NG2/MCSP Antibody (546930)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

NG2, also called MCSP (melanoma-associated chondroitin sulfate proteoglycan), CSPG4, or AN2, is a 400-500 kDa proteoglycan found on multiple cell types, including immature oligodendrocytes, osteoblasts, chondroblasts, and pericytes.  It interacts with integrin alpha 3 beta 1, galectin 3, MMP16, collagen VI and PDGFR alpha .  Mature mouse NG2 is a 2298 amino acid (aa) type I transmembrane glycoprotein.  The extracellular region is 2200 aa in length (aa 30-2229), while the cytoplasmic domain is 76 aa in size. The glycoprotein component of NG2 is approximately 300-315 kDa in size.  Proteolytic cleavage generates a 290 and 275 kDa form (excluding the chondroitin sulfate moiety).  There are two splice variants.  One shows a 38 aa substitution for aa 1657-2327, while another shows an alternate start site at Met1667.  Over aa 31-420, mouse NG2 shares 95% and 80% aa identity with rat and human NG2, respectively.    

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: ICC, IHC, Immunohistochemistry.

Showing Publications 1 - 10 of 14. Show All 14 Publications. Collapse Publications.

Publications using MAB6689	Applications	Species
Gonzalez Galofre, ZN;Kilpatrick, AM;Marques, M;Sá da Bandeira, D;Ventura, T;Gomez Salazar, M;Bouilleau, L;Marc, Y;Barbosa, AB;Rossi, F;Beltran, M;van de Werken, HJG;van IJcken, WFJ;Henderson, NC;Forbes, SJ;Crisan, M; Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo Nature communications 2024-02-23 [PMID: 38395882] (IHC, Mouse)	IHC	Mouse
Chao, AS;Matak, P;Pegram, K;Powers, J;Hutson, C;Jo, R;Dubois, L;Thompson, JW;Smith, PB;Jain, V;Liu, C;Younge, NE;Rikard, B;Reyes, EY;Shinohara, ML;Gregory, SG;Goldberg, RN;Benner, EJ; 20-?Hydroxycholesterol, an oxysterol in human breast milk, reverses mouse neonatal white matter injury through Gli-dependent oligodendrogenesis Cell stem cell 2023-08-03 [PMID: 37541211] (IHC, Mouse)	IHC	Mouse
Aue, A;Englert, N;Harrer, L;Schwiering, F;Gaab, A;König, P;Adams, R;Schmidtko, A;Friebe, A;Groneberg, D; NO-sensitive guanylyl cyclase discriminates pericyte-derived interstitial from intra-alveolar myofibroblasts in murine pulmonary fibrosis Respiratory research 2023-06-22 [PMID: 37349733] (Immunohistochemistry, Mouse)	Immunohistochemistry	Mouse
DV Oliveira, KG Coupland, W Shao, S Jin, F Del Gaudio, S Wang, R Fox, JW Rutten, J Sandin, H Zetterberg, J Lundkvist, SA Lesnik Obe, U Lendahl, H Karlström Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model Embo Molecular Medicine, 2022-12-16;0(0):e16556. 2022-12-16 [PMID: 36524456] (IHC, Mouse)	IHC	Mouse
Bretheau F, Castellanos-Molina A, B�langer D et al. The alarmin interleukin-1? triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury Nature Communications 2022-10-02 [PMID: 36184639]
D Sá da Band, AM Kilpatrick, M Marques, M Gomez-Sala, T Ventura, ZN Gonzalez, D Stefancova, F Rossi, M Vermeren, CS Vink, M Beltran, NC Henderson, B Jung, R van der Li, HJG van de Wer, WFJ van Ijcken, C Betsholtz, SJ Forbes, H Cuervo, M Crisan PDGFRbeta+ cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny Oncogene, 2022-07-19;40(3):111114. 2022-07-19 [PMID: 35858557] (IHC, Mouse)	IHC	Mouse
T Nadeem, W Bogue, B Bigit, H Cuervo Deficiency of Notch signaling in pericytes results in arteriovenous malformations JCI Insight, 2020-11-05;5(21):. 2020-11-05 [PMID: 33148887] (IHC, Mouse)	IHC	Mouse
Matthew S. Elitt, Lilianne Barbar, H. Elizabeth Shick, Berit E. Powers, Yuka Maeno-Hikichi, Mayur Madhavan et al. Suppression of proteolipid protein rescues Pelizaeus–Merzbacher disease Nature 2020-09-17 [PMID: 32610343]
EM Buhl, S Djudjaj, BM Klinkhamme, K Ermert, VG Puelles, MT Lindenmeye, CD Cohen, C He, E Borkham-Ka, R Weiskirche, B Denecke, P Trairatphi, J Saez-Rodri, TB Huber, LE Olson, J Floege, P Boor Dysregulated mesenchymal PDGFR-&beta drives kidney fibrosis EMBO Mol Med, 2020-01-14;0(0):e11021. 2020-01-14 [PMID: 31943786] (IHC, Mouse)	IHC	Mouse
JC Wang, GY Li, B Wang, SX Han, X Sun, YN Jiang, YW Shen, C Zhou, J Feng, SY Lu, JL Liu, MD Wang, PJ Liu Metformin inhibits metastatic breast cancer progression and improves chemosensitivity by inducing vessel normalization via PDGF-B downregulation J. Exp. Clin. Cancer Res., 2019-06-04;38(1):235. 2019-06-04 [PMID: 31164151] (IHC, Mouse)	IHC	Mouse
Sawaguchi S, Varshney S, Ogawa M et al. O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals eLife 2017-04-11 [PMID: 28395734]
N Yang, W Zhang, T He, Y Xing Silencing of galectin-1 inhibits retinal neovascularization and ameliorates retinal hypoxia in a murine model of oxygen-induced ischemic retinopathy Exp. Eye Res, 2017-02-28;0(0):. 2017-02-28 [PMID: 28257831] (ICC, Mouse)	ICC	Mouse
Mattia Quattrocelli, Giorgia Giacomazzi, Sarah Y. Broeckx, Liesbeth Ceelen, Selin Bolca, Jan H. Spaas et al. Equine-Induced Pluripotent Stem Cells Retain Lineage Commitment Toward Myogenic and Chondrogenic Fates Stem Cell Reports 2016-01-12 [PMID: 26771353]
Paez-Gonzalez Patricia, Asrican Brent, Rodriguez Erica, Kuo Chay T. Identification of distinct ChAT(+) neurons and activity-dependent control of postnatal SVZ neurogenesis. Nat Neurosci. 6/1/2014 [PMID: 24880216]
Show All 14 Publications. Collapse Publications.

Array MAB6689

• NG2/MCSP Antibodies
• NG2/MCSP ELISA Kits
• NG2/MCSP Proteins
• NG2/MCSP Proteins and Enzyme