PLZF Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human PLZF is a 74 kDa nuclear protein that belongs to the POK family of transcriptional repressors. It is a 673 amino acid protein that contains an N-terminal BTB domain, followed by an acidic domain, a proline-rich region and a C-terminal zinc-finger domain. PLZF forms homodimers with RAR alpha and LAZ3 with its zinc-finger region. Alternate splice forms exist which are tissue-specific and show a deletion of either the BTB domain, the acidic region, or the proline-rich region. Human PLZF shares 96%, 97%, 96%, and 96% amino acid identity with rat, mouse, canine, and bovine PLZF, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 9 applications: Flow Cytometry, ICC, IHC, IHC-F, IHC-P, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot.

Showing Publications 1 - 10 of 45. Show All 45 Publications. Collapse Publications.

Publications using AF2944	Applications	Species
Houston, BJ;Nguyen, J;Merriner, DJ;O'Connor, AE;Lopes, AM;Nagirnaja, L;Friedrich, C;Kliesch, S;Tüttelmann, F;Aston, KI;Conrad, DF;Hobbs, RM;Dunleavy, JEM;O'Bryan, MK; AXDND1 is required to balance spermatogonial commitment and for sperm tail formation in mice and humans Cell death & disease 2024-07-12 [PMID: 38997255] (Immunohistochemistry, Mouse)	Immunohistochemistry	Mouse
Wei, X;Zhang, Z;Gu, Y;Zhang, R;Huang, J;Li, F;He, Y;Lu, S;Wu, Y;Zeng, W;Liu, X;Liu, C;Liu, J;Ao, L;Shi, F;Chen, Q;Lin, Y;Du, J;Jin, G;Xia, Y;Ma, H;Zheng, Y;Huo, R;Cao, J;Shen, H;Hu, Z; Inter- and trans-generational impacts of real-world PM2.5 exposure on male-specific primary hypogonadism Cell discovery 2024-04-23 [PMID: 38649348] (Immunohistochemistry, Mouse)	Immunohistochemistry	Mouse
Lei, WL;Du, Z;Meng, TG;Su, R;Li, YY;Liu, W;Sun, SM;Liu, MY;Hou, Y;Zhang, CH;Gui, Y;Schatten, H;Han, Z;Liu, C;Sun, F;Wang, ZB;Qian, WP;Sun, QY; SRSF2 is required for mRNA splicing during spermatogenesis BMC biology 2023-10-23 [PMID: 37867192] (Immunocytochemistry, Mouse)	Immunocytochemistry	Mouse
Lei, WL;Li, YY;Du, Z;Su, R;Meng, TG;Ning, Y;Hou, G;Schatten, H;Wang, ZB;Han, Z;Sun, F;Qian, WP;Liu, C;Sun, QY; SRSF1-mediated alternative splicing is required for spermatogenesis International journal of biological sciences 2023-09-11 [PMID: 37781512] (IHC, Mouse)	IHC	Mouse
Yamanaka, S;Furihata, H;Yanagihara, Y;Taya, A;Nagasaka, T;Usui, M;Nagaoka, K;Shoya, Y;Nishino, K;Yoshida, S;Kosako, H;Tanokura, M;Miyakawa, T;Imai, Y;Shibata, N;Sawasaki, T; Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation Nature communications 8/18/2023 [PMID: 37596276]
Liu W, Lu X, Zhao ZH et al. SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing eLife 11/10/2022 [PMID: 36355419]
Minyan Li, Yuxi Chen, Jianping Ou, Junjiu Huang, Xiya Zhang PDCL2 is essential for spermiogenesis and male fertility in mice Cell Death Discovery 10/17/2022 [PMID: 36253364]
Peart NJ, Johnson TA, Lee S et al. The germ cell-specific RNA binding protein RBM46 is essential for spermatogonial differentiation in mice PLOS Genetics 9/21/2022 [PMID: 36129965]
Peart NJ, Johnson TA, Lee S et al. The germ cell-specific RNA binding protein RBM46 is essential for spermatogonial differentiation in mice PLOS Genetics 2022-09-21 [PMID: 36129965]
JE Burda, TM O'Shea, Y Ao, KB Suresh, S Wang, AM Bernstein, A Chandra, S Deverasett, R Kawaguchi, JH Kim, S McCallum, A Rogers, S Wahane, MV Sofroniew Divergent transcriptional regulation of astrocyte reactivity across disorders Nature, 2022-05-25;0(0):. 2022-05-25 [PMID: 35614216] (IHC, Human)	IHC	Human
Hairuo Dang, Ana Martin‐Villalba, Elmar Schiebel Centrosome linker protein C‐Nap1 maintains stem cells in mouse testes EMBO reports 7/5/2022 [PMID: 35599622]
KM Smith, DT Dinh, LK Akison, M Nicholls, KR Dunning, A Morimoto, JP Lydon, DL Russell, RL Robker Intraovarian, Isoform-Specific Transcriptional Roles of Progesterone Receptor in Ovulation Cells, 2022-05-05;11(9):. 2022-05-05 [PMID: 35563869] (Western Blot, Mouse)	Western Blot	Mouse
V Barroca, C Racine, L Pays, P Fouchet, M Coureuil, I Allemand The netrin-1 receptor UNC5C contributes to the homeostasis of undifferentiated spermatogonia in adult mice Stem Cell Research, 2022-02-25;60(0):102723. 2022-02-25 [PMID: 35247845] (Flow Cytometry, Human)	Flow Cytometry	Human
S Yamanaka, Y Horiuchi, S Matsuoka, K Kido, K Nishino, M Maeno, N Shibata, H Kosako, T Sawasaki A proximity biotinylation-based approach to identify protein-E3 ligase interactions induced by PROTACs and molecular glues Nature Communications, 2022-01-10;13(1):183. 2022-01-10 [PMID: 35013300] (Western Blot, Human)	Western Blot	Human
Wenwen Liu, Lingfeng Zhang, Anning Gao, Muhammad Babar Khawar, Fengyi Gao, Wei Li Food-Derived High Arginine Peptides Promote Spermatogenesis Recovery in Busulfan Treated Mice Frontiers in Cell and Developmental Biology 12/21/2021 [PMID: 34993200]
WL Lei, YY Li, TG Meng, Y Ning, SM Sun, CH Zhang, Y Gui, ZB Wang, WP Qian, QY Sun Specific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis Cell Death & Disease, 2021-09-27;12(10):883. 2021-09-27 [PMID: 34580275] (IHC, Mouse)	IHC	Mouse
Shinnosuke Suzuki, John R. McCarrey, Brian P. Hermann Differential RA responsiveness among subsets of mouse late progenitor spermatogonia Reproduction 6/1/2021 [PMID: 33835049]
Satoshi Yamanaka, Hidetaka Murai, Daisuke Saito, Gembu Abe, Etsuko Tokunaga, Takahiro Iwasaki et al. Thalidomide and its metabolite 5‐hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF The EMBO Journal 2/15/2021 [PMID: 33470442]
MM Mikedis, Y Fan, PK Nicholls, T Endo, EK Jackson, SA Cobb, DG de Rooij, DC Page DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors Elife, 2020-07-20;9(0):. 2020-07-20 [PMID: 32686646] (IHC-P, Mouse)	IHC-P	Mouse
M Wang, L Yu, S Wang, F Yang, M Wang, L Li, X Wu LIN28A binds to meiotic gene transcripts and modulates translation in male germ cells J. Cell. Sci., 2020-06-16;0(0):. 6/16/2020 [PMID: 32376786]
JMD Legrand, AL Chan, HM La, FJ Rossello, ML Änkö, FV Fuller-Pac, RM Hobbs DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia Nat Commun, 2019;10(1):2278. 2019 [PMID: 31123254] (IHC, Human)	IHC	Human
K Fu, S Tian, H Tan, C Wang, H Wang, M Wang, Y Wang, Z Chen, Y Wang, Q Yue, Q Xu, S Zhang, H Li, J Xie, M Lin, M Luo, F Chen, L Ye, K Zheng Biological and RNA regulatory function of MOV10 in mammalian germ cells BMC Biol., 2019-05-14;17(1):39. 2019-05-14 [PMID: 31088452] (IHC-F, Mouse)	IHC-F	Mouse
RL Tang, LQ Fan PLZFposc-KITpos-delineated A1-A4-differentiating spermatogonia by subset and stage detection upon Bouin fixation Asian J. Androl., 2019-05-01;21(3):309-318. 2019-05-01 [PMID: 30719983] (IHC, Mouse)	IHC	Mouse
Min-Bo Minbo, Zhou Qiao, Yun-Fei Yunfei, Ming-Xi Mingxi, Zuo-Min Zuomin Effects of chemotherapeutic agent bendamustine for non-hodgkin lymphoma on spermatogenesis in mice The Journal of Biomedical Research 11/20/2018 [PMID: 30333280]
Hue M. La, Ai-Leen Chan, Julien M. D. Legrand, Fernando J. Rossello, Christina G. Gangemi, Antonella Papa et al. GILZ-dependent modulation of mTORC1 regulates spermatogonial maintenance Development 3/16/2018 [PMID: 30126904]
HM La, JA Mäkelä, AL Chan, FJ Rossello, CM Nefzger, JMD Legrand, M De Seram, JM Polo, RM Hobbs Identification of dynamic undifferentiated cell states within the male germline Nat Commun, 2018-07-19;9(1):2819. 7/19/2018 [PMID: 30026551]
A Gely-Perno, C Hao, L Legoff, L Multigner, SC D'Cruz, C Kervarrec, B Jégou, S Tevosian, F Smagulova Gestational exposure to chlordecone promotes transgenerational changes in the murine reproductive system of males Sci Rep, 2018-07-06;8(1):10274. 7/6/2018 [PMID: 29980752]
Shun Bai, Kaiqiang Fu, Huiqi Yin, Yiqiang Cui, Qiuling Yue, Wenbo Li et al. Sox30 initiates transcription of haploid genes during late meiosis and spermiogenesis in mouse testes Development 2/23/2018 [PMID: 29866902]
S Saeidi, F Shapouri, RU de Iongh, F Casagranda, JM Sutherland, PS Western, EA McLaughlin, M Familari, GR Hime Esrp1 is a marker of mouse fetal germ cells and differentially expressed during spermatogenesis PLoS ONE, 2018-01-11;13(1):e0190925. 1/11/2018 [PMID: 29324788]
SP Jamin, FG Petit, C Kervarrec, F Smagulova, D Illner, H Scherthan, M Primig EXOSC10/Rrp6 is post-translationally regulated in male germ cells and controls the onset of spermatogenesis Sci Rep, 2017-11-08;7(1):15065. 2017-11-08 [PMID: 29118343] (IHC-P, Mouse)	IHC-P	Mouse
K Gassei, Y Sheng, A Fayomi, P Mital, M Sukhwani, CC Lin, KA Peters, A Althouse, H Valli, KE Orwig DDX4-EGFP transgenic rat model for the study of germline development and spermatogenesis Biol. Reprod., 2017-03-01;96(3):707-719. 2017-03-01 [PMID: 28339678] (IHC-P, Rat)	IHC-P	Rat
Travis Kotzur, Roberto Benavides-Garcia, Jennifer Mecklenburg, Jamila R. Sanchez, Matthew Reilly, Brian P. Hermann Granulocyte colony-stimulating factor (G-CSF) promotes spermatogenic regeneration from surviving spermatogonia after high-dose alkylating chemotherapy Reproductive Biology and Endocrinology 12/1/2017 [PMID: 28077131]
The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells Nat. Immunol, 2016-12-19;0(0):. 2016-12-19 [PMID: 27992400] (Western Blot, Mouse)	Western Blot	Mouse
Ai-Ping Mao Multiple layers of transcriptional regulation by PLZF in NKT-cell development Proc Natl Acad Sci USA, 2016-06-20;0(0):. 2016-06-20 [PMID: 27325774] (Immunoprecipitation, Human)	Immunoprecipitation	Human
DL Lovelace, Z Gao, K Mutoji, YC Song, J Ruan, BP Hermann The regulatory repertoire of PLZF and SALL4 in undifferentiated spermatogonia Development, 2016-04-11;0(0):. 4/11/2016 [PMID: 27068105]
Li M, Huang R, Jiang X, Chen Y, Zhang Z, Zhang X, Liang P, Zhan S, Cao S, Songyang Z, Huang J CRISPR/Cas9 Promotes Functional Study of Testis Specific X-Linked Gene In Vivo. PLoS ONE, 2015-11-24;10(11):e0143148. 2015-11-24 [PMID: 26599493] (IHC-P, Mouse)	IHC-P	Mouse
Gely-Pernot A, Hao C, Becker E et al. The epigenetic processes of meiosis in male mice are broadly affected by the widely used herbicide atrazine. BMC Genomics. 10/30/2015 [PMID: 26518232]
Aurore Gely-Pernot, Mathilde Raverdeau, Marius Teletin, Nadège Vernet, Betty Féret, Muriel Klopfenstein et al. Retinoic Acid Receptors Control Spermatogonia Cell-Fate and Induce Expression of the SALL4A Transcription Factor PLOS Genetics 10/1/2015 [PMID: 26427057]
Quan Zhou, Yueshuai Guo, Bo Zheng, Binbin Shao, Min Jiang, Gaigai Wang et al. Establishment of a proteome profile and identification of molecular markers for mouse spermatogonial stem cells Journal of Cellular and Molecular Medicine 3/1/2015 [PMID: 25352495]
Aloisio G, Nakada Y, Saatcioglu H, Pena C, Baker M, Tarnawa E, Mukherjee J, Manjunath H, Bugde A, Sengupta A, Amatruda J, Cuevas I, Hamra F, Castrillon D PAX7 expression defines germline stem cells in the adult testis. J Clin Invest, 2014-08-18;124(9):3929-44. 2014-08-18 [PMID: 25133429] (IHC-P, Mouse)	IHC-P	Mouse
Hanna Valli, Meena Sukhwani, Serena L. Dovey, Karen A. Peters, Julia Donohue, Carlos A. Castro et al. Fluorescence- and magnetic-activated cell sorting strategies to isolate and enrich human spermatogonial stem cells Fertility and Sterility 8/1/2014 [PMID: 24890267]
Makela J, Toppari J, Rivero-Muller A, Ventela S Reconstruction of mouse testicular cellular microenvironments in long-term seminiferous tubule culture. PLoS ONE, 2014-03-11;9(3):e90088. 2014-03-11 [PMID: 24619130] (ICC, Mouse)	ICC	Mouse
Cao , JingPing, Zhu , Shu, Zhou , Wei, Li , Jie, Liu , Chang, Xuan , HanQing, Yan , Jie, Zheng , Lin, Zhou , LiXin, Yu , JianXiu, Chen , GuoQiang, Huang , YiRan, Yu , Zhuo, Feng , LiXin PLZF mediates the PTEN/AKT/FOXO3a signaling in suppression of prostate tumorigenesis. PLoS ONE, 2013-12-10;8(12):e77922. 2013-12-10 [PMID: 24339862] (Western Blot, Human)	Western Blot	Human
Kathrin Gassei, Kyle E. Orwig SALL4 Expression in Gonocytes and Spermatogonial Clones of Postnatal Mouse Testes PLoS ONE 1/11/2013 [PMID: 23326552]
Mathew , Rebecca, Seiler , Michael, Scanlon , Seth T, Mao , Ai-ping, Constantinides , Michael, Bertozzi-Villa , Clara, Singer , Jeffrey, Bendelac , Albert BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs. Nature, 2012-10-21;491(7425):618-21. 2012-10-21 [PMID: 23086144] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Show All 45 Publications. Collapse Publications.

Array AF2944

• PLZF Antibodies
• PLZF Lysate
• PLZF Proteins