SUZ12 Antibody (448909) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

SUZ12 (suppressor of zeste 12; also known as Joined to JazF1) is a 90-95 kDa member of the Polycomb group of transcriptional regulators. It is part of a transcription repression complex termed PRC2 (Polycomb repressive complex 2) that methylates histones in the nucleus, resulting in homeotic (pattern-inducing) gene silencing. Human SUZ12 is 739 amino acids (aa) in length. It contains one C2H2-type zinc finger region (aa 44-8471) and a C-terminal VEFS-box (aa 563-639). There is one potential splice form that shows a deletion of 51 aa over aa 129-197. Human SUZ12 shares 90% and 99% aa identity with mouse and dog SUZ12, respectively. Over the immunogen sequence in MAB4184, aa identity between human and mouse is 99%.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.

Showing Publication 1 - 1 of 1.

Publication using MAB4184	Applications	Species
M Le Duff, J Gouju, B Jonchère, J Guillon, B Toutain, A Boissard, C Henry, C Guette, E Lelièvre, O Coqueret Regulation of senescence escape by the cdk4-EZH2-AP2M1 pathway in response to chemotherapy Cell Death Dis, 2018-02-07;9(2):199. 2018-02-07 [PMID: 29415991] (Western Blot, Human)	Western Blot	Human

Array MAB4184

• SUZ12 Antibodies
• SUZ12 Lysate
• SUZ12 Proteins