Neurofibromin 1 Antibody

Neurofibromin 1 (NF1), the Nf1 gene product, is a large protein which contains a central Ras-GTPase-activating (RasGAP) domain and is suggested to function as a negative regulator of proto-oncogene RAS and downstream effectors. It stimulates the GTPase activity of RAS and acts as regulator of RAS signaling. Consistent with its biochemical activity, NF1 functions as a tumor-suppressor gene in juvenile myelomonocytic leukemia (JMML), and diseased BM cells exhibit aberrant Raf/MEK/ERK signaling. Moreover, NF1 shows greater affinity for Ras GAP, but lower specific activity. Besides JMML, defects in NF1 have also been linked to neurofibromatosis type 1 (NF1), Watson syndrome (WS), familial spinal neurofibromatosis (FSNF), neurofibromatosis-Noonan syndrome (NFNS), colorectal cancer (CRC).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 3 applications: ICC/IF, IF/IHC, IHC-P.

Showing Publications 1 - 4 of 4.

Publications using NB300-155	Applications	Species
Yoshioka N, Gros E, Li HR et al. Efficient Generation of Human iPSCs by a Synthetic Self-Replicative RNA. Cell Stem Cell 2013-08-01 [PMID: 23910086] (IF/IHC, ICC/IF, Mouse)	IF/IHC, ICC/IF	Mouse
Wallace MD, Pfefferle AD, Shen L et al. Comparative Oncogenomics Implicates the Neurofibromin 1 Gene (NF1) as a Breast Cancer Driver. Genetics 2012-10-01 [PMID: 22851646]
Kuorilehto, T et al. NF1 gene expression in mouse fracture healing and in experimental rat pseudarthrosis. J Histochem Cytochem;54(3):363-70. 2006-03-01 [PMID: 16314442] (IHC-P, Mouse, Rat)	IHC-P	Mouse, Rat
Kuorilehto T, Nissinen M, Koivunen J et al. NF1 tumor suppressor protein and mRNA in skeletal tissues of developing and adult normal mouse and NF1-deficient embryos. J Bone Miner Res. 2004-06-01 [PMID: 15125795] (IHC-P, Mouse)	IHC-P	Mouse

Array NB300-155

• Neurofibromin 1 Antibodies
• Neurofibromin 1 Proteins