mtTFA Antibody (18G102B2E11)

mtTFA (transcription factor A, mitochondrial) is an essential protein that binds mitochondrial DNA (mtDNA) with or without sequence specificity to control mitochondrial transcription initiation and mtDNA copy number. mtTFA exists as monomer localized in mitochondrion matrix/nucleoid where it binds DNA and interacts with TFB1M/TFB2M. mtTFA associates with mitochondrial light strand promoter for controlling transcription and is essential for correct/efficient mtRNA polymerase promoter recognition. mtTFA is capable of unwinding DNA and bending mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes, and mtTFA is essential for controlling mtDNA levels as well as its organization/compaction. mtDNA is a multicopy, circular genome that is required for respiratory function and interference with mitochondrial genome sequence fidelity, transcription, or translation can cause ATP insufficiency and several pathologies including progressive external ophthalmoplegia, amyotrophic lateral sclerosis (ALS), Alpers' disease, Parkinson's disease, Alzheimer's disease, aging, cardiovascular disease, diabetes and cancer.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 6 applications: ELISA, ICC/IF, IHC-P, KO, Simple Western, WB.

Showing Publications 1 - 10 of 19. Show All 19 Publications. Collapse Publications.

Publications using NBP1-71648	Applications	Species
Gui J, Qiao W, Hu C et al. Chemotherapy potentiates CD8+ T cell cytotoxicity through stimulating cancer cell-autonomous type I IFN induction via oxidized mtDNA sensing Research Square 2022-12-06 (ICC/IF, Mouse)	ICC/IF	Mouse
Xu W, Zhao L. An Enzyme-Linked Immunosorbent Assay for the Detection of Mitochondrial DNA-Protein Cross-Links from Mammalian Cells DNA (Basel) 2023-08-21 [PMID: 37601565] (ELISA)	ELISA
Saal KA, Shaib AH, Mougios N et al. Heat denaturation enables multicolor X10-STED microscopy Scientific reports 2023-04-01 [PMID: 37005431] (ICC/IF, Human)	ICC/IF	Human
Xu W, Zhao L An Enzyme-Linked Immunosorbent Assay for the Detection of Mitochondrial DNA-Protein Cross-Links from Mammalian Cells DNA 2022-11-11 (WB, Human)	WB	Human
Xu R, Huang L, Liu J et al. Remodeling of Mitochondrial Metabolism by a Mitochondria-Targeted RNAi Nanoplatform for Effective Cancer Therapy Small (Weinheim an der Bergstrasse, Germany) 2023-11-02 [PMID: 37919865]
Ilamathi H, Benhammouda S, Lounas A et al. Contact sites between endoplasmic reticulum sheets and mitochondria regulate mitochondrial DNA replication and segregation iScience 2023-06-01 [PMID: 37534187] (ICC/IF, Human)	ICC/IF	Human
Vidali S, Feichtinger RG, Emberger M et al. Ageing is associated with a reduction in markers of mitochondrial energy metabolism in the human epidermis Experimental dermatology 2023-02-27 [PMID: 36851889] (IHC-P, Human)	IHC-P	Human
Limagne E, Nuttin L, Thibaudin M et al. MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells Cancer cell 2022-01-17 [PMID: 35051357]
Patrick S, Gowda P, Lathoria K Et al. Diminished YAP1 affects mitochondrial dynamics in IDH1 mutant glioma Journal of cell science 2021-10-15 [PMID: 34651186]
SA Harper, JR Bassler, S Peramsetty, Y Yang, LM Roberts, D Drummer, RT Mankowski, C Leeuwenbur, K Ricart, RP Patel, MM Bamman, SD Anton, BC Jaeger, TW Buford Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial Exp Gerontol, 2020-10-15;0(0):111111. 2020-10-15 [PMID: 33068691] (Simple Western, Human)	Simple Western	Human
Takishita Y, Yasuda H, Shimizu M et al. Formation of neutrophil extracellular traps in mitochondrial DNA-deficient cells J Clin Biochem Nutr 2020-01-01 [PMID: 32001952] (KO, WB, Mouse)	KO, WB	Mouse
Widdrington JD, Gomez-Duran A, Pyle A et al. Exposure of Monocytic Cells to Lipopolysaccharide Induces Coordinated Endotoxin Tolerance, Mitochondrial Biogenesis, Mitophagy, and Antioxidant Defenses. Front Immunol. 2018-09-27 [PMID: 30319656] (WB, Human)	WB	Human
Dlaskova A, Engstova H, Spacek T et al. 3D super-resolution microscopy reflects mitochondrial cristae alternations and mtDNA nucleoid size and distribution Biochim Biochim Biophys Acta Bioenerg. 2018-05-01 [PMID: 29727614] (ICC/IF, Human) Details: Citation using the Alexa Fluor 647 form of this antibody.	ICC/IF	Human
Huang C, Wang K, Yang Y et al. Gastrodia elata alleviates mutant huntingtin aggregation through mitochondrial function and biogenesis mediation Phytomedicine 2018-01-01 [PMID: 29433686] (Rat)		Rat
Widdrington JD, Gomez-Duran A, Steyn JS et al. Mitochondrial DNA depletion induces innate immune dysfunction rescued by IFN-gamma J. Allergy Clin. Immunol. 2017-06-17 [PMID: 28629747] (WB, Human)	WB	Human
Mastrocola R, Penna C et al. Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways. Oxid Med Cell Longev 2017-06-01 [PMID: 28053692] (WB, Mouse)	WB	Mouse
Sun Q, Zhong W, Zhang W, Zhou Z Defect of mitochondrial respiratory chain is a mechanism of ROS overproduction in a rat model of alcoholic liver disease: role of zinc deficiency. Am J Physiol Gastrointest Liver Physiol 2016-02-01 [PMID: 26585415]
Choi J, Chandrasekaran K, Demarest TG et al. Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity. Annals of Clinical and Translational Neurology 2014-01-01 [PMID: 25356430]
Morris EM, Meers GM, Booth FW et al. PGC-1alpha Overexpression Results in Increased Hepatic Fatty Acid Oxidation with Reduced Triacylglycerol Accumulation and Secretion Am J Physiol Gastrointest Liver Physiol 2012-08-16 [PMID: 22899824] (WB, Rat)	WB	Rat
Show All 19 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Prashant Rai	ICC	Mouse	08/27/2021	View Summary Application Immunocytochemistry Sample Tested mice primary macrophages Species Mouse Lot A-8 Comments Comments 0.1 % Triton X100 permeabilization
Enlarge	4 reviewed by: Verified Customer	WB	Rat	03/07/2018	View Summary Application Western Blot Sample Tested Liver Species Rat Lot a1

Array NBP1-71648

• mtTFA Antibodies
• mtTFA Lysate
• mtTFA Proteins