Name: XIAP Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF8221
Price: 489 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	Hu, Mu, RtSpecies Glossary
Applications	WB, Simple Western, IHC, KO
Clonality	Polyclonal
Host	Goat
Conjugate	Unconjugated
Concentration	LYOPH

Conjugate	Catalog #	Availability	Size	Price
Biotin	BAF8221

Immunogen	E. coli-derived recombinant human XIAP Met1-Ser497 (Ser162Cys) Accession # P98170
Specificity	Detects human, mouse and rat XIAP in Western blots.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Goat
Gene	XIAP
Purity Statement	Antigen Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

XIAP Antibody [Unconjugated]

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Publications for XIAP Antibody (AF8221)(23)

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Bioinformatics

Publications using AF8221	Applications	Species
B Dumétier, A Zadoroznyj, J Berthelet, S Causse, J Allègre, P Bourgeois, F Cattin, C Racoeur, C Paul, C Garrido, L Dubrez cIAP1/TRAF2 interplay promotes tumor growth through the activation of STAT3 Oncogene, 2022-11-18;0(0):. 2022-11-18 [PMID: 36400972] (Western Blot, Human)	Western Blot	Human
E Sugisawa, T Kondo, Y Kumagai, H Kato, Y Takayama, K Isohashi, E Shimosegaw, N Takemura, Y Hayashi, T Sasaki, MM Martino, M Tominaga, K Maruyama Nociceptor-derived Reg3gamma prevents endotoxic death by targeting kynurenine pathway in microglia Cell Reports, 2022-03-08;38(10):110462. 2022-03-08 [PMID: 35263589] (Western Blot, Mouse)	Western Blot	Mouse
Yu Ren, Xue Wang, Shuaishuai Huang, Yangkai Xu, Guobin Weng, Rui Yu Alternol Sensitizes Renal Carcinoma Cells to TRAIL-Induced Apoptosis Frontiers in Pharmacology 2021-03-25 [PMID: 33841136]
Y An, J Jeon, L Sun, A Derakhshan, J Chen, S Carlson, H Cheng, C Silvin, X Yang, C Van Waes, Z Chen Death agonist antibody against TRAILR2/DR5/TNFRSF10B enhances birinapant anti-tumor activity in HPV-positive head and neck squamous cell carcinomas Scientific Reports, 2021-03-18;11(1):6392. 2021-03-18 [PMID: 33737574] (Western Blot, Human)	Western Blot	Human
Yung-Chieh Chang, Chun Hei Antonio Cheung, Yao-Lung Kuo Tamoxifen Rechallenge Decreases Metastatic Potential but Increases Cell Viability and Clonogenicity in a Tamoxifen-Mediated Cytotoxicity-Resistant Subline of Human Breast MCF7 Cancer Cells Frontiers in Cell and Developmental Biology 2020-06-30 [PMID: 32695778]
Roy Xiao, Yi An, Wenda Ye, Adeeb Derakhshan, Hui Cheng, Xinping Yang et al. Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV(−) and HPV(+) Head and Neck Cancers To TNF alpha , TRAIL, and Radiation Therapy Clinical Cancer Research 2019-11-01 [PMID: 31266830]
GA Ward, EJ Lewis, JS Ahn, CN Johnson, JF Lyons, V Martins, JM Munck, SJ Rich, T Smyth, NT Thompson, PA Williams, NE Wilsher, NG Wallis, G Chessari ASTX660, a novel non-peptidomimetic antagonist of cIAP1/2 and XIAP, potently induces TNF-? dependent apoptosis in cancer cell lines and inhibits tumor growth Mol. Cancer Ther., 2018-04-25;0(0):. 2018-04-25 [PMID: 29695633] (Immunoprecipitation, Western Blot, Human)	Immunoprecipitation, Western Blot	Human
R Fan, LM Schrott, T Arnold, S Snelling, M Rao, D Graham, A Cornelius, NL Korneeva Chronic oxycodone induces axonal degeneration in rat brain BMC Neurosci, 2018-03-23;19(1):15. 2018-03-23 [PMID: 29571287] (Western Blot, Rat)	Western Blot	Rat
V Liapis, A Zysk, M DeNichilo, I Zinonos, S Hay, V Panagopoul, A Shoubridge, C Difelice, V Ponomarev, W Ingman, GJ Atkins, DM Findlay, ACW Zannettino, A Evdokiou Anticancer efficacy of the hypoxia-activated prodrug evofosfamide is enhanced in combination with proapoptotic receptor agonists against osteosarcoma Cancer Med, 2017-08-10;0(0):. 2017-08-10 [PMID: 28799237] (Western Blot, Human)	Western Blot	Human
HL Hayes, BS Peterson, JM Haldeman, CB Newgard, HE Hohmeier, SB Stephens Delayed apoptosis allows islet ?-cells to implement an autophagic mechanism to promote cell survival PLoS ONE, 2017-02-17;12(2):e0172567. 2017-02-17 [PMID: 28212395] (Western Blot, Rat)	Western Blot	Rat
Pro-Apoptotic Activity of New Honokiol/Triphenylmethane Analogues in B-Cell Lymphoid Malignancies Molecules, 2016-07-30;21(8):. 2016-07-30 [PMID: 27483232] (Flow Cytometry, Human)	Flow Cytometry	Human
Katharina Engel USP9X stabilizes XIAP to regulate mitotic cell death and chemoresistance in aggressive B-cell lymphoma EMBO Mol Med, 2016-08-01;0(0):. 8/1/2016 [PMID: 27317434]
Delivery of a survivin promoter-driven antisense survivin-expressing plasmid DNA as a cancer therapeutic: a proof-of-concept study Onco Targets Ther, 2016-05-03;9(0):2601-13. 2016-05-03 [PMID: 27217778] (Western Blot, Human)	Western Blot	Human
Yi XP, Han T, Li YX et al. Simultaneous silencing of XIAP and survivin causes partial mesenchymal-epithelial transition of human pancreatic cancer cells via the PTEN/PI3K/Akt pathway Mol Med Rep. 2/20/2015 [PMID: 25707849]
Zinonos I, Labrinidis A, Liapis V, Hay S, Panagopoulos V, Denichilo M, Ponomarev V, Ingman W, Atkins G, Findlay D, Zannettino A, Evdokiou A Doxorubicin overcomes resistance to drozitumab by antagonizing Inhibitor of Apoptosis Proteins (IAPs). Anticancer Res, 2014-12-01;34(12):7007-20. 2014-12-01 [PMID: 25503127] (Western Blot, Human)	Western Blot	Human
Smolewski P, Witkowska M, Zwolinska M, Cebula-Obrzut B, Majchrzak A, Jeske A, Darzynkiewicz Z, Ardelt W, Ardelt B, Robak T Cytotoxic activity of the amphibian ribonucleases onconase and r-amphinase on tumor cells from B cell lymphoproliferative disorders. Int J Oncol, 2014-04-28;45(1):419-25. 2014-04-28 [PMID: 24789756] (Flow Cytometry, Human)	Flow Cytometry	Human
Levin A, Iannuzzi M, Montgomery C, Trudeau S, Datta I, Adrianto I, Chitale D, McKeigue P, Rybicki B Admixture fine-mapping in African Americans implicates XAF1 as a possible sarcoidosis risk gene. PLoS ONE, 2014-03-24;9(3):e92646. 2014-03-24 [PMID: 24663488] (IHC-Fr, Human)	IHC-Fr	Human
Engesaeter B, Engebraaten O, Florenes V, Maelandsmo G Dacarbazine and the agonistic TRAIL receptor-2 antibody lexatumumab induce synergistic anticancer effects in melanoma. PLoS ONE, 2012-09-20;7(9):e45492. 9/20/2012 [PMID: 23029050]
Yasuhiro Kawamoto, Hidefumi Ito, Masafumi Ihara, Ryosuke Takahashi Immunohistochemical localization of X-linked inhibitor of apoptosis protein in brainstem-type and cortical Lewy bodies NeuroReport 2012-02-15 [PMID: 22273571]
Toosi , Siavash, Habib , Nancy, Torres , Geneviev, Reynolds , Sandra R, Bystryn , Jean-Cla Serum levels of inhibitors of apoptotic proteins (IAPs) change with IVIg therapy in pemphigus. J Invest Dermatol, 2011-06-30;131(11):2327-9. 2011-06-30 [PMID: 21716321] (Western Blot, Human)	Western Blot	Human
Fessing MY, Sharova TY, Sharov AA, Atoyan R, Botchkarev VA Involvement of the Edar signaling in the control of hair follicle involution (catagen). Am. J. Pathol., 2006-12-01;169(6):2075-84. 2006-12-01 [PMID: 17148670] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Lane D, Cote M, Grondin R, Couture MC, Piche A Acquired resistance to TRAIL-induced apoptosis in human ovarian cancer cells is conferred by increased turnover of mature caspase-3. Mol. Cancer Ther., 2006-03-01;5(3):509-21. 2006-03-01 [PMID: 16546965] (Western Blot, Human)	Western Blot	Human
Mitsiades CS, Mitsiades N, Poulaki V, Schlossman R, Akiyama M, Chauhan D, Hideshima T, Treon SP, Munshi NC, Richardson PG, Anderson KC Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications. Oncogene, 2002-08-22;21(37):5673-83. 2002-08-22 [PMID: 12173037] (Western Blot, Human)	Western Blot	Human
Show All 23 Publications. Collapse Publications.

Catalog# & Formulation	Size	Price
Carrier Free AF8221-SP

Gene Symbol	XIAP
Uniprot	P98170()