Survivin [p Thr34] Antibody

Survivin (BIRC5 or IAP4) is the smallest member of the inhibitor of apoptosis (IAP) proteins, containing only a single baculovirus IAP repeat (BIR) domain and lacking the C-terminal RING domain. Survivin has a theoretical molecular weight of 16.5 kDa (wild-type protein) and exists as ten splice variant forms including the most predominant isoforms, survivin-2B and surviving-DeltaEx3 (1). It also undergoes phosphorylation by PKA, Plk1, Cdk1, CKII and Aurora B at multiple sites (e.g. Serine 20 and Threonine 34, 53 and 117).

Besides being highly abundant in fetal development and expressed in proliferating adult cells such as activated T lymphocytes, erythroblasts, and self-renewing stem cells, survivin is generally absent in adult tissues. However, it is elevated in common cancers such as lung, colon, pancreas, breast and prostate where it drives proliferation, metastasis, poor prognosis, and decreased patient survival (2).

Survivin has been shown to be involved in multiple cellular processes including cell cycle progression, mitotic spindle assembly, kinetochore attachment, angiogenesis, migration, and its anti-apoptotic activity has been linked to both its monomeric and homodimeric forms. Survivin impacts the function of other IAP members, c-IAP1 and c-IAP-2, or modulates the inhibitory activity of XIAP against caspases by forming a stable complex with XIAP and HBXIP. During the intrinsic apoptotic pathway, survivin may prevent the release of mitochondrial APAF1 into the cytoplasm or hinder the association of SMAC with other IAPS, which results in prolonged cell survival (3).

References

1. Sah NK, Seniya C. (2015) Survivin splice variants and their diagnostic significance. Tumour Biol. 36(9):6623-31. PMID: 26245993

2. Lladser A, Sanhueza C, Kiessling R, Quest AF. (2011) Is survivin the potential Achilles' heel of cancer? Adv Cancer Res. 111:1-37. PMID: 21704829

3. Wheatley SP, Altieri DC. (2019) Survivin at a glance. J Cell Sci. 132(7). PMID: 30948431

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 10 of 10.

Publications using NB500-236	Applications	Species
Salah M, Akasaka H, Shimizu Y et al. Reactive oxygen species-inducing titanium peroxide nanoparticles as promising radiosensitizers for eliminating pancreatic cancer stem cells Journal of experimental & clinical cancer research : CR 2022-04-15 [PMID: 35428310] (WB, Human)	WB	Human
Babkoff A, Cohen-Kfir E, Aharon H et al. A direct interaction between survivin and myosin II is required for cytokinesis J. Cell. Sci. 2019-07-17 [PMID: 31315909]
Eiteneuer A, Seiler J, Weith M et al. Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1. EMBO J. 2014-10-08 [PMID: 25298395] (WB, Human)	WB	Human
Guzman E, Maher M, Temkin A et al. Spongiatriol inhibits nuclear factor kappa B activation and induces apoptosis in pancreatic cancer cells Mar Drugs 2013-04-02 [PMID: 23549285] (ICC/IF, Human)	ICC/IF	Human
Cheng CW, Chow AK, Pang R et al. PIN1 Inhibits Apoptosis in Hepatocellular Carcinoma through Modulation of the Antiapoptotic Function of Survivin. Am J Pathol 2013-01-18 [PMID: 23333752]
AbouAlaiwi WA, Ratnam S, Booth RL et al. Endothelial cells from humans and mice with polycystic kidney disease are characterized by polyploidy and chromosome segregation defects through survivin down-regulation Hum Mol Genet 2011-01-01 [PMID: 21041232] (WB, Mouse)	WB	Mouse
Ferrario A, Gomer CJ. Targeting the 90 kDa heat shock protein improves photodynamic therapy Cancer Lett 2010-03-28 [PMID: 19733005] (WB, Mouse)	WB	Mouse
Bhatnagar N, Li X, Chen Y et al. 3,3'-Diindolylmethane Enhances the Efficacy of Butyrate in Colon Cancer Prevention through Down-Regulation of Survivin. Cancer Prevention Research;2(6):581-589. 2009-01-01 [PMID: 19470789]
Ferrario, A et al. Survivin, a Member of the Inhibitor of Apoptosis Family, Is Induced by Photodynamic Therapy Is a Target for Improving Treatment Response. Cancer Res 67: 4989-4995. 2007-01-01 [PMID: 17510430] (WB, Mouse, Human)	WB	Mouse, Human
Liu T, Brouha B, Grossman D. Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells. Oncogene. 2004-01-08 [PMID: 14712209] (WB, Human)	WB	Human

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	WB	Mouse	06/07/2010	View Summary Application Western Blot Sample Tested Cancer Cells Species Mouse

Array NB500-236

• Survivin Antibodies
• Survivin Antibody Pack
• Survivin Lysate
• Survivin Proteins
• Survivin ELISAs
• Survivin Proteins and Enzyme