Mitofusin 2 Antibody (4H8)

This product is produced by and distributed for Abnova, a company based in Taiwan.

MFN2 encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 10 of 40. Show All 40 Publications. Collapse Publications.

Publications using H00009927-M03	Applications	Species
Deepaneeta S, Abhishek S, Aishika D et al. Cardiolipin-Mediated Alleviation of Mitochondrial Dysfunction Is a Neuroprotective Effect of Statin in Animal Model of Ischemic Stroke. ACS Chem Neurosci. 2023-01-27 [PMID: 36706354]
Michael K, Liliana R, Maryam G et al. Chronic social stress disrupts the intracellular redistribution of brain hexokinase 3 induced by shifts in peripheral glucose levels. J Mol Med (Berl). 2022-08-09 [PMID: 35943566]
Christina W, Alireza P, Sara B et al. GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton. Commun Biol. 2022-06-03 [PMID: 35662277]
Rosella S, Francesca A, Consiglia P et al. Myoglobin expression by alternative transcript in different mesenchymal stem cells compartments. Stem Cell Res Ther. 2022-05-21 [PMID: 35598009]
James S, Tina F, Yan Z et al. Vmp1, Vps13D, and Marf/Mfn2 function in a conserved pathway to regulate mitochondria and ER contact in development and disease. Curr Biol. 2021-05-20 [PMID: 34019822]
R Peruzzo, S Corrà, R Costa, M Brischigli, T Varanita, L Biasutto, C Rampazzo, D Ghezzi, L Leanza, M Zoratti, M Zeviani, C De Pittà, C Viscomi, R Costa, I Szabò Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction Nature Communications, 2021-04-08;12(1):2103. 2021-04-08 [PMID: 33833234]
Guglielmina C, Anna P, Flavio F et al. The Age-Sensitive Efficacy of Calorie Restriction on Mitochondrial Biogenesis and mtDNA Damage in Rat Liver. Int J Mol Sci. 2021-02-07 [PMID: 33562258]
Ota A, Ishihara T, Ishihara N et al. Mitochondrial nucleoid morphology and respiratory function are altered in Drp1-deficient HeLa cells. J Biochem. 2019-12-24 [PMID: 31873747]
Faustini G, Marchesan E, Zonta L et al. Alpha-Synuclein Preserves Mitochondrial Fusion and Function in Neuronal Cells. Oxid Med Cell Longev. 2019-11-23 [PMID: 31871549]
Antonucci S, Di M, Sileikyte J et al. A novel class of cardioprotective small-molecule PTP inhibitors. Pharmacol Res. 2019-11-20 [PMID: 31759087]
Wolf C, Zimmermann R, Thaher O et al. The Charcot-Marie Tooth Disease Mutation R94Q in MFN2 Decreases ATP Production but Increases Mitochondrial Respiration under Conditions of Mild Oxidative Stress. Cells. 2019-10-21 [PMID: 31640251]
Stacchiotti A, Grossi I, Garcia-Gomez R et al. Melatonin Effects on Non-Alcoholic Fatty Liver Disease Are Related to MicroRNA-34a-5p/Sirt1 Axis and Autophagy. Cells. 2019-09-08 [PMID: 31500354]
Donkervoort S, Sabouny R, Yun P et al. MSTO1 mutations cause mtDNA depletion, manifesting as muscular dystrophy with cerebellar involvement. Acta Neuropathol. 2019-08-29 [PMID: 31463572]
Sabouny R, Wong R, Lee-Glover L et al. Characterization of the C584R variant in the mtDNA depletion syndrome gene FBXL4, reveals a novel role for FBXL4 as a regulator of mitochondrial fusion. Biochim Biophys Acta Mol Basis Dis. 2019-08-20 [PMID: 31442532]
Costa R, Peruzzo R, Bachmann M et al. Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction. Cell Rep. 2019-08-20 [PMID: 31433973]
Morani F, Doccini S, Sirica R et al. Functional Transcriptome Analysis in ARSACS KO Cell Model Reveals a Role of Sacsin in Autophagy. Sci Rep. 2019-08-15 [PMID: 31417125]
Zhou Q, Li H, Li Y et al. Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells. JCI Insight. 2019-05-04 [PMID: 30668548]
Ishikawa K, Yamamoto S, Hattori S et al. Acquired expression of mutant Mitofusin 2 causes progressive neurodegeneration and abnormal behavior. J Neurosci. 2019-02-03 [PMID: 30606759]
Esteves AR, Palma AM, Gomes R et al. Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's and Parkinson disease pathology. Biochim Biophys Acta Mol Basis 2019-01-08 [PMID: 30572013]
Picca A, Sirago G, Pesce V et al. Administration of Enalapril Started Late in Life Attenuates Hypertrophy and Oxidative Stress Burden, Increases Mitochondrial Mass, and Modulates Mitochondrial Quality Control Signaling in the Rat Heart. Biomolecules. 2018-12-17 [PMID: 30563025]
Desmoulins L, Chretien C, Paccoud R et al. Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing. Mol Metab. 2019-01-02 [PMID: 30553770]
Larsen S, Lundby AM, Dandanell S et al. Four days of bed rest increases intrinsic mitochondrial respiratory capacity in young healthy males. Physiol Rep 2018-09-06 [PMID: 30221830]
Basso V, Marchesan E, Peggion C et al. Regulation of Endoplasmic Reticulum-Mitochondria contacts by Parkin via Mfn2. Pharmacol Res 2018-09-13 [PMID: 30219582]
Mattie S, Riemer J, Wideman JG et al. A new mitofusin topology places the redox-regulated C terminus in the mitochondrial intermembrane space. J Cell Biol 2017-12-06 [PMID: 29212658]
Zhao YG, Chen Y, Miao G et al. The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation. Mol Cell 2017-09-07 [PMID: 28890335]
Nicassio L, Fracasso F, Sirago G et al. Dietary supplementation with acetyl-l-carnitine counteracts age-related alterations of mitochondrial biogenesis, dynamics and antioxidant defenses in brain of old rats. Exp Gerontol 2017-08-12 [PMID: 28807823]
Thaher O, Wolf C, Dey PN et al. The thiol switch C684 in Mitofusin-2 mediates redox-induced alterations of mitochondrial shape and respiration. Neurochem Int 2017-05-17 [PMID: 28527631]
Lundby C, Montero D, Gehrig S et al. Physiological, biochemical, anthropometric and biomechanical influences on exercise economy in humans. Scand J Med Sci Sports 2017-02-05 [PMID: 28164383]
Silva DF, Esteves AR, Oliveira CR, Cardoso SM et al. Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer's-Disease Related Pathology. Mol Neurobiol 2016-06-17 [PMID: 27311773]
Chen M, Chen Z, Wang Y et al. Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy. Autophagy 2016-04-02 [PMID: 27050458]
Oettinghaus B, D'Alonzo D, Barbieri E et al. DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress. Biochim Biophys Acta 2016-03-17 [PMID: 26997499]
Mignarri A, Rubegni A, Tessa A et al. Mitochondrial dysfunction in hereditary spastic paraparesis with mutations in DDHD1/SPG28. J Neurol Sci 2016-02-04 [PMID: 26944165]
Jacobs RA, Lundby AM, Fenk S et al. Twenty-eight days of exposure to 3,454 m increases mitochondrial volume density in human skeletal muscle. J Physiol. 2015-09-04 [PMID: 26339730]
Esteves AR, G-Fernandes M, Santos D et al. The Upshot of LRRK2 Inhibition to Parkinson's Disease Paradigm. Mol Neurobiol. 2014-11-15 [PMID: 25394383]
Fiuza-Luces C, Delmiro A, Soares-Miranda L et al. Exercise training can induce cardiac autophagy at end-stage chronic conditions: Insights from a graft-versus-host-disease mouse model. Brain Behav Immun. 2013-11-14 [PMID: 24239952]
Russell AP, Lamon S, Boon H et al. Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short term endurance training. J Physiol. 2013-06-24 [PMID: 23798494]
Lally JS, Herbst EA, Matravadia S et al. Over-expressing mitofusin-2 in healthy mature Mammalian skeletal muscle does not alter mitochondrial bioenergetics. PLoS One. 2013-01-31 [PMID: 23383258]
Cosson P, Marchetti A, Ravazzola M, Orci L. Mitofusin-2 independent juxtaposition of endoplasmic reticulum and mitochondria: an ultrastructural study. PLoS One. 2012-09-28 [PMID: 23029466]
Moran M, Rivera H, Sanchez-Arago M et al. Mitochondrial bioenergetics and dynamics interplay in complex i-deficient fibroblasts. Biochim Biophys Acta. 2010-02-11 [PMID: 20153825]
Holloway GP, Perry CG, Thrush AB et al. PGC1{alpha} relationship with skeletal muscle palmitate oxidation is not present with obesity, despite maintained ained PGC1{alpha} and PGC1{beta} protein. Am J Physiol Endocrinol Metab 2008-03-18 [PMID: 18349111]
Show All 40 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Julian Wong	Simple Western	Rat	08/18/2017	View Summary Application Simple Western Sample Tested cell line, whole cell lysate Species Rat Lot H7101-4H8

Array H00009927-M03

• Mitofusin 2 Antibodies
• Mitofusin 2 Lysates
• Mitofusin 2 Proteins