AMPK alpha 2 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

AMP-activated protein kinase (AMPK) is a heterotrimeric complex consisting of a catalytic alpha subunit and regulatory beta and gamma subunits. Each subunit exists as alternate isoforms ( alpha 1, alpha 2, beta 1, beta 2, gamma 1, gamma 2, gamma 3), with all 12 combinations able to form complexes. The catalytic alpha subunit of AMPK is activated allosterically by AMP, and by phosphorylation via the AMPK kinase LKB1. AMPK’s role in metabolic regulation has implicated this serine/threonine kinase as a therapeutic target in heart disease, obesity, and diabetes.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Transgenic Mouse.

We have publications tested in 4 applications: ChIP, IHC, Immunohistochemistry, Western Blot.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using AF2850	Applications	Species
Lee, TJ;Sasaki, Y;Ruzycki, PA;Ban, N;Lin, JB;Wu, HT;Santeford, A;Apte, RS; Catalytic isoforms of AMP-activated protein kinase differentially regulate IMPDH activity and photoreceptor neuron function JCI insight 2024-01-16 [PMID: 38227383] (Immunohistochemistry, Western Blot, Transgenic Mouse)	Immunohistochemistry, Western Blot	Transgenic Mouse
CH Chan, SN Wu, BY Bao, HW Li, TL Lu MST3 Involvement in Na+ and K+ Homeostasis with Increasing Dietary Potassium Intake International Journal of Molecular Sciences, 2021-01-20;22(3):. 2021-01-20 [PMID: 33498219] (IHC, Mouse)	IHC	Mouse
Te-Jung Lu, Wei-Chih Kan, Sung-Sen Yang, Si-Tse Jiang, Sheng-Nan Wu, Pin Ling et al. MST3 is involved in ENaC-mediated hypertension American Journal of Physiology-Renal Physiology 7/1/2019 [PMID: 30969802]
M Domise, F Sauvé, S Didier, R Caillerez, S Bégard, S Carrier, M Colin, C Marinangel, L Buée, V Vingtdeux Neuronal AMP-activated protein kinase hyper-activation induces synaptic loss by an autophagy-mediated process Cell Death Dis, 2019-03-04;10(3):221. 2019-03-04 [PMID: 30833547] (Western Blot, Mouse)	Western Blot	Mouse
MS Lee, HJ Han, SY Han, IY Kim, S Chae, CS Lee, SE Kim, SG Yoon, JW Park, JH Kim, S Shin, M Jeong, A Ko, HY Lee, KJ Oh, YH Lee, KH Bae, SH Koo, JW Kim, JK Seong, D Hwang, J Song Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation Nat Commun, 2018-08-24;9(1):3404. 8/24/2018 [PMID: 30143610]
Cha JH, Yang WH, Xia W et al. Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1 Mol. Cell 8/16/2018 [PMID: 30118680]
Manon Domise AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo Sci Rep, 2016-05-27;6(0):26758. 2016-05-27 [PMID: 27230293] (IHC, Mouse)	IHC	Mouse
Jiang S, Park D, Stigler W, Creighton J, Ravi S, Darley-Usmar V, Zmijewski J Mitochondria and AMP-activated protein kinase-dependent mechanism of efferocytosis. J Biol Chem, 2013-07-29;288(36):26013-26. 2013-07-29 [PMID: 23897815] (Western Blot, Mouse)	Western Blot	Mouse
Komori T, Doi A, Nosaka T, Furuta H, Akamizu T, Kitamura T, Senba E, Morikawa Y Regulation of AMP-activated protein kinase signaling by AFF4 protein, member of AF4 (ALL1-fused gene from chromosome 4) family of transcription factors, in hypothalamic neurons. J. Biol. Chem., 2012-04-23;287(24):19985-96. 2012-04-23 [PMID: 22528490] (Western Blot, Mouse)	Western Blot	Mouse
Gan Z, Burkart-Hartman EM, Han DH, Finck B, Leone TC, Smith EY, Ayala JE, Holloszy J, Kelly DP The nuclear receptor PPARbeta/delta programs muscle glucose metabolism in cooperation with AMPK and MEF2. Genes Dev., 2011-12-01;25(24):2619-30. 2011-12-01 [PMID: 22135324] (ChIP, Mouse)	ChIP	Mouse
Rintarou Okoshi, Kazumasa Ohta, Ayako Ishikawa, Yutaka Sato, Harutoshi Kizaki Expression of 5′-AMP-activated Protein Kinase with Starvation in Murine Thymocytes The Bulletin of Tokyo Dental College 4/7/2011 [PMID: 21467778]
Show All 11 Publications. Collapse Publications.

Array AF2850

• AMPK alpha 2 Antibodies
• AMPK alpha 2 Lysate
• AMPK alpha 2 Proteins