Name: Mitofusin 1 Antibody (3C9)
Brand: Novus Biologicals
SKU: H00055669-M04
Price: 519 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	Hu, Mu, RtSpecies Glossary
Applications	WB, ELISA, Flow, ICC/IF, IP, KD
Clone	3C9
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated

Immunogen	MFN1 (AAH40557, 1 a.a. ~ 741 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MAEPVSPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEATYKNPELDRIATEDDLVEMQGYKDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVRVFWPKAKCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRRQHMERCLHFLVEELKVVNALEAQNRIFFVSAKEVLSARKQKAQGMPESGVALAEGFHARLQEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLDFIRNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPNPDVLKIYKSELNKHIEDGMGRNLADRCTDEVNALVLQTQQEIIENLKPLLPAGIQDKLHTLIPCKKFDLSYNLNYHKLCSDFQEDIVFRFSLGWSSLVHRFLGPRNAQRVLLGLSEPIFQLPRSLASTPTAPTTPATPDNASQEELMITLVTGLASVTSRTSMGIIIVGGVIWKTIGWKLLSVSLTMYGALYLYERLSWTTHAKERAFKQQFVNYATEKLRMIVSSTSANCSHQVKQQIATTFARLCQQVDITQKQLEEEIARLPKEIDQLEKIQNNSKLLRNKAVQLENELENFTKQFLPSSNEES
Marker	Mitochondrial Fusion Marker
Specificity	MFN1 - mitofusin 1. This antibody may cross react with MFN2 protein.
Isotype	IgG2a Kappa
Clonality	Monoclonal
Host	Mouse
Gene	MFN1
Purity	IgG purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer	In 1x PBS, pH 7.4
Preservative	No Preservative
Purity	IgG purified

Publications using H00055669-M04	Applications	Species
Yingjie G, Huan Z, Chen Y et al. Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction. Nat Chem Biol. 2023-01-12 [PMID: 36635564]
Katharina Z, Anna L, Nicolas N et al. Temporal Analysis of Protein Ubiquitylation and Phosphorylation During Parkin-Dependent Mitophagy. Mol Cell Proteomics. 2021-12-30 [PMID: 34974192]
D Hu, X Sun, A Magpusao, Y Fedorov, M Thompson, B Wang, K Lundberg, DJ Adams, X Qi Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease Nature Communications, 2021-09-06;12(1):5305. 2021-09-06 [PMID: 34489447]
Lei L, Yanyan X, Nan J et al. VDAC1 as a target in cisplatin anti-tumor activity through promoting mitochondria fusion. Biochem Biophys Res Commun. 2021-05-07 [PMID: 33971568]
Shigeto S, Sachiko N, Satoru T et al. Homeostatic p62 levels and inclusion body formation in CHCHD2 knockout mice. Hum Mol Genet. 2021-04-30 [PMID: 33631794]
Koyano F, Yamano K, Kosako H et al. Parkin-mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes. EMBO Rep. 2019-10-10 [PMID: 31602805]
Gundersen A, Kugler B, McDonald P et al. Altered Mitochondrial Network Morphology and Regulatory Proteins in Mitochondrial Quality Control in Myotubes from Severely Obese Humans With or Without Type 2 Diabetes. Appl Physiol Nutr Metab. 2019-07-29 [PMID: 31356754]
Zhao Y, Sun X, Hu D et al. ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects. Nat Commun. 2019-03-26 [PMID: 30914652]
Zhou Q, Li H, Li Y et al. Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells. JCI Insight. 2019-05-04 [PMID: 30668548]
Ferreira JCB, Campos JC, Qvit N et al. A selective inhibitor of mitofusin 1-beta IIPKC association improves heart failure outcome in rats. Nat Commun. 2019-04-09 [PMID: 30659190]
Ishikawa K, Yamamoto S, Hattori S et al. Acquired expression of mutant Mitofusin 2 causes progressive neurodegeneration and abnormal behavior. J Neurosci. 2019-02-03 [PMID: 30606759]
Wei Q, Sun H, Song S et al. microRNA-668 represses MTP18 to preserve mitochondrial dynamics in ischemic acute kidney injury. J Clin Invest 2018-11-12 [PMID: 30325740]
Furuya N, Kakuta S, Sumiyoshi K et al. NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy. EMBO Rep 2018-10-11 [PMID: 30309841]
Vukotic M, Nolte H, Konig T et al. Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria. Mol Cell 2017-07-14 [PMID: 28712724]
Guedouari H, Daigle T, Scorrano L, Hebert-Chatelain E. Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2016-11-15 [PMID: 28340937]
Chen M, Chen Z, Wang Y et al. Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy. Autophagy 2016-04-02 [PMID: 27050458]
Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y. Lysine 63-linked Polyubiquitination Is Dispensable for Parkin-mediated Mitophagy. J Biol Chem. 2014-11-28 [PMID: 25336644]
Baba T, Kashiwagi Y, Arimitsu N et al. Phosphatidic Acid (PA)-Preferring Phospholipase A1 Regulates Mitochondrial Dynamics. J Biol Chem. 2013-11-01 [PMID: 24599962]
Yue W, Chen Z, Liu H et al. A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30. Cell Res. 2014-02-11 [PMID: 24513856]
Furuya N, Ikeda S, Sato S et al. PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation. Autophagy. 2014-04-01 [PMID: 24451648] (Mouse)		Mouse
Fulop L, Rajki A, Katona D et al. Extramitochondrial OPA1 and adrenocortical function. Mol Cell Endocrinol. 2013-12-05 [PMID: 23906536] (Human)		Human
Ban-Ishihara R, Ishihara T, Sasaki N et al. Dynamics of nucleoid structure regulated by mitochondrial fission contributes to cristae reformation and release of cytochrome c. Proc Natl Acad Sci U S A. 2013-07-02 [PMID: 23821750]
Russell AP, Lamon S, Boon H et al. Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short term endurance training. J Physiol. 2013-06-24 [PMID: 23798494]
Goller T, Seibold UK, Kremmer E et al. Atad3 Function Is Essential for Early Post-Implantation Development in the Mouse. PLoS One 2013-01-25 [PMID: 23372768]
Takamura H, Koyama Y, Matsuzaki S et al. TRAP1 Controls Mitochondrial Fusion/Fission Balance through Drp1 and Mff Expression. PLoS One. 2012-12-20 [PMID: 23284813]
Shiba-Fukushima K, Imai Y, Yoshida S et al. PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy. Sci Rep. 2012-12-19 [PMID: 23256036]
Lin HY, Lai RH, Lin ST et al. Suppressor of cytokine signaling 6 (SOCS6) promotes mitochondrial fission via regulating DRP1 translocation. Cell Death Differ. 2012-09-07 [PMID: 22955947]
Chung SH, Calafiore M, Plane JM et al. Apoptosis inducing factor deficiency causes reduced mitofusion 1 expression and patterned Purkinje cell degeneration Neurobiol Dis 2011-02-01 [PMID: 20974255] (WB, FLOW, Mouse)	WB, FLOW	Mouse
Bui M, Gilady SY, Fitzsimmons RE et al. Rab32 modulates apoptosis onset and mitochondria-associated membrane (MAM) properties. J Biol Chem. 2010-07-29 [PMID: 20670942]
Wang X, Su B, Lee HG et al. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J Neurosci. 2009-07-15 [PMID: 19605646] Details: 1. IHC (p), Fig 1C,D: Hippocampus from Alzheimer's and normal human brain. Tissues were fixed in methacarn (methanol:chloroform:acetic acid, 6:3:1) and embedded in paraffin. See publication for additional details 2. WB, Fig 1A: Hippocampus from Alzheimer'
Wang H, Lim PJ, Karbowski M et al. Effects of overexpression of Huntingtin proteins on mitochondrial integrity. Hum Mol Genet 18(4):737-752. 2009-01-01 [PMID: 19039036]
Holloway GP, Perry CG, Thrush AB et al. PGC1{alpha} relationship with skeletal muscle palmitate oxidation is not present with obesity, despite maintained ained PGC1{alpha} and PGC1{beta} protein. Am J Physiol Endocrinol Metab 2008-03-18 [PMID: 18349111]
Zanna C, Ghelli A, Porcelli AM et al. OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation mitochondrial fusion. Brain 131(Pt 2): 352-67. 2008-02-01 [PMID: 18222991]
Show All 33 Publications. Collapse Publications.

Mitofusin 1 Antibody (3C9)

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Bioinformatics

Gene Symbol	MFN1
Entrez	55669(Human)
OMIM	608506(Human)
Uniprot	AAH40557(Human)