Survivin Antibody (60.11) - Unpurified

Survivin (BIRC5 or IAP4) is the smallest member of the inhibitor of apoptosis (IAP) proteins, containing only a single baculovirus IAP repeat (BIR) domain and lacking the C-terminal RING domain. Survivin has a theoretical molecular weight of 16.5 kDa (wild-type protein) and exists as ten splice variant forms including the most predominant isoforms, survivin-2B and surviving-DeltaEx3 (1). It also undergoes phosphorylation by PKA, Plk1, Cdk1, CKII and Aurora B at multiple sites (e.g. Serine 20 and Threonine 34, 53 and 117).

Besides being highly abundant in fetal development and expressed in proliferating adult cells such as activated T lymphocytes, erythroblasts, and self-renewing stem cells, survivin is generally absent in adult tissues. However, it is elevated in common cancers such as lung, colon, pancreas, breast and prostate where it drives proliferation, metastasis, poor prognosis, and decreased patient survival (2).

Survivin has been shown to be involved in multiple cellular processes including cell cycle progression, mitotic spindle assembly, kinetochore attachment, angiogenesis, migration, and its anti-apoptotic activity has been linked to both its monomeric and homodimeric forms. Survivin impacts the function of other IAP members, c-IAP1 and c-IAP-2, or modulates the inhibitory activity of XIAP against caspases by forming a stable complex with XIAP and HBXIP. During the intrinsic apoptotic pathway, survivin may prevent the release of mitochondrial APAF1 into the cytoplasm or hinder the association of SMAC with other IAPS, which results in prolonged cell survival (3).

References

1. Sah NK, Seniya C. (2015) Survivin splice variants and their diagnostic significance. Tumour Biol. 36(9):6623-31. PMID: 26245993

2. Lladser A, Sanhueza C, Kiessling R, Quest AF. (2011) Is survivin the potential Achilles' heel of cancer? Adv Cancer Res. 111:1-37. PMID: 21704829

3. Wheatley SP, Altieri DC. (2019) Survivin at a glance. J Cell Sci. 132(7). PMID: 30948431

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 6 applications: ICC/IF, IHC, IHC-Fr, IHC-P, PLA, WB.

Showing Publications 1 - 10 of 23. Show All 23 Publications. Collapse Publications.

Publications using NB500-205	Applications	Species
Breder-Bonk C, Docter D, Barz M et al. The Apoptosis Inhibitor Protein Survivin Is a Critical Cytoprotective Resistor against Silica-Based Nanotoxicity Nanomaterials (Basel, Switzerland) 2023-09-12 [PMID: 37764575] (ICC/IF, IHC, Mouse, Human)	ICC/IF, IHC	Mouse, Human
Kim S, Shin M, Lee A et al. Improvement of Inflammation through Antioxidant Pathway of Gardeniae Fructus 50% EtOH Extract (GE) from Acute Reflux Esophagitis Rats Biomed Res Int. [PMID: 32185206]
Ring A, Nguyen C, Smbatyan G et al. CBP/beta-Catenin/FOXM1 Is a Novel Therapeutic Target in Triple Negative Breast Cancer Cancers (Basel). 2018-12-19 [PMID: 30572639] (WB, Human) Details: Citation used the Unpurified format of this antibody.	WB	Human
Dheekollu J, Malecka K, Wiedmer A et al. Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency Oncotarget 2017-01-31 [PMID: 28077791] (PLA)	PLA
Kapinas Kristina, Kim Heesun, Mandeville Matthew et al. microRNA-mediated survivin control of pluripotency. J Cell Physiol. [PMID: 24891298] (Human) Details: Citation using the Unpurified form of this antibody.		Human
Hoel AW, Yu P, Nguyen KP, et al. Mitochondrial Heat Shock Protein-90 Modulates Vascular Smooth Muscle Cell Survival and the Vascular Injury Response in Vivo. Am J Pathol. [PMID: 22841823] (WB, IHC-Fr, Human) Details: Citation using the Unpurified form of this antibody.	WB, IHC-Fr	Human
de Souza HS, West GA, Rebert N et al. Increased Levels of Survivin, via Association With Heat Shock Protein 90, in Mucosal T Cells From Patients With Crohn's Disease. Gastroenterology. [PMID: 22749932] (Human) Details: Citation using the Unpurified form of this antibody.		Human
Lechler P, Balakrishnan S, Schaumburger J et al. The oncofetal gene survivin is re-expressed in osteoarthritis and is required for chondrocyte proliferation in vitro. BMC Musculoskelet Disord. 2011-07-05 [PMID: 21729321]
Knauer SK, Heinrich UR, Bier C et al. An otoprotective role for the apoptosis inhibitor protein survivin. Cell Death Dis . [PMID: 21364656] Details: Citation using the Unpurified form of this antibody.
Habtemichael N, Wunsch D, Bier C et al. Cloning and functional characterization of the guinea pig apoptosis inhibitor protein Survivin. Gene. [PMID: 20727954] Details: Citation using the Unpurified form of this antibody.
Habtemichael N, Heinrich UR, Knauer SK et al. Expression analysis suggests a potential cytoprotective role of Birc5 in the inner ear. Mol Cell Neurosci . [PMID: 20627126] Details: Citation using the Unpurified form of this antibody.
Huang H, Fletcher L, Beeharry N et al. Abnormal cytokinesis after X-irradiation in tumor cells that override the G2 DNA damage checkpoint. Cancer Res. [PMID: 18483255] (ICC/IF, Human) Details: Citation using the Unpurified form of this antibody.	ICC/IF	Human
Levkau B, Schafers M, Wohlschlaeger J et al. Survivin determines cardiac function by controlling total cardiomyocyte number. Circulation. [PMID: 18332262] (WB, IHC-P, Human) Details: Citation using the Unpurified form of this antibody.	WB, IHC-P	Human
Hino R, Uozaki H, Inoue Y et al. Survival advantage of EBV-associated gastric carcinoma: survivin up-regulation by viral latent membrane protein 2A. Cancer Res. [PMID: 18316606] (ICC/IF, WB, Human) Details: Citation using the Unpurified form of this antibody.	ICC/IF, WB	Human
Brocardo M et al. Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: regulation of Bcl-2 and implications for cell survival. J Biol Chem283(9):5950-9. 2008-02-29 [PMID: 18160396]
Ryan, B et al. Expression of survivin and its splice variants survivin-2B and survivin-DeltaEx3 in breast cancer. Br J Cancer92(1):120-4. 2005-01-17 [PMID: 15611790]
Ansell, S et al. Inhibition of survivin expression suppresses the growth of aggressive non-Hodgkin's lymphoma. Leukemia. [PMID: 14749704] (WB, Human) Details: Citation using the Unpurified form of this antibody.	WB	Human
Koyama S. Differential expression of intracellular apoptotic signaling molecules in tumor and tumor-infiltrating lymphocytes during development of invasion and/or metastasis of gastric carcinoma. Dig Dis Sci48(12):2290-300. 2003-12-01 [PMID: 14714615]
Ku JH, Kwak C, Lee HS, Park HK, Lee E, Lee SE. Expression of survivin, a novel inhibitor of apoptosis, in superficial transitional cell carcinoma of the bladder. J Urol171(2 Pt 1):631-5. 2004-02-01 [PMID: 14713775]
Xu, Z et al. Promyelocytic leukemia protein 4 induces apoptosis by inhibition of survivin expression. J Biol Chem279(3):1838-44. 2004-01-16 [PMID: 14597622]
Allen, S et al. Survivin expression in mouse skin prevents papilloma regression and promotes chemical-induced tumor progression. Cancer Res63(3):567-72. 2003-02-01 [PMID: 12566297]
Fortugno P, Wall NR, Giodini A, O'Connor DS, Plescia J, Padgett KM, Tognin S, Marchisio PC, Altieri DC. Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function. J Cell Sci115(Pt 3):575-85. 2002-02-01 [PMID: 11861764]
Zhu, L et al. Anti-apoptotic protein survivin plays a significant role in tubular morphogenesis of human coronary arteriolar endothelial cells by hypoxic preconditioning. FEBS Lett508(3):369-74. 2001-11-23 [PMID: 11728454]
Show All 23 Publications. Collapse Publications.

Array NB500-205

• Survivin Antibodies
• Survivin Antibody Pack
• Survivin Lysate
• Survivin Proteins
• Survivin ELISAs
• Survivin Proteins and Enzyme