LKB1/STK11 Antibody - BSA Free

Liver kinase B1 (LKB1), also known as serine/threonine-protein kinase STK11, is a member of the serine/threonine kinase family. LKB1 is a tumor suppressor that helps control cell structure, apoptosis and energy homeostasis through regulation of numerous downstream kinases. More specifically, LKB1 controls the activity of AMP-activated protein kinase (AMPK) family members, regulates cell polarity by remodeling the actin cytoskeleton, regulates the inhibition of cell growth signaling pathways in response to low energy levels, regulates autophagy in response to nutrient deprivation, and is involved in DNA damage response by differentiating B-cells in the germinal center. LKB1 phosphorylation in cells occurs at several sites, including human LKB1 at Ser31/325/428 and Thr189/336/363. LKB1 is ubiquitously expressed in tissues with the strongest expression in testis and fetal liver. Defects in the LKB1 gene have been known to cause Peutz-Jeghers syndrome (PJS), testicular germ cell tumors (TGCT), non-small cell lung cancer (NSCLC), and other sporadic cancers. While not thoroughly characterized, alternate transcriptional splice variants of the LKB1 gene have been observed.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.

Showing Publication 1 - 1 of 1.

Publication using NBP2-14835	Applications	Species
Ohtake Y, Sami A, Jiang X et al. Promoting Axon Regeneration in Adult CNS by Targeting Liver Kinase B1. Small. 2018-11-12 [PMID: 30509565] (WB, Mouse)	WB	Mouse

Array NBP2-14835

• LKB1/STK11 Antibodies
• LKB1/STK11 Lysate
• LKB1/STK11 Proteins