Sirtuin 3/SIRT3 Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

SIRT3 (SIR2-like protein 3) is a 28-30 kDa, NAD⁺-dependent class III member of the sirtuin protein family. It is widely expressed, and found apparently in both the nucleus, where it deacetylates histones, and in the mitochondrial matrix, where it is involved in the regulation of both oxidative stress and the physiology associated with fasting or caloric restriction. Relative to the mitochondria, SIRT3 deacetylates multiple enzyme substrates, including SOD2, IDH2, LCAD, OTC and HMGCS2, an action that results in enzyme activation. Human SIRT3 is 399 amino acids (aa) in length. It contains a mitochondrial targeting sequence within the first 100 aa, followed by a sertuin-type deacetylase domain (aa 126-382) that contains an NAD binding segment (aa 145-165). Although uncertainty exists relative to its intracellular location, it would appear that SIRT3 is initially synthesized as a 42-44 kDa "precursor" in the cytosol. From here, it can translocate into mitochondria where it is cleaved between Arg99Arg100 to generate a 28-30 kDa short form. There is one potential alternative start site at Met143. Over aa 101-399, human and mouse SIRT3 share 84% aa sequence identity.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array AF7488

• Sirtuin 3/SIRT3 Antibodies
• Sirtuin 3/SIRT3 ELISA Kits
• Sirtuin 3/SIRT3 Kit
• Sirtuin 3/SIRT3 Lysates
• Sirtuin 3/SIRT3 Proteins
• Sirtuin 3/SIRT3 Proteins and Enzyme