Human
S Lito, A Sidibe, S Ilmjarv, P Burda, M Baumgartne, B Wehrle-Hal, KH Krause, A Marteyn Induced Pluripotent Stem Cells to Understand Mucopolysaccharidosis. I: Demonstration of a Migration Defect in Neural Precursors Cells, 2020-12-03;9(12):. 2020-12-03 [PMID: 33287330] (Bioassay, Human)	Bioassay	Human
J Giacomoni, A Bruzelius, CA Stamouli, D Rylander O Direct Conversion of Human Stem Cell-Derived Glial Progenitor Cells into GABAergic Interneurons Cells, 2020-11-10;9(11):. 2020-11-10 [PMID: 33182669] (Bioassay, Human)	Bioassay	Human
N Ramesh, EL Daley, AM Gleixner, JR Mann, S Kour, D Mawrie, EN Anderson, J Kofler, CJ Donnelly, E Kiskinis, UB Pandey RNA dependent suppression of C9orf72 ALS/FTD associated neurodegeneration by Matrin-3 Acta Neuropathol Commun, 2020-10-31;8(1):177. 2020-10-31 [PMID: 33129345] (Cell Culture, Human)	Cell Culture	Human
Y Kwon, Y Bang, SH Moon, A Kim, HJ Choi Amitriptyline interferes with autophagy-mediated clearance of protein aggregates via inhibiting autophagosome maturation in neuronal cells Cell Death Dis, 2020-10-17;11(10):874. 2020-10-17 [PMID: 33070168] (Bioassay, Human)	Bioassay	Human
S Nolbrant, J Giacomoni, DB Hoban, A Bruzelius, M Birtele, D Chandler-M, M Pereira, DR Ottosson, SA Goldman, M Parmar Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons Stem Cell Reports, 2020-09-24;0(0):. 2020-09-24 [PMID: 32976765] (Bioassay, Human)	Bioassay	Human
JW Kim, X Yin, A Jhaldiyal, MR Khan, I Martin, Z Xie, T Perez-Rose, M Kumar, L Abalde-Atr, J Xu, L Chen, SM Eacker, DJ Surmeier, NT Ingolia, TM Dawson, VL Dawson Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis Cell Stem Cell, 2020-08-25;27(4):633-645.e7. 2020-08-25 [PMID: 32846140] (Bioassay, Human)	Bioassay	Human
KM Prautsch, A Schmidt, V Paradiso, DJ Schaefer, R Guzman, DF Kalbermatt, S Madduri Modulation of Human Adipose Stem Cells' Neurotrophic Capacity Using a Variety of Growth Factors for Neural Tissue Engineering Applications: Axonal Growth, Transcriptional, and Phosphoproteomic Analyses In Vitro Cells, 2020-08-21;9(9):. 2020-08-21 [PMID: 32839392] (Bioassay, Cell Culture, Human)	Bioassay, Cell Culture	Human
K Hirata, T Nambara, K Kawatani, N Nawa, H Yoshimatsu, H Kusakabe, K Banno, K Nishimura, M Ohtaka, M Nakanishi, H Taniguchi, H Arahori, K Wada, K Ozono, Y Kitabatake 4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates Sci Rep, 2020-08-20;10(1):14047. 2020-08-20 [PMID: 32820178] (Bioassay, Human)	Bioassay	Human
CA Tristan, P Ormanoglu, J Slamecka, C Malley, PH Chu, VM Jovanovic, Y Gedik, C Bonney, E Barnaeva, J Braisted, SK Mallanna, D Dorjsuren, MJ Iannotti, TC Voss, S Michael, A Simeonov, I Singeç Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells bioRxiv, 2020-08-03;0(0):. 2020-08-03 [PMID: 32793899] (Bioassay, Human)	Bioassay	Human
LS VandenBosc, SG Wohl, MS Wilken, M Hooper, C Finkbeiner, K Cox, L Chipman, TA Reh Developmental changes in the accessible chromatin, transcriptome and Ascl1-binding correlate with the loss in M�ller Glial regenerative potential Sci Rep, 2020-08-12;10(1):13615. 2020-08-12 [PMID: 32788677] (Bioassay, Mouse)	Bioassay	Mouse
SI Mae, M Ryosaka, S Sakamoto, K Matsuse, A Nozaki, M Igami, R Kabai, A Watanabe, K Osafune Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential Cell Rep, 2020-07-28;32(4):107963. 2020-07-28 [PMID: 32726627] (Bioassay, Human)	Bioassay	Human
N Michel, P Narayanan, O Shomroni, M Schmidt Maturational Changes in Mouse Cutaneous Touch and Piezo2-Mediated Mechanotransduction Cell Rep, 2020-07-21;32(3):107912. 2020-07-21 [PMID: 32697985] (Bioassay, Mouse)	Bioassay	Mouse
S Das Sharma, R Pal, BK Reddy, BT Selvaraj, N Raj, KK Samaga, DJ Srinivasan, L Ornelas, D Sareen, MR Livesey, GJ Bassell, CN Svendsen, PC Kind, S Chandran, S Chattarji, DJA Wyllie Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns Mol Autism, 2020-06-19;11(1):52. 2020-06-19 [PMID: 32560741] (Bioassay, Human)	Bioassay	Human
SK Rastogi, R Garg, MG Scopelliti, BI Pinto, JE Hartung, S Kim, CGE Murphey, N Johnson, D San Roman, F Bezanilla, JF Cahoon, MS Gold, M Chamanzar, T Cohen-Karn Remote nongenetic optical modulation of neuronal activity using fuzzy graphene Proc. Natl. Acad. Sci. U.S.A., 2020-06-01;0(0):. 2020-06-01 [PMID: 32482882] (Bioassay, Rat)	Bioassay	Rat
H Tsujimoto, T Kasahara, SI Sueta, T Araoka, S Sakamoto, C Okada, SI Mae, T Nakajima, N Okamoto, D Taura, M Nasu, T Shimizu, M Ryosaka, Z Li, M Sone, M Ikeya, A Watanabe, K Osafune A Modular Differentiation System Maps Multiple Human Kidney Lineages from Pluripotent Stem Cells Cell Rep, 2020-04-07;31(1):107476. 2020-04-07 [PMID: 32268094] (Bioassay, Human)	Bioassay	Human
P Gee, MSY Lung, Y Okuzaki, N Sasakawa, T Iguchi, Y Makita, H Hozumi, Y Miura, LF Yang, M Iwasaki, XH Wang, MA Waller, N Shirai, YO Abe, Y Fujita, K Watanabe, A Kagita, KA Iwabuchi, M Yasuda, H Xu, T Noda, J Komano, H Sakurai, N Inukai, A Hotta Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping Nat Commun, 2020-03-13;11(1):1334. 2020-03-13 [PMID: 32170079] (Bioassay, Human)	Bioassay	Human
K Matsumura, K Seiriki, S Okada, M Nagase, S Ayabe, I Yamada, T Furuse, H Shibuya, Y Yasuda, H Yamamori, M Fujimoto, K Nagayasu, K Yamamoto, K Kitagawa, H Miura, N Gotoda-Nis, H Igarashi, M Hayashida, M Baba, M Kondo, S Hasebe, K Ueshima, A Kasai, Y Ago, A Hayata-Tak, N Shintani, T Iguchi, M Sato, S Yamaguchi, M Tamura, S Wakana, A Yoshiki, AM Watabe, H Okano, K Takuma, R Hashimoto, H Hashimoto, T Nakazawa Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes Nat Commun, 2020-02-26;11(1):859. 2020-02-26 [PMID: 32103003] (Bioassay, Human)	Bioassay	Human
Y Yuan, L Li, Q Cheng, F Diao, Q Zeng, X Yang, Y Wu, H Zhang, M Huang, J Chen, Q Zhou, Y Zhu, R Hua, J Tian, X Wang, Z Zhou, J Hao, J Yu, D Hua, J Liu, X Guo, Q Zhou, J Sha In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids Cell Res., 2020-02-21;0(0):. 2020-02-21 [PMID: 32086476] (Bioassay, Human)	Bioassay	Human
K Onodera, D Shimojo, Y Ishihara, M Yano, F Miya, H Banno, N Kuzumaki, T Ito, R Okada, B de Araújo, M Ohyama, M Yoshida, T Tsunoda, M Katsuno, M Doyu, G Sobue, H Okano, Y Okada Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs Mol Brain, 2020-02-19;13(1):18. 2020-02-19 [PMID: 32070397] (Bioassay, Human)	Bioassay	Human
K Takeda, Y Kawamoto, Y Nagasaki, Y Okuno, Y Goto, M Iida, I Yajima, N Ohgami, M Kato Peptides containing the MXXCW motif inhibit oncogenic RET kinase activity with a novel mechanism of action Am J Cancer Res, 2020-01-01;10(1):336-349. 2020-01-01 [PMID: 32064171] (Cell Culture, Human)	Cell Culture	Human
CW Gantner, IR de Luzy, JA Kauhausen, N Moriarty, JC Niclis, CR Bye, V Penna, CPJ Hunt, CM Ermine, CW Pouton, D Kirik, LH Thompson, CL Parish Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease Cell Stem Cell, 2020-02-13;0(0):. 2020-02-13 [PMID: 32059808] (Bioassay, Human)	Bioassay	Human
T Chakroun, V Evsyukov, NP Nykänen, M Höllerhage, A Schmidt, F Kamp, VC Ruf, W Wurst, TW Rösler, GU Höglinger Alpha-synuclein fragments trigger distinct aggregation pathways Cell Death Dis, 2020-02-03;11(2):84. 2020-02-03 [PMID: 32015326] (Bioassay, Human)	Bioassay	Human
P Kielkowski, IY Buchsbaum, VC Kirsch, NC Bach, M Drukker, S Cappello, SA Sieber FICD activity and AMPylation remodelling modulate human neurogenesis Nat Commun, 2020-01-24;11(1):517. 2020-01-24 [PMID: 31980631] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
AR Nickolls, MM Lee, DF Espinoza, M Szczot, RM Lam, Q Wang, J Beers, J Zou, MQ Nguyen, HJ Solinski, AA AlJanahi, KR Johnson, ME Ward, AT Chesler, CG Bönnemann Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells Cell Rep, 2020-01-21;30(3):932-946.e7. 2020-01-21 [PMID: 31968264] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
H Munezane, H Oizumi, T Wakabayash, S Nishio, T Hirasawa, T Sato, A Harada, T Yoshida, T Eguchi, Y Yamanashi, T Hashimoto, T Iwatsubo Roles of Collagen XXV and Its Putative Receptors PTPsigma/delta in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder Cell Rep, 2019-12-24;29(13):4362-4376.e6. 2019-12-24 [PMID: 31875546] (Cell Culture, Mouse)	Cell Culture	Mouse
A Bonafina, MF Trinchero, AS Ríos, P Bekinschte, AF Schinder, G Paratcha, F Ledda GDNF and GFRalpha1 Are Required for Proper Integration of Adult-Born Hippocampal Neurons Cell Rep, 2019-12-24;29(13):4308-4319.e4. 2019-12-24 [PMID: 31875542] (Cell Culture, Mouse)	Cell Culture	Mouse
M Chumarina, K Russ, C Azevedo, A Heuer, M Pihl, A Collin, EÅ Frostner, E Elmer, P Hyttel, G Cappellett, M Zini, S Goldwurm, L Roybon Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene Acta Neuropathol Commun, 2019-12-16;7(1):208. 2019-12-16 [PMID: 31843010] (Bioassay, Human)	Bioassay	Human
S Mahajani, A Raina, C Fokken, S Kügler, M Bähr Homogenous generation of dopaminergic neurons from multiple hiPSC lines by transient expression of transcription factors Cell Death Dis, 2019-11-27;10(12):898. 2019-11-27 [PMID: 31776327] (Cell Culture, Human)	Cell Culture	Human
T Hyvärinen, A Hyysalo, FE Kapucu, L Aarnos, A Vinogradov, SJ Eglen, L Ylä-Outine, S Narkilahti Functional characterization of human pluripotent stem cell-derived cortical networks differentiated on laminin-521 substrate: comparison to rat cortical cultures Sci Rep, 2019-11-20;9(1):17125. 2019-11-20 [PMID: 31748598] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
D Leitner, M Ramamoorth, M Dejosez, TP Zwaka Immature mDA neurons ameliorate motor deficits in a 6-OHDA Parkinson's disease mouse model and are functional after cryopreservation Stem Cell Res, 2019-10-24;41(0):101617. 2019-10-24 [PMID: 31731178] (Cell Culture, In vitro, Human, Mouse)	Cell Culture, In vitro	Human, Mouse
HM Larsen, SK Hansen, JD Mikkelsen, P Hyttel, TC Stummann Alpha7 nicotinic acetylcholine receptors and neural network synaptic transmission in human induced pluripotent stem cell-derived neurons Stem Cell Res, 2019-10-31;41(0):101642. 2019-10-31 [PMID: 31707211] (Cell Culture, Human)	Cell Culture	Human
IR de Luzy, JC Niclis, CW Gantner, JA Kauhausen, CPJ Hunt, C Ermine, CW Pouton, LH Thompson, CL Parish Isolation of LMX1a ventral midbrain progenitors improves the safety and predictability of human pluripotent stem cell-derived neural transplants in Parkinsonian Disease J. Neurosci., 2019-10-22;0(0):. 2019-10-22 [PMID: 31641054] (Bioassay, Human)	Bioassay	Human
JC Butts, N Iyer, N White, R Thompson, S Sakiyama-E, TC McDevitt V2a interneuron differentiation from mouse and human pluripotent stem cells Nat Protoc, 2019-10-18;0(0):. 2019-10-18 [PMID: 31628445] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
J Luo, Y Xia, Y Yin, J Luo, M Liu, H Zhang, C Zhang, Y Zhao, L Yang, L Kong ATF4 destabilizes RET through nonclassical GRP78 inhibition to enhance chemosensitivity to bortezomib in human osteosarcoma Theranostics, 2019-08-14;9(21):6334-6353. 2019-08-14 [PMID: 31534554] (Bioassay, Human)	Bioassay	Human
CY Lin, M Yoshida, LT Li, A Ikenaka, S Oshima, K Nakagawa, H Sakurai, E Matsui, T Nakahata, MK Saito iPSC-derived functional human neuromuscular junctions model the pathophysiology of neuromuscular diseases JCI Insight, 2019-09-19;4(18):. 2019-09-19 [PMID: 31534050] (Bioassay, Human)	Bioassay	Human
KN Babos, KE Galloway, K Kisler, M Zitting, Y Li, Y Shi, B Quintino, RH Chow, BV Zlokovic, JK Ichida Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming Cell Stem Cell, 2019-09-12;25(4):486-500.e9. 2019-09-12 [PMID: 31523028] (Cell Culture, Mouse)	Cell Culture	Mouse
J Cholewa-Wa, R Shah, S Webb, K Chhatbar, B Ramsahoye, O Pusch, M Yu, P Greulich, B Waclaw, AP Bird Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic Proc. Natl. Acad. Sci. U.S.A., 2019-07-09;116(30):14995-15000. 2019-07-09 [PMID: 31289233] (Bioassay, Human)	Bioassay	Human
H Yang, D Hao, C Liu, D Huang, B Chen, H Fan, C Liu, L Zhang, Q Zhang, J An, J Zhao Generation of functional dopaminergic neurons from human spermatogonial stem cells to rescue parkinsonian phenotypes Stem Cell Res Ther, 2019-06-27;10(1):195. 2019-06-27 [PMID: 31248447] (Cell Culture, Human)	Cell Culture	Human
T Ryynänen, A Pelkonen, K Grigoras, OME Ylivaara, T Hyvärinen, J Ahopelto, M Prunnila, S Narkilahti, J Lekkala Microelectrode Array With Transparent ALD TiN Electrodes Front Neurosci, 2019-03-22;13(0):226. 2019-03-22 [PMID: 30967754] (Bioassay, Human)	Bioassay	Human
M Elkouris, G Kouroupi, A Vourvoukel, N Papagianna, V Kaltezioti, R Matsas, L Stefanis, M Xilouri, PK Politis Long Non-coding RNAs Associated With Neurodegeneration-Linked Genes Are Reduced in Parkinson's Disease Patients Front Cell Neurosci, 2019-02-22;13(0):58. 2019-02-22 [PMID: 30853899] (Bioassay, Human)	Bioassay	Human
J Ooi, SR Langley, X Xu, KH Utami, B Sim, Y Huang, NP Harmston, YL Tay, A Ziaei, R Zeng, D Low, F Aminkeng, RM Sobota, F Ginhoux, E Petretto, MA Pouladi Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects Cell Rep, 2019-02-26;26(9):2494-2508.e7. 2019-02-26 [PMID: 30811996] (Bioassay, Human)	Bioassay	Human
J Gong, ÉM Szeg?, A Leonov, E Benito, S Becker, A Fischer, M Zweckstett, T Outeiro, A Schneider Translocator protein ligand protects against neurodegeneration in the MPTP mouse model of Parkinsonism J. Neurosci., 2019-02-22;0(0):. 2019-02-22 [PMID: 30796158] (Bioassay, Human)	Bioassay	Human
M Wu, L Ma, L Xue, W Ye, Z Lu, X Li, Y Jin, X Qin, D Chen, W Tang, Y Chen, Z Hong, J Zhang, A Luo, S Wang Resveratrol alleviates chemotherapy-induced oogonial stem cell apoptosis and ovarian aging in mice Aging (Albany NY), 2019-02-14;11(3):1030-1044. 2019-02-14 [PMID: 30779707] (Bioassay, Mouse)	Bioassay	Mouse
C Iwasawa, N Kuzumaki, Y Suda, R Kagawa, Y Oka, N Hattori, H Okano, M Narita Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations Mol Brain, 2019-01-18;12(1):5. 2019-01-18 [PMID: 30658665] (Bioassay, Human)	Bioassay	Human
Z Melamed, J López-Erau, MW Baughn, O Zhang, K Drenner, Y Sun, F Freyermuth, MA McMahon, MS Beccari, JW Artates, T Ohkubo, M Rodriguez, N Lin, D Wu, CF Bennett, F Rigo, S Da Cruz, J Ravits, C Lagier-Tou, DW Cleveland Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration Nat. Neurosci., 2019-01-14;22(2):180-190. 2019-01-14 [PMID: 30643298] (Bioassay, Human)	Bioassay	Human
JR Klim, LA Williams, F Limone, I Guerra San, BN Davis-Duse, DA Mordes, A Burberry, MJ Steinbaugh, KK Gamage, R Kirchner, R Moccia, SH Cassel, K Chen, BJ Wainger, CJ Woolf, K Eggan ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair Nat. Neurosci., 2019-01-14;22(2):167-179. 2019-01-14 [PMID: 30643292] (Bioassay, Human)	Bioassay	Human
S Gutbier, AS Spreng, J Delp, S Schildknec, C Karreman, I Suciu, T Brunner, M Groettrup, M Leist Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress Cell Death Differ., 2018-11-02;0(0):. 2018-11-02 [PMID: 30390092] (Bioassay, Human)	Bioassay	Human
K Kirino, T Nakahata, T Taguchi, MK Saito Efficient derivation of sympathetic neurons from human pluripotent stem cells with a defined condition Sci Rep, 2018-08-27;8(1):12865. 2018-08-27 [PMID: 30150715] (Bioassay, Human)	Bioassay	Human
K Fujimori, M Ishikawa, A Otomo, N Atsuta, R Nakamura, T Akiyama, S Hadano, M Aoki, H Saya, G Sobue, H Okano Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent Nat. Med., 2018-08-20;0(0):. 2018-08-20 [PMID: 30127392] (Bioassay, Human)	Bioassay	Human
S Koyuncu, I Saez, HJ Lee, R Gutierrez-, W Pokrzywa, A Fatima, T Hoppe, D Vilchez The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients Nat Commun, 2018-07-23;9(1):2886. 2018-07-23 [PMID: 30038412] (Bioassay, Human)	Bioassay	Human
N Tsuburaya, K Homma, T Higuchi, A Balia, H Yamakoshi, N Shibata, S Nakamura, H Nakagawa, SI Ikeda, N Umezawa, N Kato, S Yokoshima, M Shibuya, M Shimonishi, H Kojima, T Okabe, T Nagano, I Naguro, K Imamura, H Inoue, T Fujisawa, H Ichijo A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model Nat Commun, 2018-07-10;9(1):2668. 2018-07-10 [PMID: 29991716] (Bioassay, Human)	Bioassay	Human
Y Yehuda, B Blumenfeld, N Mayorek, K Makedonski, O Vardi, L Cohen-Dani, Y Mansour, S Baror-Sebb, H Masika, M Farago, M Berger, S Carmi, Y Buganim, A Koren, I Simon Germline DNA replication timing shapes mammalian genome composition Nucleic Acids Res., 2018-09-19;0(0):. 2018-09-19 [PMID: 29986092] (Bioassay, Mouse)	Bioassay	Mouse
G Collo, L Cavalleri, M Zoli, U Maskos, E Ratti, E Merlo Pich Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons Front Pharmacol, 2018-06-01;9(0):572. 2018-06-01 [PMID: 29910731] (Bioassay, Human)	Bioassay	Human
R Nehme, E Zuccaro, SD Ghosh, C Li, JL Sherwood, O Pietilaine, LE Barrett, F Limone, KA Worringer, S Kommineni, Y Zang, D Cacchiarel, A Meissner, R Adolfsson, S Haggarty, J Madison, M Muller, P Arlotta, Z Fu, G Feng, K Eggan Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission Cell Rep, 2018-05-22;23(8):2509-2523. 2018-05-22 [PMID: 29791859] (Bioassay, Human)	Bioassay	Human
K Kakiuchi, K Taniguchi, H Kubota Conserved and non-conserved characteristics of porcine glial cell line-derived neurotrophic factor expressed in the testis Sci Rep, 2018-05-16;8(1):7656. 2018-05-16 [PMID: 29769589] (Bioassay, Mouse)	Bioassay	Mouse
MJ Ziller, JA Ortega, KA Quinlan, DP Santos, H Gu, EJ Martin, C Galonska, R Pop, S Maidl, A Di Pardo, M Huang, HY Meltzer, A Gnirke, CJ Heckman, A Meissner, E Kiskinis Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology Cell Stem Cell, 2018-03-15;0(0):. 2018-03-15 [PMID: 29551301] (Bioassay, Human)	Bioassay	Human
G Collo, L Cavalleri, F Bono, C Mora, S Fedele, RW Invernizzi, M Gennarelli, G Piovani, T Kunath, MJ Millan, E Merlo Pich, P Spano Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling Neural Plast., 2018-02-04;2018(0):4196961. 2018-02-04 [PMID: 29531524] (Bioassay, Human)	Bioassay	Human
R Jalili, J Horecka, JR Swartz, RW Davis, HHJ Persson Streamlined circular proximity ligation assay provides high stringency and compatibility with low-affinity antibodies Proc. Natl. Acad. Sci. U.S.A., 2018-01-16;0(0):. 2018-01-16 [PMID: 29339495] (Bioassay)	Bioassay
N Avaliani, U Pfisterer, A Heuer, M Parmar, M Kokaia, M Andersson Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus Stem Cells Int, 2017-11-26;2017(0):5718608. 2017-11-26 [PMID: 29317869] (Bioassay, Human)	Bioassay	Human
E Silvestris, P Cafforio, S D'Oronzo, C Felici, F Silvestris, G Loverro In vitro differentiation of human oocyte-like cells from oogonial stem cells: single-cell isolation and molecular characterization Hum. Reprod., 2018-03-01;0(0):. 2018-03-01 [PMID: 29304224] (Bioassay, Human)	Bioassay	Human
EA Newman, S Chukkapall, D Bashllari, TT Thomas, RA Van Noord, ER Lawlor, MJ Hoenerhoff, AW Opipari, VP Opipari Alternative NHEJ pathway proteins as components of MYCN oncogenic activity in human neural crest stem cell differentiation: implications for neuroblastoma initiation Cell Death Dis, 2017-12-13;8(12):3208. 2017-12-13 [PMID: 29238067] (Bioassay, Human)	Bioassay	Human
O Awad, LM Panicker, RM Deranieh, MP Srikanth, RA Brown, A Voit, T Peesay, TS Park, ET Zambidis, RA Feldman Altered Differentiation Potential of Gaucher's Disease iPSC Neuronal Progenitors due to Wnt/?-Catenin Downregulation Stem Cell Reports, 2017-11-30;9(6):1853-1867. 2017-11-30 [PMID: 29198828] (Bioassay, Human)	Bioassay	Human
T Ruetz, U Pfisterer, B Di Stefano, J Ashmore, M Beniazza, TV Tian, DF Kaemena, L Tosti, W Tan, JR Manning, E Chantzoura, DR Ottosson, S Collombet, A Johnsson, E Cohen, K Yusa, S Linnarsson, T Graf, M Parmar, K Kaji Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming Cell Stem Cell, 2017-11-22;0(0):. 2017-11-22 [PMID: 29174331] (Bioassay, Human)	Bioassay	Human
A Taguchi, R Nishinakam Higher-Order Kidney Organogenesis from Pluripotent Stem Cells Cell Stem Cell, 2017-11-09;0(0):. 2017-11-09 [PMID: 29129523] (Bioassay, Human)	Bioassay	Human
M Ferreira, S Boens, C Winkler, K Szekér, I Verbinnen, A Van Eynde, M Fardilha, M Bollen The protein phosphatase 1 regulator NIPP1 is essential for mammalian spermatogenesis Sci Rep, 2017-10-17;7(1):13364. 2017-10-17 [PMID: 29042623] (Bioassay, Mouse)	Bioassay	Mouse
M Höllerhage, C Moebius, J Melms, WH Chiu, JN Goebel, T Chakroun, T Koeglsperg, WH Oertel, TW Rösler, M Bickle, GU Höglinger Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells Sci Rep, 2017-09-13;7(1):11469. 2017-09-13 [PMID: 28904388] (Bioassay, Human)	Bioassay	Human
J Liu, D Shang, Y Xiao, P Zhong, H Cheng, R Zhou Isolation and characterization of string-forming female germline stem cells from ovaries of neonatal mice J. Biol. Chem., 2017-08-21;0(0):. 2017-08-21 [PMID: 28827310] (Bioassay, Mouse)	Bioassay	Mouse
J Drouin-Oue, S Lau, PL Brattås, D Rylander O, K Pircs, DA Grassi, LM Collins, R Vuono, A Andersson, G Westergren, C Graff, L Minthon, H Toresson, RA Barker, J Jakobsson, M Parmar REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways EMBO Mol Med, 2017-08-01;9(8):1117-1131. 2017-08-01 [PMID: 28646119] (Bioassay, Human)	Bioassay	Human
HJ Park, EC Bolton RET-mediated glial cell line derived neurotrophic factor signaling inhibits mouse prostate development Development, 2017-05-15;0(0):. 2017-05-15 [PMID: 28506996] (Bioassay, Mouse)	Bioassay	Mouse
K Gassei, Y Sheng, A Fayomi, P Mital, M Sukhwani, CC Lin, KA Peters, A Althouse, H Valli, KE Orwig DDX4-EGFP transgenic rat model for the study of germline development and spermatogenesis Biol. Reprod., 2017-03-01;96(3):707-719. 2017-03-01 [PMID: 28339678] (Cell Culture, Rat)	Cell Culture	Rat
JC Niclis, CW Gantner, WF Alsanie, SJ McDougall, CR Bye, AG Elefanty, EG Stanley, JM Haynes, CW Pouton, LH Thompson, CL Parish Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents Stem Cells Transl Med, 2016-10-14;6(3):937-948. 2016-10-14 [PMID: 28297587] (Bioassay, Human)	Bioassay	Human
I Gat, L Maghen, M Filice, B Wyse, K Zohni, K Jarvi, KC Lo, A Gauthier F, C Librach Optimal culture conditions are critical for efficient expansion of human testicular somatic and germ cells in�vitro Fertil. Steril, 2017-03-01;107(3):595-605.e7. 2017-03-01 [PMID: 28259258] (Bioassay, Human)	Bioassay	Human
M Sambi, T Chow, J Whiteley, M Li, S Chua, V Raileanu, IM Rogers Acellular Mouse Kidney ECM can be Used as a Three-Dimensional Substrate to Test the Differentiation Potential of Embryonic Stem Cell Derived Renal Progenitors Stem Cell Rev, 2017-08-01;0(0):. 2017-08-01 [PMID: 28239758] (Bioassay, Mouse)	Bioassay	Mouse
S Menges, G Minakaki, PM Schaefer, H Meixner, I Prots, U Schlötzer-, K Friedland, B Winner, TF Outeiro, KF Winklhofer, CA von Arnim, W Xiang, J Winkler, J Klucken Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress Sci Rep, 2017-02-22;7(0):42942. 2017-02-22 [PMID: 28224980] (Bioassay, Human)	Bioassay	Human
SK Goparaju, K Kohda, K Ibata, A Soma, Y Nakatake, T Akiyama, S Wakabayash, M Matsushita, M Sakota, H Kimura, M Yuzaki, SB Ko, MS Ko Rapid differentiation of human pluripotent stem cells into functional neurons by mRNAs encoding transcription factors Sci Rep, 2017-02-13;7(0):42367. 2017-02-13 [PMID: 28205555] (Bioassay, Human)	Bioassay	Human
MJ Boland, KL Nazor, HT Tran, A Szücs, CL Lynch, R Paredes, F Tassone, PP Sanna, RJ Hagerman, JF Loring Molecular analyses of neurogenic defects in a human pluripotent stem cell model of fragile X syndrome Brain, 2017-03-01;140(3):582-598. 2017-03-01 [PMID: 28137726] (Bioassay, Human)	Bioassay	Human
SA Liddelow, KA Guttenplan, LE Clarke, FC Bennett, CJ Bohlen, L Schirmer, ML Bennett, AE Mnch, WS Chung, TC Peterson, DK Wilton, A Frouin, BA Napier, N Panicker, M Kumar, MS Buckwalter, DH Rowitch, VL Dawson, TM Dawson, B Stevens, BA Barres Neurotoxic reactive astrocytes are induced by activated microglia Nature, 2017-01-18;541(7638):481-487. 2017-01-18 [PMID: 28099414] (Bioassay, Human)	Bioassay	Human
Z Zhao, Y Ma, Z Chen, Q Liu, Q Li, D Kong, K Yuan, L Hu, T Wang, X Chen, Y Peng, W Jiang, Y Yu, X Liu Effects of Feeder Cells on Dopaminergic Differentiation of Human Embryonic Stem Cells Front Cell Neurosci, 2016-12-20;10(0):291. 2016-12-20 [PMID: 28066186] (Bioassay, Human)	Bioassay	Human
Enrique Armijo Increased susceptibility to a? toxicity in neuronal cultures derived from familial Azheimer's disease (PSEN1-A246E) induced pluripotent stem cells Neurosci. Lett, 2016-12-26;0(0):. 2016-12-26 [PMID: 28034781] (Bioassay, Human)	Bioassay	Human
Peizhou Jiang Histones facilitate ?-synuclein aggregation during neuronal apoptosis Acta Neuropathol, 2016-12-21;0(0):. 2016-12-21 [PMID: 28004278] (Bioassay, Human)	Bioassay	Human
Divya Varun A robust vitronectin-derived peptide for the scalable long-term expansion and neuronal differentiation of human pluripotent stem cell (hPSC)-derived neural progenitor cells (hNPCs) Acta Biomater, 2016-10-27;0(0):. 2016-10-27 [PMID: 27989923] (Bioassay, Human)	Bioassay	Human
Small molecules increase direct neural conversion of human fibroblasts Sci Rep, 2016-12-05;6(0):38290. 2016-12-05 [PMID: 27917895] (Bioassay, Human)	Bioassay	Human
Sustained synchronized neuronal network activity in a human astrocyte co-culture system Sci Rep, 2016-11-07;6(0):36529. 2016-11-07 [PMID: 27819315] (Bioassay, Human)	Bioassay	Human
T Yoshikawa, Hisano Y, Iwayama Y, Toyota T, Itasaka N, Dean B Analysis of induced pluripotent stem cells carrying 22q11.2 deletion. Transl Psychiatry, 2016-11-01;6(11):e934. 2016-11-01 [PMID: 27801899] (Bioassay, Human)	Bioassay	Human
MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells Sci Rep, 2016-09-09;6(0):32532. 2016-09-09 [PMID: 27608814] (Bioassay, Human)	Bioassay	Human
Microglial AGE-albumin is critical for neuronal death in Parkinson's disease: a possible implication for theranostics Int J Nanomedicine, 2016-08-23;10(0):281-92. 2016-08-23 [PMID: 27601894] (Bioassay, Human)	Bioassay	Human
Microfabric Vessels for Embryoid Body Formation and Rapid Differentiation of Pluripotent Stem Cells Sci Rep, 2016-08-10;6(0):31063. 2016-08-10 [PMID: 27507707] (Bioassay, Human)	Bioassay	Human
A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients Elife, 2016-07-26;5(0):. 2016-07-26 [PMID: 27458797] (Bioassay, Human)	Bioassay	Human
Raquel Pinho Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles PLoS ONE, 2016-06-20;11(6):e0157852. 2016-06-20 [PMID: 27322389] (Bioassay, Human)	Bioassay	Human
Margriet A Huisman Isolation, expansion and neural differentiation of stem cells from human plucked hair: a further step towards autologous nerve recovery Cytotechnology, 2015-12-24;68(5):1849-58. 2015-12-24 [PMID: 26702932] (Bioassay, Human)	Bioassay	Human
Jonas R, Klusch A, Schmelz M, Petersen M, Carr R Assessment of TTX-s and TTX-r Action Potential Conduction along Neurites of NGF and GDNF Cultured Porcine DRG Somata. PLoS ONE, 2015-09-25;10(9):e0139107. 2015-09-25 [PMID: 26407014] (Bioassay, Porcine)	Bioassay	Porcine
Lim M, Shin M, Lee S, Minn Y, Hoh J, Cho Y, Kim D, Lee S, Kim C, Park C Noggin Over-Expressing Mouse Embryonic Fibroblasts and MS5 Stromal Cells Enhance Directed Differentiation of Dopaminergic Neurons from Human Embryonic Stem Cells. PLoS ONE, 2015-09-18;10(9):e0138460. 2015-09-18 [PMID: 26383864] (Bioassay, Human)	Bioassay	Human
Laguna A, Schintu N, Nobre A, Alvarsson A, Volakakis N, Jacobsen J, Gomez-Galan M, Sopova E, Joodmardi E, Yoshitake T, Deng Q, Kehr J, Ericson J, Svenningsson P, Shupliakov O, Perlmann T Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease. Nat Neurosci, 2015-04-27;18(6):826-35. 2015-04-27 [PMID: 25915474] (Bioassay, Mouse)	Bioassay	Mouse
Merkle F, Maroof A, Wataya T, Sasai Y, Studer L, Eggan K, Schier A Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells. Development, 2015-02-15;142(4):633-43. 2015-02-15 [PMID: 25670790] (Bioassay, Human)	Bioassay	Human
Chen X, Wales P, Quinti L, Zuo F, Moniot S, Herisson F, Rauf N, Wang H, Silverman R, Ayata C, Maxwell M, Steegborn C, Schwarzschild M, Outeiro T, Kazantsev A The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia. PLoS ONE, 2015-01-21;10(1):e0116919. 2015-01-21 [PMID: 25608039] (Bioassay, Human)	Bioassay	Human
Devlin , Anna-Cla, Burr , Karen, Borooah , Shyamang, Foster , Joshua D, Cleary , Elaine M, Geti , Imbisaat, Vallier , Ludovic, Shaw , Christop, Chandran , Siddhart, Miles , Gareth B Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability. Nat Commun, 2015-01-12;6(0):5999. 2015-01-12 [PMID: 25580746] (Bioassay, Human)	Bioassay	Human
Jin H, Kanthasamy A, Harischandra D, Kondru N, Ghosh A, Panicker N, Anantharam V, Rana A, Kanthasamy A Histone hyperacetylation up-regulates protein kinase Cdelta in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease. J Biol Chem, 2014-10-23;289(50):34743-67. 2014-10-23 [PMID: 25342743] (Bioassay, Human)	Bioassay	Human
Pereira , Maria, Pfisterer , Ulrich, Rylander , Daniella, Torper , Olof, Lau , Shong, Lundblad , Martin, Grealish , Shane, Parmar , Malin Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain. Sci Rep, 2014-09-11;4(0):6330. 2014-09-11 [PMID: 25208484] (Bioassay, Human)	Bioassay	Human
Weng , Matthias, Natarajan , Karthick, Scholz , Diana, Ivanova , Violeta, Sachinidis , Agapios, Hengstler , Jan G, Waldmann , Tanja, Leist , Marcel Lineage-specific regulation of epigenetic modifier genes in human liver and brain. PLoS ONE, 2014-07-23;9(7):e102035. 2014-07-23 [PMID: 25054330] (Bioassay, Human)	Bioassay	Human
Peng , Lisheng, Adler , Michael, Demogines , Ann, Borrell , Andrew, Liu , Huisheng, Tao , Liang, Tepp , William, Zhang , Su-Chun, Johnson , Eric A, Sawyer , Sara L, Dong , Min Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins. PLoS Pathog, 2014-07-10;10(7):e1004177. 2014-07-10 [PMID: 25010769] (Bioassay, Human)	Bioassay	Human
Ali F, Cheng K, Kirwan P, Metcalfe S, Livesey F, Barker R, Philpott A The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro. Development, 2014-05-12;141(11):2216-24. 2014-05-12 [PMID: 24821983] (Bioassay, Human)	Bioassay	Human
Wang T, Bruggeman K, Sheean R, Turner B, Nisbet D, Parish C Characterization of the stability and bio-functionality of tethered proteins on bioengineered scaffolds: implications for stem cell biology and tissue repair. J Biol Chem, 2014-04-03;289(21):15044-51. 2014-04-03 [PMID: 24700461] (Bioassay, N/A, Synthetic)	Bioassay	N/A, Synthetic
Doers , Matthew, Musser , Michael, Nichol , Robert, Berndt , Erich R, Baker , Mei, Gomez , Timothy, Zhang , Su-Chun, Abbeduto , Leonard, Bhattacharyya , Anita iPSC-derived forebrain neurons from FXS individuals show defects in initial neurite outgrowth. Stem Cells Dev, 2014-04-30;23(15):1777-87. 2014-04-30 [PMID: 24654675] (Bioassay, Human)	Bioassay	Human
Zou , Qingjian, Yan , Quanmei, Zhong , Juan, Wang , Kepin, Sun , Haitao, Yi , Xiaoling, Lai , Liangxue Direct conversion of human fibroblasts into neuronal restricted progenitors. J Biol Chem, 2014-01-02;289(8):5250-60. 2014-01-02 [PMID: 24385434] (Bioassay, Human)	Bioassay	Human
Hasegawa K, Namekawa S, Saga Y MEK/ERK signaling directly and indirectly contributes to the cyclical self-renewal of spermatogonial stem cells. Stem Cells, 2013-11-01;31(11):2517-27. 2013-11-01 [PMID: 23897718] (Cell Culture, Mouse)	Cell Culture	Mouse
Quintino L, Manfre G, Wettergren E, Namislo A, Isaksson C, Lundberg C Functional neuroprotection and efficient regulation of GDNF using destabilizing domains in a rodent model of Parkinson's disease. Mol Ther, 2013-07-24;21(12):2169-80. 2013-07-24 [PMID: 23881415] (Bioassay, Human)	Bioassay	Human
Prots I, Veber V, Brey S, Campioni S, Buder K, Riek R, Bohm K, Winner B alpha-Synuclein oligomers impair neuronal microtubule-kinesin interplay. J Biol Chem, 2013-06-06;288(30):21742-54. 2013-06-06 [PMID: 23744071] (Bioassay, Human)	Bioassay	Human
Higurashi N, Uchida T, Lossin C, Misumi Y, Okada Y, Akamatsu W, Imaizumi Y, Zhang B, Nabeshima K, Mori M, Katsurabayashi S, Shirasaka Y, Okano H, Hirose S A human Dravet syndrome model from patient induced pluripotent stem cells. Mol Brain, 2013-05-02;6(0):19. 2013-05-02 [PMID: 23639079] (Bioassay, Human)	Bioassay	Human
Yang Y, Gupta S, Kim K, Powers B, Cerqueira A, Wainger B, Ngo H, Rosowski K, Schein P, Ackeifi C, Arvanites A, Davidow L, Woolf C, Rubin L A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. Cell Stem Cell, 2013-04-18;12(6):713-26. 2013-04-18 [PMID: 23602540] (Bioassay, Human)	Bioassay	Human
Woods D, Tilly J Isolation, characterization and propagation of mitotically active germ cells from adult mouse and human ovaries. Nat Protoc, 2013-04-18;8(5):966-88. 2013-04-18 [PMID: 23598447] (Bioassay, Human)	Bioassay	Human
Stappert L, Borghese L, Roese-Koerner B, Weinhold S, Koch P, Terstegge S, Uhrberg M, Wernet P, Brustle O MicroRNA-based promotion of human neuronal differentiation and subtype specification. PLoS ONE, 2013-03-18;8(3):e59011. 2013-03-18 [PMID: 23527072] (Bioassay, Human)	Bioassay	Human
Luo , Y, Tsuchiya , K D, Il Park , D, Fausel , R, Kanngurn , S, Welcsh , P, Dzieciatkowski , S, Wang , J, Grady , W M RET is a potential tumor suppressor gene in colorectal cancer. Oncogene, 2012-07-02;32(16):2037-47. 2012-07-02 [PMID: 22751117] (Bioassay, Human)	Bioassay	Human
Lundgren TK, Nakahata K, Fritz N, Rebellato P, Zhang S, Uhlen P RET PLC-gamma phosphotyrosine binding domain regulates Ca2+ signaling and neocortical neuronal migration. PLoS ONE, 2012-02-15;7(2):e31258. 2012-02-15 [PMID: 22355350] (Bioassay, Human)	Bioassay	Human
Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth. J. Biol. Chem., 2011-07-07;286(34):30034-46. 2011-07-07 [PMID: 21737454] (Surface Plasmon Resonance, Human, Mouse)	Surface Plasmon Resonance	Human, Mouse
Kubota H, Wu X, Goodyear SM, Avarbock MR, Brinster RL Glial cell line-derived neurotrophic factor and endothelial cells promote self-renewal of rabbit germ cells with spermatogonial stem cell properties. FASEB J., 2011-04-27;25(0):2604-14. 2011-04-27 [PMID: 21525489] (Bioassay, Rabbit)	Bioassay	Rabbit
Hadaczek P, Johnston L, Forsayeth J, Bankiewicz KS Pharmacokinetics and bioactivity of glial cell line-derived factor (GDNF) and neurturin (NTN) infused into the rat brain. Neuropharmacology, 2010-02-11;58(7):1114-21. 2010-02-11 [PMID: 20153340] (In Vivo, Rat)	In Vivo	Rat
Wang YC, Wu YT, Huang HY, Lin HI, Lo LW, Tzeng SF, Yang CS Sustained intraspinal delivery of neurotrophic factor encapsulated in biodegradable nanoparticles following contusive spinal cord injury. Biomaterials, 2008-09-06;29(34):4546-53. 2008-09-06 [PMID: 18774604] (In Vivo, Rat)	In Vivo	Rat
Lu B, PereiraPerrin M A novel immunoprecipitation strategy identifies a unique functional mimic of the glial cell line-derived neurotrophic factor family ligands in the pathogen Trypanosoma cruzi. Infect. Immun., 2008-06-09;76(8):3530-8. 2008-06-09 [PMID: 18541656] (ELISA (Capture), Bacteria)	ELISA (Capture)	Bacteria
Ladewig J, Koch P, Endl E, Meiners B, Opitz T, Couillard-Despres S, Aigner L, Brustle O Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons. Stem Cells, 2008-04-17;26(7):1705-12. 2008-04-17 [PMID: 18420830] (Bioassay, Human)	Bioassay	Human
Ai X, Kitazawa T, Do AT, Kusche-Gullberg M, Labosky PA, Emerson CP SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation. Development, 2007-09-01;134(18):3327-38. 2007-09-01 [PMID: 17720696] (Bioassay, Mouse)	Bioassay	Mouse
Pankratz MT, Li XJ, Lavaute TM, Lyons EA, Chen X, Zhang SC Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage. Stem Cells, 2007-03-01;25(6):1511-20. 2007-03-01 [PMID: 17332508] (Bioassay, Human, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Human, Primate - Macaca mulatta (Rhesus Macaque)
Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C Multipotent adult progenitor cells from swine bone marrow. Stem Cells, 2006-08-24;24(11):2355-66. 2006-08-24 [PMID: 16931778] (Bioassay, Porcine)	Bioassay	Porcine
Nagy N, Goldstein AM Endothelin-3 regulates neural crest cell proliferation and differentiation in the hindgut enteric nervous system. Dev. Biol., 2006-03-06;293(1):203-17. 2006-03-06 [PMID: 16519884] (Bioassay, Chicken)	Bioassay	Chicken
Girard BM, Young BA, Buttolph TR, Locknar SA, White SL, Parsons RL Trophic factor modulation of cocaine- and amphetamine-regulated transcript peptide expression in explant cultured guinea-pig cardiac neurons. Neuroscience, 2006-03-03;139(4):1329-41. 2006-03-03 [PMID: 16516394] (Bioassay, Guinea Pig)	Bioassay	Guinea Pig
Castelo-Branco G, Sousa KM, Bryja V, Pinto L, Wagner J, Arenas E Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion. Mol. Cell. Neurosci., 2005-10-21;31(2):251-62. 2005-10-21 [PMID: 16243537] (Bioassay, Rat)	Bioassay	Rat
Perrier AL, Tabar V, Barberi T, Rubio ME, Bruses J, Topf N, Harrison NL, Studer L Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A., 2004-08-13;101(34):12543-8. 2004-08-13 [PMID: 15310843] (Bioassay, Human, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Human, Primate - Macaca mulatta (Rhesus Macaque)
Esper RM, Loeb JA Rapid axoglial signaling mediated by neuregulin and neurotrophic factors. J. Neurosci., 2004-07-07;24(27):6218-27. 2004-07-07 [PMID: 15240814] (Bioassay, Chicken)	Bioassay	Chicken
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Array 212-GD

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