S1P1/EDG-1 Antibody (713412) [Phycoerythrin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

S1P₁ (sphingosine 1-phosphate receptor-1), also known as EDG-1 (endothelial differentiation, G-protein coupled receptor-1) or S1PR1 (sphingosine-1-phosphate receptor 1) is a widely expressed, 37-40 kDa, G protein coupled receptor within the S1P subfamily of the EDG family. S1P₁ is one of five receptors for the bioactive lipid S1P and mediates most of S1P effects on angiogenesis, vascular maturation, and cell migration, especially T cell egress from lymphoid organs. Human and mouse S1P₁ share 84% amino acid identity within the N-terminal extracellular portion used as an immunogen.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 10 of 10.

Publications using FAB7089P	Applications	Species
Janneh AH, Kassir MF, Atilgan FC et al. Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis Cell Reports 2022-12-06 [PMID: 36476873]
Tao Yang, Qingguo Zhao, Meijun Hu, Simin Pan, Linying Zhang, Ruoxi Zhu et al. Sphingosine-1-Phosphate Alleviates Irradiation Induced Salivary Gland Hypofunction through Preserving Endothelial Cells and Resident Macrophages Antioxidants (Basel) 2022-10-18 [PMID: 36290773]
R Sun, X Gu, C Lei, L Chen, S Chu, G Xu, MA Doll, Y Tan, W Feng, L Siskind, CJ McClain, Z Deng Neutral ceramidase-dependent regulation of macrophage metabolism directs intestinal immune homeostasis and controls enteric infection Cell Reports, 2022-03-29;38(13):110560. 2022-03-29 [PMID: 35354041] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
D Pazos-Cast, Z Gonzalez-K, AY Montalvo, G Hernandez-, A Romero-Sah, V Esteban, M Garrido-Ar, J Tome-Amat, A Diaz-Peral NLRP3 priming due to skin damage precedes LTP allergic sensitization in a mouse model Scientific Reports, 2022-02-28;12(1):3329. 2022-02-28 [PMID: 35228630] (Flow Cytometry, Human)	Flow Cytometry	Human
Guillaume Harlé, Camille Kowalski, Juan Dubrot, Dale Brighouse, Gaëlle Clavel, Robert Pick et al. Macroautophagy in lymphatic endothelial cells inhibits T cell–mediated autoimmunity Journal of Experimental Medicine 2021-06-07 [PMID: 33861848]
K Zhao, Y Tian, J Wang, C Chen, B Pan, Z Yan, S Zhu, K Xu Fluvastatin-Pretreated Donor Cells Attenuated Murine aGVHD by Balancing Effector T Cell Distribution and Function under the Regulation of KLF2 BioMed Research International, 2020-12-19;2020(0):7619849. 2020-12-19 [PMID: 33415155] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Paramita Chakraborty, Silvia G. Vaena, Krishnamurthy Thyagarajan, Shilpak Chatterjee, Amir Al-Khami, Shanmugam Panneer Selvam et al. Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity Cell Reports 2019-08-13 [PMID: 31412253]
A Salas-Perd, F Miró-Mur, M Gallizioli, VH Brait, C Justicia, A Meissner, X Urra, A Chamorro, AM Planas Role of the S1P pathway and inhibition by fingolimod in preventing hemorrhagic transformation after stroke Sci Rep, 2019-06-05;9(1):8309. 2019-06-05 [PMID: 31165772] (Flow Cytometry, Human)	Flow Cytometry	Human
Abudureyimujiang Aili, Jie Zhang, Jia Wu, Haoming Wu, Xiuyuan Sun, Qihua He et al. CCR2 Signal Facilitates Thymic Egress by Priming Thymocyte Responses to Sphingosine-1-Phosphate Frontiers in Immunology 2018-06-07 [PMID: 29930553]
IY Hwang, C Park, K Harrison, JH Kehrl Normal Thymocyte Egress, T Cell Trafficking, and CD4(+) T Cell Homeostasis Require Interactions between RGS Proteins and G?i2 J. Immunol, 2017-02-24;0(0):. 2017-02-24 [PMID: 28235863] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse

Array FAB7089P

• S1P1/EDG-1 Antibodies
• S1P1/EDG-1 ELISA Kit
• S1P1/EDG-1 Proteins