Sphingosine Kinase 1/SPHK1 Antibody (1D6)

This product is produced by and distributed for Abnova, a company based in Taiwan.

Sphingosine-1-phosphate (SPP) is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1 (MIM 601974). Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (e.g., MIM 173430) and serum.[supplied by OMIM]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IHC-P, WB.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using H00008877-M01	Applications	Species
Fraunhoffer NA, Abuelafia AM, Bigonnet M et al. Multi-omics data integration and modeling unravels new mechanisms for pancreatic cancer and improves prognostic prediction NPJ precision oncology 2022-08-17 [PMID: 35978026] (IHC-P, Human) Details: Dilutions: 1:100	IHC-P	Human
Kim MH, Park JW, Lee EJ et al. C16-ceramide and sphingosine 1-phosphate/S1PR2 have opposite effects on cell growth through mTOR signaling pathway regulation. Oncol Rep 2018-09-07 [PMID: 30226616]
Zhang H, Wang Q, Zhao Q, Di W. MiR-124 inhibits the migration and invasion of ovarian cancer cells by targeting SphK1. J Ovarian Res. 2013-01-01 [PMID: 24279510] (WB)	WB
Bohm A, Flosser A, Ermler S et al. Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells. Cardiovasc Res. 2013-05-07 [PMID: 23658376]
Sheu JJ, Lee CC, Hua CH et al. LRIG1 modulates aggressiveness of head and neck cancers by regulating EGFR-MAPK-SPHK1 signaling and extracellular matrix remodeling. Oncogene. 2013-04-29 [PMID: 23624915]
Schroder M, Richter C, Juan MH et al. The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen. Mol Immunol. 2011-03-22 [PMID: 21435724]
Asher V, Warren A, Shaw R et al. The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line. Cancer Cell Int. 2011-03-10 [PMID: 21392380]
Ali-Rahmani F, Hengst JA, Connor JR, Schengrund CL. Effect of HFE Variants on Sphingolipid Expression by SH-SY5Y Human Neuroblastoma Cells. Neurochem Res. 2011-01-18 [PMID: 21243428]
Schenten V, Melchior C, Steinckwich N et al. Sphingosine kinases regulate NOX2 activity via p38 MAPK-dependent translocation of S100A8/A9. J Leukoc Biol. 2011-01-13 [PMID: 21233411]
Sinha UK, Schorn VJ, Hochstim C et al. Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition. Wiley InterScience. 2011-02-01 [PMID: 20848438]
Wang S, Zhang Z, Lin X et al. A polysaccharide, MDG-1, induces S1P1 and bFGF expression and augments survival and angiogenesis in the ischemic heart. Glycobiology 20(4):473-84. 2010-01-01 [PMID: 20008963]
Ter Braak M, Danneberg K, Lichte K et al. G{alpha}q-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors. Biochim Biophys Acta. 2009-02-03 [PMID: 19416644]
Billich A, Urtz N, Reuschel R et al. Sphingosine kinase 1 is essential for proteinase-activated receptor-1 signalling in epithelial endothelial cells. Int J Biochem Cell Biol 41(7):1547-55. 2009-07-01 [PMID: 19162217]
Show All 13 Publications. Collapse Publications.

Array H00008877-M01

• Sphingosine Kinase 1/SPHK1 Antibodies
• Sphingosine Kinase 1/SPHK1 ELISA Kits
• Sphingosine Kinase 1/SPHK1 Lysate
• Sphingosine Kinase 1/SPHK1 Proteins and Enzymes