DRP1 Antibody - BSA Free

DRP1 (dynamin-related protein 1) is a highly conserved large GTPase protein which implicates in several important structural features of mitochondria, including mitochondrial shape, size, distribution, remodeling and maintenance. It functions in mitochondrial as well as peroxisomal division, and facilitates membrane fission via oligomerization into ring-like structures that wrap around fission site to constrict/split the membranes through a GTP hydrolysis-dependent mechanism. For normal brain development, DRP1 plays an essential role by mediating developmentally-regulated apoptosis during neural tube development. It is also required for a normal rate of cytochrome c release or caspase activation during apoptosis and for mitochondrial fission during mitosis, programmed necrosis execution and also for vesicle transport. Moreover, it is associated with mitochondrial structural and functional alterations such as fragmentation, phosphorylation, SUMOylation, ubiquitination and cell death. Drp1 interacts with amyloid beta, causing abnormal mitochondrial dynamics and neuronal damage in Alzheimer's disease patients, and defective DRP1 is also linked to encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Fish.

We have publications tested in 9 applications: ICC/IF, IF/IHC, IHC-P, IP, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Simple Western, WB, Western Blot.

Showing Publications 1 - 10 of 48. Show All 48 Publications. Collapse Publications.

Publications using NB110-55288	Applications	Species
Mesquita PHC, Godwin JS, Ruple BA et al. Resistance training diminishes mitochondrial adaptations to subsequent endurance training in healthy untrained men The Journal of physiology 2023-07-20 [PMID: 37470322]
Woo J, Seo H, Lee J et al. Polypropylene microplastic exposure leads to lung inflammation through p38-mediated NF- kappa B pathway due to mitochondrial damage Research Square 2022-07-08 [PMID: 36624477] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Mesquita PHC, Osburn SC, Godwin JS et al. Effects of aging and long-term physical activity on mitochondrial physiology and redox state of the cortex and cerebellum of female rats Physiological reports 2022-12-01 [PMID: 36543327] (WB, Rat)	WB	Rat
Mariacristina Filice, Alfonsina Gattuso, Sandra Imbrogno, Rosa Mazza, Daniela Amelio, Alessia Caferro, Claudio Agnisola, José Manuel Icardo, Maria Carmela Cerra Functional, structural, and molecular remodelling of the goldfish ( Carassius auratus) heart under moderate hypoxia Fish Physiology and Biochemistry 2024-01-10 [PMID: 38198074]
Acosta CH, Clemons GA, Citadin CT et al. PRMT7 can prevent neurovascular uncoupling, blood-brain barrier permeability, and mitochondrial dysfunction in repetitive and mild traumatic brain injury Experimental neurology 2023-05-15 [PMID: 37196697] (Simple Western, Mouse)	Simple Western	Mouse
Mesquita PHC, Godwin JS, Ruple BA et al. Resistance Training Diminishes Mitochondrial Adaptations to Subsequent Endurance Training bioRxiv 2023-04-11 [PMID: 37066356] (Immunohistochemistry, Western Blot)	Immunohistochemistry, Western Blot
Saito ER, Warren CE, Hanegan CM et al. A Novel Ketone-Supplemented Diet Improves Recognition Memory and Hippocampal Mitochondrial Efficiency in Healthy Adult Mice Metabolites 2022-10-25 [PMID: 36355101] (WB, Mouse)	WB	Mouse
Xie J, Zhong F, Guo Z et al. Hyperinsulinemia impairs the metabolic switch to ketone body utilization in proximal renal tubular epithelial cells under energy crisis via the inhibition of the SIRT3/SMCT1 pathway Front Endocrinol (Lausanne) 2022-09-27 [PMID: 36237185] (Western Blot)	Western Blot
Kshirsagar S, Alvir RV, Pradeepkiran JA et al. A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer's Disease Cells 2022-08-27 [PMID: 36078067] (Immunocytochemistry/ Immunofluorescence)	Immunocytochemistry/ Immunofluorescence
Vijayan M, Reddy PH Reduced VDAC1, Maintained Mitochondrial Dynamics and Enhanced Mitochondrial Biogenesis in a Transgenic Tau Mouse Model of Alzheimer's Disease International journal of molecular sciences 2022-08-02 [PMID: 35955694] (IF/IHC, Mouse) Details: WB dilution used 1:1000, IHC dilution used 1:102	IF/IHC	Mouse
Luk HY, Jiwan NC, Appell CR et al. Sex-specific mitochondrial dynamics and mitophagy response to muscle damage Physiological Reports 2022-05-25 [PMID: 35611770]
Ramasubramanian B, Griffith C, Hanson M et al. Protective Effects of Chaya against Mitochondrial and Synaptic Toxicities in the Type 2 Diabetes Mouse Model TallyHO Cells 2022-02-21 [PMID: 35203393] (WB, IF/IHC, Mouse)	WB, IF/IHC	Mouse
Li J, Zhang Z, Wang L et al. Maresin 1 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury via Inhibiting NOX4/ROS/NF-kappaB Pathway Frontiers in pharmacology 2021-12-10 [PMID: 34955852]
Yan H, Yang H, Wang L et al. Disulfiram inhibits IL-1beta secretion and inflammatory cells recruitment in Aspergillus fumigatus keratitis International immunopharmacology 2022-01-01 [PMID: 34883353]
Parry H, Randall R, Hyatt H et al. Short and long-term effect of reproduction on mitochondrial dynamics and autophagy in rats Heliyon 2021-09-01 [PMID: 34622072] (WB, Rat)	WB	Rat
Gao QY, Zhang HF, Tao J et al. Mitochondrial Fission and Mitophagy Reciprocally Orchestrate Cardiac Fibroblasts Activation Frontiers in Cell and Developmental Biology 2021-01-21 [PMID: 33585469]
Grieco J, Allen M, Perry J, et al. Progression-Mediated Changes in Mitochondrial Morphology Promotes Adaptation to Hypoxic Peritoneal Conditions in Serous Ovarian Cancer Frontiers in Oncology 2021-01-13 [PMID: 33520711] (WB, Mouse)	WB	Mouse
Tiku V, Kofoed EM, Yan D, et al. Outer membrane vesicles containing OmpA induce mitochondrial fragmentation to promote pathogenesis of Acinetobacter baumannii Scientific reports 2021-01-12 [PMID: 33436835] (ICC/IF, Mouse, Human)	ICC/IF	Mouse, Human
Chen S, Liu S, Wang J et al. TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology Mol Cell 2020-10-29 [PMID: 33171123]
Abid H, Ryan ZC, Delmotte P et al. Extramyocellular interleukin-6 influences skeletal muscle mitochondrial physiology through canonical JAK/STAT signaling pathways FASEB J. 2020-09-03 [PMID: 32885495]
Teodorof-Diedrich C, Spector SA Human Immunodeficiency Virus Type-1 and Methamphetamine Mediated Mitochondrial Damage and Neuronal Degeneration in Human Neurons J. Virol. 2020-08-12 [PMID: 32796068]
Mesquita PHC, Lamb DA, Parry HA et al. Acute and chronic effects of resistance training on skeletal muscle markers of mitochondrial remodeling in older adults Physiol Rep 2020-08-01 [PMID: 32748504] (WB, Human)	WB	Human
Panes, J D, Godoy, P A Et al. Changes in PGC-1 alpha /SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model. Front Pharmacol 2020-06-12 [PMID: 32523530]
Weatherly, L M, Shane, H L Et al. Topical Application of the Antimicrobial Agent Triclosan Induces NLRP3 Inflammasome Activation and Mitochondrial Dysfunction. Toxicol Sci 2020-07-01 [PMID: 32321163] (WB, Human)	WB	Human
Maremanda K, Sundar I, Rahman I Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice Toxicology and Applied Pharmacology 2019-10-01 [PMID: 31678243] (WB, Mouse)	WB	Mouse
Navas-Madronal M, Rodriguez C, Kassan M et al. Enhanced endoplasmic reticulum and mitochondrial stress in abdominal aortic aneurysm Clin. Sci. 2019-06-25 [PMID: 31239294] (Human)		Human
Zhong X, Cui P, Cai Y et al. Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells Cell Metab. 2018-12-01 [PMID: 30527743] (WB, Mouse)	WB	Mouse
Pan JX, Tang F, Xiong F et al. APP promotes osteoblast survival and bone formation by regulating mitochondrial function and preventing oxidative stress. Cell Death Dis. 2018-10-22 [PMID: 30349052] (WB, Mouse)	WB	Mouse
Tarpey MD, Davy KP, McMillan RP et al. Skeletal muscle autophagy and mitophagy in endurance-trained runners before and after a high-fat meal. Mol Metab. 2017-10-21 [PMID: 29097020] (Human)		Human
Kandimalla R, Manczak M, Yin X et al. Hippocampal Phosphorylated Tau Induced Cognitive Decline, Dendritic Spine Loss and Mitochondrial Abnormalities in a Mouse Model of Alzheimer's Disease. Hum. Mol. Genet. 2017-10-12 [PMID: 29040533] (Mouse)		Mouse
Vartanian V, Tumova J, Dobrzyn P et al. 8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle PLoS ONE 2017-07-20 [PMID: 28727777] (WB, Mouse)	WB	Mouse
Wang L, Zhang T, Wang L et al. Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission. EMBO J. 2017-04-04 [PMID: 28377463] (WB, Mouse)	WB	Mouse
Chan YL, Saad S, Al-Odat I et al. Maternal L-Carnitine Supplementation Improves Brain Health in Offspring from Cigarette Smoke Exposed Mothers. Front Mol Neurosci. 2017-02-28 [PMID: 28243190] (WB, Mouse)	WB	Mouse
Xu S, Wang P, Zhang H et al. CaMKII induces permeability transition through Drp1 phosphorylation during chronic B-AR stimulation. Nat Commun 2016-10-14 [PMID: 27739424] (IP, WB, Rat)	IP, WB	Rat
Chen H, Chan YL, Nguyen LT et al. Moderate traumatic brain injury is linked to acute behaviour deficits and long term mitochondrial alterations. Clin. Exp. Pharmacol. Physiol. 2016-08-25 [PMID: 27557565] (IF/IHC, Rat)	IF/IHC	Rat
Lennon FE, Cianci GC, Kanteti R et al. Unique fractal evaluation and therapeutic implications of mitochondrial morphology in malignant mesothelioma. Sci Rep. 2016-04-15 [PMID: 27080907] (WB, Human) Details: DRP1 antibody was used for WB analysis of total cell lysates as well as mitochondrial fractions from MeT-5A (control transformed non-tumorigenic mesothelial cells), and mesothelioma cell lines namely H28, H513, H2052, H2461 (Epithelioid) and H2373, H2596	WB	Human
Zhang M, Sun T, Jian C et al. Remodeling of Mitochondrial Flashes in Muscular Development and Dystrophy in Zebrafish. PLoS One 2015-01-01 [PMID: 26186000] (ICC/IF)	ICC/IF
Palubinsky AM, Stankowski JN, Kale AC et al. CHIP is an Essential Determinant of Neuronal Mitochondrial Stress Signaling Antioxid. Redox Signal. 2015-01-20 [PMID: 25602369] (WB, Mouse) Details: PINK1 antibody used for WB on whole brain lysates of PND35 CHIP/C-terminus of HSC70-interacting protein knockout mouse model (FIG 2A) and on whole cell lysates of neuronal rat cultures (DIV 21-25) harvested at different recovery time frames following exposure to oxygen-glucose deprivation/OGD (FIG 3A). PINK1 antibody was also used at 1:500 dilution for ICC-IF application on neuronal rat cultures (DIV 21-25) subjected to 90 minutes of OGD followed by 6 hours of recovery (FIG. 4C).	WB	Mouse
Su YC, Chiu HW, Hung JC, Hong JR. Beta-nodavirus B2 protein induces hydrogen peroxide production, leading to Drp1-recruited mitochondrial fragmentation and cell death via mitochondrial targeting. Apoptosis 2014-07-10 [PMID: 25008790] (WB, Fish) Details: DRP1 antibody used for WB at 1:500 dilution on mitochondrial fractions isolated from Grouper/Epinephelus coioides cell line GF-1 cells (a cell line susceptible to grouper nervous necrosis virus - GNNV) transfected with EYFP or EYFP-B2 and treated with and without NAC or Mdivi for 48 h (Fig 6C).	WB	Fish
Amadoro G, Corsetti V, Florenzano F et al. AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons. Neurobiol. Dis. 2014-02-01 [PMID: 24411077] (WB, Rat)	WB	Rat
Kawada I, Hasina R, Lennon FE et al. Paxillin Mutations Affect Focal Adhesions and Lead to Altered Mitochondrial Dynamics: Relevance to Lung Cancer. Cancer Biol Ther 2013-05-31 [PMID: 23792636] (WB, IHC-P, Human)	WB, IHC-P	Human
Tseng AH, Shieh SS, Ling Wang D. SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage. Free Radic Biol Med 2013-05-07 [PMID: 23665396] (WB, Human)	WB	Human
Bajpai P, Sangar MC, Singh S et al. Metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine by Mitochondrion-targeted Cytochrome P450 2D6: IMPLICATIONS IN PARKINSON DISEASE. J Biol Chem 2013-02-08 [PMID: 23258538] (ICC/IF, Mouse)	ICC/IF	Mouse
Luzzo KM, Wang Q, Purcell SH et al. High fat diet induced developmental defects in the mouse: oocyte meiotic aneuploidy and fetal growth retardation/brain defects PLoS One 2012-01-01 [PMID: 23152876] (IF/IHC, ICC/IF, Mouse)	IF/IHC, ICC/IF	Mouse
Ferrari LF, Chum A, Bogen O et al. Role of drp1, a key mitochondrial fission protein, in neuropathic pain. J Neurosci;31(31):11404-11410. 2011-08-03 [PMID: 21813700]
Tang D, Kang R, Livesey KM et al. High-mobility group box 1 is essential for mitochondrial quality control Cell Metab 2011-06-01 [PMID: 21641551] (WB, Mouse)	WB	Mouse
Manczak M, Calkins MJ, Reddy PH. Impaired Mitochondrial Dynamics and Abnormal Interaction of Amyloid Beta with Mitochondrial Protein Drp1 in Neurons from Patients with Alzheimer’s Disease: Implications for Neuronal Damage. Hum Mol Genet. 2011-03-31 [PMID: 21459773] (ICC/IF, WB, IP, Human)	ICC/IF, WB, IP	Human
Show All 48 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Celeste Wu	Simple Western	Mouse	02/06/2023	View Summary Application Simple Western Sample Tested Brain (hippocampus) tissue Species Mouse Lot can't find lot number
Enlarge	5 reviewed by: nitesh sharma	WB	Human	10/05/2018	View Summary Application Western Blot Sample Tested Jurkat cell line Species Human Lot D-2
	5 reviewed by: Verified Customer	WB	Other	06/09/2014	View Summary Application Western Blot Sample Tested PC12 whole cell lysate Species Other Lot N/A
Enlarge	5 reviewed by: Hyun Yi	WB	Rat	04/25/2014	View Summary Application Western Blot Sample Tested Rat Species Rat Lot C1

Array NB110-55288

• DRP1 Antibodies
• DRP1 Lysates
• DRP1 Proteins