Gazestani, V;Kamath, T;Nadaf, NM;Burris, SJ;Rooney, B;Junkkari, A;Vanderburg, C;Rauramaa, T;Therrien, M;Tegtmeyer, M;Herukka, SK;Abdulraouf, A;Marsh, S;Malm, T;Hiltunen, M;Nehme, R;Stevens, B;Leinonen, V;Macosko, EZ; Early Alzheimer's disease pathology in human cortex is associated with a transient phase of distinct cell states bioRxiv : the preprint server for biology 2023-06-05 [PMID: 37333365] (Bioassay, Human) |
Bioassay |
Human |
YW Jun, S Lee, BK Ban, JA Lee, FB Gao Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis Autophagy, 2023-02-27;0(0):1-17. 2023-02-27 [PMID: 36849436] (Bioassay, Human) |
Bioassay |
Human |
HW Ong, Y Liang, W Richardson, ER Lowry, CI Wells, X Chen, M Silvestre, K Dempster, JA Silvaroli, JL Smith, H Wichterle, NS Pabla, SK Ultanir, AN Bullock, DH Drewry, AD Axtman A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective bioRxiv : the preprint server for biology, 2023-02-10;0(0):. 2023-02-10 [PMID: 36798313] (Bioassay, Human) |
Bioassay |
Human |
GR Linares, Y Li, WH Chang, J Rubin-Sigl, S Mendonca, S Hong, Y Eoh, W Guo, YH Huang, J Chang, S Tu, N Dorjsuren, M Santana, ST Hung, J Yu, J Perez, M Chickering, TY Cheng, CC Huang, SJ Lee, HJ Deng, KT Bach, K Gray, V Subramanya, J Rosenfeld, SV Alworth, H Goodarzi, JK Ichida SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS Cell Stem Cell, 2023-02-02;30(2):171-187.e14. 2023-02-02 [PMID: 36736291] (Bioassay, Human) |
Bioassay |
Human |
O Pietiläine, A Trehan, D Meyer, J Mitchell, M Tegtmeyer, V Valakh, H Gebre, T Chen, E Vartiainen, SL Farhi, K Eggan, SA McCarroll, R Nehme Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons Cell Reports, 2023-01-12;42(1):111988. 2023-01-12 [PMID: 36640364] (Bioassay, Human) |
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Human |
Z Álvarez, JA Ortega, K Sato, IR Sasselli, AN Kolberg-Ed, R Qiu, KA Marshall, TP Nguyen, CS Smith, KA Quinlan, V Papakis, Z Syrgiannis, NA Sather, C Musumeci, E Engel, SI Stupp, E Kiskinis Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons Cell Stem Cell, 2023-01-12;0(0):. 2023-01-12 [PMID: 36638801] (Bioassay, Human) |
Bioassay |
Human |
CB Pantazis, A Yang, E Lara, JA McDonough, C Blauwendra, L Peng, H Oguro, J Kanaujiya, J Zou, D Sebesta, G Pratt, E Cross, J Blockwick, P Buxton, L Kinner-Bib, C Medura, C Tompkins, S Hughes, M Santiana, F Faghri, MA Nalls, D Vitale, S Ballard, YA Qi, DM Ramos, KM Anderson, J Stadler, P Narayan, J Papademetr, L Reilly, MP Nelson, S Aggarwal, LU Rosen, P Kirwan, V Pisupati, SL Coon, SW Scholz, T Priebe, M Öttl, J Dong, M Meijer, LJM Janssen, VS Lourenco, R van der Ka, D Crusius, D Paquet, AC Raulin, G Bu, A Held, BJ Wainger, RMC Gabriele, JM Casey, S Wray, D Abu-Bonsra, CL Parish, MS Beccari, DW Cleveland, E Li, IVL Rose, M Kampmann, C Calatayud, P Verstreken, L Heinrich, MY Chen, B Schüle, D Dou, ELF Holzbaur, MC Zanellati, R Basundra, M Deshmukh, S Cohen, R Khanna, M Raman, ZS Nevin, M Matia, J Van Lent, V Timmerman, BR Conklin, K Johnson Ch, K Zhang, S Funes, DA Bosco, L Erlebach, M Welzer, D Kronenberg, G Lyu, E Arenas, E Coccia, L Sarrafha, T Ahfeldt, JC Marioni, WC Skarnes, MR Cookson, ME Ward, FT Merkle A reference human induced pluripotent stem cell line for large-scale collaborative studies Cell Stem Cell, 2022-12-01;29(12):1685-1702.e22. 2022-12-01 [PMID: 36459969] (Bioassay, Human) |
Bioassay |
Human |
JR Herdy, L Traxler, RK Agarwal, L Karbacher, JCM Schlachetz, L Boehnke, D Zangwill, D Galasko, CK Glass, J Mertens, FH Gage Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer's disease Cell Stem Cell, 2022-12-01;29(12):1637-1652.e6. 2022-12-01 [PMID: 36459967] (Bioassay, Human) |
Bioassay |
Human |
M Jones, A Cunningham, N Frank, D Sethi The monoculture of cord-blood-derived CD34+ cells by an automated, membrane-based dynamic perfusion system with a novel cytokine cocktail Stem Cell Reports, 2022-11-03;0(0):. 2022-11-03 [PMID: 36332632] (Bioassay, Human) |
Bioassay |
Human |
G Kim, L Nakayama, JA Blum, T Akiyama, S Boeynaems, M Chakrabort, J Couthouis, E Tassoni-Ts, CM Rodriguez, MC Bassik, AD Gitler Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2 Cell Reports, 2022-10-25;41(4):111508. 2022-10-25 [PMID: 36288714] (Bioassay, Human) |
Bioassay |
Human |
C Seah, MS Breen, T Rusielewic, HN Bader, C Xu, CJ Hunter, B McCarthy, PJM Deans, M Chattopadh, J Goldberg, F Desarnaud, I Makotkine, JD Flory, LM Bierer, M Staniskyte, NYSCF Glob, SA Noggle, LM Huckins, D Paull, KJ Brennand, R Yehuda Modeling gene � environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression Nature Neuroscience, 2022-10-20;25(11):1434-1445. 2022-10-20 [PMID: 36266471] (Bioassay, Human) |
Bioassay |
Human |
T Patel, J Hammelman, S Aziz, S Jang, M Closser, TL Michaels, JA Blum, DK Gifford, H Wichterle Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro Nature Communications, 2022-09-15;13(1):5427. 2022-09-15 [PMID: 36109497] (Cell Culture, Mouse) |
Cell Culture |
Mouse |
L Mahoney-Sa, H Bouchaoui, I Boussaad, A Jonneaux, K Timmerman, O Berdeaux, S Ayton, R Krüger, JA Duce, D Devos, JC Devedjian Alpha synuclein determines ferroptosis sensitivity in dopaminergic neurons via modulation of ether-phospholipid membrane composition Cell Reports, 2022-08-23;40(8):111231. 2022-08-23 [PMID: 36001957] (Bioassay, Human) |
Bioassay |
Human |
R Lieberman, LK Cortes, G Gao, H Park, B Wang, PL Jones, RB Hunter, JP Leonard, RH Barker Human iPSC-derived astrocytes generated from donors with globoid cell leukodystrophy display phenotypes associated with disease PLoS ONE, 2022-08-03;17(8):e0271360. 2022-08-03 [PMID: 35921286] (Bioassay, Human) |
Bioassay |
Human |
K ?uczkowska, O Taryma-Le?, J Bi?kowski, KE Soko?owska, D Strapagiel, J Jarczak, E Paczkowska, B Machali?sk, TK Wojdacz Long-Term Treatment with Bortezomib Induces Specific Methylation Changes in Differentiated Neuronal Cells Cancers, 2022-07-13;14(14):. 2022-07-13 [PMID: 35884461] (Bioassay, Human) |
Bioassay |
Human |
M Sawamura, K Imamura, R Hikawa, T Enami, A Nagahashi, H Yamakado, H Ichijo, T Fujisawa, H Yamashita, S Minamiyama, M Kaido, H Wada, M Urushitani, H Inoue, N Egawa, R Takahashi Cellular analysis of SOD1 protein-aggregation propensity and toxicity: a case of ALS with slow progression harboring homozygous SOD1-D92G mutation Scientific Reports, 2022-07-25;12(1):12636. 2022-07-25 [PMID: 35879519] (Bioassay, Human) |
Bioassay |
Human |
Y Chen, Q Yin, XY Cheng, JR Zhang, H Jin, K Li, CJ Mao, F Wang, HZ Bei, CF Liu G2019S LRRK2 Mutation Enhances MPP+-Induced Inflammation of Human Induced Pluripotent Stem Cells-Differentiated Dopaminergic Neurons Frontiers in Neuroscience, 2022-07-06;16(0):947927. 2022-07-06 [PMID: 35873822] (Bioassay, Human) |
Bioassay |
Human |
MA Hossain, M Hasegawa-O, Y Manome, M Igarashi, C Wu, K Suzuki, J Igarashi, T Iwamoto, HJ Okano, Y Eto Generation and characterization of motor neuron progenitors and motor neurons using metachromatic leukodystrophy-induced pluripotent stem cells Oncogene, 2022-02-21;31(0):100852. 2022-02-21 [PMID: 35782608] (Bioassay, Human) |
Bioassay |
Human |
MK Eltahir, M Nakamori, S Hattori, T Kimura, H Mochizuki, S Nagano Pharmacotherapy alleviates pathological changes in human direct reprogrammed neuronal cell model of myotonic dystrophy type 1 PLoS ONE, 2022-07-01;17(7):e0269683. 2022-07-01 [PMID: 35776705] (Bioassay, Human) |
Bioassay |
Human |
FC Yang, JL Vivian, C Traxler, SM Shapiro, JA Stanford MGE-Like Neural Progenitor Cell Survival and Expression of Parvalbumin and Proenkephalin in a Jaundiced Rat Model of Kernicterus Cell Transplantation, 2022-01-01;31(0):9636897221101. 2022-01-01 [PMID: 35596532] (Bioassay, Human) |
Bioassay |
Human |
AK Holzer, I Suciu, C Karreman, T Goj, M Leist Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro International Journal of Molecular Sciences, 2022-03-29;23(7):. 2022-03-29 [PMID: 35409095] (Differentiation, Differentiation, Human) |
Differentiation, Differentiation |
Human |
Salokas K, Liu X, Ohman T, Chowdhury I, Gawriyski L, Keskitalo S, Varjosalo M Physical and functional interactome atlas of human receptor tyrosine kinases. EMBO Rep, 2022-04-05;23(6):e54041. 2022-04-05 [PMID: 35384245] (Bioassay, Human) |
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Human |
JM Suárez-Riv, CJ Pastor-Mal, A Romero-Gon, D Gómez-Fern, S Povea-Cabe, M Álvarez-Có, I Villalón-G, M Talaverón-, A Suárez-Car, M Munuera-Ca, JA Sánchez-Al Pterostilbene in Combination With Mitochondrial Cofactors Improve Mitochondrial Function in Cellular Models of Mitochondrial Diseases Frontiers in Pharmacology, 2022-03-18;13(0):862085. 2022-03-18 [PMID: 35370630] (Bioassay, Human) |
Bioassay |
Human |
M Häkli, S Jäntti, T Joki, L Sukki, K Tornberg, K Aalto-Setä, P Kallio, M Pekkanen-M, S Narkilahti Human Neurons Form Axon-Mediated Functional Connections with Human Cardiomyocytes in Compartmentalized Microfluidic Chip International Journal of Molecular Sciences, 2022-03-15;23(6):. 2022-03-15 [PMID: 35328569] (Bioassay, Human) |
Bioassay |
Human |
L Torres-Gar, JM P Domingue, E Brandi, C Haikal, JM Mudannayak, IC Brás, E Gerhardt, W Li, A Svanbergss, TF Outeiro, GK Gouras, JY Li Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation Scientific Reports, 2022-02-22;12(1):2987. 2022-02-22 [PMID: 35194057] (Bioassay, Human) |
Bioassay |
Human |
N Moriarty, CW Gantner, CPJ Hunt, CM Ermine, S Frausin, S Viventi, DA Ovchinniko, D Kirik, CL Parish, LH Thompson A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells Cell Stem Cell, 2022-02-17;29(3):434-448.e5. 2022-02-17 [PMID: 35180398] (Bioassay, Human) |
Bioassay |
Human |
WM Seo, J Yoon, JH Lee, Y Lee, H Lee, D Geum, W Sun, MR Song Modeling axonal regeneration by changing cytoskeletal dynamics in stem cell-derived motor nerve organoids Scientific Reports, 2022-02-08;12(1):2082. 2022-02-08 [PMID: 35136073] (Bioassay, Human) |
Bioassay |
Human |
R Mzezewa, J Lotila, H Kiiski, A Vinogradov, FE Kapucu, J Peltola, S Hagman, S Narkilahti A kainic acid-induced seizure model in human pluripotent stem cell-derived cortical neurons for studying the role of IL-6 in the functional activity Stem Cell Research, 2022-01-17;60(0):102665. 2022-01-17 [PMID: 35091307] (Bioassay, Human) |
Bioassay |
Human |
P Nouri, A Zimmer, S Brüggemann, R Friedrich, R Kühn, N Prakash Generation of a NES-mScarlet Red Fluorescent Reporter Human iPSC Line for Live Cell Imaging and Flow Cytometric Analysis and Sorting Using CRISPR-Cas9-Mediated Gene Editing Cells, 2022-01-13;11(2):. 2022-01-13 [PMID: 35053384] (Bioassay, Human) |
Bioassay |
Human |
A Bruzelius, S Kidnapilla, J Drouin-Oue, T Stoker, RA Barker, D Rylander O Reprogramming Human Adult Fibroblasts into GABAergic Interneurons Cells, 2021-12-08;10(12):. 2021-12-08 [PMID: 34943958] (Bioassay, Human) |
Bioassay |
Human |
D Segelcke, HK Fischer, M Hütte, S Dennerlein, F Benseler, N Brose, EM Pogatzki-Z, M Schmidt Tmem160 contributes to the establishment of discrete nerve injury-induced pain behaviors in male mice Cell Reports, 2021-12-21;37(12):110152. 2021-12-21 [PMID: 34936870] (Bioassay, Mouse) |
Bioassay |
Mouse |
C Vajhøj, B Schmid, A Alik, R Melki, K Fog, B Holst, TC Stummann Establishment of a human induced pluripotent stem cell neuronal model for identification of modulators of A53T alpha-synuclein levels and aggregation PLoS ONE, 2021-12-21;16(12):e0261536. 2021-12-21 [PMID: 34932569] (Bioassay, Human) |
Bioassay |
Human |
AM Earley, LF Burbulla, D Krainc, R Awatramani Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons Scientific Reports, 2021-11-15;11(1):22257. 2021-11-15 [PMID: 34782629] (Bioassay, Human) |
Bioassay |
Human |
P Sabatier, CM Beusch, AA Saei, M Aoun, N Moruzzi, A Coelho, N Leijten, M Nordenskjö, P Micke, D Maltseva, AG Tonevitsky, V Millischer, J Carlos Vil, S Kadekar, M Gaetani, K Altynbekov, A Kel, PO Berggren, O Simonson, KH Grinnemo, R Holmdahl, S Rodin, RA Zubarev An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation Nature Communications, 2021-11-12;12(1):6558. 2021-11-12 [PMID: 34772928] (Bioassay, Human) |
Bioassay |
Human |
Y Sonobe, J Aburas, G Krishnan, AC Fleming, G Ghadge, P Islam, EC Warren, Y Gu, MW Kankel, AEX Brown, E Kiskinis, TF Gendron, FB Gao, RP Roos, P Kratsios A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation Nature Communications, 2021-10-15;12(1):6025. 2021-10-15 [PMID: 34654821] (Bioassay, Human) |
Bioassay |
Human |
X Reed, MM Cobb, G Skinbinski, D Roosen, A Kaganovich, J Ding, S Finkbeiner, MR Cookson Transcriptional signatures in iPSC-derived neurons are reproducible across labs when differentiation protocols are closely matched Stem Cell Research, 2021-10-03;56(0):102558. 2021-10-03 [PMID: 34626895] (Cell Culture, Human) |
Cell Culture |
Human |
M Shibata, K Pattabiram, B Lorente-Ga, D Andrijevic, SK Kim, N Kaur, SK Muchnik, X Xing, G Santpere, AMM Sousa, N Sestan Regulation of prefrontal patterning and connectivity by retinoic acid Nature, 2021-10-01;0(0):. 2021-10-01 [PMID: 34599305] (Cell Culture, Human, Primate) |
Cell Culture |
Human, Primate |
Q Tang, P Gao, T Arzberger, M Höllerhage, J Herms, G Höglinger, T Koeglsperg Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion Cell Death & Disease, 2021-09-17;12(10):854. 2021-09-17 [PMID: 34535638] (Bioassay, Human) |
Bioassay |
Human |
N Gustavsson, E Savchenko, O Klementiev, L Roybon The intracellular milieu of Parkinson's disease patient brain cells modulates alpha-synuclein protein aggregation Acta neuropathologica communications, 2021-09-16;9(1):153. 2021-09-16 [PMID: 34530929] (Bioassay, Human) |
Bioassay |
Human |
K Tan, HW Song, MF Wilkinson RHOX10 drives mouse spermatogonial stem cell establishment through a transcription factor signaling cascade Cell Reports, 2021-07-20;36(3):109423. 2021-07-20 [PMID: 34289349] (Bioassay, Human) |
Bioassay |
Human |
B Calamini, N Geyer, N Huss-Braun, A Bernhardt, V Harsany, P Rival, M Cindhuchao, D Hoffmann, S Gratzer Development of a physiologically relevant and easily scalable LUHMES cell-based model of G2019S LRRK2-driven Parkinson's disease Disease Models & Mechanisms, 2021-06-11;14(6):. 2021-06-11 [PMID: 34114604] (Bioassay, Human) |
Bioassay |
Human |
IR de Luzy, KCL Law, N Moriarty, CPJ Hunt, JC Durnall, LH Thompson, A Nagy, CL Parish Human stem cells harboring a suicide gene improve the�safety and standardisation of neural transplants in Parkinsonian rats Nature Communications, 2021-05-27;12(1):3275. 2021-05-27 [PMID: 34045451] (Bioassay, Human) |
Bioassay |
Human |
ZT Olmsted, JL Paluh Co-development of central and peripheral neurons with trunk mesendoderm in human elongating multi-lineage organized gastruloids Nature Communications, 2021-05-21;12(1):3020. 2021-05-21 [PMID: 34021144] (Bioassay, Human) |
Bioassay |
Human |
A Boyer, X Zhang, A Levasseur, N Abou Nader, G St-Jean, MC Nagano, D Boerboom Constitutive activation of CTNNB1 results in a loss of spermatogonial stem cell activity in mice PLoS ONE, 2021-05-20;16(5):e0251911. 2021-05-20 [PMID: 34015032] (Bioassay, Transgenic Mouse) |
Bioassay |
Transgenic Mouse |
G Pintacuda, FH Lassen, YH Hsu, A Kim, JM Martín, E Malolepsza, JK Lim, N Fornelos, KC Eggan, K Lage Genoppi is an open-source software for robust and standardized integration of proteomic and genetic data Nature Communications, 2021-05-10;12(1):2580. 2021-05-10 [PMID: 33972534] (Bioassay, Human) |
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Human |
B Calamini, N Geyer, N Huss-Braun, A Bernhardt, V Harsany, P Rival, M Cindhuchao, D Hoffmann, S Gratzer Development of a physiologically relevant and easily scalable LUHMES cell-based model of G2019S LRRK2 driven parkinson's disease Disease Models & Mechanisms, 2021-01-01;0(0):. 2021-01-01 [PMID: 33955449] (Bioassay, Human) |
Bioassay |
Human |
J Mertens, JR Herdy, L Traxler, ST Schafer, JCM Schlachetz, L Böhnke, DA Reid, H Lee, D Zangwill, DP Fernandes, RK Agarwal, R Lucciola, L Zhou-Yang, L Karbacher, F Edenhofer, S Stern, S Horvath, ACM Paquola, CK Glass, SH Yuan, M Ku, A Szücs, LSB Goldstein, D Galasko, FH Gage Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients Cell Stem Cell, 2021-04-27;0(0):. 2021-04-27 [PMID: 33910058] (Bioassay, Human) |
Bioassay |
Human |
X Dong, L Yang, K Liu, X Ji, C Tang, W Li, L Ma, Y Mei, T Peng, B Feng, Z Wu, Q Tang, Y Gao, K Yan, W Zhou, M Xiong Transcriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment Cell Reports, 2021-03-02;34(9):108802. 2021-03-02 [PMID: 33657377] (Bioassay, Human) |
Bioassay |
Human |
B Sun, X Yang, F Hou, X Yu, Q Wang, HS Oh, P Raja, JM Pesola, EAH Vanni, S McCarron, J Morris-Lov, AHM Ng, GM Church, DM Knipe, DM Coen, D Pan Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency Nature Microbiology, 2021-02-08;0(0):. 2021-02-08 [PMID: 33558653] (Bioassay, Mouse) |
Bioassay |
Mouse |
TY Feng, Q Li, F Ren, HM Xi, DL Lv, Y Li, JH Hu Melatonin Protects Goat Spermatogonial Stem Cells against Oxidative Damage during Cryopreservation by Improving Antioxidant Capacity and Inhibiting Mitochondrial Apoptosis Pathway Oxidative Medicine and Cellular Longevity, 2020-12-31;2020(0):5954635. 2020-12-31 [PMID: 33488926] (Bioassay, Goat) |
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Goat |
A Merlevede, EM Legault, V Drugge, RA Barker, J Drouin-Oue, V Olariu A quantitative model of cellular decision making in direct neuronal reprogramming Scientific Reports, 2021-01-15;11(1):1514. 2021-01-15 [PMID: 33452356] (Bioassay, Human) |
Bioassay |
Human |
SE Howden, SB Wilson, E Groenewege, L Starks, TA Forbes, KS Tan, JM Vanslambro, EM Holloway, YH Chen, S Jain, JR Spence, MH Little Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk Cell Stem Cell, 2020-12-29;0(0):. 2020-12-29 [PMID: 33378647] (Bioassay, Human) |
Bioassay |
Human |
L Honkamäki, T Joki, NA Grigoryev, K Levon, L Ylä-Outine, S Narkilahti Novel method to produce a layered 3D scaffold for human pluripotent stem cell-derived neuronal cells Journal of neuroscience methods, 2020-12-17;350(0):109043. 2020-12-17 [PMID: 33345946] (Bioassay, Human) |
Bioassay |
Human |
K Uchimura, H Wu, Y Yoshimura, BD Humphreys Human Pluripotent Stem Cell-Derived Kidney Organoids with Improved Collecting Duct Maturation and Injury Modeling Cell Reports, 2020-12-15;33(11):108514. 2020-12-15 [PMID: 33326782] (Bioassay, Human) |
Bioassay |
Human |
D Jutzi, S Campagne, R Schmidt, S Reber, J Mechtershe, F Gypas, C Schweingru, M Colombo, C von Schroe, FE Loughlin, A Devoy, E Hedlund, M Zavolan, FH Allain, MD Ruepp Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis Nature Communications, 2020-12-11;11(1):6341. 2020-12-11 [PMID: 33311468] (Bioassay, Human) |
Bioassay |
Human |
S Lito, A Sidibe, S Ilmjarv, P Burda, M Baumgartne, B Wehrle-Hal, KH Krause, A Marteyn Induced Pluripotent Stem Cells to Understand Mucopolysaccharidosis. I: Demonstration of a Migration Defect in Neural Precursors Cells, 2020-12-03;9(12):. 2020-12-03 [PMID: 33287330] (Bioassay, Human) |
Bioassay |
Human |
J Giacomoni, A Bruzelius, CA Stamouli, D Rylander O Direct Conversion of Human Stem Cell-Derived Glial Progenitor Cells into GABAergic Interneurons Cells, 2020-11-10;9(11):. 2020-11-10 [PMID: 33182669] (Bioassay, Human) |
Bioassay |
Human |
N Ramesh, EL Daley, AM Gleixner, JR Mann, S Kour, D Mawrie, EN Anderson, J Kofler, CJ Donnelly, E Kiskinis, UB Pandey RNA dependent suppression of C9orf72 ALS/FTD associated neurodegeneration by Matrin-3 Acta Neuropathol Commun, 2020-10-31;8(1):177. 2020-10-31 [PMID: 33129345] (Cell Culture, Human) |
Cell Culture |
Human |
Y Kwon, Y Bang, SH Moon, A Kim, HJ Choi Amitriptyline interferes with autophagy-mediated clearance of protein aggregates via inhibiting autophagosome maturation in neuronal cells Cell Death Dis, 2020-10-17;11(10):874. 2020-10-17 [PMID: 33070168] (Bioassay, Human) |
Bioassay |
Human |
S Nolbrant, J Giacomoni, DB Hoban, A Bruzelius, M Birtele, D Chandler-M, M Pereira, DR Ottosson, SA Goldman, M Parmar Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons Stem Cell Reports, 2020-09-24;0(0):. 2020-09-24 [PMID: 32976765] (Bioassay, Human) |
Bioassay |
Human |
JW Kim, X Yin, A Jhaldiyal, MR Khan, I Martin, Z Xie, T Perez-Rose, M Kumar, L Abalde-Atr, J Xu, L Chen, SM Eacker, DJ Surmeier, NT Ingolia, TM Dawson, VL Dawson Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis Cell Stem Cell, 2020-08-25;27(4):633-645.e7. 2020-08-25 [PMID: 32846140] (Bioassay, Human) |
Bioassay |
Human |
KM Prautsch, A Schmidt, V Paradiso, DJ Schaefer, R Guzman, DF Kalbermatt, S Madduri Modulation of Human Adipose Stem Cells' Neurotrophic Capacity Using a Variety of Growth Factors for Neural Tissue Engineering Applications: Axonal Growth, Transcriptional, and Phosphoproteomic Analyses In Vitro Cells, 2020-08-21;9(9):. 2020-08-21 [PMID: 32839392] (Bioassay, Cell Culture, Human) |
Bioassay, Cell Culture |
Human |
K Hirata, T Nambara, K Kawatani, N Nawa, H Yoshimatsu, H Kusakabe, K Banno, K Nishimura, M Ohtaka, M Nakanishi, H Taniguchi, H Arahori, K Wada, K Ozono, Y Kitabatake 4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates Sci Rep, 2020-08-20;10(1):14047. 2020-08-20 [PMID: 32820178] (Bioassay, Human) |
Bioassay |
Human |
CA Tristan, P Ormanoglu, J Slamecka, C Malley, PH Chu, VM Jovanovic, Y Gedik, C Bonney, E Barnaeva, J Braisted, SK Mallanna, D Dorjsuren, MJ Iannotti, TC Voss, S Michael, A Simeonov, I Singeç Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells bioRxiv, 2020-08-03;0(0):. 2020-08-03 [PMID: 32793899] (Bioassay, Human) |
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Human |
LS VandenBosc, SG Wohl, MS Wilken, M Hooper, C Finkbeiner, K Cox, L Chipman, TA Reh Developmental changes in the accessible chromatin, transcriptome and Ascl1-binding correlate with the loss in M�ller Glial regenerative potential Sci Rep, 2020-08-12;10(1):13615. 2020-08-12 [PMID: 32788677] (Bioassay, Mouse) |
Bioassay |
Mouse |
SI Mae, M Ryosaka, S Sakamoto, K Matsuse, A Nozaki, M Igami, R Kabai, A Watanabe, K Osafune Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential Cell Rep, 2020-07-28;32(4):107963. 2020-07-28 [PMID: 32726627] (Bioassay, Human) |
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Human |
N Michel, P Narayanan, O Shomroni, M Schmidt Maturational Changes in Mouse Cutaneous Touch and Piezo2-Mediated Mechanotransduction Cell Rep, 2020-07-21;32(3):107912. 2020-07-21 [PMID: 32697985] (Bioassay, Mouse) |
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Mouse |
S Das Sharma, R Pal, BK Reddy, BT Selvaraj, N Raj, KK Samaga, DJ Srinivasan, L Ornelas, D Sareen, MR Livesey, GJ Bassell, CN Svendsen, PC Kind, S Chandran, S Chattarji, DJA Wyllie Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns Mol Autism, 2020-06-19;11(1):52. 2020-06-19 [PMID: 32560741] (Bioassay, Human) |
Bioassay |
Human |
SK Rastogi, R Garg, MG Scopelliti, BI Pinto, JE Hartung, S Kim, CGE Murphey, N Johnson, D San Roman, F Bezanilla, JF Cahoon, MS Gold, M Chamanzar, T Cohen-Karn Remote nongenetic optical modulation of neuronal activity using fuzzy graphene Proc. Natl. Acad. Sci. U.S.A., 2020-06-01;0(0):. 2020-06-01 [PMID: 32482882] (Bioassay, Rat) |
Bioassay |
Rat |
H Tsujimoto, T Kasahara, SI Sueta, T Araoka, S Sakamoto, C Okada, SI Mae, T Nakajima, N Okamoto, D Taura, M Nasu, T Shimizu, M Ryosaka, Z Li, M Sone, M Ikeya, A Watanabe, K Osafune A Modular Differentiation System Maps Multiple Human Kidney Lineages from Pluripotent Stem Cells Cell Rep, 2020-04-07;31(1):107476. 2020-04-07 [PMID: 32268094] (Bioassay, Human) |
Bioassay |
Human |
P Gee, MSY Lung, Y Okuzaki, N Sasakawa, T Iguchi, Y Makita, H Hozumi, Y Miura, LF Yang, M Iwasaki, XH Wang, MA Waller, N Shirai, YO Abe, Y Fujita, K Watanabe, A Kagita, KA Iwabuchi, M Yasuda, H Xu, T Noda, J Komano, H Sakurai, N Inukai, A Hotta Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping Nat Commun, 2020-03-13;11(1):1334. 2020-03-13 [PMID: 32170079] (Bioassay, Human) |
Bioassay |
Human |
K Matsumura, K Seiriki, S Okada, M Nagase, S Ayabe, I Yamada, T Furuse, H Shibuya, Y Yasuda, H Yamamori, M Fujimoto, K Nagayasu, K Yamamoto, K Kitagawa, H Miura, N Gotoda-Nis, H Igarashi, M Hayashida, M Baba, M Kondo, S Hasebe, K Ueshima, A Kasai, Y Ago, A Hayata-Tak, N Shintani, T Iguchi, M Sato, S Yamaguchi, M Tamura, S Wakana, A Yoshiki, AM Watabe, H Okano, K Takuma, R Hashimoto, H Hashimoto, T Nakazawa Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes Nat Commun, 2020-02-26;11(1):859. 2020-02-26 [PMID: 32103003] (Bioassay, Human) |
Bioassay |
Human |
Y Yuan, L Li, Q Cheng, F Diao, Q Zeng, X Yang, Y Wu, H Zhang, M Huang, J Chen, Q Zhou, Y Zhu, R Hua, J Tian, X Wang, Z Zhou, J Hao, J Yu, D Hua, J Liu, X Guo, Q Zhou, J Sha In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids Cell Res., 2020-02-21;0(0):. 2020-02-21 [PMID: 32086476] (Bioassay, Human) |
Bioassay |
Human |
K Onodera, D Shimojo, Y Ishihara, M Yano, F Miya, H Banno, N Kuzumaki, T Ito, R Okada, B de Araújo, M Ohyama, M Yoshida, T Tsunoda, M Katsuno, M Doyu, G Sobue, H Okano, Y Okada Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs Mol Brain, 2020-02-19;13(1):18. 2020-02-19 [PMID: 32070397] (Bioassay, Human) |
Bioassay |
Human |
K Takeda, Y Kawamoto, Y Nagasaki, Y Okuno, Y Goto, M Iida, I Yajima, N Ohgami, M Kato Peptides containing the MXXCW motif inhibit oncogenic RET kinase activity with a novel mechanism of action Am J Cancer Res, 2020-01-01;10(1):336-349. 2020-01-01 [PMID: 32064171] (Cell Culture, Human) |
Cell Culture |
Human |
CW Gantner, IR de Luzy, JA Kauhausen, N Moriarty, JC Niclis, CR Bye, V Penna, CPJ Hunt, CM Ermine, CW Pouton, D Kirik, LH Thompson, CL Parish Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease Cell Stem Cell, 2020-02-13;0(0):. 2020-02-13 [PMID: 32059808] (Bioassay, Human) |
Bioassay |
Human |
T Chakroun, V Evsyukov, NP Nykänen, M Höllerhage, A Schmidt, F Kamp, VC Ruf, W Wurst, TW Rösler, GU Höglinger Alpha-synuclein fragments trigger distinct aggregation pathways Cell Death Dis, 2020-02-03;11(2):84. 2020-02-03 [PMID: 32015326] (Bioassay, Human) |
Bioassay |
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P Kielkowski, IY Buchsbaum, VC Kirsch, NC Bach, M Drukker, S Cappello, SA Sieber FICD activity and AMPylation remodelling modulate human neurogenesis Nat Commun, 2020-01-24;11(1):517. 2020-01-24 [PMID: 31980631] (Differentiation, Differentiation, Human) |
Differentiation, Differentiation |
Human |
AR Nickolls, MM Lee, DF Espinoza, M Szczot, RM Lam, Q Wang, J Beers, J Zou, MQ Nguyen, HJ Solinski, AA AlJanahi, KR Johnson, ME Ward, AT Chesler, CG Bönnemann Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells Cell Rep, 2020-01-21;30(3):932-946.e7. 2020-01-21 [PMID: 31968264] (Differentiation, Differentiation, Human) |
Differentiation, Differentiation |
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H Munezane, H Oizumi, T Wakabayash, S Nishio, T Hirasawa, T Sato, A Harada, T Yoshida, T Eguchi, Y Yamanashi, T Hashimoto, T Iwatsubo Roles of Collagen XXV and Its Putative Receptors PTPsigma/delta in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder Cell Rep, 2019-12-24;29(13):4362-4376.e6. 2019-12-24 [PMID: 31875546] (Cell Culture, Mouse) |
Cell Culture |
Mouse |
A Bonafina, MF Trinchero, AS Ríos, P Bekinschte, AF Schinder, G Paratcha, F Ledda GDNF and GFRalpha1 Are Required for Proper Integration of Adult-Born Hippocampal Neurons Cell Rep, 2019-12-24;29(13):4308-4319.e4. 2019-12-24 [PMID: 31875542] (Cell Culture, Mouse) |
Cell Culture |
Mouse |
M Chumarina, K Russ, C Azevedo, A Heuer, M Pihl, A Collin, EÅ Frostner, E Elmer, P Hyttel, G Cappellett, M Zini, S Goldwurm, L Roybon Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene Acta Neuropathol Commun, 2019-12-16;7(1):208. 2019-12-16 [PMID: 31843010] (Bioassay, Human) |
Bioassay |
Human |
S Mahajani, A Raina, C Fokken, S Kügler, M Bähr Homogenous generation of dopaminergic neurons from multiple hiPSC lines by transient expression of transcription factors Cell Death Dis, 2019-11-27;10(12):898. 2019-11-27 [PMID: 31776327] (Cell Culture, Human) |
Cell Culture |
Human |
T Hyvärinen, A Hyysalo, FE Kapucu, L Aarnos, A Vinogradov, SJ Eglen, L Ylä-Outine, S Narkilahti Functional characterization of human pluripotent stem cell-derived cortical networks differentiated on laminin-521 substrate: comparison to rat cortical cultures Sci Rep, 2019-11-20;9(1):17125. 2019-11-20 [PMID: 31748598] (Differentiation, Differentiation, Human) |
Differentiation, Differentiation |
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D Leitner, M Ramamoorth, M Dejosez, TP Zwaka Immature mDA neurons ameliorate motor deficits in a 6-OHDA Parkinson's disease mouse model and are functional after cryopreservation Stem Cell Res, 2019-10-24;41(0):101617. 2019-10-24 [PMID: 31731178] (Cell Culture, In vitro, Human, Mouse) |
Cell Culture, In vitro |
Human, Mouse |
HM Larsen, SK Hansen, JD Mikkelsen, P Hyttel, TC Stummann Alpha7 nicotinic acetylcholine receptors and neural network synaptic transmission in human induced pluripotent stem cell-derived neurons Stem Cell Res, 2019-10-31;41(0):101642. 2019-10-31 [PMID: 31707211] (Cell Culture, Human) |
Cell Culture |
Human |
IR de Luzy, JC Niclis, CW Gantner, JA Kauhausen, CPJ Hunt, C Ermine, CW Pouton, LH Thompson, CL Parish Isolation of LMX1a ventral midbrain progenitors improves the safety and predictability of human pluripotent stem cell-derived neural transplants in Parkinsonian Disease J. Neurosci., 2019-10-22;0(0):. 2019-10-22 [PMID: 31641054] (Bioassay, Human) |
Bioassay |
Human |
JC Butts, N Iyer, N White, R Thompson, S Sakiyama-E, TC McDevitt V2a interneuron differentiation from mouse and human pluripotent stem cells Nat Protoc, 2019-10-18;0(0):. 2019-10-18 [PMID: 31628445] (Bioassay, Human, Mouse) |
Bioassay |
Human, Mouse |
J Luo, Y Xia, Y Yin, J Luo, M Liu, H Zhang, C Zhang, Y Zhao, L Yang, L Kong ATF4 destabilizes RET through nonclassical GRP78 inhibition to enhance chemosensitivity to bortezomib in human osteosarcoma Theranostics, 2019-08-14;9(21):6334-6353. 2019-08-14 [PMID: 31534554] (Bioassay, Human) |
Bioassay |
Human |
CY Lin, M Yoshida, LT Li, A Ikenaka, S Oshima, K Nakagawa, H Sakurai, E Matsui, T Nakahata, MK Saito iPSC-derived functional human neuromuscular junctions model the pathophysiology of neuromuscular diseases JCI Insight, 2019-09-19;4(18):. 2019-09-19 [PMID: 31534050] (Bioassay, Human) |
Bioassay |
Human |
KN Babos, KE Galloway, K Kisler, M Zitting, Y Li, Y Shi, B Quintino, RH Chow, BV Zlokovic, JK Ichida Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming Cell Stem Cell, 2019-09-12;25(4):486-500.e9. 2019-09-12 [PMID: 31523028] (Cell Culture, Mouse) |
Cell Culture |
Mouse |
J Cholewa-Wa, R Shah, S Webb, K Chhatbar, B Ramsahoye, O Pusch, M Yu, P Greulich, B Waclaw, AP Bird Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic Proc. Natl. Acad. Sci. U.S.A., 2019-07-09;116(30):14995-15000. 2019-07-09 [PMID: 31289233] (Bioassay, Human) |
Bioassay |
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H Yang, D Hao, C Liu, D Huang, B Chen, H Fan, C Liu, L Zhang, Q Zhang, J An, J Zhao Generation of functional dopaminergic neurons from human spermatogonial stem cells to rescue parkinsonian phenotypes Stem Cell Res Ther, 2019-06-27;10(1):195. 2019-06-27 [PMID: 31248447] (Cell Culture, Human) |
Cell Culture |
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T Ryynänen, A Pelkonen, K Grigoras, OME Ylivaara, T Hyvärinen, J Ahopelto, M Prunnila, S Narkilahti, J Lekkala Microelectrode Array With Transparent ALD TiN Electrodes Front Neurosci, 2019-03-22;13(0):226. 2019-03-22 [PMID: 30967754] (Bioassay, Human) |
Bioassay |
Human |
M Elkouris, G Kouroupi, A Vourvoukel, N Papagianna, V Kaltezioti, R Matsas, L Stefanis, M Xilouri, PK Politis Long Non-coding RNAs Associated With Neurodegeneration-Linked Genes Are Reduced in Parkinson's Disease Patients Front Cell Neurosci, 2019-02-22;13(0):58. 2019-02-22 [PMID: 30853899] (Bioassay, Human) |
Bioassay |
Human |
J Ooi, SR Langley, X Xu, KH Utami, B Sim, Y Huang, NP Harmston, YL Tay, A Ziaei, R Zeng, D Low, F Aminkeng, RM Sobota, F Ginhoux, E Petretto, MA Pouladi Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects Cell Rep, 2019-02-26;26(9):2494-2508.e7. 2019-02-26 [PMID: 30811996] (Bioassay, Human) |
Bioassay |
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J Gong, ÉM Szeg?, A Leonov, E Benito, S Becker, A Fischer, M Zweckstett, T Outeiro, A Schneider Translocator protein ligand protects against neurodegeneration in the MPTP mouse model of Parkinsonism J. Neurosci., 2019-02-22;0(0):. 2019-02-22 [PMID: 30796158] (Bioassay, Human) |
Bioassay |
Human |
M Wu, L Ma, L Xue, W Ye, Z Lu, X Li, Y Jin, X Qin, D Chen, W Tang, Y Chen, Z Hong, J Zhang, A Luo, S Wang Resveratrol alleviates chemotherapy-induced oogonial stem cell apoptosis and ovarian aging in mice Aging (Albany NY), 2019-02-14;11(3):1030-1044. 2019-02-14 [PMID: 30779707] (Bioassay, Mouse) |
Bioassay |
Mouse |
C Iwasawa, N Kuzumaki, Y Suda, R Kagawa, Y Oka, N Hattori, H Okano, M Narita Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations Mol Brain, 2019-01-18;12(1):5. 2019-01-18 [PMID: 30658665] (Bioassay, Human) |
Bioassay |
Human |
Z Melamed, J López-Erau, MW Baughn, O Zhang, K Drenner, Y Sun, F Freyermuth, MA McMahon, MS Beccari, JW Artates, T Ohkubo, M Rodriguez, N Lin, D Wu, CF Bennett, F Rigo, S Da Cruz, J Ravits, C Lagier-Tou, DW Cleveland Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration Nat. Neurosci., 2019-01-14;22(2):180-190. 2019-01-14 [PMID: 30643298] (Bioassay, Human) |
Bioassay |
Human |
JR Klim, LA Williams, F Limone, I Guerra San, BN Davis-Duse, DA Mordes, A Burberry, MJ Steinbaugh, KK Gamage, R Kirchner, R Moccia, SH Cassel, K Chen, BJ Wainger, CJ Woolf, K Eggan ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair Nat. Neurosci., 2019-01-14;22(2):167-179. 2019-01-14 [PMID: 30643292] (Bioassay, Human) |
Bioassay |
Human |
S Gutbier, AS Spreng, J Delp, S Schildknec, C Karreman, I Suciu, T Brunner, M Groettrup, M Leist Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress Cell Death Differ., 2018-11-02;0(0):. 2018-11-02 [PMID: 30390092] (Bioassay, Human) |
Bioassay |
Human |
K Kirino, T Nakahata, T Taguchi, MK Saito Efficient derivation of sympathetic neurons from human pluripotent stem cells with a defined condition Sci Rep, 2018-08-27;8(1):12865. 2018-08-27 [PMID: 30150715] (Bioassay, Human) |
Bioassay |
Human |
K Fujimori, M Ishikawa, A Otomo, N Atsuta, R Nakamura, T Akiyama, S Hadano, M Aoki, H Saya, G Sobue, H Okano Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent Nat. Med., 2018-08-20;0(0):. 2018-08-20 [PMID: 30127392] (Bioassay, Human) |
Bioassay |
Human |
S Koyuncu, I Saez, HJ Lee, R Gutierrez-, W Pokrzywa, A Fatima, T Hoppe, D Vilchez The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients Nat Commun, 2018-07-23;9(1):2886. 2018-07-23 [PMID: 30038412] (Bioassay, Human) |
Bioassay |
Human |
N Tsuburaya, K Homma, T Higuchi, A Balia, H Yamakoshi, N Shibata, S Nakamura, H Nakagawa, SI Ikeda, N Umezawa, N Kato, S Yokoshima, M Shibuya, M Shimonishi, H Kojima, T Okabe, T Nagano, I Naguro, K Imamura, H Inoue, T Fujisawa, H Ichijo A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model Nat Commun, 2018-07-10;9(1):2668. 2018-07-10 [PMID: 29991716] (Bioassay, Human) |
Bioassay |
Human |
Y Yehuda, B Blumenfeld, N Mayorek, K Makedonski, O Vardi, L Cohen-Dani, Y Mansour, S Baror-Sebb, H Masika, M Farago, M Berger, S Carmi, Y Buganim, A Koren, I Simon Germline DNA replication timing shapes mammalian genome composition Nucleic Acids Res., 2018-09-19;0(0):. 2018-09-19 [PMID: 29986092] (Bioassay, Mouse) |
Bioassay |
Mouse |
G Collo, L Cavalleri, M Zoli, U Maskos, E Ratti, E Merlo Pich Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons Front Pharmacol, 2018-06-01;9(0):572. 2018-06-01 [PMID: 29910731] (Bioassay, Human) |
Bioassay |
Human |
R Nehme, E Zuccaro, SD Ghosh, C Li, JL Sherwood, O Pietilaine, LE Barrett, F Limone, KA Worringer, S Kommineni, Y Zang, D Cacchiarel, A Meissner, R Adolfsson, S Haggarty, J Madison, M Muller, P Arlotta, Z Fu, G Feng, K Eggan Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission Cell Rep, 2018-05-22;23(8):2509-2523. 2018-05-22 [PMID: 29791859] (Bioassay, Human) |
Bioassay |
Human |
K Kakiuchi, K Taniguchi, H Kubota Conserved and non-conserved characteristics of porcine glial cell line-derived neurotrophic factor expressed in the testis Sci Rep, 2018-05-16;8(1):7656. 2018-05-16 [PMID: 29769589] (Bioassay, Mouse) |
Bioassay |
Mouse |
MJ Ziller, JA Ortega, KA Quinlan, DP Santos, H Gu, EJ Martin, C Galonska, R Pop, S Maidl, A Di Pardo, M Huang, HY Meltzer, A Gnirke, CJ Heckman, A Meissner, E Kiskinis Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology Cell Stem Cell, 2018-03-15;0(0):. 2018-03-15 [PMID: 29551301] (Bioassay, Human) |
Bioassay |
Human |
G Collo, L Cavalleri, F Bono, C Mora, S Fedele, RW Invernizzi, M Gennarelli, G Piovani, T Kunath, MJ Millan, E Merlo Pich, P Spano Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling Neural Plast., 2018-02-04;2018(0):4196961. 2018-02-04 [PMID: 29531524] (Bioassay, Human) |
Bioassay |
Human |
R Jalili, J Horecka, JR Swartz, RW Davis, HHJ Persson Streamlined circular proximity ligation assay provides high stringency and compatibility with low-affinity antibodies Proc. Natl. Acad. Sci. U.S.A., 2018-01-16;0(0):. 2018-01-16 [PMID: 29339495] (Bioassay) |
Bioassay |
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N Avaliani, U Pfisterer, A Heuer, M Parmar, M Kokaia, M Andersson Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus Stem Cells Int, 2017-11-26;2017(0):5718608. 2017-11-26 [PMID: 29317869] (Bioassay, Human) |
Bioassay |
Human |
E Silvestris, P Cafforio, S D'Oronzo, C Felici, F Silvestris, G Loverro In vitro differentiation of human oocyte-like cells from oogonial stem cells: single-cell isolation and molecular characterization Hum. Reprod., 2018-03-01;0(0):. 2018-03-01 [PMID: 29304224] (Bioassay, Human) |
Bioassay |
Human |
EA Newman, S Chukkapall, D Bashllari, TT Thomas, RA Van Noord, ER Lawlor, MJ Hoenerhoff, AW Opipari, VP Opipari Alternative NHEJ pathway proteins as components of MYCN oncogenic activity in human neural crest stem cell differentiation: implications for neuroblastoma initiation Cell Death Dis, 2017-12-13;8(12):3208. 2017-12-13 [PMID: 29238067] (Bioassay, Human) |
Bioassay |
Human |
O Awad, LM Panicker, RM Deranieh, MP Srikanth, RA Brown, A Voit, T Peesay, TS Park, ET Zambidis, RA Feldman Altered Differentiation Potential of Gaucher's Disease iPSC Neuronal Progenitors due to Wnt/?-Catenin Downregulation Stem Cell Reports, 2017-11-30;9(6):1853-1867. 2017-11-30 [PMID: 29198828] (Bioassay, Human) |
Bioassay |
Human |
T Ruetz, U Pfisterer, B Di Stefano, J Ashmore, M Beniazza, TV Tian, DF Kaemena, L Tosti, W Tan, JR Manning, E Chantzoura, DR Ottosson, S Collombet, A Johnsson, E Cohen, K Yusa, S Linnarsson, T Graf, M Parmar, K Kaji Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming Cell Stem Cell, 2017-11-22;0(0):. 2017-11-22 [PMID: 29174331] (Bioassay, Human) |
Bioassay |
Human |
A Taguchi, R Nishinakam Higher-Order Kidney Organogenesis from Pluripotent Stem Cells Cell Stem Cell, 2017-11-09;0(0):. 2017-11-09 [PMID: 29129523] (Bioassay, Human) |
Bioassay |
Human |
M Ferreira, S Boens, C Winkler, K Szekér, I Verbinnen, A Van Eynde, M Fardilha, M Bollen The protein phosphatase 1 regulator NIPP1 is essential for mammalian spermatogenesis Sci Rep, 2017-10-17;7(1):13364. 2017-10-17 [PMID: 29042623] (Bioassay, Mouse) |
Bioassay |
Mouse |
M Höllerhage, C Moebius, J Melms, WH Chiu, JN Goebel, T Chakroun, T Koeglsperg, WH Oertel, TW Rösler, M Bickle, GU Höglinger Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells Sci Rep, 2017-09-13;7(1):11469. 2017-09-13 [PMID: 28904388] (Bioassay, Human) |
Bioassay |
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J Liu, D Shang, Y Xiao, P Zhong, H Cheng, R Zhou Isolation and characterization of string-forming female germline stem cells from ovaries of neonatal mice J. Biol. Chem., 2017-08-21;0(0):. 2017-08-21 [PMID: 28827310] (Bioassay, Mouse) |
Bioassay |
Mouse |
J Drouin-Oue, S Lau, PL Brattås, D Rylander O, K Pircs, DA Grassi, LM Collins, R Vuono, A Andersson, G Westergren, C Graff, L Minthon, H Toresson, RA Barker, J Jakobsson, M Parmar REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways EMBO Mol Med, 2017-08-01;9(8):1117-1131. 2017-08-01 [PMID: 28646119] (Bioassay, Human) |
Bioassay |
Human |
HJ Park, EC Bolton RET-mediated glial cell line derived neurotrophic factor signaling inhibits mouse prostate development Development, 2017-05-15;0(0):. 2017-05-15 [PMID: 28506996] (Bioassay, Mouse) |
Bioassay |
Mouse |
K Gassei, Y Sheng, A Fayomi, P Mital, M Sukhwani, CC Lin, KA Peters, A Althouse, H Valli, KE Orwig DDX4-EGFP transgenic rat model for the study of germline development and spermatogenesis Biol. Reprod., 2017-03-01;96(3):707-719. 2017-03-01 [PMID: 28339678] (Cell Culture, Rat) |
Cell Culture |
Rat |
JC Niclis, CW Gantner, WF Alsanie, SJ McDougall, CR Bye, AG Elefanty, EG Stanley, JM Haynes, CW Pouton, LH Thompson, CL Parish Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents Stem Cells Transl Med, 2016-10-14;6(3):937-948. 2016-10-14 [PMID: 28297587] (Bioassay, Human) |
Bioassay |
Human |
I Gat, L Maghen, M Filice, B Wyse, K Zohni, K Jarvi, KC Lo, A Gauthier F, C Librach Optimal culture conditions are critical for efficient expansion of human testicular somatic and germ cells in�vitro Fertil. Steril, 2017-03-01;107(3):595-605.e7. 2017-03-01 [PMID: 28259258] (Bioassay, Human) |
Bioassay |
Human |
M Sambi, T Chow, J Whiteley, M Li, S Chua, V Raileanu, IM Rogers Acellular Mouse Kidney ECM can be Used as a Three-Dimensional Substrate to Test the Differentiation Potential of Embryonic Stem Cell Derived Renal Progenitors Stem Cell Rev, 2017-08-01;0(0):. 2017-08-01 [PMID: 28239758] (Bioassay, Mouse) |
Bioassay |
Mouse |
S Menges, G Minakaki, PM Schaefer, H Meixner, I Prots, U Schlötzer-, K Friedland, B Winner, TF Outeiro, KF Winklhofer, CA von Arnim, W Xiang, J Winkler, J Klucken Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress Sci Rep, 2017-02-22;7(0):42942. 2017-02-22 [PMID: 28224980] (Bioassay, Human) |
Bioassay |
Human |
SK Goparaju, K Kohda, K Ibata, A Soma, Y Nakatake, T Akiyama, S Wakabayash, M Matsushita, M Sakota, H Kimura, M Yuzaki, SB Ko, MS Ko Rapid differentiation of human pluripotent stem cells into functional neurons by mRNAs encoding transcription factors Sci Rep, 2017-02-13;7(0):42367. 2017-02-13 [PMID: 28205555] (Bioassay, Human) |
Bioassay |
Human |
MJ Boland, KL Nazor, HT Tran, A Szücs, CL Lynch, R Paredes, F Tassone, PP Sanna, RJ Hagerman, JF Loring Molecular analyses of neurogenic defects in a human pluripotent stem cell model of fragile X syndrome Brain, 2017-03-01;140(3):582-598. 2017-03-01 [PMID: 28137726] (Bioassay, Human) |
Bioassay |
Human |
SA Liddelow, KA Guttenplan, LE Clarke, FC Bennett, CJ Bohlen, L Schirmer, ML Bennett, AE Mnch, WS Chung, TC Peterson, DK Wilton, A Frouin, BA Napier, N Panicker, M Kumar, MS Buckwalter, DH Rowitch, VL Dawson, TM Dawson, B Stevens, BA Barres Neurotoxic reactive astrocytes are induced by activated microglia Nature, 2017-01-18;541(7638):481-487. 2017-01-18 [PMID: 28099414] (Bioassay, Human) |
Bioassay |
Human |
Z Zhao, Y Ma, Z Chen, Q Liu, Q Li, D Kong, K Yuan, L Hu, T Wang, X Chen, Y Peng, W Jiang, Y Yu, X Liu Effects of Feeder Cells on Dopaminergic Differentiation of Human Embryonic Stem Cells Front Cell Neurosci, 2016-12-20;10(0):291. 2016-12-20 [PMID: 28066186] (Bioassay, Human) |
Bioassay |
Human |
Enrique Armijo Increased susceptibility to a? toxicity in neuronal cultures derived from familial Azheimer's disease (PSEN1-A246E) induced pluripotent stem cells Neurosci. Lett, 2016-12-26;0(0):. 2016-12-26 [PMID: 28034781] (Bioassay, Human) |
Bioassay |
Human |
Peizhou Jiang Histones facilitate ?-synuclein aggregation during neuronal apoptosis Acta Neuropathol, 2016-12-21;0(0):. 2016-12-21 [PMID: 28004278] (Bioassay, Human) |
Bioassay |
Human |
Divya Varun A robust vitronectin-derived peptide for the scalable long-term expansion and neuronal differentiation of human pluripotent stem cell (hPSC)-derived neural progenitor cells (hNPCs) Acta Biomater, 2016-10-27;0(0):. 2016-10-27 [PMID: 27989923] (Bioassay, Human) |
Bioassay |
Human |
Small molecules increase direct neural conversion of human fibroblasts Sci Rep, 2016-12-05;6(0):38290. 2016-12-05 [PMID: 27917895] (Bioassay, Human) |
Bioassay |
Human |
Sustained synchronized neuronal network activity in a human astrocyte co-culture system Sci Rep, 2016-11-07;6(0):36529. 2016-11-07 [PMID: 27819315] (Bioassay, Human) |
Bioassay |
Human |
T Yoshikawa, Hisano Y, Iwayama Y, Toyota T, Itasaka N, Dean B Analysis of induced pluripotent stem cells carrying 22q11.2 deletion. Transl Psychiatry, 2016-11-01;6(11):e934. 2016-11-01 [PMID: 27801899] (Bioassay, Human) |
Bioassay |
Human |
MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells Sci Rep, 2016-09-09;6(0):32532. 2016-09-09 [PMID: 27608814] (Bioassay, Human) |
Bioassay |
Human |
Microglial AGE-albumin is critical for neuronal death in Parkinson's disease: a possible implication for theranostics Int J Nanomedicine, 2016-08-23;10(0):281-92. 2016-08-23 [PMID: 27601894] (Bioassay, Human) |
Bioassay |
Human |
Microfabric Vessels for Embryoid Body Formation and Rapid Differentiation of Pluripotent Stem Cells Sci Rep, 2016-08-10;6(0):31063. 2016-08-10 [PMID: 27507707] (Bioassay, Human) |
Bioassay |
Human |
A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients Elife, 2016-07-26;5(0):. 2016-07-26 [PMID: 27458797] (Bioassay, Human) |
Bioassay |
Human |
Raquel Pinho Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles PLoS ONE, 2016-06-20;11(6):e0157852. 2016-06-20 [PMID: 27322389] (Bioassay, Human) |
Bioassay |
Human |
Margriet A Huisman Isolation, expansion and neural differentiation of stem cells from human plucked hair: a further step towards autologous nerve recovery Cytotechnology, 2015-12-24;68(5):1849-58. 2015-12-24 [PMID: 26702932] (Bioassay, Human) |
Bioassay |
Human |
Jonas R, Klusch A, Schmelz M, Petersen M, Carr R Assessment of TTX-s and TTX-r Action Potential Conduction along Neurites of NGF and GDNF Cultured Porcine DRG Somata. PLoS ONE, 2015-09-25;10(9):e0139107. 2015-09-25 [PMID: 26407014] (Bioassay, Porcine) |
Bioassay |
Porcine |
Lim M, Shin M, Lee S, Minn Y, Hoh J, Cho Y, Kim D, Lee S, Kim C, Park C Noggin Over-Expressing Mouse Embryonic Fibroblasts and MS5 Stromal Cells Enhance Directed Differentiation of Dopaminergic Neurons from Human Embryonic Stem Cells. PLoS ONE, 2015-09-18;10(9):e0138460. 2015-09-18 [PMID: 26383864] (Bioassay, Human) |
Bioassay |
Human |
Laguna A, Schintu N, Nobre A, Alvarsson A, Volakakis N, Jacobsen J, Gomez-Galan M, Sopova E, Joodmardi E, Yoshitake T, Deng Q, Kehr J, Ericson J, Svenningsson P, Shupliakov O, Perlmann T Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease. Nat Neurosci, 2015-04-27;18(6):826-35. 2015-04-27 [PMID: 25915474] (Bioassay, Mouse) |
Bioassay |
Mouse |
Merkle F, Maroof A, Wataya T, Sasai Y, Studer L, Eggan K, Schier A Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells. Development, 2015-02-15;142(4):633-43. 2015-02-15 [PMID: 25670790] (Bioassay, Human) |
Bioassay |
Human |
Chen X, Wales P, Quinti L, Zuo F, Moniot S, Herisson F, Rauf N, Wang H, Silverman R, Ayata C, Maxwell M, Steegborn C, Schwarzschild M, Outeiro T, Kazantsev A The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia. PLoS ONE, 2015-01-21;10(1):e0116919. 2015-01-21 [PMID: 25608039] (Bioassay, Human) |
Bioassay |
Human |
Devlin , Anna-Cla, Burr , Karen, Borooah , Shyamang, Foster , Joshua D, Cleary , Elaine M, Geti , Imbisaat, Vallier , Ludovic, Shaw , Christop, Chandran , Siddhart, Miles , Gareth B Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability. Nat Commun, 2015-01-12;6(0):5999. 2015-01-12 [PMID: 25580746] (Bioassay, Human) |
Bioassay |
Human |
Jin H, Kanthasamy A, Harischandra D, Kondru N, Ghosh A, Panicker N, Anantharam V, Rana A, Kanthasamy A Histone hyperacetylation up-regulates protein kinase Cdelta in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease. J Biol Chem, 2014-10-23;289(50):34743-67. 2014-10-23 [PMID: 25342743] (Bioassay, Human) |
Bioassay |
Human |
Pereira , Maria, Pfisterer , Ulrich, Rylander , Daniella, Torper , Olof, Lau , Shong, Lundblad , Martin, Grealish , Shane, Parmar , Malin Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain. Sci Rep, 2014-09-11;4(0):6330. 2014-09-11 [PMID: 25208484] (Bioassay, Human) |
Bioassay |
Human |
Weng , Matthias, Natarajan , Karthick, Scholz , Diana, Ivanova , Violeta, Sachinidis , Agapios, Hengstler , Jan G, Waldmann , Tanja, Leist , Marcel Lineage-specific regulation of epigenetic modifier genes in human liver and brain. PLoS ONE, 2014-07-23;9(7):e102035. 2014-07-23 [PMID: 25054330] (Bioassay, Human) |
Bioassay |
Human |
Peng , Lisheng, Adler , Michael, Demogines , Ann, Borrell , Andrew, Liu , Huisheng, Tao , Liang, Tepp , William, Zhang , Su-Chun, Johnson , Eric A, Sawyer , Sara L, Dong , Min Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins. PLoS Pathog, 2014-07-10;10(7):e1004177. 2014-07-10 [PMID: 25010769] (Bioassay, Human) |
Bioassay |
Human |
Ali F, Cheng K, Kirwan P, Metcalfe S, Livesey F, Barker R, Philpott A The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro. Development, 2014-05-12;141(11):2216-24. 2014-05-12 [PMID: 24821983] (Bioassay, Human) |
Bioassay |
Human |
Wang T, Bruggeman K, Sheean R, Turner B, Nisbet D, Parish C Characterization of the stability and bio-functionality of tethered proteins on bioengineered scaffolds: implications for stem cell biology and tissue repair. J Biol Chem, 2014-04-03;289(21):15044-51. 2014-04-03 [PMID: 24700461] (Bioassay, N/A, Synthetic) |
Bioassay |
N/A, Synthetic |
Doers , Matthew, Musser , Michael, Nichol , Robert, Berndt , Erich R, Baker , Mei, Gomez , Timothy, Zhang , Su-Chun, Abbeduto , Leonard, Bhattacharyya , Anita iPSC-derived forebrain neurons from FXS individuals show defects in initial neurite outgrowth. Stem Cells Dev, 2014-04-30;23(15):1777-87. 2014-04-30 [PMID: 24654675] (Bioassay, Human) |
Bioassay |
Human |
Zou , Qingjian, Yan , Quanmei, Zhong , Juan, Wang , Kepin, Sun , Haitao, Yi , Xiaoling, Lai , Liangxue Direct conversion of human fibroblasts into neuronal restricted progenitors. J Biol Chem, 2014-01-02;289(8):5250-60. 2014-01-02 [PMID: 24385434] (Bioassay, Human) |
Bioassay |
Human |
Hasegawa K, Namekawa S, Saga Y MEK/ERK signaling directly and indirectly contributes to the cyclical self-renewal of spermatogonial stem cells. Stem Cells, 2013-11-01;31(11):2517-27. 2013-11-01 [PMID: 23897718] (Cell Culture, Mouse) |
Cell Culture |
Mouse |
Quintino L, Manfre G, Wettergren E, Namislo A, Isaksson C, Lundberg C Functional neuroprotection and efficient regulation of GDNF using destabilizing domains in a rodent model of Parkinson's disease. Mol Ther, 2013-07-24;21(12):2169-80. 2013-07-24 [PMID: 23881415] (Bioassay, Human) |
Bioassay |
Human |
Prots I, Veber V, Brey S, Campioni S, Buder K, Riek R, Bohm K, Winner B alpha-Synuclein oligomers impair neuronal microtubule-kinesin interplay. J Biol Chem, 2013-06-06;288(30):21742-54. 2013-06-06 [PMID: 23744071] (Bioassay, Human) |
Bioassay |
Human |
Higurashi N, Uchida T, Lossin C, Misumi Y, Okada Y, Akamatsu W, Imaizumi Y, Zhang B, Nabeshima K, Mori M, Katsurabayashi S, Shirasaka Y, Okano H, Hirose S A human Dravet syndrome model from patient induced pluripotent stem cells. Mol Brain, 2013-05-02;6(0):19. 2013-05-02 [PMID: 23639079] (Bioassay, Human) |
Bioassay |
Human |
Yang Y, Gupta S, Kim K, Powers B, Cerqueira A, Wainger B, Ngo H, Rosowski K, Schein P, Ackeifi C, Arvanites A, Davidow L, Woolf C, Rubin L A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. Cell Stem Cell, 2013-04-18;12(6):713-26. 2013-04-18 [PMID: 23602540] (Bioassay, Human) |
Bioassay |
Human |
Woods D, Tilly J Isolation, characterization and propagation of mitotically active germ cells from adult mouse and human ovaries. Nat Protoc, 2013-04-18;8(5):966-88. 2013-04-18 [PMID: 23598447] (Bioassay, Human) |
Bioassay |
Human |
Stappert L, Borghese L, Roese-Koerner B, Weinhold S, Koch P, Terstegge S, Uhrberg M, Wernet P, Brustle O MicroRNA-based promotion of human neuronal differentiation and subtype specification. PLoS ONE, 2013-03-18;8(3):e59011. 2013-03-18 [PMID: 23527072] (Bioassay, Human) |
Bioassay |
Human |
Luo , Y, Tsuchiya , K D, Il Park , D, Fausel , R, Kanngurn , S, Welcsh , P, Dzieciatkowski , S, Wang , J, Grady , W M RET is a potential tumor suppressor gene in colorectal cancer. Oncogene, 2012-07-02;32(16):2037-47. 2012-07-02 [PMID: 22751117] (Bioassay, Human) |
Bioassay |
Human |
Lundgren TK, Nakahata K, Fritz N, Rebellato P, Zhang S, Uhlen P RET PLC-gamma phosphotyrosine binding domain regulates Ca2+ signaling and neocortical neuronal migration. PLoS ONE, 2012-02-15;7(2):e31258. 2012-02-15 [PMID: 22355350] (Bioassay, Human) |
Bioassay |
Human |
Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth. J. Biol. Chem., 2011-07-07;286(34):30034-46. 2011-07-07 [PMID: 21737454] (Surface Plasmon Resonance, Human, Mouse) |
Surface Plasmon Resonance |
Human, Mouse |
Kubota H, Wu X, Goodyear SM, Avarbock MR, Brinster RL Glial cell line-derived neurotrophic factor and endothelial cells promote self-renewal of rabbit germ cells with spermatogonial stem cell properties. FASEB J., 2011-04-27;25(0):2604-14. 2011-04-27 [PMID: 21525489] (Bioassay, Rabbit) |
Bioassay |
Rabbit |
Hadaczek P, Johnston L, Forsayeth J, Bankiewicz KS Pharmacokinetics and bioactivity of glial cell line-derived factor (GDNF) and neurturin (NTN) infused into the rat brain. Neuropharmacology, 2010-02-11;58(7):1114-21. 2010-02-11 [PMID: 20153340] (In Vivo, Rat) |
In Vivo |
Rat |
Wang YC, Wu YT, Huang HY, Lin HI, Lo LW, Tzeng SF, Yang CS Sustained intraspinal delivery of neurotrophic factor encapsulated in biodegradable nanoparticles following contusive spinal cord injury. Biomaterials, 2008-09-06;29(34):4546-53. 2008-09-06 [PMID: 18774604] (In Vivo, Rat) |
In Vivo |
Rat |
Lu B, PereiraPerrin M A novel immunoprecipitation strategy identifies a unique functional mimic of the glial cell line-derived neurotrophic factor family ligands in the pathogen Trypanosoma cruzi. Infect. Immun., 2008-06-09;76(8):3530-8. 2008-06-09 [PMID: 18541656] (ELISA (Capture), Bacteria) |
ELISA (Capture) |
Bacteria |
Ladewig J, Koch P, Endl E, Meiners B, Opitz T, Couillard-Despres S, Aigner L, Brustle O Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons. Stem Cells, 2008-04-17;26(7):1705-12. 2008-04-17 [PMID: 18420830] (Bioassay, Human) |
Bioassay |
Human |
Ai X, Kitazawa T, Do AT, Kusche-Gullberg M, Labosky PA, Emerson CP SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation. Development, 2007-09-01;134(18):3327-38. 2007-09-01 [PMID: 17720696] (Bioassay, Mouse) |
Bioassay |
Mouse |
Pankratz MT, Li XJ, Lavaute TM, Lyons EA, Chen X, Zhang SC Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage. Stem Cells, 2007-03-01;25(6):1511-20. 2007-03-01 [PMID: 17332508] (Bioassay, Human, Primate - Macaca mulatta (Rhesus Macaque)) |
Bioassay |
Human, Primate - Macaca mulatta (Rhesus Macaque) |
Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C Multipotent adult progenitor cells from swine bone marrow. Stem Cells, 2006-08-24;24(11):2355-66. 2006-08-24 [PMID: 16931778] (Bioassay, Porcine) |
Bioassay |
Porcine |
Nagy N, Goldstein AM Endothelin-3 regulates neural crest cell proliferation and differentiation in the hindgut enteric nervous system. Dev. Biol., 2006-03-06;293(1):203-17. 2006-03-06 [PMID: 16519884] (Bioassay, Chicken) |
Bioassay |
Chicken |
Girard BM, Young BA, Buttolph TR, Locknar SA, White SL, Parsons RL Trophic factor modulation of cocaine- and amphetamine-regulated transcript peptide expression in explant cultured guinea-pig cardiac neurons. Neuroscience, 2006-03-03;139(4):1329-41. 2006-03-03 [PMID: 16516394] (Bioassay, Guinea Pig) |
Bioassay |
Guinea Pig |
Castelo-Branco G, Sousa KM, Bryja V, Pinto L, Wagner J, Arenas E Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion. Mol. Cell. Neurosci., 2005-10-21;31(2):251-62. 2005-10-21 [PMID: 16243537] (Bioassay, Rat) |
Bioassay |
Rat |
Perrier AL, Tabar V, Barberi T, Rubio ME, Bruses J, Topf N, Harrison NL, Studer L Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A., 2004-08-13;101(34):12543-8. 2004-08-13 [PMID: 15310843] (Bioassay, Human, Primate - Macaca mulatta (Rhesus Macaque)) |
Bioassay |
Human, Primate - Macaca mulatta (Rhesus Macaque) |
Esper RM, Loeb JA Rapid axoglial signaling mediated by neuregulin and neurotrophic factors. J. Neurosci., 2004-07-07;24(27):6218-27. 2004-07-07 [PMID: 15240814] (Bioassay, Chicken) |
Bioassay |
Chicken |
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