| Kwon, MR;Park, JS;Ko, EJ;Park, J;Ju, EJ;Shin, SH;Son, GW;Lee, HW;Park, YY;Kang, MH;Kim, YJ;Kim, BM;Lee, HJ;Kim, TW;Kim, CJ;Song, SY;Park, SS;Jeong, SY; Ibulocydine Inhibits Migration and Invasion of TNBC Cells via MMP-9 Regulation. International journal of molecular sciences 2024-06-01 [PMID: 38892310] (Western Blot, Human) |
Western Blot |
Human |
| Alexandre Bancet, Rita Frem, Florian Jeanneret, Angélique Mularoni, Pauline Bazelle, Caroline Roelants, Jean-Guy Delcros, Jean-François Guichou, Catherine Pillet, Isabelle Coste, Toufic Renno, Christophe Battail, Claude Cochet, Thierry Lomberget, Odile Filhol, Isabelle Krimm Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric alpha D pocket iScience 2024-01-12 [PMID: 38318383] |
|
|
| Qin X, Cardoso Rodriguez F, Sufi J, Vlckova P et Al. An oncogenic phenoscape of colonic stem cell polarization Cell 2023-12-08 [PMID: 38065080] |
|
|
| John C. Biber, Andra Sullivan, Joseph A. Brazzo, Yuna Heo, Bat-Ider Tumenbayar, Amanda Krajnik, Kerry E. Poppenberg, Vincent M. Tutino, Su-Jin Heo, John Kolega, Kwonmoo Lee, Yongho Bae Survivin as a mediator of stiffness-induced cell cycle progression and proliferation of vascular smooth muscle cells APL Bioengineering 2023-12-01 [PMID: 37915752] |
|
|
| Krajnik A, Nimmer E, Brazzo JA et al. Survivin regulates intracellular stiffness and extracellular matrix production in vascular smooth muscle cells APL bioengineering 2023-12-01 [PMID: 37868708] (WB, Human) |
WB |
Human |
| Breder-Bonk C, Docter D, Barz M et al. The Apoptosis Inhibitor Protein Survivin Is a Critical Cytoprotective Resistor against Silica-Based Nanotoxicity Nanomaterials (Basel, Switzerland) 2023-09-12 [PMID: 37764575] (IHC, Mouse, Human) |
IHC |
Mouse, Human |
| Stahl P, Kollenda S, Sager J et al. Tuning Nanobodies' Bioactivity: Coupling to Ultrasmall Gold Nanoparticles Allows the Intracellular Interference with Survivin Small (Weinheim an der Bergstrasse, Germany) 2023-04-10 [PMID: 37035950] (ICC/IF, PLA, WB, Human) |
ICC/IF, PLA, WB |
Human |
| Dyshlovoy S, Shubina L, Makarieva T et al. New Guanidine Alkaloids Batzelladines O and P from the Marine Sponge Monanchora pulchra Induce Apoptosis and Autophagy in Prostate Cancer Cells Marine Drugs 2022-11-25 [PMID: 36547885] (WB, Human) |
WB |
Human |
| Dyshlovoy SA, Busenbender T, Hauschild J et al. Cytotoxic N-Methylpretrichodermamide B Reveals Anticancer Activity and Inhibits P-Glycoprotein in Drug-Resistant Prostate Cancer Cells Marine Drugs 2022-09-23 [PMID: 36286421] (Block/Neutralize) |
Block/Neutralize |
|
| Fuller RN, Kabagwira J, Vallejos PA et al. Survivin Splice Variant 2? Enhances Pancreatic Ductal Adenocarcinoma Resistance to Gemcitabine OncoTargets and Therapy 2022-10-10 [PMID: 36238134] (Western Blot) |
Western Blot |
|
| Ana G, Bernardo O, Marco N et al. Micronuclei from misaligned chromosomes that satisfy the spindle assembly checkpoint in cancer cells. Curr Biol. 2022-08-27 [PMID: 36057259] |
|
|
| Vay C, Babaei S, Safi SA et al. Clinicopathological and Prognostic Value of Survivin Expression in Surgically Resected Pancreatic Ductal Adenocarcinoma Cancers 2022-07-18 [PMID: 35884555] (IHC-P, Human) |
IHC-P |
Human |
| da Costa Lopes J, FalcAo LFM, Martins Filho AJ et al. Factors Involved in the Apoptotic Cell Death Mechanism in Yellow Fever Hepatitis Viruses 2022-06-01 [PMID: 35746675] (IF/IHC, Human) |
IF/IHC |
Human |
| Krieg S, Roderburg C, Fung S et al. Nuclear survivin is a prognosticator in gastroenteropancreatic neuroendocrine neoplasms: a meta-analysis Journal of Cancer Research and Clinical Oncology 2022-09-01 [PMID: 35428913] (Immunohistochemistry) |
Immunohistochemistry |
|
| Mackay RP, Weinberger PM, Copland JA et al. YM155 induces DNA damage and cell death in anaplastic thyroid cancer cells by inhibiting DNA topoisomerase IIalpha at the ATP binding site Molecular cancer therapeutics [PMID: 35405742] (Simple Western, Human) |
Simple Western |
Human |
| Rodrigues de Sousa J, Magno FalcAo LF, Virgolino GL et al. Different cell death mechanisms are involved in leprosy pathogenesis Microbial pathogenesis 2022-04-06 [PMID: 35398215] (IHC-P, Human) |
IHC-P |
Human |
| Almeida AC, Soares-de-Oliveira J, Drpic D et al. Augmin-dependent microtubule self-organization drives kinetochore fiber maturation in mammals Cell reports 2022-04-05 [PMID: 35385739] |
|
|
| Dennis Aschmann, Cecilia Vallet, Sunil K. Tripathi, Yasser B. Ruiz‐Blanco, Max Brabender, Carsten Schmuck, Elsa Sanchez‐Garcia, Shirley K. Knauer, Michael Giese Selective Disruption of Survivin's Protein‐Protein Interactions: A Supramolecular Approach Based on Guanidiniocarbonylpyrrole Chembiochem 2022-01-18 [PMID: 35043526] |
|
|
| Vay C, SchlUnder PM, Dizdar L et al. Targeting abundant survivin expression in liposarcoma: subtype dependent therapy responses to YM155 treatment Journal of cancer research and clinical oncology 2021-12-03 [PMID: 34860309] (WB, Human) |
WB |
Human |
| Arista-Romero M, Cascante A, Fornaguera C, BorrOs S Role of Survivin in Bladder Cancer: Issues to Be Overcome When Designing an Efficient Dual Nano-Therapy Pharmaceutics 2021-11-19 [PMID: 34834374] (ICC/IF, WB, Human) |
ICC/IF, WB |
Human |
| Dyshlovoy SA, Pelageev DN, Jakob LS et al. Activity of New Synthetic (2-Chloroethylthio)-1,4-naphthoquinones in Prostate Cancer Cells Pharmaceuticals (Basel) 2021-09-22 [PMID: 34681173] |
|
|
| Li X, Gera L, Zhang S et al. Pharmacological inhibition of noncanonical EED-EZH2 signaling overcomes chemoresistance in prostate cancer Theranostics 2021-05-08 [PMID: 34093859] |
|
|
| Di Vincenzo S, Sangiorgi C, Ferraro M et al. Cigarette smoke extract reduces FOXO3a promoting tumor progression and cell migration in lung cancer Toxicology 2021-03-15 [PMID: 33737139] (FLOW, Human) |
FLOW |
Human |
| Bagchi A, Madaj Z, Engel KB et Al. Impact of Preanalytical Factors on the Measurement of Tumor Tissue Biomarkers Using Immunohistochemistry J Histochem Cytochem 2021-05-01 [PMID: 33641490] |
|
|
| Oliveira A, Zerillo L, Cruz L et al. Maximizing the potency of oxaliplatin coated nanoparticles with folic acid for modulating tumor progression in colorectal cancer Materials Science and Engineering: C 2020-10-01 [PMID: 33545840] (IF/IHC, Human) |
IF/IHC |
Human |
| Ferguson Bennit HR, Gonda A, Kabagwira J, et al. Natural Killer Cell Phenotype and Functionality Affected by Exposure to Extracellular Survivin and Lymphoma-Derived Exosomes International journal of molecular sciences 2021-01-27 [PMID: 33513976] (WB, Human) |
WB |
Human |
| Abdo W, Elmadawy MA, Abdelhiee EY, et al. Protective effect of thymoquinone against lung intoxication induced by malathion inhalation Scientific reports 2021-01-28 [PMID: 33510276] (IF/IHC, Rat) |
IF/IHC |
Rat |
| Murillo-Pineda M, Valente LP, Dumont M, et al. Induction of spontaneous human neocentromere formation and long-term maturation The Journal of cell biology 2021-03-01 [PMID: 33443568] (ICC/IF, Human) |
ICC/IF |
Human |
| Tsunematsu T, Arakaki R, Kawai H et al. APC/CCdh1 is required for the termination of chromosomal passenger complex activity upon mitotic exit J. Cell. Sci. 2020-09-15 [PMID: 32934012] |
|
|
| Yubin Guo, Qing Ye, Pan Deng, Yanan Cao, Daheng He, Zhaohe Zhou, Chi Wang, Yekaterina Y. Zaytseva, Charles E. Schwartz, Eun Y. Lee, B. Mark Evers, Andrew J. Morris, Side Liu, Qing-Bai She Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression Nature Communications 2020-06-26 [PMID: 32591507] |
|
|
| Nourreddine S, Lavoie G, Paradis J et al. NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay Cell Rep 2020-05-19 [PMID: 32433969] (WB, KD, Human) |
WB, KD |
Human |
| Dyshlovoy S A, Pelageev D N et al. Inspired by Sea Urchins: Warburg Effect Mediated Selectivity of Novel Synthetic Non-Glycoside 1,4-Naphthoquinone-6S-Glucose Conjugates in Prostate Cancer. Mar Drugs 2020-11-05 [PMID: 32403427] (WB, Human) |
WB |
Human |
Erdogan S, Turkekul K Neferine inhibits proliferation and migration of human prostate cancer stem cells through p38 MAPK/JNK activation Food Biochem 2020-05-11 [PMID: 32394497] (WB, Human)
Details:
Citation using the Azide Free format of this antibody. |
WB |
Human |
| Thamm Dh, Joseph Jk, Rose Bj et Al. Phase-I trial of survivin inhibition with EZN-3042 in dogs with spontaneous lymphoma BMC Vet. Res. 2020-03-24 [PMID: 32209084] (IF/IHC, IHC-P, Canine) |
IF/IHC, IHC-P |
Canine |
| Brown M, Zhang W, Yan D et al. The role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC PLoS ONE 2020-01-13 [PMID: 31929540] (WB, Human) |
WB |
Human |
| Liang C, Zhang Z, Chen Q et al. Centromere-localized Aurora B kinase is required for the fidelity of chromosome segregation J. Cell Biol. 2020-02-03 [PMID: 31868888] |
|
|
| Mirshahidi S, de Necochea-Campion R, Moretta A et al. Inhibitory Effects of Indomethacin in Human MNNG/HOS Osteosarcoma Cell Line In Vitro Cancer Invest. 2019-11-26 [PMID: 31770037] |
|
|
| Zhou J, Liu S, Wang Y et al. Salinomycin effectively eliminates cancer stem-like cells and obviates hepatic metastasis in uveal melanoma Mol. Cancer 2019-11-13 [PMID: 31718679] (WB, Human) |
WB |
Human |
| Abad MA, Ruppert JG, Buzuk L et al. Borealin-nucleosome interaction secures chromosome association of the chromosomal passenger complex J. Cell Biol. 2019-09-30 [PMID: 31570499] (ICC/IF, Human) |
ICC/IF |
Human |
| Ong SM, Saeki K, Kok MK et al YM155 enhances the cytotoxic activity of EPE against canine osteosarcoma cells J Vet Med Sci. 2019-07-15 [PMID: 31308291] (IF/IHC, Mouse) |
IF/IHC |
Mouse |
| Kubo T, Tsurita G, Hirohashi Y et al. Immunohistological analysis of pancreatic carcinoma after vaccination with survivin 2B peptide: Analysis of an autopsy series Cancer Sci. 2019-08-01 [PMID: 31206934] (IHC-P, Human) |
IHC-P |
Human |
| Latifkar, A;Ling, L;Hingorani, A;Johansen, E;Clement, A;Zhang, X;Hartman, J;Fischbach, C;Lin, H;Cerione, RA;Antonyak, MA; Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity Dev. Cell 2019-04-01 [PMID: 30982660] (WB, Human) |
WB |
Human |
| Zuckerman, LM;Frames, WL;Elsissy, JG;Shields, TG;de Necochea-Campion, R;Mirshahidi, HR;Williams, NL;Mirshahidi, S; The effect of non-steroidal anti-inflammatory drugs on osteosarcoma cells Eur Rev Med Pharmacol Sci 2019-03-01 [PMID: 30964195] (WB, Rat) |
WB |
Rat |
| Zito, P;Labbozzetta, M;Notarbartolo, M;Sajeva, M;Poma, P; Essential oil of Cyphostemma juttae (Vitaceae): Chemical composition and antitumor mechanism in triple negative breast cancer cells PLoS ONE 2019-03-28 [PMID: 30921428] (WB, Human) |
WB |
Human |
| Ketteler J, Panic A, Reis H et al. Progression-Related Loss of Stromal Caveolin 1 Levels Mediates Radiation Resistance in Prostate Carcinoma via the Apoptosis Inhibitor TRIAP1 J Clin Med 2019-03-12 [PMID: 30871022] (WB, Human) |
WB |
Human |
| Lionetti MC, Mutti F, Soldati E et al. Sulforaphane Cannot Protect Human Fibroblasts From Repeated, Short and Sublethal Treatments with Hydrogen Peroxide Int J Environ Res Public Health 2019-02-23 [PMID: 30813396] (ICC/IF, Human) |
ICC/IF |
Human |
Mega Tiber P, Kocyigit Sevinc S, Kilinc O, Orun O Biological effects of whole Z.Officinale extract on chronic myeloid leukemia cell line K562. Gene. 2019-04-15 [PMID: 30684525] (WB, Human)
Details:
Citation using the Azide free version of this antibody. |
WB |
Human |
| Liu Tian, Liu Jing, Chen Qiuyue et al. Expression of USP22 and the chromosomal passenger complex is an indicator of malignant progression in oral squamous cell carcinoma. Oncology Letters 2018-12-17 [PMID: 30675271] (IF/IHC, KD, WB, Human) |
IF/IHC, KD, WB |
Human |
| Ferraro M, Di Vincenzo S, Dino P et al. Budesonide, Aclidinium and Formoterol in combination limit inflammaging processes in bronchial epithelial cells exposed to cigarette smoke Exp. Gerontol. 2019-01-16 [PMID: 30659954] (FLOW, Human) |
FLOW |
Human |
| Kim W, Ryu J, Kim JE. CCAR2/DBC1 and Hsp60 Positively Regulate Expression of Survivin in Neuroblastoma Cells. Int J Mol Sci 2019-01-01 [PMID: 30609639] (WB, Human) |
WB |
Human |
| Hwang JY, Park JH, Kim MJ et al. Isolinderalactone regulates the BCL-2/caspase-3/PARP pathway and suppresses tumor growth in a human glioblastoma multiforme xenograft mouse model Cancer Lett. 2019-02-28 [PMID: 30503550] (WB, Human) |
WB |
Human |
| Gonda A, Kabagwira J, Senthil GN et al. Exosomal survivin facilitates vesicle internalization. Oncotarget. 2018-10-09 [PMID: 30405884] (WB, Human) |
WB |
Human |
| Giuliani A, Cirilli I, Prattichizzo F et al. The mitomiR/Bcl-2 axis affects mitochondrial function and autophagic vacuole formation in senescent endothelial cells. Aging (Albany NY). 2018-10-21 [PMID: 30348904] (WB, Human) |
WB |
Human |
| Humphry NJ, Wheatley SP. Survivin inhibits excessive autophagy in cancer cells but does so independently of its interaction with LC3. Biol Open. Oct 22 2018 [PMID: 30348810] (WB, Human) |
WB |
Human |
| Wang T, Huang J, Vue M et al. avB3 INTEGRIN MEDIATES RADIORESISTANCE OF PROSTATE CANCER CELLS THROUGH REGULATION OF SURVIVIN Mol. Cancer Res. 2018-09-28 [PMID: 30266752] (WB, Human) |
WB |
Human |
| Troiano G, Guida A, Aquino G et al. Integrative Histologic and Bioinformatics Analysis of BIRC5/Survivin Expression in Oral Squamous Cell Carcinoma. Int J Mol Sci 2018-09-08 [PMID: 30205554] (IF/IHC, Human) |
IF/IHC |
Human |
| Gock M, Mullins CS, Harnack C et al. Establishment, functional and genetic characterization of a colon derived large cell neuroendocrine carcinoma cell line. World J. Gastroenterol. 2018-09-07 [PMID: 30197480] (WB, Human) |
WB |
Human |
| Lee HS, Carmena M, Liskovykh M et al. Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy. Cancer Res. 2018-08-30 [PMID: 30166419] (ICC/IF, Human) |
ICC/IF |
Human |
| Erdogan S, Turkekul K, Dibirdik I et al. Midkine downregulation increases the efficacy of quercetin on prostate cancer stem cell survival and migration through PI3K/AKT and MAPK/ERK pathway Biomed. Pharmacother. 2018-08-21 [PMID: 30142541] (WB, Human) |
WB |
Human |
| Novais-Cruz M, Alba Abad M, van IJcken WF et al. Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription. Elife 2018-08-06 [PMID: 30080136] (WB, Human) |
WB |
Human |
| Rauch A, Carlstedt A, Emmerich C et al. Survivin antagonizes chemotherapy-induced cell death of colorectal cancer cells Oncotarget. 2018-06-11 [PMID: 29963241] (WB, Human) |
WB |
Human |
| Kiweler N, Brill B, Wirth M et al. The histone deacetylases HDAC1 and HDAC2 are required for the growth and survival of renal carcinoma cells Arch. Toxicol. 2018-05-29 [PMID: 29845424] (Human, Mouse) |
|
Human, Mouse |
| Drpic Danica, Almeida Ana C, Aguiar Paulo et al. Chromosome Segregation Is Biased by Kinetochore Size. Current Biology : Cb 2018-01-01 [PMID: 29706521] (B/N) |
B/N |
|
| Dizdar L, Junemann LM, Werner TA et al. Clinicopathological and functional implications of the inhibitor of apoptosis proteins survivin and XIAP in esophageal cancer. Oncol Lett 2018-03-01 [PMID: 29467895] (IF/IHC) |
IF/IHC |
|
| Wei Q, Li J, Tang F et al. Synthesis and biological evaluation of novel 2-arylvinyl-substituted naphtho[2,3-d]imidazolium halide derivatives as potent antitumor agents. Eur J Med Chem 2017-12-06 [PMID: 29288947] (Human) |
|
Human |
| Survivin expression, HPV positivity and microvessel density in oropharyngeal carcinomas and relationship with survival time. Tastekin E, Caloglu VY, Durankus NK Arch Med Sci [PMID: 29181079] (IF/IHC, Human) |
IF/IHC |
Human |
| Liang C, Chen Q, Yi Q et al. A kinase-dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion EMBO Rep. 2017-11-14 [PMID: 29138236] (ICC/IF) |
ICC/IF |
|
| Dizdar L, Tomczak M, Werner TA et al. Survivin and XIAP expression in distinct tumor compartments of surgically resected gastric cancer: XIAP as a prognostic marker in diffuse and mixed type adenocarcinomas Oncology Letters 2017-09-19 [PMID: 29109763] (IF/IHC, Human) |
IF/IHC |
Human |
| Zhang J, Jin Y, Pan J. Inhibitory effect of the anthelmintic drug pyrvinium pamoate on T315I BCR-ABL-positive CML cells. Mol Med Rep. 2017-10-02 [PMID: 28990077] (Human) |
|
Human |
| Khan S, Simpson J, Lynch JC et al. Racial differences in the expression of inhibitors of apoptosis (IAP) proteins in extracellular vesicles (EV) from prostate cancer patients. PLoS ONE. 2017-10-05 [PMID: 28981528] (WB, Human) |
WB |
Human |
| Taglieri L, Rubinacci G, Giuffrida A et al. The kinesin Eg5 inhibitor K858 induces apoptosis and reverses the malignant invasive phenotype in human glioblastoma cells. Invest New Drugs. 2017-09-30 [PMID: 28965307] (Human) |
|
Human |
| Ong SM, Saeki K, Kok MK et al Anti-tumour efficacy of EPE alone and in combination with piroxicam against canine osteosarcoma in a xenograft model Res Vet Sci 2017-09-19 [PMID: 28957780] (WB, Canine) |
WB |
Canine |
TAGLIERI L, DE IULIIS F, GIUFFRIDA A et al. Resistance to the mTOR inhibitor everolimus is reversed by the downregulation of survivin in breast cancer cells Oncology Letters 2017-08-17 [PMID: 28927154] (WB, Human)
Details:
The Novus survivin antibody was used to look at the effect of YM155 treatment on the upregulation of survivin induced by RAD001. |
WB |
Human |
| Werner TA, Dizdar L, Nolten I et al. Survivin and XIAP - two potential biological targets in follicular thyroid carcinoma Sci Rep 2017-09-12 [PMID: 28900184] (IHC-P, Human) |
IHC-P |
Human |
| Craparo EF, Ferraro M, Pace E et al. Polyaspartamide-Based Nanoparticles Loaded with Fluticasone Propionate and the In Vitro Evaluation towards Cigarette Smoke Effects Nanomaterials (Basel) 2017-08-13 [PMID: 28805713] (FLOW, Human) |
FLOW |
Human |
| Bradford EM, Ryu SH, Singh AP et al. Epithelial TNF receptor signaling promotes mucosal repair in IBD J Immunol. 2017-07-25 [PMID: 28747340] (IHC-P, Human) |
IHC-P |
Human |
| Bin Chen, Li Ma, Hyojung Paik, Marina Sirota, Wei Wei, Mei-Sze Chua, Samuel So, Atul J. Butte Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets Nature Communications 2017-07-12 [PMID: 28699633] |
|
|
| Wang H, Jin S, Lu H et al. Expression of survivin, MUC2 and MUC5 in colorectal cancer and their association with clinicopathological characteristics Oncol Lett. 2017-05-18 [PMID: 28693267] (IHC-P, WB, Human) |
IHC-P, WB |
Human |
| Magadum A, Ding Y, He L et al. Live cell screening platform identifies PPARdelta as a regulator of cardiomyocyte proliferation and cardiac repair. Cell Res. 2017-06-16 [PMID: 28621328] (ICC/IF, Rat) |
ICC/IF |
Rat |
| Scheer A, Knauer SK, Verhaegh R. Survivin expression pattern in the intestine of normoxic and ischemic rats. BMC Gastroenterol. 2017-06-14 [PMID: 28615071] (IF/IHC, Rat) |
IF/IHC |
Rat |
| Tung J, Tew LS, Hsu YM, Khung YL. A novel 4-arm DNA/RNA Nanoconstruct triggering Rapid Apoptosis of Triple Negative Breast Cancer Cells within 24 hours. Sci Rep 2017-04-11 [PMID: 28400564] (WB, Human) |
WB |
Human |
| Liu S, Shi L et al. Nuclear survivin promoted by acetylation is associated with the aggressive phenotype of oral squamous cell carcinoma. Cell Cycle 2017-03-05 [PMID: 28384094] (ICC/IF, Human) |
ICC/IF |
Human |
| Chen B, Wei W, Ma L, Yang B. Computational discovery of niclosamide ethanolamine as a repurposed drug for hepatocellular carcinoma that acts through inhibition of CDC37-mediated signaling. cmghjournal.org. 2018-01-01 [PMID: 28284560] (WB, Mouse) |
WB |
Mouse |
| Kim W, Cheon MG, Kim JE. Mitochondrial CCAR2/DBC1 is required for cell survival against rotenone-induced mitochondrial stress. Biochem Biophys Res Commun 2017-02-27 [PMID: 28254432] |
|
|
| Kiweler N Impact of class I HDACs and their inhibitors on renal and colorectal tumor cell fate decisions Thesis 2019-01-01 (WB, KD, Human, Mouse) |
WB, KD |
Human, Mouse |
| Komuczki J, Tuzlak S, Friebel E et al. Direct Nucleosome Binding of Borealin Secures Chromosome Association and Function of the Chromosomal Passenger complex bioRxiv 2019-04-26 (ICC/IF, Human) |
ICC/IF |
Human |
| Dheekollu J, Malecka K, Wiedmer A et al. Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency Oncotarget 2017-01-31 [PMID: 28077791] (PLA, PLA, Human) |
PLA, PLA |
Human |
| Kreger BT, Johansen ER, Cerione RA, Antonyak MA The Enrichment of Survivin in Exosomes from Breast Cancer Cells Treated with Paclitaxel Promotes Cell Survival and Chemoresistance Cancers (Basel). 2016-12-08 [PMID: 27941677] (ICC/IF, Human) |
ICC/IF |
Human |
| Genshaft AS Methods to interrogate cells and their interactions with single-cell resolution Thesis 2020-01-01 |
|
|
| Dizdar L, Oesterwind KA, Riemer JC et Al. Preclinical assesement of survivin and XIAP as prognostic biomarkers and therapeutic targets in gastroenteropancreatic neuroendocrine neoplasia Oncotarget 2017-01-31 [PMID: 28039474] (Immunohistochemistry, Western Blot) |
Immunohistochemistry, Western Blot |
|
| Nonagase Yoshikane, Yonesaka Kimio, Kawakami Hisato et al. Heregulin-expressing HER2-positive breast and gastric cancer exhibited heterogeneous susceptibility to the anti-HER2 agents lapatinib, trastuzumab and T-DM1. Oncotarget 2016-01-01 [PMID: 27768588] (WB, Mouse) |
WB |
Mouse |
| Unruhe-Knauf B, Knauer SK. Analysis of HDACi-Induced Changes in Chromosomal Passenger Complex Localization. Methods Mol. Biol. 2016-10-20 [PMID: 27761812] |
|
|
| Redli PM, Gasic I, Meraldi P et al. The Ska complex promotes Aurora B activity to ensure chromosome biorientation. J. Cell Biol. 2016-10-10 [PMID: 27697923] (WB, Human) |
WB |
Human |
Lettini G, Sisinni L, Condelli V et al. TRAP1 regulates stemness through Wnt/beta-catenin pathway in human colorectal carcinoma Cell Death Differ 2016-11-01 [PMID: 27662365] (Human)
Details:
This reference used the HRP version of NB500-201. |
|
Human |
| Makii C, Oda K, Ikeda Y et al. MDM2 is a potential therapeutic target and prognostic factor for ovarian clear cell carcinomas with wild type TP53. Oncotarget. 2016-11-15 [PMID: 27659536] (WB, Human) |
WB |
Human |
| Genshaft AS, Li S, Gallant CJ et al. Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction Genome Biol. 2016-09-19 [PMID: 27640647] (ICC/IF, Human) |
ICC/IF |
Human |
| Dyshlovoy SA, Otte K, Alsdorf WH et Al. Marine compound rhizochalinin shows high in vitro and in vivo efficacy in castration resistant prostate cancer Oncotarget 2016-10-25 [PMID: 27626485] |
|
|
| Varughese RK, Torp SH . Survivin and gliomas: A literature review. Oncol Lett. 2016-09-01 [PMID: 27588117] (IF/IHC, Human) |
IF/IHC |
Human |
| Tastekin E, Caloglu VY, Puyan FO et al. Prognostic Value of Angiogenesis and Survivin Expression in Patients with Glioblastoma. Turk Neurosurg 2016-01-01 [PMID: 27400093] |
|
|
| Alzoubi S, Brody L, Rahman S et al. Synergy between histone deacetylase inhibitors and DNA-damaging agents is mediated by histone deacetylase 2 in colorectal cancer Oncotarget 2016-07-12 [PMID: 27283986] (WB, Mouse) |
WB |
Mouse |
| Pace E, Di Vincenzo S, Ferraro M et al. Carbocysteine counteracts the effects of cigarette smoke on cell growth and on the SIRT1/FoxO3 axis in bronchial epithelial cells. Exp. Gerontol. 2016-05-26 [PMID: 27237816] |
|
|
| Iimori M, Watanabe S, Kiyonari S et al. Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability. Nat Commun. 2016-03-31 [PMID: 27030108] (WB, Human) |
WB |
Human |
| Qi G, Kudo Y et al. PARP6 acts as a tumor suppressor via downregulating Survivin expression in colorectal cancer. Oncotarget 2016-05-04 [PMID: 26934315] (WB, IF/IHC, Human) |
WB, IF/IHC |
Human |
| Wu X, Tang W, Marquez RT et al. Overcoming chemo/radio-resistance of pancreatic cancer by inhibiting STAT3 signaling Oncotarget 2016-02-12 [PMID: 26887043] (WB, Human) |
WB |
Human |
| Werner TA, Tamkan-Olcek Y, Dizdar L et al. Survivin and XIAP: two valuable biomarkers in medullary thyroid carcinoma Br. J. Cancer 2016-02-16 [PMID: 26882066] (IHC-P, Human) |
IHC-P |
Human |
| Lotti R, Palazzo E, Petrachi T et al. Survivin Modulates Squamous Cell Carcinoma-Derived Stem-Like Cell Proliferation, Viability and Tumor Formation in Vivo. Int J Mol Sci. 2016-01-16 [PMID: 26771605] (IHC-P, WB, Human) |
IHC-P, WB |
Human |
| Christenson JL, Denny EC, Kane SE. t-Darpp overexpression in HER2-positive breast cancer confers a survival advantage in lapatinib. Oncotarget 2015-10-20 [PMID: 26430732] (ICC/IF) |
ICC/IF |
|
| Wang H, Yang M, Xu J et al. Survivin mRNA-circulating tumor cells are associated with prostate cancer metastasis. Tumour Biol. 2015-08-06 [PMID: 26242261] (IHC-P, Human) |
IHC-P |
Human |
| Velummailum R. Involvement of NLRP5 in the maintenance of genome integrity in murine oocytes [Internet]. 2011-01-01 |
|
|
| Fukuda T, Wada-Hiraike O, Oda K et al. Putative tumor suppression function of SIRT6 in endometrial cancer FEBS Lett. 2015-08-04 [PMID: 26183563] (WB, Human) |
WB |
Human |
| Labarrade F, Bergeron L, Serre C et al. Modulating the expression of survivin and other basal epidermal proteins protects human skin from UVB damage and oxidative stress J Cosmet Dermatol. 2015-07-14 [PMID: 26177774] (IHC-P, Human) |
IHC-P |
Human |
| Papini D, Langemeyer L, Abad MA et al. TD-60 links RalA GTPase function to the CPC in mitosis Nat Commun. 2015-07-10 [PMID: 26158537] (ICC/IF, Human) |
ICC/IF |
Human |
| Yamazaki H, Takagi S, Hosoya K, Okumura M. Influence of a survivin suppressor YM155 on the chemoresistance of canine histiocytic sarcoma cells. The Veterinary Journal. 2015-05-08 [PMID: 26048444] (WB, Canine) |
WB |
Canine |
| Locke FL, Menges M, Veerapathran A et al. Survivin-specific CD4+ T cells are decreased in patients with survivin-positive myeloma. J Immunother Cancer. 2015-05-20 [PMID: 25992291] (IHC-P, Human) |
IHC-P |
Human |
Valenzuela MM, Ferguson Bennit HR, Gonda A et al. Exosomes Secreted from Human Cancer Cell Lines Contain Inhibitors of Apoptosis (IAP). Cancer Microenviron. 2015-05-16 [PMID: 25982218] (WB, Human)
Details:
Survivin antibody was used for WB on lysates from cell lines namely - Human embryonic kidney cell line (HEK293), Diffuse Large Cell Cleaved (DLCL), cervical (HeLa), breast (MCF-7), pancreatic (Panc-1), and prostate (PC3) (Fig. 1). |
WB |
Human |
Bongiovanni L, D'Andrea A, Porcellato I et al. Canine cutaneous melanocytic tumours: significance of B-catenin and survivin immunohistochemical expression. Vet. Dermatol. 2015-05-12 [PMID: 25962968] (IHC-P, Canine)
Details:
Survivin antibody was used for IHC-P analysis of tissue samples from canine cutaneous melanocytic tumours and the immunoassay implicated - fixation of tissues in 10% neutral buffered formalin, 5um paraffin sections, antigen retrieval via heat-treating of sections in citrate buffer at pH 6 in a pressure cooker for 20 minutes, endogenous peroxidases blocking with 3% H2O2 in absolute methanol for 45 minutes, blocking using 5% bovine milk, use of primary diluted at 0.7 ug?mL with ON 4C incubation, detection via anti-rabbit secondary antibody - streptavidin–peroxidase - 3-amino-9-ethylcarbazole (AEC + substrate-chromogen solution) method followed by counterstaining with haematoxylin (Figure 2). |
IHC-P |
Canine |
| Sadowski SM, Boufraqech M, Zhang L et al. Torin2 targets dysregulated pathways in anaplastic thyroid cancer and inhibits tumor growth and metastasis. Oncotarget 2015-07-20 [PMID: 25945839] (IF/IHC) |
IF/IHC |
|
| Mehta A, Zhang L, Boufraqech M et al. Inhibition of survivin with YM155 induces durable tumor response in anaplastic thyroid cancer. Clin. Cancer Res. 2015-05-05 [PMID: 25944801] (IHC-P, Human) |
IHC-P |
Human |
| Lan L, Appelman C, Smith AR et al. Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1. Mol Oncol 2015-04-10 [PMID: 25933687] |
|
|
| Cornago Protomartir M. Caracterizacion de los efectos de los inhibidores de las histona desacetilasas en lineas celulares de glioma Thesis. 2014-09-01 (WB, ICC/IF, Human) |
WB, ICC/IF |
Human |
| Zhang L, Zhang Y, Mehta A et al. Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer. Oncotarget 2015-04-20 [PMID: 25940539] (IF/IHC) |
IF/IHC |
|
| Sulaiman MK, Chu Z, Blanco VM et al. SapC-DOPS nanovesicles induce Smac- and Bax-dependent apoptosis through mitochondrial activation in neuroblastomas Mol. Cancer 2015-04-19 [PMID: 25889084] (WB, Human) |
WB |
Human |
| Meidhof S, Brabletz S, Lehmann W et al. ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat. EMBO Mol Med 2015-06-01 [PMID: 25872941] (WB, Human) |
WB |
Human |
| Shaw D, Wang X, Brown L et al. Infection-derived lipids elicit an immune deficiency circuit in arthropods. Nature Communications. [PMID: 25790189] |
|
|
Yamazaki H, Takagi S, Hosoya K. Survivin suppressor (YM155) enhances chemotherapeutic efficacy against canine histiocytic sarcoma in murine transplantation models Research in Veterinary Science. 2015-02-11 [PMID: 25744435] (IHC-P, Canine)
Details:
Survivin antibody used at 1:500 dilution in IHC-P application on sections of canine histiocytic sarcoma/HS xenografts from mice treated or not with survivin suppressor sepantronium bromide / YM155. Canine HS cell lines used in these experiments were CHS-4, CTT, and LHS and their derivatives CHS-4-CR, CTT-CR, and LHS-CR as CCNU-resistant HS cells (see full text for detailed protocols, data images shown in Fig 5a). |
IHC-P |
Canine |
| Wu Xin, Yamamoto Hirofumi, Nakanishi Hiroyuki et al. Innovative delivery of siRNA to solid tumors by super carbonate apatite. PLoS One 2015-01-01 [PMID: 25738937] (ICC/IF, WB, Mouse) |
ICC/IF, WB |
Mouse |
| Yi XP, Han T, Li YX et al. Simultaneous silencing of XIAP and survivin causes partial mesenchymal-epithelial transition of human pancreatic cancer cells via the PTEN/PI3K/Akt pathway Mol Med Rep. 2015-02-20 [PMID: 25707849] |
|
|
| Fu Dah-Renn, Kato Daiki, Watabe Ai et al. Prognostic utility of apoptosis index, Ki-67 and survivin expression in dogs with nasal carcinoma treated with orthovoltage radiation therapy. J Vet Med Sci. 2014-08-25 [PMID: 25452259] (IF/IHC) |
IF/IHC |
|
| Lu H, Cao X, Chen Q et al. The Expression and Role of MEKK3 in Renal Clear Cell Carcinoma. ANat Rec (Hoboken). 2014-11-12 [PMID: 25388155] |
|
|
| Vogt N, Abramov D, Koch K et al. No evidence of cell cycle dysregulation in mantle cell lymphoma in vivo. Leuk. Lymphoma. 2014-10-15 [PMID: 25315075] (ICC/IF, Human) |
ICC/IF |
Human |
Cornago M, Garcia-Alberich C, Blasco-Angulo N et al. Histone deacetylase inhibitors promote glioma cell death by G2 checkpoint abrogation leading to mitotic catastrophe. Cell Death Dis. 2014-10-03 [PMID: 25275596] (WB, ICC/IF, Human)
Details:
Survivin antibody used for ICC-IF on U251-MG cells in metaphase after HDAC inhibitor suberanilohydroxamic acid/SAHA treatment (Figure 7a). Antibody also used for WB on lysates of glioma cell lines U87, U251-MG, LN229 cells as well as human GBM primary cultures C55, C65, C48 and C60 treated or not with HDAC inhibitor SAHA and valproic acid/VPA (Figure 7b and c) |
WB, ICC/IF |
Human |
Grazia G, Vegetti C, Benigni F et al. Synergistic anti-tumor activity and inhibition of angiogenesis by cotargeting of oncogenic and death receptor pathways in human melanoma. Cell Death Dis. 2014-10-03 [PMID: 25275595] (WB, Human)
Details:
Survivin antibody used for WB on lysates of melanoma/mesothelioma cells lines Me13 and Me41 treated or not with AZD6244 (A), BEZ235 (B) TRAIL (T) and their combinations (AB, ABT). Blots shown in Figure 5a |
WB |
Human |
| Artesi M, Kroonen J, Bredel M et al. Connexin 30 expression inhibits growth of human malignant gliomas but protects them against radiation therapy. Neuro-oncology. 2014-08-25 [PMID: 25155356] (WB, Human) |
WB |
Human |
| Fu DR, Kato D, Watabe A et al. Prognostic Utility of Apoptosis Index, Ki-67 and Survivin Expression in Dogs with Nasal Carcinoma Treated with Orthovoltage Radiation Therapy. J Vet. Med. Sci. 2014-08-25 [PMID: 25151945] (IHC-P, Canine) |
IHC-P |
Canine |
Althoff K, Lindner S, Odersky A et al. miR-542-3p exerts tumor suppressive functions in neuroblastoma by downregulating Survivin. Int. J. Cancer 2014-07-21 [PMID: 25046253] (ICC/IF, Human)
Details:
Survivin antibody used in ICC-IF on IMR-32, SHEP, SK-N-BE and WAC II human neuroblastoma cell lines after miR-542-3p or control expression - Cells fixed in 4% paraformaldehyde, permeabilized in PBS containing 0.1% Triton X-100 for 10 min, primary used at 1:250 dilution with 1 hour incubation (Figure 3C). |
ICC/IF |
Human |
Cao XQ, Lu HS, Zhang L et al. MEKK3 and Survivin Expression in Cervical Cancer: Association with Clinicopathological Factors and Prognosis. Asian Pac. J. Cancer Prev. 2014-07-21 [PMID: 25040987] (WB, IHC-P, Human)
Details:
Survivin antibody used for WB (1:1000 dilution/ 4C ON incubation) on tissues from patients of cervical cancer and chronic cervicitis (Figure 2). Antibody also used for IHC-P at 1:100 dilution - 4C ON incubation on cases of cervical cancer, cervical intraepithelial neoplasia and chronic cervicitis (Figure 4). |
WB, IHC-P |
Human |
Ramirez-Labrada A, Lopez-Royuela N, Jarauta V et al. Two death pathways induced by sorafenib in myeloma cells: Puma-mediated apoptosis and necroptosis. Clin Transl Oncol 2014-07-19 [PMID: 25037851] (WB, Human)
Details:
Survivin antibody used for WB on lysates of multiple myeloma (MM) cell lines - MM.1S, H929, U266 and RPMI 8226 cells treated or not with 7 uM sorafenib for 24 h at 4 different time points (Fig. 5a). |
WB |
Human |
Kapinas Kristina, Kim Heesun, Mandeville Matthew et al. microRNA-mediated survivin control of pluripotency. J Cell Physiol. [PMID: 24891298] (Human)
Details:
Citation using the Unpurified form of this antibody. |
|
Human |
Sun B, Kawahara M, Ehata S et al. AAG8 promotes carcinogenesis by activating STAT3. Cell Signal 2014-04-12 [PMID: 24726897] (WB, Human)
Details:
Using the HRP conjugated version of NB500-201, catalog number NB500-201H. |
WB |
Human |
| Khan S, Bennit HF, Turay D et al. Early diagnostic value of survivin and its alternative splice variants in breast cancer. BMC Cancer 2014-03-19 [PMID: 24620748] (IHC-P, WB, Human) |
IHC-P, WB |
Human |
| Monique E. Verhaegen, Doris Mangelberger, Jack W. Weick, Tracy D. Vozheiko, Paul W. Harms, Kevin T. Nash, Elsa Quintana, Paul Baciu, Timothy M. Johnson, Christopher K. Bichakjian, Andrzej A. Dlugosz Merkel Cell Carcinoma Dependence on Bcl-2 Family Members for Survival The Journal of investigative dermatology 2014-04-24 [PMID: 24614157] |
|
|
| Jin B, Ding K, Pan J. Ponatinib induces apoptosis in imatinib-resistant human mast cells by dephosphorylating mutant D816V KIT and silencing beta-catenin signaling. Mol. Cancer Ther. 2014-02-20 [PMID: 24552773] (WB, Human) |
WB |
Human |
| Galloway Nicholas R, Diaz Osterman Carlos J, Reiber Karl et al. Yin Yang 1 regulates the transcriptional repression of Survivin. Biochem Biophys Res Commun. 2014-02-28 [PMID: 24508259] (WB, Human) |
WB |
Human |
| Li L, Hao X, Qin J et Al. Antibody against CD44s inhibits pancreatic tumor initiation and postradiation recurrence in mice Gastroenterology 2014-05-15 [PMID: 24397969] |
|
|
| Taniguchi F, Higaki H, Izawa M et al. The Cellular Inhibitor of Apoptosis Protein-2 is a Possible Target of Novel Treatment for Endometriosis. Am J Reprod Immunol 2014-01-02 [PMID: 24382102] (WB, Human) |
WB |
Human |
| Alaggio R, Turrini R, Boldrin D et al. Survivin expression and prognostic significance in pediatric malignant peripheral nerve sheath tumors (MPNST). PLoS One 2013-11-26 [PMID: 24303016] (IHC-P, Human) |
IHC-P |
Human |
| Yamazaki H, Takagi S, Hoshino Y et al. Inhibition of Survivin Influences the Biological Activities of Canine Histiocytic Sarcoma Cell Lines. PLoS One. 2013-11-15 [PMID: 24260303] (WB, Canine) |
WB |
Canine |
| Zhang M, Zhang X, Zhao S et al. Prognostic value of survivin and EGFR protein expression in triple-negative breast cancer (TNBC) patients. Target Oncol. 2013-11-15 [PMID: 24233638] (IHC-P, Human) |
IHC-P |
Human |
| Wang B, Zhao B, North P et al. Expression of NgBR is highly associated with estrogen receptor alpha and survivin in breast cancer. PLoS One 2013-01-01 [PMID: 24223763] (Human) |
|
Human |
| Li L, Tang W, Karnak D et al. HAb18G/CD147 Promotes pSTAT3-Mediated Pancreatic Cancer Development via CD44s. Clin Cancer Res. 2013-10-16 [PMID: 24132924] (WB, Human) |
WB |
Human |
| Sayeed A, Fedele C, Trerotola M et al. IGF-IR Promotes Prostate Cancer Growth by Stabilizing alpha5beta1 Integrin Protein Levels. PLoS One. 2013-10-09 [PMID: 24130778] |
|
|
| Pannone G, Santoro A, Pasquali D et al. THE ROLE OF SURVIVIN IN THYROID TUMORS: DIFFERENCES OF EXPRESSION IN WELL DIFFERENTIATED (WDTC), NON-WELL DIFFERENTIATED (NON-WDTC) AND ANAPLASTIC (ATC) THYROID CANCERS. Thyroid. 2013-10-11 [PMID: 24117205] |
|
|
| Matteucci C, Sorrentino R, Bellis L et al. Detection of high levels of Survivin-IgM immune complex in sera from hepatitis C virus infected patients with cirrhosis. Hepatol Res. 2013-09-16 [PMID: 24102797] (ELISA, Human) |
ELISA |
Human |
| Dallaglio K, Petrachi T, Marconi A et al. Isolation and Characterization of Squamous Cell Carcinoma-Derived Stem-like Cells: Role in Tumor Formation. Int J Mol Sci. 2013-09-26 [PMID: 24077125] (WB, IHC-P, Human) |
WB, IHC-P |
Human |
| Takagi K, Ishida T, Miki Y et al. Intratumoral concentration of estrogens and clinicopathological changes in ductal carcinoma in situ following aromatase inhibitor letrozole treatment. Br J Cancer 2013-07-09 [PMID: 23756858] (IF/IHC, Human) |
IF/IHC |
Human |
| Kunze D, Erdmann K, Froehner M et al. Enhanced Inhibition of Bladder Cancer Cell Growth by Simultaneous Knockdown of Antiapoptotic Bcl-xL and Survivin in Combination with Chemotherapy. Int J Mol Sci 2013-06-07 [PMID: 23749114] (WB, Human) |
WB |
Human |
| Tyagi A, Raina K, Gangar S et al. Differential Effect of Grape Seed Extract against Human Non-small-Cell Lung Cancer Cells: The Role of Reactive Oxygen Species and Apoptosis Induction. Nutr Cancer 2013-01-01 [PMID: 23682782] (WB, Human) |
WB |
Human |
| Slagter-Jager JG, Raney A, Lewis WE et al. Evaluation of RNA Amplification Methods to Improve DC Immunotherapy Antigen Presentation and Immune Response. Mol Ther Nucleic Acids 2013-05-07 [PMID: 23653155] (WB, Human) |
WB |
Human |
| Chiappara G, Gjomarkaj M, VirziA et al. The role of p21 Waf1/Cip1 in large airway epithelium in smokers with and without COPD. Biochim Biophys Acta 2013-04-29 [PMID: 23639631] (IHC-P, Human) |
IHC-P |
Human |
| Dallaglio K, Marconi A, Truzzi F et al. E-FABP induces differentiation in normal human keratinocytes and modulates the differentiation process in psoriatic keratinocytes in vitro. Exp Dermatol. 2013-04-01 [PMID: 23528210] |
|
|
| Honegger A, Leitz J, Bulkescher J et al. Silencing of Human papillomavirus (HPV) E6/E7 oncogene expression affects both the contents and the amounts of extracellular microvesicles released from HPV-positive cancer cells. Int J Cancer 2013-03-23 [PMID: 23526637] (WB, Human) |
WB |
Human |
| Ng L, Tung-Ping Poon R, Yau S et al. uppression of actopaxin impairs hepatocellular carcinoma metastasis through modulation of cell migration and invasion Hepatology. 2013-08-01 [PMID: 23504997] (WB, Human) |
WB |
Human |
| Kan CY, Petti C, Bracken L et al. Upregulation of survivin during immortalization of human myofibroblasts is linked to repression of tumor suppressor p16INK4a and confers resistance to oxidative stress. J Biol Chem 2013-02-28 [PMID: 23449974] (WB, Human) |
WB |
Human |
| Chiou SK, Hoa N, Ge L, Jadus MR. Nutrient Availability Alters the Effect of Autophagy on Sulindac Sulfide-Induced Colon Cancer Cell Apoptosis. Gastroenterol Res Pract. 2012-01-01 [PMID: 23431290] (WB, Human) |
WB |
Human |
| Wang Z, Zheng Y, Park HJ et al. Targeting FoxM1 Effectively Retards p53-Null Lymphoma and Sarcoma. Mol Cancer Ther 2013-05-01 [PMID: 23427295] (WB, Mouse) |
WB |
Mouse |
| Hori M, Miki T, Okamoto M et al. The Detergent-Soluble Cytoplasmic Pool of Survivin Suppresses Anoikis and Its Expression Is Associated with Metastatic Disease of Human Colon Cancer. PLoS One 2013-01-01 [PMID: 23405201] (WB, Human, Hamster) |
WB |
Human, Hamster |
| Erba HP, Sayar H, Juckett M et al. Safety and pharmacokinetics of the antisense oligonucleotide (ASO) LY2181308 as a single-agent or in combination with idarubicin and cytarabine in patients with refractory or relapsed acute myeloid leukemia (AML). Invest New Drugs 2013-02-10 [PMID: 23397500] (ELISA, Human) |
ELISA |
Human |
| Goel HL, Sayeed A, Breen M et al. beta1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase1. J Cell Physiol 2013-01-28 [PMID: 23359252] (WB, Human) |
WB |
Human |
| Cheng CW, Chow AK, Pang R et al. PIN1 Inhibits Apoptosis in Hepatocellular Carcinoma through Modulation of the Antiapoptotic Function of Survivin. Am J Pathol 2013-01-18 [PMID: 23333752] |
|
|
| Bongiovanni L, D'Andrea A, Romanucci M et al. Epithelial-to-mesenchymal transition: immunohistochemical investigation of related molecules in canine cutaneous epithelial tumours. Vet Dermatol 2013-02-01 [PMID: 23331698] (IHC-P, Canine) |
IHC-P |
Canine |
| Tecleab A, Sebti SM. Depletion of K-Ras promotes proteasome degradation of survivin. Cell Cycle 2013-02-01 [PMID: 23324341] (IP, Human) |
IP |
Human |
| Nakata Y, Yasuda T, Fukaya M et al. Accumulation of alpha-synuclein triggered by presynaptic dysfunction. J Neurosci 2012-11-28 [PMID: 23197711] (Mouse) |
|
Mouse |
| Gnana-Prakasam JP, Veeranan-Karmegam R, Coothankandaswamy V et al. Loss of Hfe leads to progression of tumor phenotype in primary retinal pigment epithelial cells Invest Ophthalmol Vis Sci 2012-11-20 [PMID: 23169885] |
|
|
| Knauer SK, Unruhe B, Karczewski S et al. Functional Characterization of Novel Mutations Affecting Survivin (BIRC5)-Mediated Therapy Resistance in Head and Neck Cancer Patients Hum Mutat 2012-11-15 [PMID: 23161837] (IF/IHC, Human) |
IF/IHC |
Human |
| Wang F, Ulyanova NP, Daum JR et al. Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation J Cell Biol 2012-10-15 [PMID: 23071152] |
|
|
| Semrau R, Duerbaum H, Temming S et al. Prognostic impact of human papillomavirus status, survivin, and epidermal growth factor receptor expression on survival in patients treated with radiochemotherapy for very advanced nonresectable oropharyngeal cancer. Head Neck. 2013-09-01 [PMID: 23042483] (IHC-P, Human) |
IHC-P |
Human |
| Min L, Ji Y, Bakiri L et al. Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin Nat Cell Biol 2012-10-07 [PMID: 23041974] (IF/IHC, Human) |
IF/IHC |
Human |
| Sun Y, Cheng MK, Griffiths TR et al. Inhibition of STAT signalling in bladder cancer by diindolylmethane: relevance to cell adhesion, migration and proliferation. Curr Cancer Drug Targets 2013-01-01 [PMID: 22920439] (WB, Human) |
WB |
Human |
| Kunze D, Kraemer K, Erdmann K et al. Simultaneous siRNA-mediated knockdown of antiapoptotic BCL2, Bcl-xL, XIAP and survivin in bladder cancer cells. Int J Oncol 2012-10-01 [PMID: 22797576] (WB, Human) |
WB |
Human |
| Tuncel H, Shimamoto F, Kaneko Guangying Qi H et al. Nuclear Aurora B and cytoplasmic Survivin expression is involved in lymph node metastasis of colorectal cancer. Oncol Lett 2012-05-01 [PMID: 22783401] (IF/IHC) |
IF/IHC |
|
de Souza HS, West GA, Rebert N et al. Increased Levels of Survivin, via Association With Heat Shock Protein 90, in Mucosal T Cells From Patients With Crohn's Disease. Gastroenterology. [PMID: 22749932] (IF/IHC, ICC/IF, IP, Human)
Details:
Citation using the Unpurified form of this antibody. |
IF/IHC, ICC/IF, IP |
Human |
| Jiang C, Yi XP, Shen H, Li YX. Targeting X-linked inhibitor of apoptosis protein inhibits pancreatic cancer cell growth through p-Akt depletion World J Gastroenterol 2012-06-21 [PMID: 22736919] (WB, Human) |
WB |
Human |
| Okamoto W, Okamoto I, Arao T et al. Antitumor Action of the MET Tyrosine Kinase Inhibitor Crizotinib (PF-02341066) in Gastric Cancer Positive for MET Amplification Mol Cancer Ther 2012-06-22 [PMID: 22729845] (WB, Human) |
WB |
Human |
| Chao C, Silverberg MJ, Martinez-Maza O et al. Epstein-Barr Virus Infection and Expression of B-cell Oncogenic Markers in HIV-Related Diffuse Large B-cell Lymphoma Clin Cancer Res 2012-09-01 [PMID: 22711707] (IF/IHC, Human) |
IF/IHC |
Human |
| Bongiovanni L, Mazzocchetti F, Malatesta D et al. Immunohistochemical investigation of cell cycle and apoptosis regulators (Survivin, beta-Catenin, P53, Caspase 3) in canine appendicular osteosarcoma BMC Vet Res 2012-06-11 [PMID: 22686277] (IF/IHC, Canine) |
IF/IHC |
Canine |
| Bongiovanni L, Suter MM, Malatesta D et al. Nuclear survivin expression as a potentially useful tool for the diagnosis of canine cutaneous sebaceous lesions Vet Dermatol 2012-06-11 [PMID: 22681570] (IF/IHC, Canine) |
IF/IHC |
Canine |
| Dhawan D, Ramos-Vara JA, Hahn NM, Waddell J, Olbricht GR, Zheng R, Stewart JC, Knapp DW. DNMT1: An emerging target in the treatment of invasive urinary bladder cancer. Urol Oncol. 2012-05-18 [PMID: 22609058] (WB, Canine) |
WB |
Canine |
| Ebata A, Suzuki T, Takagi K et al. Oestrogen-induced genes in ductal carcinoma in situ: their comparison with invasive ductal carcinoma Endocr Relat Cancer 2012-07-18 [PMID: 22569827] (IF/IHC, Human) |
IF/IHC |
Human |
| Jacob NK, Cooley JV, Shirai K, Chakravarti A. Survivin splice variants are not essential for mitotic progression or inhibition of apoptosis induced by doxorubicin and radiation Onco Targets Ther 2012-01-01 [PMID: 22375097] (WB, Human) |
WB |
Human |
| Stauber RH, Knauer SK, Habtemichael N et al. A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer. Oncotarget 2012-01-01 [PMID: 22289787] |
|
|
| Francisco R, Perez-Perarnau A, Cortes C et al. Histone deacetylase inhibition induces apoptosis and autophagy in human neuroblastoma cells Cancer Letters 4104-01-01 [PMID: 22186300] (WB, Human) |
WB |
Human |
| Felisiak-Golabek A, Rembiszewska A, Rzepecka IK et al. Nuclear survivin expression is a positive prognostic factor in taxane-platinum-treated ovarian cancer patients. Journal of Ovarian Research 104(1):20. 2011-11-01 [PMID: 22075440] |
|
|
| Yakirevich E, Samkari A, Holloway MP, Lu S, Singh K, Yu J, Fenton MA, Altura RA. Total Survivin and acetylated Survivin correlate with distinct molecular subtypes of breast cancer. Hum Pathol. 2011-11-03 [PMID: 22055399] (IF/IHC, Human) |
IF/IHC |
Human |
| Diaz A, Valera A, Carrera C, Hakim S, Aguilera P, Garcia A, Palou J, Puig S, Malvehy J, Alos L. Pigmented spindle cell nevus: clues for differentiating it from spindle cell malignant melanoma. A comprehensive survey including clinicopathologic, immunohistochemical, and FISH studies. Am J Surg Pathol;35(11):1733-42. 2011-11-01 [PMID: 21997694] (IF/IHC, Human) |
IF/IHC |
Human |
| Saxena P, Trerotola M, Wang T, Li J, Sayeed A, Vanoudenhove J, Adams DS, Fitzgerald TJ, Altieri DC, Languino LR. PSA regulates androgen receptor expression in prostate cancer cells. Prostate;72(7):769-76. 2012-05-15 [PMID: 21956655] (WB, Human) |
WB |
Human |
| Kavitha CV, Agarwal C, Agarwal R, Deep G. Asiatic Acid inhibits pro-angiogenic effects of VEGF and human gliomas in endothelial cell culture models. PLo S ONE;6(8):e22745. 2011-01-01 [PMID: 21826202] |
|
|
| Page BDG, Fletcher S, Yue P et al. Identification of a Non-phosphorylated, Cell Permeable, Small Molecule Ligand for the Stat3 SH2 Domain. Bioorganic & Medicinal Chemistry Letters. 2011-01-01 [PMID: 21788134] |
|
|
| Lechler P, Balakrishnan S, Schaumburger J et al. The oncofetal gene survivin is re-expressed in osteoarthritis and is required for chondrocyte proliferation in vitro. BMC Musculoskelet Disord. 2011-07-05 [PMID: 21729321] |
|
|
| Lechler P, Schaumburger J, Kock FX et al. The Oncofetal Gene Survivin Promotes Cell Proliferation and Survival in Primary Human Osteoblastic Cells. Calcif Tissue Int. 2011-06-15 [PMID: 21674243] (ICC/IF, Human) |
ICC/IF |
Human |
| El Ghamrasni S, Pamidi A, Halaby MJ et al. Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer. PLoS Genet. PLoS Genet. 2011-05-07 [PMID: 21625617] |
|
|
| Kim GY, Lim SJ, Kim YW. Expression of HuR, COX-2, and survivin in lung cancers; cytoplasmic HuR stabilizes cyclooxygenase-2 in squamous cell carcinomas. Mod Pathol 2011-10-01 [PMID: 21572400] (IF/IHC, Human) |
IF/IHC |
Human |
| Chen B, Yuping S, Ni J. Rapamycin decreases survivin expression to induce NSCLC cell apoptosis under hypoxia through inhibiting HIF-1a induction. Mol Biol Rep. 2012-01-01 [PMID: 21567203] (WB, Human) |
WB |
Human |
| Peach G. Russia pledges $4 billion for Pharma-2020 plan. Nat Med 2011-05-01 [PMID: 21546945] (IF/IHC) |
IF/IHC |
|
| Scuto Anna, Kujawski Maciej, Kowolik Claudia et al. STAT3 inhibition is a therapeutic stRategy for ABC-like diffuse large B-cell lymphoma. Cancer Research 2011-01-01 [PMID: 21521803] (WB, Mouse) |
WB |
Mouse |
| Chiou S-K, Hoa N, Hodges A. Sulindac sulfide induces autophagic death in gastric epithelial cells via Survivin down-regulation: A mechanism of NSAIDs-induced gastric injury. Biochem Pharmacol. 81(11):1317-23. doi: 10.1016/j.bcp.2011.03.019. 2011-06-01 [PMID: 21458423] |
|
|
| Lechler P, Renkawitz T, Campean V et al. The antiapoptotic gene survivin is highly expressed in human chondrosarcoma and promotes drug resistance in chondrosarcoma cells in vitro. BMC Cancer11(1):120. 2011-04-02 [PMID: 21457573] |
|
|
| Fossey SL, Bear MD, Lin J, et al. The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines BMC Cancer 2011-03-01 [PMID: 21443800] (WB, Canine, Human) |
WB |
Canine, Human |
| Emmanuel C, Gava N, Kennedy C et al. Comparison of expression profiles in ovarian epithelium in vivo and ovarian cancer identifies novel candidate genes involved in disease pathogenesis. PLoS One 2011-01-01 [PMID: 21423607] |
|
|
| Kim SH, Bommareddy A, Singh SV. Garlic constituent diallyl trisulfide suppresses x-linked inhibitor of apoptosis protein in prostate cancer cells in culture and in vivo Cancer Prev Res (Phila) 2011-06-01 [PMID: 21411500] (WB, IF/IHC, Mouse, Human) |
WB, IF/IHC |
Mouse, Human |
| Finkelstein SE, Iclozan C, Bui MM et al. Combination of External Beam Radiotherapy (EBRT) with Intratumoral Injection of Dendritic Cells as Neo-Adjuvant Treatment of High-Risk Soft Tissue Sarcoma Patients. Int J Radiat Oncol Biol Phys. 2011-03-11 [PMID: 21398051] |
|
|
Knauer SK, Heinrich UR, Bier C et al. An otoprotective role for the apoptosis inhibitor protein survivin. Cell Death Dis . [PMID: 21364656] (IHC-P, Guinea Pig)
Details:
Citation using the Unpurified form of this antibody. |
IHC-P |
Guinea Pig |
Wei W, Chua MS, Grepper S, So SK et al. Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin. Mol Cancer 2011-01-01 [PMID: 21314951]
Details:
Using the HRP conjugated version of NB500-201, catalog number NB500-201H. |
|
|
| El-Maarri O, Walier M, Behne F et al. Methylation at global LINE-1 repeats in human blood are affected by gender but not by age or natural hormone cycles. PLoS One 2011-01-01 [PMID: 21311577] (WB, Human) |
WB |
Human |
| Chun KS, Langenbach R. The prostaglandin E2 receptor, EP2, regulates survivin expression via an EGFR/STAT3 pathway in UVB-exposed mouse skin. Mol Carcinog;50(6):439-48. 2011-06-01 [PMID: 21268125] (WB, Mouse) |
WB |
Mouse |
| Niibe Y, Watanabe J, Tsunoda S et al. Concomitant expression of HER2 and HIF-1alpha is a predictor of poor prognosis in uterine cervical carcinoma treated with concurrent chemoradiotherapy: prospective analysis (KGROG0501). Eur J Gynaecol Oncol;31(5):491-6. 2010-01-01 [PMID: 21061787] |
|
|
| AbouAlaiwi WA, Ratnam S, Booth RL et al. Endothelial cells from humans and mice with polycystic kidney disease are characterized by polyploidy and chromosome segregation defects through survivin down-regulation Hum Mol Genet 2011-01-01 [PMID: 21041232] (WB, Mouse) |
WB |
Mouse |
| Talbot D, Ranson M, Davies J et al. Tumor Survivin is Downregulated by the Antisense Oligonucleotide LY2181308: A Proof of Concept, First-in-Human Dose Study. Clin Cancer Res. 2010-11-12 [PMID: 21041181] |
|
|
| Chock KL, Allison JM, Shimizu Y, ElShamy WM. BRCA1-IRIS overexpression promotes cisplatin resistance in ovarian cancer cells. Cancer Res 2010-11-01 [PMID: 20940403] (WB, Human) |
WB |
Human |
| Xia M, Knezevic D, Vassilev LT. p21 does not protect cancer cells from apoptosis induced by nongenotoxic p53 activation. Oncogene. 2010-09-27 [PMID: 20871630] |
|
|
| Diaz R, Gonzalez-Sancho JM, Soldevilla B et al. Differential regulation of TP73 isoforms by 1alpha,25-dihydroxyvitamin D3 and survivin in human colon and breast carcinomas. Genes Chromosomes Cancer 2010-12-01 [PMID: 20842728] (WB, Human) |
WB |
Human |
Habtemichael N, Wunsch D, Bier C et al. Cloning and functional characterization of the guinea pig apoptosis inhibitor protein Survivin. Gene. [PMID: 20727954]
Details:
Citation using the Unpurified form of this antibody. |
|
|
| Khan S, Jutzy JM, Aspe JR et al. Survivin is released from cancer cells via exosomes. Apoptosis;16(1):1-12. 2011-01-01 [PMID: 20717727] |
|
|
| Ruckert F, Samm N, Lehner AK et al. Simultaneous gene silencing of Bcl-2, XIAP and Survivin re-sensitizes pancreatic cancer cells towards apoptosis. BMC Cancer 2010-07-20 [PMID: 20646298] (WB, Human) |
WB |
Human |
| Velmurugan B, Gangar SC, Kaur M et al. Silibinin exerts sustained growth suppressive effect against human colon carcinoma SW480 xenograft by targeting multiple signaling molecules. Pharm Res 2010-10-01 [PMID: 20628792] (IHC-P, Human) |
IHC-P |
Human |
Habtemichael N, Heinrich UR, Knauer SK et al. Expression analysis suggests a potential cytoprotective role of Birc5 in the inner ear. Mol Cell Neurosci . [PMID: 20627126]
Details:
Citation using the Unpurified form of this antibody. |
|
|
| Lee S, Donehower LA, Herron AJ et al. Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice. PLoS One 2010-01-01 [PMID: 20539819] (IF/IHC, Mouse) |
IF/IHC |
Mouse |
| Kabbarah O, Nogueira C, Feng B et al. Integrative genome comparison of primary and metastatic melanomas. PLoS One 2010-05-24 [PMID: 20520718] (IF/IHC, Human) |
IF/IHC |
Human |
| Tango Y, Kano R, Maruyama H et al. Detection of autoantibodies against survivin in sera from cancer dogs. J Vet Med Sci 2010-07-01 [PMID: 20179386] |
|
|
| Allison SJ, Jiang M, Milner J. Oncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cells. Aging (Albany NY) 2009-03-01 [PMID: 20157519] (WB) |
WB |
|
| Qi G, Kudo Y, Ando T et al. Nuclear Survivin expression is correlated with malignant behaviors of head and neck cancer together with Aurora-B. Oral Oncol 2010-04-01 [PMID: 20138567] (IF/IHC, Human) |
IF/IHC |
Human |
| Wimmershoff J, Polkinghorne A, Grest P et al. Immunohistochemical detection of survivin in canine lymphoma. J Comp Pathol 2010-05-01 [PMID: 20116802] (IF/IHC, Canine) |
IF/IHC |
Canine |
| Weber A, Boger R, Vick B et al. Hepatocyte-specific deletion of the antiapoptotic protein myeloid cell leukemia-1 triggers proliferation and hepatocarcinogenesis in mice. Hepatology 2010-04-01 [PMID: 20099303] (WB, Mouse) |
WB |
Mouse |
| Svec J, Musilkova J, Bryndova J et al. Enhanced expression of proproliferative and antiapoptotic genes in ulcerative colitis-associated neoplasia. Inflamm Bowel Dis 2010-07-01 [PMID: 20027603] (IF/IHC, Human) |
IF/IHC |
Human |
| Y Lou, Q Peng, B Nolan et al. Oral administration of caffeine during voluntary exercise markedly decreases tissue fat and stimulates apoptosis and cyclin B1 in UVB-treated skin of hairless p53-knockout mice. Carcinogenesis; 31 (4): 671-678. 2010-01-01 [PMID: 19926639] |
|
|
| Lopez-Royuela N, Balsas P, Galan-Malo P et al. Bim is the key mediator of glucocorticoid-induced apoptosis and of its potentiation by rapamycin in human myeloma cells. Biochim Biophys Acta 2010-02-01 [PMID: 19914305] (WB, Human) |
WB |
Human |
| Dean E J, Ward T, Pinilla C et al. A small molecule inhibitor of XIAP induces apoptosis and synergises with vinorelbine and cisplatin in NSCLC. British Journal of Cancer 2010-01-01 [PMID: 19904270] (WB, Human) |
WB |
Human |
| Shariat SF, Karakiewicz PI, Godoy G et al. Survivin as a prognostic marker for urothelial carcinoma of the bladder: a multicenter external validation study. Clin Cancer Res;15(22):7012-9. 2009-11-15 [PMID: 19903782] |
|
|
| Kim EY, Teh SJ, Yang J et al. TNFR2-deficient memory CD8 T cells provide superior protection against tumor cell growth. J Immunol;183(10):6051-7. 2009-11-15 [PMID: 19841176] |
|
|
Wei W, Chua MS, Grepper S, So SK et al. Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells. Mol Cancer 2009-01-01 [PMID: 19778454]
Details:
Using the HRP conjugated version of NB500-201, catalog number NB500-201H. |
|
|
| Qi G, Tuncel H, Aoki E et al. Intracellular localization of survivin determines biological behavior in colorectal cancer. Oncol Rep 2009-09-01 [PMID: 19639203] (WB, Human) |
WB |
Human |
| Eberhard Y, McDermott S, Wang X et al. Chelation of intracellular iron with the anti-fungal agent ciclopirox olamine induces cell death in leukemia myeloma cells. Blood :blood-2009-2003-209965. 2009-01-01 [PMID: 19589922] |
|
|
| Jia L, Soengas MS, Sun Y. ROC1/RBX1 E3 ubiquitin ligase silencing suppresses tumor cell growth via sequential induction of G2-M arrest, apoptosis, and senescence Cancer Res 2009-06-15 [PMID: 19509229] (WB) |
WB |
|
| Yuan J, Yang BM, Zhong ZH et al. Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase. Oncogene 2009-07-23 [PMID: 19483728] (ICC/IF, Human) |
ICC/IF |
Human |
| Guha M, Plescia J, Leav I et al. Endogenous Tumor Suppression Mediated by PTEN Involves Survivin Gene Silencing. Cancer Res:0008-5472 CAN-0009-0584. 2009-01-01 [PMID: 19470765] |
|
|
| Augello C, Caruso L, Maggioni M et al. Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma. BMC Cancer 2009-04-27 [PMID: 19397802] (IF/IHC, Human) |
IF/IHC |
Human |
| Filion Tera M, Qiao Meng, Ghule Prachi N et al. Survival responses of human embryonic stem cells to DNA damage. Journal of Cellular Physiology 2009-01-01 [PMID: 19373864] (IF/IHC, Human) |
IF/IHC |
Human |
| Song KY, Jung CK, Park WS et al. Expression of the Antiapoptosis Gene Survivin Predicts Poor Prognosis of Stage III Gastric Adenocarcinoma. Jpn J Clin Oncol;39(5):290-296. 2009-01-01 [PMID: 19336448] |
|
|
| Rothberg BEG, Bracken MB, Rimm DL. Tissue Biomarkers for Prognosis in Cutaneous Melanoma: A Systematic Review Meta-analysis. J Natl Cancer Inst;101(7):452-474. 2009-01-01 [PMID: 19318635] |
|
|
| Khan S, Aspe JR, Asumen MG et al. Extracellular, cell-permeable survivin inhibits apoptosis while promoting proliferative and metastatic potential. Br J Cancer. 2009-04-01 [PMID: 19293795] (WB, Human) |
WB |
Human |
| Maxia C, Perra MT, Demurtas P et al. Relationship between the expression of cyclooxygenase-2 and survivin in primary pterygium. Mol Vis 2009-01-01 [PMID: 19247455] (IHC-P, Human) |
IHC-P |
Human |
| Adler M, Muller K, Rached E et al. Modulation of key regulators of mitosis linked to chromosomal instability is an early event in ochratoxin A carcinogenicity. Carcinogenesis 2009-04-01 [PMID: 19237604] (IHC-P, Rat) |
IHC-P |
Rat |
| Lu J, Tan M, Huang W-C et al. Mitotic Deregulation by Survivin in ErbB2-Overexpressing Breast Cancer Cells Contributes to Taxol Resistance. Clin Cancer Res 15(4):1326-34. 2009-02-15 [PMID: 19228734] |
|
|
| Fetz V, Bier C, Habtemichael N et al. Inducible NO synthase confers chemoresistance in head and neck cancer by modulating survivin. Int J Cancer 2009-05-01 [PMID: 19130609] (WB, IHC-P, ICC/IF, Human) |
WB, IHC-P, ICC/IF |
Human |
| Lee JH, Palaia T, Ragolia L. Impaired insulin-mediated vasorelaxation in diabetic Goto-Kakizaki rats is caused by impaired Akt phosphorylation. Am J Physiol Cell Physiol 296(2):C327-38. 2009-02-01 [PMID: 19052261] |
|
|
| Jiang X, Zhou J, Yuen NK et al. Imatinib targeting of KIT-mutant oncoprotein in melanoma. Clin Cancer Res 14(23):7726-32. 2008-12-01 [PMID: 19047099] |
|
|
| Dai Y, Liu M, Tang W et al. Molecularly targeted radiosensitization of human prostate cancer by modulating inhibitor of apoptosis. Clin Cancer Res 14(23):7701-10. 2008-12-01 [PMID: 19047096] |
|
|
| Zhang L, Murray F, Zahno A et al. Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 105(49):19532-7. 2008-12-09 [PMID: 19033455] |
|
|
| Baba HA, Wohlschlaeger J, Schmitz KJ et al. Survivin is upregulated during liver regeneration in rats and humans and is associated with hepatocyte proliferation. Liver Int 2009-04-01 [PMID: 19018973] (IHC-P, WB, Rat) |
IHC-P, WB |
Rat |
| Appleyard MV, O'Neill MA, Murray KE et al. Seliciclib (CYC202, R-roscovitine) enhances the antitumor effect of doxorubicin in vivo in a breast cancer xenograft model. Int J Cancer 2009-01-15 [PMID: 19003963] (IHC-P, Human) |
IHC-P |
Human |
| Wang RH, Sengupta K, Li C et al. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 2008-10-07 [PMID: 18835033] (WB) |
WB |
|
| Seo SI, Gera L, Zhau HE et al. BKM1740, an acyl-tyrosine bisphosphonate amide derivative, inhibits the bone metastatic growth of human prostate cancer cells by inducing apoptosis. Clin Cancer Res 14(19):6198-206. 2008-10-01 [PMID: 18829499] |
|
|
| Symes JC, Kurin M, Fleshner NE et al. Fas-mediated killing of primary prostate cancer cells is increased by mitoxantrone and docetaxel. Mol Cancer Ther 7(9):3018-28. 2008-09-01 [PMID: 18790782] |
|
|
| Balkhi MY, Christopeit M, Chen Y et al. AML1/ETO-induced survivin expression inhibits transcriptional regulation of myeloid differentiation. Exp Hematol 2008-11-01 [PMID: 18687517] (WB, Mouse) |
WB |
Mouse |
| Schaue D, Comin-uix B, Ribas A et al. T-cell responses to survivin in cancer patients undergoing radiation therapy. Clin Cancer Res 14(15):4883-90. 2008-08-01 [PMID: 18676762] |
|
|
| Lee CW, Raskett CM, Prudovsky I et al. Molecular dependence of estrogen receptor-negative breast cancer on a notch-survivin signaling axis. Cancer Res 68(13):5273-81. 2008-07-01 [PMID: 18593928] |
|
|
| Engels K, Knauer SK, Loibl S et al. NO signaling confers cytoprotectivity through the survivin network in ovarian carcinomas. Cancer Res 68(13):5159-66. 2008-07-01 [PMID: 18593915] |
|
|
| Xia F, Canovas PM, Guadagno TM et al. A survivin-ran complex regulates spindle formation in tumor cells. Mol Cell Biol 28(17):5299-311. 2008-09-01 [PMID: 18591255] |
|
|
| Hebb ALO, Moore CS, Bhan V et al. Expression of the inhibitor of apoptosis protein family in multiple sclerosis reveals a potential immunomodulatory role during autoimmune mediated demyelination. Mult Scler 14(5):577-94. 2008-06-01 [PMID: 18566024] |
|
|
| Kunze D, Wuttig D, Kausch I et al. Antisense-mediated inhibition of survivin, hTERT and VEGF in bladder cancer cells in vitro and in vivo. Int J Oncol 2008-05-01 [PMID: 18425331] (IHC-P, Mouse) |
IHC-P |
Mouse |
| Thirunavukkarasu, M, Han, Z, Zhan, L et al. Adeno-sh-beta-catenin abolishes ischemic preconditioning-mediated cardioprotection by downregulation of its target genes VEGF, Bcl-2, and survivin in ischemic rat myocardium. Antioxid Redox Signal 10(8):1475-84. 2008-08-01 [PMID: 18407748] |
|
|
| Mellai M, Caldera V, Patrucco A et al. Survivin expression in glioblastomas correlates with proliferation, but not with apoptosis. Anticancer Res 2008-01-01 [PMID: 18383832] (IHC-P, Human) |
IHC-P |
Human |
| Xia F, Lee CW, Altieri DC. Tumor cell dependence on Ran-GTP-directed mitosis. Cancer Res 68(6):1826-33. 2008-03-15 [PMID: 18339863] |
|
|
| Borghouts, C, C Kunz et al. Monomeric recombinant peptide aptamers are required for efficient intracellular uptake and target inhibition. Mol Cancer Res 6(2):267-81. 2008-02-01 [PMID: 18314488] |
|
|
| Friedman J, Dunn RL, Wood D et al. Neoadjuvant docetaxel and capecitabine in patients with high risk prostate cancer. J Urol 2008-03-01 [PMID: 18207190] (IF/IHC, Human) |
IF/IHC |
Human |
| Singh, R P et al. Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin. Clin Cancer Res 14(1):300-8. 2008-01-01 [PMID: 18172282] |
|
|
| Tyagi, A et al. Chemopreventive effects of silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice. Mol Cancer Ther 6(12 Pt 1):3248-55. 2007-12-01 [PMID: 18089718] |
|
|
| Ghosh JC et al. Hsp60 regulation of tumor cell apoptosis. J Biol Chem;283(8):5188-94. 2008-02-22 [PMID: 18086682] |
|
|
| Connell, C M, R Colnaghi et al. Nuclear survivin has reduced stability and is not cytoprotective. J Biol Chem 283(6):3289-96. 2008-02-08 [PMID: 18057009] |
|
|
| Skoufias, DA et al. Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed. J Cell Biol 179(4):671-85. 2007-11-19 [PMID: 18025303] |
|
|
| Moiseeva, EP et al. Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells. Mol Cancer Ther 6(11):3071-9. 2007-11-01 [PMID: 18025290] |
|
|
| Lechler P, Wu X, Bernhardt W et al. The tumor gene survivin is highly expressed in adult renal tubular cells: implications for a pathophysiological role in the kidney. Am J Pathol171(5):1483-98. 2007-11-01 [PMID: 17982126] (IHC-P, Human, Mouse, Rat) |
IHC-P |
Human, Mouse, Rat |
| Hoffarth S, Zitzer A, Wiewrodt R et al. pp32/PHAPI determines the apoptosis response of non-small-cell lung cancer. Cell Death Differ 2008-01-01 [PMID: 17962813] (WB) |
WB |
|
| Niedbala, W et al. Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40. Proc Natl Acad Sci U S A 104(39):15478-83. 2007-09-25 [PMID: 17875988] (FLOW, Mouse) |
FLOW |
Mouse |
| Kindt, N, A Menzebach et al. Protective role of the inhibitor of apoptosis protein, survivin, in toxin-induced acute renal failure. FASEB J 22(2):510-21. 2008-02-01 [PMID: 17804696] |
|
|
| Gong, J et al. Attenuation of apoptosis by chromogranin A-induced Akt and survivin pathways in prostate cancer cells. Endocrinology 148(9):4489-99. 2007-09-01 [PMID: 17584963] |
|
|
| Wuttig D, Kunze D, Fuessel S et al. Are overexpressed alternative survivin transcripts in human bladder cancer suitable targets for siRNA-mediated in vitro inhibition? Int J Oncol 2007-06-01 [PMID: 17487351] (IHC-P, WB, Human) |
IHC-P, WB |
Human |
| Huang et al. Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments. J Cell Biol;177(3):413-24. 2007-05-07 [PMID: 17485487] |
|
|
| Vischioni B, Oudejans JJ, Kruyt FA et al. Immunohistochemical detection of nuclear survivin in NSCLC: a comparison of commercial antibodies. Histopathology 2007-04-01 [PMID: 17394508] (Human) |
|
Human |
| Deep, G et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells. Carcinogenesis;28(7):1533-42. 2007-07-01 [PMID: 17389612] |
|
|
| Engels K, Knauer SK, Metzler D et al. Dynamic intracellular survivin in oral squamous cell carcinoma: underlying molecular mechanism and potential as an early prognostic marker. J Pathol 2007-04-01 [PMID: 17334981] (IF/IHC, Human) |
IF/IHC |
Human |
| Margulis Vitaly, Shariat Shahrokh F, Ashfaq Raheela et al. Expression of cyclooxygenase-2 in normal urothelium, and superficial and advanced transitional cell carcinoma of bladder. The Journal of Urology 2007-01-01 [PMID: 17296438] (IF/IHC, Human) |
IF/IHC |
Human |
| Ryan M Investigating Induction of DNA Damage and Angiogenic Processes as Therapeutic Targets in the Treatment of Anaplastic Thyroid Cancer Thesis 2023-01-01 |
|
|
| Soling A, Plugge EM, Schmitz M et al. Autoantibodies to the inhibitor of apoptosis protein survivin in patients with brain tumors. Int J Oncol 2007-01-01 [PMID: 17143520] (Human) |
|
Human |
| Vischioni B, Oudejans JJ, Vos W et al. Frequent overexpression of aurora B kinase, a novel drug target, in non-small cell lung carcinoma patients. Mol Cancer Ther 2006-11-01 [PMID: 17121938] (ICC/IF, Human) |
ICC/IF |
Human |
| Knauer SK, Kramer OH, Knosel T et al. Nuclear export is essential for the tumor-promoting activity of survivin FASEB J. 2007-01-01 [PMID: 17099069] |
|
|
| Robles, Ana I et al. Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines. Clin Cancer Res;12(21):6547-56. 2006-11-01 [PMID: 17085670] |
|
|
Rice K Survivin Is a Mediator of Stiffness-Induced Migration of Vascular Smooth Muscle Cell Thesis 2023-01-01 (ICC/IF, Human)
Details:
1:100 dilution |
ICC/IF |
Human |
| Caldas, H et al. Dissecting the role of endothelial SURVIVIN DeltaEx3 in angiogenesis. Blood;109(4):1479-89. 2007-02-15 [PMID: 17038538] |
|
|
| Yip KW, Shi W, Pintilie M et al. Prognostic significance of the Epstein-Barr virus, p53, Bcl-2, and survivin in nasopharyngeal cancer. Clin Cancer Res;12(19):5726-32. 2006-10-01 [PMID: 17020977] (IHC-P, Human) |
IHC-P |
Human |
| Dumont J, Million K, Sunderland K et al. Formin-2 is required for spindle migration and for the late steps of cytokinesis in mouse oocytes. Dev Biol 2007-01-01 [PMID: 16989804] (ICC/IF, Mouse) |
ICC/IF |
Mouse |
| Stauber RH, Rabenhorst U, Rekik A et al. Nucleocytoplasmic shuttling and the biological activity of mouse survivin are regulated by an active nuclear export signal. Traffic 2006-11-01 [PMID: 16984408] (WB, Mouse) |
WB |
Mouse |
| Hahn, Joo-Yong et al. Beta-catenin overexpression reduces myocardial infarct size through differential effects on cardiomyocytes and cardiac fibroblasts. J Biol Chem;281(41):30979-89. 2006-10-13 [PMID: 16920707] |
|
|
| Bafford R, Sui XX, Wang G et al. Angiotensin II and tumor necrosis factor-alpha upregulate survivin and Kruppel-like factor 5 in smooth muscle cells: Potential relevance to vein graft hyperplasia. Surgery 2006-08-01 [PMID: 16904982] (WB) |
WB |
|
| Kang BH, Altieri DC. Regulation of survivin stability by the aryl hydrocarbon receptor-interacting protein. J Biol Chem;281(34):24721-7. 2006-08-25 [PMID: 16807248] |
|
|
| Fukuda, S, Pelus, LM. Survivin, a cancer target with an emerging role in normal adult tissues. Mol Cancer Ther;5(5):1087-98. 2006-05-01 [PMID: 16731740] |
|
|
| Scase TJ, Edwards D, Miller J et al. Canine mast cell tumors: correlation of apoptosis and proliferation markers with prognosis. J Vet Intern Med 2006-01-01 [PMID: 16496935] |
|
|
| Xie D, Zeng YX, Wang HJ et al. Expression of cytoplasmic and nuclear Survivin in primary and secondary human glioblastoma. Br J Cancer 2006-01-16 [PMID: 16404364] (IF/IHC, Human) |
IF/IHC |
Human |
| Mao, JT et al. Celecoxib decreases Ki-67 proliferative index in active smokers. Clin Cancer Res;12(1):314-20. 2006-01-01 [PMID: 16397057] |
|
|
| Kim, EY et al. TNF receptor type 2 (p75) functions as a costimulator for antigen-driven T cell responses in vivo. J Immunol;176(2):1026-35. 2006-01-15 [PMID: 16393990] (FLOW, ICC/IF, Mouse) |
FLOW, ICC/IF |
Mouse |
| Asanuma, H et al. Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast cancer cells. Cancer Res;65(23):11018-25. 2005-12-01 [PMID: 16322251] |
|
|
| Hata, T et al. Role of p21waf1/cip1 in effects of oxaliplatin in colorectal cancer cells. Mol Cancer Ther;4(10):1585-94. 2005-10-01 [PMID: 16227409] |
|
|
| Jung JE, Kim TK, Lee JS et al. Survivin inhibits anti-growth effect of p53 activated by aurora B. Biochem Biophys Res Commun 2005-11-04 [PMID: 16171786] (WB) |
WB |
|
| Pennati, M et al. Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther;4(9):1328-37. 2005-09-01 [PMID: 16170024] |
|
|
| Campisi G, Di Fede O, Giovannelli L et al. Use of fuzzy neural networks in modeling relationships of HPV infection with apoptotic and proliferation markers in potentially malignant oral lesions. Oral Oncol 2005-11-01 [PMID: 16129653] (IF/IHC) |
IF/IHC |
|
| Pizem J, Cort A, Zadravec-Zaletel L, Popovic M. Survivin is a negative prognostic marker in medulloblastoma. Neuropathol Appl Neurobiol 2005-08-01 [PMID: 16008826] (IF/IHC, Human) |
IF/IHC |
Human |
| MacCallum, D et al. Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1. Cancer Res;65(12):5399-407. 2005-06-15 [PMID: 15958589] |
|
|
| McMurtry MS, Archer SL, Altieri DC et al. Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. J Clin Invest 2005-06-01 [PMID: 15931388] |
|
|
| Lin CY, Hung HC, Kuo RC et al. Survivin expression predicts poorer prognosis in patients with areca quid chewing-related oral squamous cell carcinoma in Taiwan. Oral Oncol 2005-07-01 [PMID: 15927524] (Human) |
|
Human |
| Ponnelle T, Chapusot C, Martin L et al. Cellular localisation of survivin: impact on the prognosis in colorectal cancer. J Cancer Res Clin Oncol 2005-08-01 [PMID: 15902487] (IF/IHC, Human) |
IF/IHC |
Human |
| Song J, So T, Cheng M et al. Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. Immunity 2005-05-01 [PMID: 15894279] (Mouse) |
|
Mouse |
| Hayashi N, Asano K, Suzuki H et al Adenoviral infection of survivin antisense sensitizes prostate cancer cells to EPE in vivo Prostate 2005-09-15 [PMID: 15799033] (WB, WB) |
WB, WB |
|
| Lo Muzio L, D'Angelo M, Procaccini M et al. Expression of cell cycle markers and human papillomavirus infection in oral squamous cell carcinoma: use of fuzzy neural networks. Int J Cancer 2005-07-10 [PMID: 15729691] (IF/IHC) |
IF/IHC |
|
| Okada Y, Sakai H, Kohiki E et al. A dopamine D4 receptor antagonist attenuates ischemia-induced neuronal cell damage via upregulation of neuronal apoptosis inhibitory protein. J Cereb Blood Flow Metab 2005-07-01 [PMID: 15729293] (Human) |
|
Human |
| Fangusaro JR, Jiang Y, Holloway MP et al. Survivin, Survivin-2B, and Survivin-deItaEx3 expression in medulloblastoma: biologic markers of tumour morphology and clinical outcome. Br J Cancer 2005-01-31 [PMID: 15655550] (WB, Human) |
WB |
Human |
| Lubet, R et al. 4-Hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers in mice: characterization of FHIT and survivin expression and chemopreventive effects of indomethacin. Carcinogenesis;26(3):571-8. 2005-03-01 [PMID: 15591090] (IHC-P, Mouse) |
IHC-P |
Mouse |
| Vischioni, B et al. Nuclear localization of survivin is a positive prognostic factor for survival in advanced non-small-cell lung cancer. Ann Oncol;15(11):1654-60. 2004-11-01 [PMID: 15520067] |
|
|
| Scrittori, L et al. A small C-terminal sequence of Aurora B is responsible for localization and function. Mol Biol Cell;16(1):292-305. 2005-01-01 [PMID: 15509656] (ICC/IF, WB, Human) |
ICC/IF, WB |
Human |
| Ferrer, A et al. Activation of mitochondrial apoptotic pathway in mantle cell lymphoma: high sensitivity to mitoxantrone in cases with functional DNA-damage response genes. Oncogene;23(55):8941-9. 2004-11-25 [PMID: 15480431] |
|
|
| Xu Y, Fang, F, Ludewig, G et al. A mutation found in the promoter region of the human survivin gene is correlated to overexpression of survivin in cancer cells. DNA Cell Biol;23(9):527-37. 2004-09-01 [PMID: 15383173] |
|
|
| Krysan, K et al. Cyclooxygenase 2-dependent expression of survivin is critical for apoptosis resistance in non-small cell lung cancer. Cancer Res;64 (18):6359-62. 2004-09-15 [PMID: 15374938] |
|
|
| Chen, J et al. Cancer-specific activation of the survivin promoter and its potential use in gene therapy. Cancer Gene Ther;11(11):740-7. 2004-11-01 [PMID: 15359286] |
|
|
| Mallikarjuna, G et al. Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling. Cancer Res;64(17):6349-56. 2004-09-01 [PMID: 15342425] |
|
|
| Chakravarti, A et al. Survivin enhances radiation resistance in primary human glioblastoma cells via caspase-independent mechanisms. Oncogene23(45):7494-506. 2004-09-30 [PMID: 15326475] |
|
|
| Gassman, R et al. Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol;166(2):179-91. 2004-07-19 [PMID: 15249581] |
|
|
| Amin, H et al. Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma. Oncogene;23(32):5426-34. 2004-07-15 [PMID: 15184887] |
|
|
| Lo Muzio L, Campisi G, Giovannelli L et al. HPV DNA and survivin expression in epithelial oral carcinogenesis: a relationship? Oral Oncol 2004-08-01 [PMID: 15172644] |
|
|
| Geddis, A et al. Megakaryocytes express functional Aurora-B kinase in endomitosis. Blood;104(4):1017-24. 2004-08-15 [PMID: 15130946] (ICC/IF, Human, Mouse) |
ICC/IF |
Human, Mouse |
| Schlette, E et al. Survivin expression predicts poorer prognosis in anaplastic large-cell lymphoma. J Clin Oncol;22(9):1682-8. 2004-05-01 [PMID: 15117990] |
|
|
| Johnson, V et al. Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression. J Cell Sci;117(Pt 8):1577-89. 2004-03-15 [PMID: 15020684] |
|
|
| Asanuma, K et al. Survivin enhances Fas ligand expression via up-regulation of specificity protein 1-mediated gene transcription in colon cancer cells. J Immunol;172(6):3922-9. 2004-03-15 [PMID: 15004200] |
|
|
| Komuro Y, Watanabe T, Tsurita G, Muto T, Nagawa H. Survivin expression in ovarian carcinoma: correlation with apoptotic markers and prognosis. Mod Pathol;17(2):264. 2004-02-01 [PMID: 14963460] |
|
|
| Zha, H et al. Similarities of prosurvival signals in Bcl-2-positive and Bcl-2-negative follicular lymphomas identified by reverse phase protein microarray. Lab Invest;84(2):235-44. 2004-02-01 [PMID: 14767488] |
|
|
| Martinez, A et al. Nuclear survivin expression in mantle cell lymphoma is associated with cell proliferation and survival. Am J Pathol;164(2):501-10. 2004-02-01 [PMID: 14742256] |
|
|
| Kirkiles-Smith, N et al. IL-11 protects human microvascular endothelium from alloinjury in vivo by induction of survivin expression. J Immunol;172(3):1391-6. 2004-02-01 [PMID: 14734714] |
|
|
| Liu T, Brouha B, Grossman D. Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells. Oncogene. 2004-01-08 [PMID: 14712209] |
|
|
| Lo Muzio, L et al. Survivin expression in oral squamous cell carcinoma. Br J Cancer;89(12):2244-8. 2003-12-15 [PMID: 14676801] |
|
|
| Rudkowski, J et al. Roles of iNOS and nNOS in sepsis-induced pulmonary apoptosis. Am J Physiol Lung Cell Mol Physiol;286(4):L793-800. 2004-04-01 [PMID: 14660484] (WB, Rat) |
WB |
Rat |
| Chen, J et al. Gene expression and mitotic exit induced by microtubule-stabilizing drugs. Cancer Res;63(22):7891-9. 2003-11-15 [PMID: 14633718] |
|
|
| Fortugno P, Beltrami E, Plescia et al. Regulation of survivin function by Hsp90. Proc Natl Acad Sci U S A. 2003-11-25 [PMID: 14614132] |
|
|
| Krysan, K. : COX-2-dependent stabilization of survivin in non-small cell lung cancer. FASEB J;18(1):206-8. 2004-01-01 [PMID: 14597555] |
|
|
| Altura, R et al. Nuclear expression of Survivin in paediatric ependymomas and choroid plexus tumours correlates with morphologic tumour grade. Br J Cancer;89(9):1743-9. 2003-11-03 [PMID: 14583779] |
|
|
| Beltrami, E et al. Acute ablation of survivin uncovers p53-dependent mitotic checkpoint functions and control of mitochondrial apoptosis. J Biol Chem;279(3):2077-84. 2004-01-16 [PMID: 14581472] |
|
|
| Zhao Z, Ho L, Suh J et al. A role of P301L tau mutant in anti-apoptotic gene expression, cell cycle and apoptosis. Mol Cell Neurosci 2003-10-01 [PMID: 14572459] (WB, Human) |
WB |
Human |
| Fornaro, M et al. Fibronectin protects prostate cancer cells from tumor necrosis factor-alpha-induced apoptosis via the AKT/survivin pathway. J Biol Chem;278(50):50402-11. 2003-12-12 [PMID: 14523021] |
|
|
| Neef, R et al. Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis. J Cell Biol;162(5):863-75. 2003-09-01 [PMID: 12939256] |
|
|
| Honda, R et al. Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Mol Biol Cell;14(8):3325-41. 2003-08-01 [PMID: 12925766] |
|
|
| Chen, Y et al. Loss of inhibitor of apoptosis proteins as a determinant of polyamine analog-induced apoptosis in human melanoma cells. Oncogene. 2003-08-07 [PMID: 12902979] |
|
|
| Blanc-Brude OP et al. Therapeutic targeting of the survivin pathway in cancer: initiation of mitochondrial apoptosis and suppression of tumor-associated angiogenesis. Clin Cancer Res;9(7):2683-92. 2003-07-01 [PMID: 12855648] |
|
|
| Carvalho A, Carmena M, Sambade C, Earnshaw WC, Wheatley SP. Survivin is required for stable checkpoint activation in taxol-treated HeLa cells. J Cell Sci116(Pt 14):2987-98. 2003-07-15 [PMID: 12783991] |
|
|
| Ramp, U et al. Apoptosis induction in renal cell carcinoma by TRAIL and gamma-radiation is impaired by deficient caspase-9 cleavage. Br J Cancer;88(11):1800-7. 2003-06-02 [PMID: 12771998] |
|
|
| Weinman EC, Roche PC, Kasperbauer JL et al. Characterization of antigen processing machinery and Survivin expression in tonsillar squamous cell carcinoma. Cancer 2003-05-01 [PMID: 12712472] (Human) |
|
Human |
| Hauf, S et al. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol;161(2):281-94. 2003-04-28 [PMID: 12707311] |
|
|
| Kennedy, S et al. Prognostic importance of survivin in breast cancer. Br J Cancer;88(7):1077-83. 2003-04-07 [PMID: 12671708] (IHC-P, IHC-Fr, Human) |
IHC-P, IHC-Fr |
Human |
| Faderl, S et al. Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces antiapoptotic and proapoptotic signals in acute myeloid leukemia. Blood;102(2):630-7. 2003-07-15 [PMID: 12663443] |
|
|
| Miranda MB, Dyer KF, Grandis JR, Johnson DE. Differential activation of apoptosis regulatory pathways during monocytic vs granulocytic differentiation: a requirement for Bcl-X(L)and XIAP in the prolonged survival of monocytic cells. Leukemia;17(2):390-400. 2003-02-01 [PMID: 12592339] |
|
|
| Grabowski, P et al. Prognostic value of nuclear survivin expression in oesophageal squamous cell carcinoma. Br J Cancer;88(1):115-9. 2003-01-13 [PMID: 12556969] |
|
|
| Mahotka, C et al. Differential subcellular localization of functionally divergent survivin splice variants. Cell Death Differ;9(12):1334-42. 2002-12-01 [PMID: 12478470] |
|
|
| Blanc-Brude OP, Yu J, Simosa H et al. Inhibitor of apoptosis protein survivin regulates vascular injury. Nat Med. 2002-09-01 [PMID: 12172543] (IHC-Fr, ICC/IF, WB, Rat) |
IHC-Fr, ICC/IF, WB |
Rat |
| O'Connor, DS et al. A p34(cdc2) survival checkpoint in cancer. Cancer Cell;2(1):43-54. 2002-07-01 [PMID: 12150824] (WB, IP, Human) |
WB, IP |
Human |
| Mahotka C, Krieg T, Krieg A et al. Distinct in vivo expression patterns of survivin splice variants in renal cell carcinomas. Int J Cancer 2002-07-01 [PMID: 12115583] (WB, Human) |
WB |
Human |
| Yu J, Leung WK, Ebert MP et al. Increased expression of survivin in gastric cancer patients and in first degree relatives. Br J Cancer;87(1):91-7. 2002-07-01 [PMID: 12085263] (IHC-P, WB, Human) |
IHC-P, WB |
Human |
| Qanungo, S et al. 2-Methoxyestradiol induces mitochondria dependent apoptotic signaling in pancreatic cancer cells. Oncogene;21(26):4149-57. 2002-06-13 [PMID: 12037671] |
|
|
| Zhang, C et al. Induction of apoptosis by bexarotene in cutaneous T-cell lymphoma cells: relevance to mechanism of therapeutic action. Clin Cancer Res;8(5):1234-40. 2002-05-01 [PMID: 12006543] |
|
|
| Giodini, A et al. Regulation of microtubule stability and mitotic progression by survivin. Cancer Res62(9):2462-7. 2002-05-01 [PMID: 11980633] (Human) |
|
Human |
| Fortugno P, Wall NR, Giodini A, O'Connor DS, Plescia J, Padgett KM, Tognin S, Marchisio PC, Altieri DC. Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function. J Cell Sci115(Pt 3):575-85. 2002-02-01 [PMID: 11861764] (ICC/IF, IP, WB, Human) |
ICC/IF, IP, WB |
Human |
| Chakravarti A, Noll E, Black PM et al. Quantitatively determined survivin expression levels are of prognostic value in human gliomas. J Clin Oncol;20(4):1063-8. 2002-02-15 [PMID: 11844831] (WB, Human) |
WB |
Human |
| Zeitlin, S et al. CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. J Cell Biol;155(7):1147-57. 2001-12-24 [PMID: 11756469] (ICC/IF, WB, Human) |
ICC/IF, WB |
Human |
| Zhu, L et al. Anti-apoptotic protein survivin plays a significant role in tubular morphogenesis of human coronary arteriolar endothelial cells by hypoxic preconditioning. FEBS Lett508(3):369-74. 2001-11-23 [PMID: 11728454] |
|
|
| Wheatley SP, Carvalho A, Vagnarelli P, Earnshaw WC. INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. Curr Biol11(11):886-90. 2001-06-05 [PMID: 11516652] (ICC/IF, Human) |
ICC/IF |
Human |
|
Show All 379 Publications.
Collapse Publications.
|
![Dual RNAscope ISH-IHC: Survivin Antibody [NB500-201] - Formalin-fixed paraffin-embedded tissue sections of human esophagus squamous cell carcinoma were probed for Survivin mRNA (ACD RNAScope Probe, [465361]; Fast Red chromogen, ACD [322360]). Adjacent tissue section was processed for immunohistochemistry using rabbit polyclonal [NB500-201] at 1.5ug/mL with overnight incubation at 4 degrees Celsius followed by incubation with anti-rabbit IgG VisUCyte HRP Polymer Antibody [VC003] and DAB chromogen (yellow-brown). Tissue was counterstained with hematoxylin (blue). Specific staining was localized to tumor cells.](http://images.novusbio.com/fullsize/Survivin-Antibody-Dual-RNAscope-ISH-IHC-NB500-201-img0026.jpg "Dual RNAscope ISH-IHC: Survivin Antibody [NB500-201] - Formalin-fixed paraffin-embedded tissue sections of human esophagus squamous cell carcinoma were probed for Survivin mRNA (ACD RNAScope Probe, [465361]; Fast Red chromogen, ACD [322360]). Adjacent tissue section was processed for immunohistochemistry using rabbit polyclonal [NB500-201] at 1.5ug/mL with overnight incubation at 4 degrees Celsius followed by incubation with anti-rabbit IgG VisUCyte HRP Polymer Antibody [VC003] and DAB chromogen (yellow-brown). Tissue was counterstained with hematoxylin (blue). Specific staining was localized to tumor cells.")
![Western Blot AKT [p Ser473] Antibody [Unconjugated] - Pan Specific](https://images.novusbio.com/images2/Akt3_AF887_Western_Blot_5930.jpg)
![Simple Western AKT [p Ser473] Antibody [Unconjugated] - Pan Specific](https://images.novusbio.com/images2/16332.jpg)
![Intracellular Staining by Flow Cytometry AKT [p Ser473] Antibody [Unconjugated] - Pan Specific](https://images.novusbio.com/images2/Akt3_AF887_Flow_Cytometry_8283.jpg)
![Immunohistochemistry EGFR Antibody [Unconjugated]](https://images.novusbio.com/images2/EGF_R_AF231_Immunohistochemistry_20892.jpg)
![Immunocytochemistry EGFR Antibody [Unconjugated]](https://images.novusbio.com/images2/EGF_R_AF231_Immunocytochemistry__Immunofluorescence_21143.jpg)
![Western Blot EGFR Antibody [Unconjugated]](https://images.novusbio.com/images2/EGF_R_AF231_Western_Blot_19925.jpg)
-(01-ml)_NB500-201_8336.bmp)
![Western Blot: Survivin Antibody [NB500-201] - Western blot analysis using Survivin and flotillin antibodies was performed on lysates of DMSO- and PTX-treated MDAMB231 cells ectopically expressing either control siRNA or Survivin siRNA (panels labeled WCL), as well as on the exosomes these cells generated (panels labeled Exos). Image collected and cropped by CiteAb from the following publication (//www.mdpi.com/2072-6694/8/12/111) licensed under a CC-BY license.](http://images.novusbio.com/fullsize/Survivin-Antibody-Knockdown-Validated-NB500-201-img0037.jpg "Western Blot: Survivin Antibody [NB500-201] - Western blot analysis using Survivin and flotillin antibodies was performed on lysates of DMSO- and PTX-treated MDAMB231 cells ectopically expressing either control siRNA or Survivin siRNA (panels labeled WCL), as well as on the exosomes these cells generated (panels labeled Exos). Image collected and cropped by CiteAb from the following publication (//www.mdpi.com/2072-6694/8/12/111) licensed under a CC-BY license.")
![Immunohistochemistry: Survivin Antibody [NB500-201] - Protein expression pattern of Survivin in HCC tissues and non-neoplastic liver parenchyma. IAP members immunoreactivity was estimated by tissue microarray in a subset of HCC patients (n = 40). A-D, Representative Survivin cytoplasmatic immunostaining in a tumor core (A), in a tumor proximal to cirrhosis (C, N: cirrhosis, K: HCC), and in adjacent and long-distance non-neoplastic parenchyma (B and D, respectively). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/19397802) licensed under a CC-BY license.](http://images.novusbio.com/fullsize/Survivin-Antibody-Immunohistochemistry-NB500-201-img0038.jpg "Immunohistochemistry: Survivin Antibody [NB500-201] - Protein expression pattern of Survivin in HCC tissues and non-neoplastic liver parenchyma. IAP members immunoreactivity was estimated by tissue microarray in a subset of HCC patients (n = 40). A-D, Representative Survivin cytoplasmatic immunostaining in a tumor core (A), in a tumor proximal to cirrhosis (C, N: cirrhosis, K: HCC), and in adjacent and long-distance non-neoplastic parenchyma (B and D, respectively). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/19397802) licensed under a CC-BY license.")
![Knockdown Validated: Survivin Antibody [NB500-201] - Anti-tumor effects and functional evidence of sCA-survivin-siRNA in HCT116 and HT29 solid tumor models. Immunostaining of survivin in the tumor tissues on day 19 using [NB500-201]. Scale bar, 50 um. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0116022) licensed under a CC-BY license.](http://images.novusbio.com/fullsize/Survivin-Antibody-Knockdown-Validated-NB500-201-img0033.jpg "Knockdown Validated: Survivin Antibody [NB500-201] - Anti-tumor effects and functional evidence of sCA-survivin-siRNA in HCT116 and HT29 solid tumor models. Immunostaining of survivin in the tumor tissues on day 19 using [NB500-201]. Scale bar, 50 um. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0116022) licensed under a CC-BY license.")
![Immunocytochemistry/Immunofluorescence: Survivin Antibody [NB500-201] - Analysis using the HRP conjugate of [NB500-201]. Staining of Telophase with accumulation of survivin in the midbodies of two daughter cells. Survivin detection using [NB500-201].](http://images.novusbio.com/fullsize/Survivin-Antibody-Immunocytochemistry-Immunofluorescence-NB500-201-img0018.jpg "Immunocytochemistry/Immunofluorescence: Survivin Antibody [NB500-201] - Analysis using the HRP conjugate of [NB500-201]. Staining of Telophase with accumulation of survivin in the midbodies of two daughter cells. Survivin detection using [NB500-201].")
![Western Blot: Survivin Antibody [NB500-201] - Analysis of 30ug of HeLa whole cell lysate [NB800-PC1] using rabbit polyclonal [NB500-201] at 1ug/ml. Detection was performed using ECL method with 1 minute exposure. Band detected at higher molecular weight than the predicted MW (16 kDa).](http://images.novusbio.com/fullsize/Survivin-Antibody-Western-Blot-NB500-201-img0017.jpg "Western Blot: Survivin Antibody [NB500-201] - Analysis of 30ug of HeLa whole cell lysate [NB800-PC1] using rabbit polyclonal [NB500-201] at 1ug/ml. Detection was performed using ECL method with 1 minute exposure. Band detected at higher molecular weight than the predicted MW (16 kDa).")
![Immunohistochemistry-Paraffin: Survivin Antibody [NB500-201] - Immunohistochemical staining of Survivin in human rectal cancer using [NB500-201] and DAB with hematoxylin counterstain.](http://images.novusbio.com/fullsize/Survivin-Antibody-Immunohistochemistry-Paraffin-NB500-201-img0008.jpg "Immunohistochemistry-Paraffin: Survivin Antibody [NB500-201] - Immunohistochemical staining of Survivin in human rectal cancer using [NB500-201] and DAB with hematoxylin counterstain.")
![Flow Cytometry: Survivin Antibody [NB500-201] - An intracellular stain was performed on HeLa cells with [NB500-201] and a matched isotype control. Cells were fixed with 4% PFA and then permeablized with 0.1% saponin. Cells were incubated in an antibody dilution of 2.5 ug/mL for 30 minutes at room temperature, followed by Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Dylight 550.](http://images.novusbio.com/fullsize/Survivin-Antibody-Flow-Cytometry-NB500-201-img0025.jpg "Flow Cytometry: Survivin Antibody [NB500-201] - An intracellular stain was performed on HeLa cells with [NB500-201] and a matched isotype control. Cells were fixed with 4% PFA and then permeablized with 0.1% saponin. Cells were incubated in an antibody dilution of 2.5 ug/mL for 30 minutes at room temperature, followed by Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Dylight 550.")
![Western Blot: Survivin Antibody [NB500-201] - Western blot analysis using Survivin Antibody [NB500-201]. Effects of siRNA transfection on the expression of Bcl-xL and survivin. Bcl-xL and survivin protein content detected by Western Blotting 48 h after transfection. Bcl-xL and survivin levels are shown normalized to the reference protein beta-actin and relative to the ns-si control. Image collected and cropped by CiteAb from the following publication (//www.mdpi.com/1422-0067/14/6/12297) licensed under a CC-BY license.](http://images.novusbio.com/fullsize/Survivin-Antibody-Western-Blot-NB500-201-img0032.jpg "Western Blot: Survivin Antibody [NB500-201] - Western blot analysis using Survivin Antibody [NB500-201]. Effects of siRNA transfection on the expression of Bcl-xL and survivin. Bcl-xL and survivin protein content detected by Western Blotting 48 h after transfection. Bcl-xL and survivin levels are shown normalized to the reference protein beta-actin and relative to the ns-si control. Image collected and cropped by CiteAb from the following publication (//www.mdpi.com/1422-0067/14/6/12297) licensed under a CC-BY license.")
![Western Blot: Survivin Antibody [NB500-201] - Analysis of Survivin in human hepatocytes from cancer patient (left) and HeLa cell lysate (right) using [NB500-201]. Image from verified customer review. Note: bands detected at higher molecular weight than predicted (16 kDa)](http://images.novusbio.com/fullsize/Survivin-Antibody-Western-Blot-NB500-201-img0013.jpg "Western Blot: Survivin Antibody [NB500-201] - Analysis of Survivin in human hepatocytes from cancer patient (left) and HeLa cell lysate (right) using [NB500-201]. Image from verified customer review. Note: bands detected at higher molecular weight than predicted (16 kDa)")
![Western Blot: Survivin Antibody [NB500-201] - Western blot analysis using [NB500-201]. Survivin protein is degraded by ubiquitin proteasome in serum-free and serum-containing media. Western blots and protein quantitation graphs showing that addition of MG-132 proteasome inhibitor (10 uM) extended survivin protein half-life in serum-free and serum-containing media. One representative western blot out of triplicate experiments was shown for each treatment and condition. *Indicates the time at which survivin protein is half of the amount at 0 hours (half-life), P 100. ** p-value 100. ** p-value < .01 using student t-test. H. PFGE analysis of EBV episomes & linears at 7 days post-transduction with lentivirus shRNA for shControl or shSurvivin in MUTU I or RAJI cell lines. Human alpha satellite DNA is used for DNA loading control Western blot of Survivin & Actin are shown below for each cell at 7 days post-transduction. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28077791), licensed under a CC-BY license. Not internally tested by Novus Biologicals.](http://images.novusbio.com/fullsize/nb500-201_rabbit-polyclonal-survivin-antibody-310202416171444.jpg "Western Blot: Survivin Antibody [NB500-201] - Western blot analysis using [NB500-201]. Survivin protein is degraded by ubiquitin proteasome in serum-free and serum-containing media. Western blots and protein quantitation graphs showing that addition of MG-132 proteasome inhibitor (10 uM) extended survivin protein half-life in serum-free and serum-containing media. One representative western blot out of triplicate experiments was shown for each treatment and condition. *Indicates the time at which survivin protein is half of the amount at 0 hours (half-life), P 100. ** p-value 100. ** p-value < .01 using student t-test. H. PFGE analysis of EBV episomes & linears at 7 days post-transduction with lentivirus shRNA for shControl or shSurvivin in MUTU I or RAJI cell lines. Human alpha satellite DNA is used for DNA loading control Western blot of Survivin & Actin are shown below for each cell at 7 days post-transduction. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28077791), licensed under a CC-BY license. Not internally tested by Novus Biologicals.")
![Western Blot: Survivin Antibody - BSA Free [NB500-201] - The p53-p21 axis facilitates downregulation of survivin via cell cycle(A) HCT116 wild typeand p21-deficient (p21-/-) cells were treated with 5 μM L-OHP for 24 hours. Whole cell lysates were analyzed with antibodies against p53, p21, & survivin; vinculin serves as loading control. (B) Cell cycle distribution was analyzed after 24 hours treatment by flow cytometry analysis (n = 3). (C) To induce p21, RKO p21ind cells were treated with 3 nM Muristerone A for 24 hours & tested for the levels of p21 & survivin; vinculin, loading control. (D)BIRC5 mRNA levels were analyzed by quantitative real-time PCR after 24 hours treatment with MurA in RKO p21ind cells (n = 3). (E) Cell cycle distribution was measured by flow cytometry analyses of cellular DNA content (n = 3). (F) Scheme summarizing the supposed mechanisms of survivin regulation after L-OHP & CPT-11 treatment. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/29963241), licensed under a CC-BY license. Not internally tested by Novus Biologicals.](http://images.novusbio.com/fullsize/nb500-201_rabbit-polyclonal-survivin-antibody-310202416182643.jpg "Western Blot: Survivin Antibody - BSA Free [NB500-201] - The p53-p21 axis facilitates downregulation of survivin via cell cycle(A) HCT116 wild typeand p21-deficient (p21-/-) cells were treated with 5 μM L-OHP for 24 hours. Whole cell lysates were analyzed with antibodies against p53, p21, & survivin; vinculin serves as loading control. (B) Cell cycle distribution was analyzed after 24 hours treatment by flow cytometry analysis (n = 3). (C) To induce p21, RKO p21ind cells were treated with 3 nM Muristerone A for 24 hours & tested for the levels of p21 & survivin; vinculin, loading control. (D)BIRC5 mRNA levels were analyzed by quantitative real-time PCR after 24 hours treatment with MurA in RKO p21ind cells (n = 3). (E) Cell cycle distribution was measured by flow cytometry analyses of cellular DNA content (n = 3). (F) Scheme summarizing the supposed mechanisms of survivin regulation after L-OHP & CPT-11 treatment. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/29963241), licensed under a CC-BY license. Not internally tested by Novus Biologicals.")
![Western Blot: Survivin Antibody - BSA Free [NB500-201] - Apoptosis & survival signaling after L-OHP & CPT-11(A) Western blot analysis using antibodies against p53 & pro-apoptotic BAX & PIG-3 after treatment with 5 μM L-OHP or 10 μM CPT-11. (B) Immunodetection of NF-kappa B p65, RELB & anti-apoptotic survivin, XIAP, BCL-XL & MCL1; vinculin serves as loading control. (C) Effects of increasing doses L-OHP & CPT-11 on caspase-3 & PARP1 cleavage after 24 hours treatment; alpha -tubulin serves as loading control. (D) Cells were treated with a combination of L-OHP & the caspase-inhibitor Z-VAD-FMK (50 μM). Immunodetection of survivin, p53 & full-length caspase-3 was conducted. Detection of apoptosis was determined by cleavage products of caspase-3 & PARP1; beta -actin serves as loading control. Please note: Figure 4A & 4B, as well as Supplementary Figure 2A show signals acquired by different detection methods, but originate from the same Western blots. This is due to a switch in the immunoblot chemiluminescence detection system from X-ray films (darker background) to a CCD camera system (Fusion Solo S, Vilber Lourmat; lighter background). Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/29963241), licensed under a CC-BY license. Not internally tested by Novus Biologicals.](http://images.novusbio.com/fullsize/nb500-201_rabbit-polyclonal-survivin-antibody-310202416175291.jpg "Western Blot: Survivin Antibody - BSA Free [NB500-201] - Apoptosis & survival signaling after L-OHP & CPT-11(A) Western blot analysis using antibodies against p53 & pro-apoptotic BAX & PIG-3 after treatment with 5 μM L-OHP or 10 μM CPT-11. (B) Immunodetection of NF-kappa B p65, RELB & anti-apoptotic survivin, XIAP, BCL-XL & MCL1; vinculin serves as loading control. (C) Effects of increasing doses L-OHP & CPT-11 on caspase-3 & PARP1 cleavage after 24 hours treatment; alpha -tubulin serves as loading control. (D) Cells were treated with a combination of L-OHP & the caspase-inhibitor Z-VAD-FMK (50 μM). Immunodetection of survivin, p53 & full-length caspase-3 was conducted. Detection of apoptosis was determined by cleavage products of caspase-3 & PARP1; beta -actin serves as loading control. Please note: Figure 4A & 4B, as well as Supplementary Figure 2A show signals acquired by different detection methods, but originate from the same Western blots. This is due to a switch in the immunoblot chemiluminescence detection system from X-ray films (darker background) to a CCD camera system (Fusion Solo S, Vilber Lourmat; lighter background). Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/29963241), licensed under a CC-BY license. Not internally tested by Novus Biologicals.")
![Western Blot: Survivin Antibody - BSA Free [NB500-201] - Anti-tumor effects & functional evidence of sCA-survivin-siRNA in HCT116 & HT29 solid tumor models.(A) For western blot analysis, HCT116 cells were seeded into 6-well plates & transfected with 100 pmol/well of either control or survivin siRNA by Lp (Lipofectamine 2000) or sCA. Actin blots served as loading controls. (B) For proliferation assays, cells were uniformly seeded into 96-well plates (1 × 104 cells/well), & 5 pmol/well siRNA was used. Cell viability was examined at 48 & 72 h by WST-8 assay. Data represent mean ± SEM. *P = 0.0294, **P = 0.0304 (n = 4, Wilcoxon rank test). (C) In vivo tumor growth. Each vehicle, carrying 15 μg of control siRNA or survivin siRNA, was administered by intravenous injection to mice with HCT116 tumors. Data represent the mean ± SEM (n = 10 tumors, Wilcoxon rank test). (D) Immunostaining of survivin in the tumor tissues on day 19. Scale bar, 50 μm. (E) In vivo live imaging of sCA-siRNA (6-FAM labeled) in HT29 tumor by multiphoton microscopy at 90 min. (F) Fluorescent detection of naked-siRNA (6-FAM labeled) or sCA-siRNA (6-FAM labeled) in the HT29 tumor at 4 h. Green: 6-FAM labeled siRNA; Red: microvasculature; Blue: DAPI stained nuclei. Scale bar, 50 μm. (G) Mice were administered with 40 μg of naked-survivin-siRNA or sCA-survivin-siRNA on days 0, 1, & 2. Tumors were removed on day 3, & western blot analysis for survivin was performed. (H) Many tumor cells treated with sCA-survivin-siRNA (6-FAM labeled) had condensed nuclei & were positive for TUNEL assay. Scale bar, 50 μm. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/25738937), licensed under a CC-BY license. Not internally tested by Novus Biologicals.](http://images.novusbio.com/fullsize/nb500-201_rabbit-polyclonal-survivin-antibody-310202416175225.jpg "Western Blot: Survivin Antibody - BSA Free [NB500-201] - Anti-tumor effects & functional evidence of sCA-survivin-siRNA in HCT116 & HT29 solid tumor models.(A) For western blot analysis, HCT116 cells were seeded into 6-well plates & transfected with 100 pmol/well of either control or survivin siRNA by Lp (Lipofectamine 2000) or sCA. Actin blots served as loading controls. (B) For proliferation assays, cells were uniformly seeded into 96-well plates (1 × 104 cells/well), & 5 pmol/well siRNA was used. Cell viability was examined at 48 & 72 h by WST-8 assay. Data represent mean ± SEM. *P = 0.0294, **P = 0.0304 (n = 4, Wilcoxon rank test). (C) In vivo tumor growth. Each vehicle, carrying 15 μg of control siRNA or survivin siRNA, was administered by intravenous injection to mice with HCT116 tumors. Data represent the mean ± SEM (n = 10 tumors, Wilcoxon rank test). (D) Immunostaining of survivin in the tumor tissues on day 19. Scale bar, 50 μm. (E) In vivo live imaging of sCA-siRNA (6-FAM labeled) in HT29 tumor by multiphoton microscopy at 90 min. (F) Fluorescent detection of naked-siRNA (6-FAM labeled) or sCA-siRNA (6-FAM labeled) in the HT29 tumor at 4 h. Green: 6-FAM labeled siRNA; Red: microvasculature; Blue: DAPI stained nuclei. Scale bar, 50 μm. (G) Mice were administered with 40 μg of naked-survivin-siRNA or sCA-survivin-siRNA on days 0, 1, & 2. Tumors were removed on day 3, & western blot analysis for survivin was performed. (H) Many tumor cells treated with sCA-survivin-siRNA (6-FAM labeled) had condensed nuclei & were positive for TUNEL assay. Scale bar, 50 μm. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/25738937), licensed under a CC-BY license. Not internally tested by Novus Biologicals.")
![Western Blot: Survivin Antibody - BSA Free [NB500-201] - Survivin is essential for the salinomycin-induced apoptosis in UM cells. a UM cells were treated with salinomycin for 24 h & the protein levels of apoptosis-related proteins were detected by Western blot. b & c UM cells were transduced with lentiviral pTSB-Survivin cDNA (b), Survivin-shRNA constructs (c), or their corresponding empty vectors, & then incubated in the presence of puromycin (1 μg/mL) for 5 days to reach stable clones. Such survivin-manipulated cells were then exposed to salinomycin for 24 h, & subjected to trypan blue exclusion assay (left) & Western blot assay (right). Data represent mean ± SD. ns, not significant; *, P < 0.05; **, P < 0.01; ***, P < 0.001, Student’s t test. d qRT-PCR analysis of BIRC5 mRNA level was done in the 92.1 & Mel270 cells treated with salinomycin for 24 h. **, P < 0.01; ***, P < 0.001, one-way ANOVA, post hoc comparisons, Tukey’s test Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/31718679), licensed under a CC-BY license. Not internally tested by Novus Biologicals.](http://images.novusbio.com/fullsize/nb500-201_rabbit-polyclonal-survivin-antibody-310202416161820.jpg "Western Blot: Survivin Antibody - BSA Free [NB500-201] - Survivin is essential for the salinomycin-induced apoptosis in UM cells. a UM cells were treated with salinomycin for 24 h & the protein levels of apoptosis-related proteins were detected by Western blot. b & c UM cells were transduced with lentiviral pTSB-Survivin cDNA (b), Survivin-shRNA constructs (c), or their corresponding empty vectors, & then incubated in the presence of puromycin (1 μg/mL) for 5 days to reach stable clones. Such survivin-manipulated cells were then exposed to salinomycin for 24 h, & subjected to trypan blue exclusion assay (left) & Western blot assay (right). Data represent mean ± SD. ns, not significant; *, P < 0.05; **, P < 0.01; ***, P < 0.001, Student’s t test. d qRT-PCR analysis of BIRC5 mRNA level was done in the 92.1 & Mel270 cells treated with salinomycin for 24 h. **, P < 0.01; ***, P < 0.001, one-way ANOVA, post hoc comparisons, Tukey’s test Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/31718679), licensed under a CC-BY license. Not internally tested by Novus Biologicals.")
![Immunocytochemistry/ Immunofluorescence: Survivin Antibody - BSA Free [NB500-201] - Anti-tumor effects & functional evidence of sCA-survivin-siRNA in HCT116 & HT29 solid tumor models.(A) For western blot analysis, HCT116 cells were seeded into 6-well plates & transfected with 100 pmol/well of either control or survivin siRNA by Lp (Lipofectamine 2000) or sCA. Actin blots served as loading controls. (B) For proliferation assays, cells were uniformly seeded into 96-well plates (1 × 104 cells/well), & 5 pmol/well siRNA was used. Cell viability was examined at 48 & 72 h by WST-8 assay. Data represent mean ± SEM. *P = 0.0294, **P = 0.0304 (n = 4, Wilcoxon rank test). (C) In vivo tumor growth. Each vehicle, carrying 15 μg of control siRNA or survivin siRNA, was administered by intravenous injection to mice with HCT116 tumors. Data represent the mean ± SEM (n = 10 tumors, Wilcoxon rank test). (D) Immunostaining of survivin in the tumor tissues on day 19. Scale bar, 50 μm. (E) In vivo live imaging of sCA-siRNA (6-FAM labeled) in HT29 tumor by multiphoton microscopy at 90 min. (F) Fluorescent detection of naked-siRNA (6-FAM labeled) or sCA-siRNA (6-FAM labeled) in the HT29 tumor at 4 h. Green: 6-FAM labeled siRNA; Red: microvasculature; Blue: DAPI stained nuclei. Scale bar, 50 μm. (G) Mice were administered with 40 μg of naked-survivin-siRNA or sCA-survivin-siRNA on days 0, 1, & 2. Tumors were removed on day 3, & western blot analysis for survivin was performed. (H) Many tumor cells treated with sCA-survivin-siRNA (6-FAM labeled) had condensed nuclei & were positive for TUNEL assay. Scale bar, 50 μm. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/25738937), licensed under a CC-BY license. Not internally tested by Novus Biologicals.](http://images.novusbio.com/fullsize/nb500-201_rabbit-polyclonal-survivin-antibody-310202416182634.jpg "Immunocytochemistry/ Immunofluorescence: Survivin Antibody - BSA Free [NB500-201] - Anti-tumor effects & functional evidence of sCA-survivin-siRNA in HCT116 & HT29 solid tumor models.(A) For western blot analysis, HCT116 cells were seeded into 6-well plates & transfected with 100 pmol/well of either control or survivin siRNA by Lp (Lipofectamine 2000) or sCA. Actin blots served as loading controls. (B) For proliferation assays, cells were uniformly seeded into 96-well plates (1 × 104 cells/well), & 5 pmol/well siRNA was used. Cell viability was examined at 48 & 72 h by WST-8 assay. Data represent mean ± SEM. *P = 0.0294, **P = 0.0304 (n = 4, Wilcoxon rank test). (C) In vivo tumor growth. Each vehicle, carrying 15 μg of control siRNA or survivin siRNA, was administered by intravenous injection to mice with HCT116 tumors. Data represent the mean ± SEM (n = 10 tumors, Wilcoxon rank test). (D) Immunostaining of survivin in the tumor tissues on day 19. Scale bar, 50 μm. (E) In vivo live imaging of sCA-siRNA (6-FAM labeled) in HT29 tumor by multiphoton microscopy at 90 min. (F) Fluorescent detection of naked-siRNA (6-FAM labeled) or sCA-siRNA (6-FAM labeled) in the HT29 tumor at 4 h. Green: 6-FAM labeled siRNA; Red: microvasculature; Blue: DAPI stained nuclei. Scale bar, 50 μm. (G) Mice were administered with 40 μg of naked-survivin-siRNA or sCA-survivin-siRNA on days 0, 1, & 2. Tumors were removed on day 3, & western blot analysis for survivin was performed. (H) Many tumor cells treated with sCA-survivin-siRNA (6-FAM labeled) had condensed nuclei & were positive for TUNEL assay. Scale bar, 50 μm. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/25738937), licensed under a CC-BY license. Not internally tested by Novus Biologicals.")
![Immunocytochemistry Caspase-3 Antibody [Unconjugated] - Active](https://images.novusbio.com/images2/Caspase-3_AF835_Immunocytochemistry_6532.jpg)
![Immunohistochemistry Caspase-3 Antibody [Unconjugated] - Active](https://images.novusbio.com/images2/Caspase3_AF835_Immunohistochemistry_22976.jpg)
![Immunocytochemistry Caspase-3 Antibody [Unconjugated] - Active](https://images.novusbio.com/images2/Caspase-3_AF835_Immunocytochemistry_9340.jpg)
![Western Blot XIAP Antibody [Unconjugated]](https://images.novusbio.com/images2/XIAP_AF8221_Western_Blot_5911.jpg)
![Simple Western XIAP Antibody [Unconjugated]](https://images.novusbio.com/images2/XIAP_AF8221_Simple_Western_16640.jpg)
![Knockout Validated XIAP Antibody [Unconjugated]](https://images.novusbio.com/images2/XIAP_AF8221_Knockout_Validated_22488.jpg)
![Western Blot CD47 Antibody [Unconjugated]](https://images.novusbio.com/images2/CD47_AF4670_Western_Blot_15788.jpg)
![Neutralization CD47 Antibody [Unconjugated]](https://images.novusbio.com/images2/CD47_AF4670_Block_Neutralize_11560.jpg)
![Immunohistochemistry CD47 Antibody [Unconjugated]](https://images.novusbio.com/images2/CD47_AF4670_Immunohistochemistry_6841.jpg)
![N/A VEGF [HRP]](https://images.novusbio.com/images2/DATA_VEGF_DVE00_ELISA_871.jpg)
![N/A VEGF [HRP]](https://images.novusbio.com/images2/DATA_VEGF_DVE00_ELISA_872.jpg)
![N/A VEGF [HRP]](https://images.novusbio.com/images2/VEGF_DVE00_ELISA_208.jpg)
![Knockout Validated STAT3 Antibody (232209) [Unconjugated]](https://images.novusbio.com/images2/STAT3_MAB1799_Simple_Western_21000.jpg)
![Western Blot STAT3 Antibody (232209) [Unconjugated]](https://images.novusbio.com/images2/STAT3_MAB1799_Western_Blot_5993.jpg)
![Knockout Validated STAT3 Antibody (232209) [Unconjugated]](https://images.novusbio.com/images2/STAT3_MAB1799_Knockout_Validated_21531.jpg)
![Western Blot: Goat anti-Rabbit IgG (H+L) Secondary Antibody [HRP] [NB7160] - Western blot showing vemurafenib treatment in BRAFV600E CRC cells inhibits fission mediator DRP1 with no significant effect on fusion proteins (Mfn1 & 2) using MFN-1 antibody (NBP1-51841) and corresponding secondary antibody, goat anti-rabbit IgG-HRP (NB7160). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/33738242).](https://images.novusbio.com/images/Goat-anti-Rabbit-IgG-H+L-Secondary-Antibody-HRP-Western-Blot-NB7160-img0001.jpg "Western Blot: Goat anti-Rabbit IgG (H+L) Secondary Antibody [HRP] [NB7160] - Western blot showing vemurafenib treatment in BRAFV600E CRC cells inhibits fission mediator DRP1 with no significant effect on fusion proteins (Mfn1 & 2) using MFN-1 antibody (NBP1-51841) and corresponding secondary antibody, goat anti-rabbit IgG-HRP (NB7160). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/33738242).")
![Flow Cytometry: Rabbit IgG Isotype Control [NBP2-24891] - Intracellular FACS analysis of mouse TLR6 polyclonal antibody (red), rabbit isotype control (green), RAW cells alone (shaded). Two micrograms of antibodies were used. Goat anti-rabbit FITC (Novus, 20302) was used as secondary.](https://images.novusbio.com/images/Rabbit--Mouse-IgG-Isotype-Control-Flow-Cytometry-NBP2-24891-img0001.jpg "Flow Cytometry: Rabbit IgG Isotype Control [NBP2-24891] - Intracellular FACS analysis of mouse TLR6 polyclonal antibody (red), rabbit isotype control (green), RAW cells alone (shaded). Two micrograms of antibodies were used. Goat anti-rabbit FITC (Novus, 20302) was used as secondary.")
