S1P1/EDG-1 Antibody (713412) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

S1P₁ (sphingosine 1-phosphate receptor-1), also known as EDG-1 (endothelial differentiation, G-protein coupled receptor-1) or S1PR1 (sphingosine-1-phosphate receptor 1) is a widely expressed, 37-40 kDa, G protein coupled receptor within the S1P subfamily of the EDG family. S1P₁ is one of five receptors for the bioactive lipid S1P and mediates most of S1P effects on angiogenesis, vascular maturation, and cell migration, especially T cell egress from lymphoid organs. Human and mouse S1P₁ share 84% amino acid identity within the N-terminal extracellular portion used as an immunogen.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Transgenic Mouse.

We have publications tested in 2 applications: Flow Cytometry, IHC.

Showing Publications 1 - 10 of 27. Show All 27 Publications. Collapse Publications.

Publications using MAB7089	Applications	Species
DB Blanco, NM Chapman, JL Raynor, C Xu, W Su, A Kc, W Li, SA Lim, S Schattgen, H Shi, I Risch, Y Sun, Y Dhungana, Y Kim, J Wei, S Rankin, G Neale, PG Thomas, K Yang, H Chi PTEN? directs developmental and metabolic signaling for innate-like T cell fate and tissue homeostasis Nature Cell Biology, 2022-10-27;24(11):1642-1654. 2022-10-27 [PMID: 36302969] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
J Nie, AC Carpenter, LB Chopp, T Chen, M Balmaceno-, T Ciucci, Q Xiao, MC Kelly, DB McGavern, Y Belkaid, R Bosselut The transcription factor LRF promotes integrin beta7 expression by and gut homing of CD8alphaalpha+ intraepithelial lymphocyte precursors Nature Immunology, 2022-03-30;23(4):594-604. 2022-03-30 [PMID: 35354951] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
S Tsiomita, EM Liveri, P Vardaka, A Vogiatzi, A Skiadaresi, G Saridis, I Tsigkas, TM Michaelidi, G Mavrothala, G Thyphronit ETS2 repressor factor (ERF) is involved in T lymphocyte maturation acting as regulator of thymocyte lineage commitment Journal of leukocyte biology, 2022-03-08;0(0):. 2022-03-08 [PMID: 35258130] (Flow Cytometry, Human)	Flow Cytometry	Human
C Liu, L Ma, Y Wang, J Zhao, P Chen, X Chen, Y Wang, Y Hu, Y Liu, X Jia, Z Yang, X Yin, J Wu, S Wu, H Zheng, X Ma, X Sun, Y He, L Lin, Y Fu, K Liao, X Zhou, S Jiang, G Fu, J Tang, W Han, XL Chen, W Fan, Y Hong, J Han, X Huang, BA Li, N Xiao, C Xiao, G Fu, WH Liu Glycogen synthase kinase 3 drives thymocyte egress by suppressing beta-catenin activation of Akt Science Advances, 2021-10-08;7(41):eabg6262. 2021-10-08 [PMID: 34623920] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
M Okuniewska, V Fang, A Baeyens, V Raghavan, JY Lee, DR Littman, SR Schwab SPNS2 enables T�cell egress from lymph nodes during an immune response Cell Reports, 2021-07-13;36(2):109368. 2021-07-13 [PMID: 34260944] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
A Baeyens, S Bracero, VS Chaluvadi, A Khodadadi-, M Cammer, SR Schwab Monocyte-derived S1P in the lymph node regulates immune responses Nature, 2021-03-03;0(0):. 2021-03-03 [PMID: 33658712] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
R Vallion, J Divoux, S Glauzy, E Ronin, Y Lombardi, M Lubrano di, S Grégoire, I Nemazanyy, A Durand, D Fradin, B Lucas, BL Salomon Regulatory T Cell Stability and Migration Are Dependent on mTOR J. Immunol., 2020-08-24;0(0):. 2020-08-24 [PMID: 32839235] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Leandro V, Matt T, Andrew Z et al. TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate. Cell. 2020-07-02 [PMID: 32619424]
X Geng, K Yanagida, RG Akwii, D Choi, L Chen, Y Ho, B Cha, MR Mahamud, K Berman de, H Ichise, H Chen, J Wythe, CM Mikelis, T Hla, RS Srinivasan S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling JCI Insight, 2020-07-23;0(0):. 2020-07-23 [PMID: 32544090] (IHC, Transgenic Mouse)	IHC	Transgenic Mouse
MJ McCarron, M Irla, A Sergé, SM Soudja, JC Marie Transforming Growth Factor-beta signaling in alphabeta thymocytes promotes negative selection Nat Commun, 2019-12-19;10(1):5690. 2019-12-19 [PMID: 31857584] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
K Shimano, Y Maeda, H Kataoka, M Murase, S Mochizuki, H Utsumi, K Oshita, K Sugahara Amiselimod (MT-1303), a novel sphingosine 1-phosphate receptor-1 functional antagonist, inhibits progress of chronic colitis induced by transfer of CD4+CD45RBhigh�T cells PLoS ONE, 2019-12-05;14(12):e0226154. 2019-12-05 [PMID: 31805144] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
J Choi, PT Rudak, S Lesage, SMM Haeryfar Glycolipid Stimulation of Invariant NKT Cells Expands a Unique Tissue-Resident Population of Precursors to Mature NK Cells Endowed with Oncolytic and Antimetastatic Properties J. Immunol., 2019-08-28;0(0):. 2019-08-28 [PMID: 31462506] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
MM Moretto, S Hwang, K Chen, IA Khan Complex and Multilayered Role of IL-21 Signaling during Thymic Development J. Immunol., 2019-07-24;0(0):. 2019-07-24 [PMID: 31341076] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Kieran D. James, Emilie J. Cosway, Beth Lucas, Andrea J. White, Sonia M. Parnell, Manuela Carvalho-Gaspar et al. Endothelial cells act as gatekeepers for LT beta R-dependent thymocyte emigration Journal of Experimental Medicine 2018-12-03 [PMID: 30425120]
MJ Lang, M Mori, J Ruer-Laven, J Pieters A Coronin 1-Dependent Decision Switch in Juvenile Mice Determines the Population of the Peripheral Naive T Cell Compartment J. Immunol., 2017-08-18;0(0):. 2017-08-18 [PMID: 28821585] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
A Audemard-V, M Rivière, A Durand, E Peranzoni, V Guichard, P Hamon, N Bonilla, T Guilbert, A Boissonnas, C Auffray, G Eberl, B Lucas, B Martin Macrophages Induce Long-Term Trapping of ?? T Cells with Innate-like Properties within Secondary Lymphoid Organs in the Steady State J. Immunol., 2017-08-04;0(0):. 2017-08-04 [PMID: 28779024] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
DP Golec, RE Hoeppli, LM Henao Cavi, J McCann, MK Levings, TA Baldwin Thymic progenitors of TCR??(+) CD8?? intestinal intraepithelial lymphocytes require RasGRP1 for development J. Exp. Med., 2017-06-26;0(0):. 2017-06-26 [PMID: 28652304] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
A Mendoza, V Fang, C Chen, M Serasinghe, A Verma, J Muller, VS Chaluvadi, ML Dustin, T Hla, O Elemento, JE Chipuk, SR Schwab Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells Nature, 2017-05-24;0(0):. 2017-05-24 [PMID: 28538737] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
R Ruscher, RL Kummer, YJ Lee, SC Jameson, KA Hogquist CD8?? intraepithelial lymphocytes arise from two main thymic precursors Nat. Immunol., 2017-05-22;0(0):. 2017-05-22 [PMID: 28530714] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
VM Turner, NA Mabbott Ageing adversely affects the migration and function of marginal zone B cells Immunology, 2017-05-04;151(3):349-362. 2017-05-04 [PMID: 28369800] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Sugata Manna, Jong Kyong Kim, Catherine Baugé, Margaret Cam, Yongmei Zhao, Jyoti Shetty et al. Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation Nature Communications 2015-09-02 [PMID: 26328764]
Maeda Y, Seki N, Kataoka H, Takemoto K, Utsumi H, Fukunari A, Sugahara K, Chiba K IL-17-Producing Vgamma4+ gammadelta T Cells Require Sphingosine 1-Phosphate Receptor 1 for Their Egress from the Lymph Nodes under Homeostatic and Inflammatory Conditions. J Immunol, 2015-07-13;195(4):1408-16. 2015-07-13 [PMID: 26170380] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Xu , Shengli, Ou , Xijun, Huo , Jianxin, Lim , Kristen, Huang , Yuhan, Chee , Sheena, Lam , Kong-Pen Mir-17-92 regulates bone marrow homing of plasma cells and production of immunoglobulin G2c. Nat Commun, 2015-04-17;6(0):6764. 2015-04-17 [PMID: 25881561] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Nakai A, Hayano Y, Furuta F, Noda M, Suzuki K Control of lymphocyte egress from lymph nodes through beta2-adrenergic receptors. J Exp Med, 2014-11-24;211(13):2583-98. 2014-11-24 [PMID: 25422496] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Nomachi , Akira, Yoshinaga , Masanori, Liu , Jaron, Kanchanawong , Pakorn, Tohyama , Kiyoshi, Thumkeo , Dean, Watanabe , Takeshi, Narumiya , Shuh, Hirata , Takako Moesin controls clathrin-mediated S1PR1 internalization in T cells. PLoS ONE, 2013-12-16;8(12):e82590. 2013-12-16 [PMID: 24358210] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Arnon , Tal I, Horton , Robert M, Grigorova , Irina L, Cyster , Jason G Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress. Nature, 2012-12-23;493(7434):684-8. 2012-12-23 [PMID: 23263181] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Green JA, Suzuki K, Cho B, Willison LD, Palmer D, Allen CD, Schmidt TH, Xu Y, Proia RL, Coughlin SR, Cyster JG The sphingosine 1-phosphate receptor S1P(2) maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat. Immunol., 2011-06-05;12(7):672-80. 2011-06-05 [PMID: 21642988] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Show All 27 Publications. Collapse Publications.

Array MAB7089

• S1P1/EDG-1 Antibodies
• S1P1/EDG-1 ELISA Kit
• S1P1/EDG-1 Proteins