GFAP Antibody

Glial fibrillary acidic protein (GFAP) is a class III intermediate filament protein that is largely expressed in astrocytes in addition to non-myelinating Schwann cells and glial cells (1,2). Other members of the type III intermediate filament family include desmin, peripherin, and vimentin (2-4). GFAP was first identified in the brains of multiple sclerosis patients (2). Human GFAP protein is 432 amino acids in length with a theoretical molecular weight of ~50 kDa (1,3). GFAP has at least 10 known isoforms, with the most prevalent and common in the brain being GFAP-alpha which is made of a head domain, a rod domain with four coils (1A, 1B, 2A, 2B) joined by linker regions, and a tail domain (1). GFAP is a marker of mature astrocytes, but is also expressed throughout development in both fetal and adult neural stem cells (2). While the exact function of GFAP is still elusive, it has been shown to play a role in cellular processes such as migration, mitosis, structural integrity, and signaling (2).

An increase in GFAP levels is often associated with neuroinflammation which results in the activation and proliferation of astroglia cell population (1,2). GFAP expression is also observed in brains of patients with neurodegenerative diseases including Alzheimer's and Parkinson's, epilepsy disorders, and brain injuries (1-4). Lesion sites associated with neurodegeneration can exhibit an array of gliosis characteristics from glial scarring with reduced astrocyte proliferation to activated, GFAP-positive astrocytes surrounding amyloid plaques (2). Furthermore, the GFAP gene is a target of single nucleotide polymorphisms in the coding region, considered a gain-of-function mutation, characterized by astrocytic inclusions, termed Rosenthal fibers, resulting in Alexander Disease (1-4). GFAP is also a center of many post-translational modifications, such as phosphorylation, which can alter various aspects of filament assembly (1,4).

References

1. Yang, Z., & Wang, K. K. (2015). Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker. Trends in Neurosciences. https://doi.org/10.1016/j.tins.2015.04.003

2. Hol, E. M., & Capetanaki, Y. (2017). Type III Intermediate Filaments Desmin, Glial Fibrillary Acidic Protein (GFAP), Vimentin, and Peripherin. Cold Spring Harbor Perspectives in Biology. https://doi.org/10.1101/cshperspect.a021642

3. Potokar, M., Morita, M., Wiche, G., & Jorgacevski, J. (2020). The Diversity of Intermediate Filaments in Astrocytes. Cells. https://doi.org/10.3390/cells9071604

4. Viedma-Poyatos, a., Pajares, M. A., & Perez-Sala, D. (2020). Type III intermediate filaments as targets and effectors of electrophiles and oxidants. Redox Biology. https://doi.org/10.1016/j.redox.2020.101582

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 6 confirmed species: Human, Mouse, Rat, Chicken, Guinea Pig, Rabbit.

We have publications tested in 8 applications: B/N, Chemotaxis, ICC/IF, IF/IHC, IHC, IHC-Fr, IHC-P, WB.

Showing Publications 1 - 10 of 102. Show All 102 Publications. Collapse Publications.

Publications using NB300-141	Applications	Species
chen p, Lin M, Chen R et al. NeuroD1 improved neurocognitive function in a mouse model of subarachnoid hemorrhage Research Square 2023-04-03 (IHC, Mouse)	IHC	Mouse
Yang P, Liao C, Hu Q et al. Benzene, 1,2,4-Trimethoxy-5-(2-Methyl-1-Propen-1-yl) Attenuates D-galactose/AlCl3-induced Cognitive Impairment by Inhibiting Inflammation, Apoptosis, and improving Expression of Memory-Related Proteins Neuroscience 2023-06-14 [PMID: 37327966]
Richards K, Coulthard L, Rome C et al. Glass-brain mapping provides an adjunct tool for structural analysis in mouse models of neurodevelopmental disease Neuroimage: Reports 2021-06-01
Liao Z, Wang W, Deng W et al. Human Umbilical Cord Mesenchymal Stem Cells-Secreted TSG-6 Is Anti-Inflammatory and Promote Tissue Repair After Spinal Cord Injury ASN Neuro 2021-01-01 (IF/IHC, Rat)	IF/IHC	Rat
Chang CY, Hung JH, Wu CC et al. Enhancer regulation for induced WNT3A expression during neuronal regeneration bioRxiv 2019-12-02 (Chemotaxis, Rat)	Chemotaxis	Rat
Chen Y, Wu XL, Hu HB et al. Neuronal MeCP2 in the dentate gyrus regulates mossy fiber sprouting of mice with temporal lobe epilepsy Neurobiology of disease 2023-11-01 [PMID: 37931884] (IHC, Mouse) Details: Dilution 1:2000	IHC	Mouse
Tan R, Hu X, Wang X et al. Leptin Promotes the Proliferation and Neuronal Differentiation of Neural Stem Cells through the Cooperative Action of MAPK/ERK1/2, JAK2/STAT3 and PI3K/AKT Signaling Pathways International journal of molecular sciences 2023-10-13 [PMID: 37894835] (ICC/IF, Rat)	ICC/IF	Rat
Richards T, Perron JC, Patel K et al. Therapeutic Intervention of Neuroinflammatory Alzheimer Disease Model by Inhibition of Classical Complement Pathway with the Use of Anti-C1r Loaded Exosomes Research square 2023-10-18 [PMID: 37886595] (IHC, Rat) Details: ICC/IF dilution 1:200; IHC dilution 1:500	IHC	Rat
de Paiva I, Silva R, Mendonça I et al. Semaglutide Attenuates Anxious And Depressive-Like Behaviors and Reverses The Cognitive Impairment in a Type 2 Diabetes Mellitus Via The Microbiota-Gut-Brain Axis Research Square 2023-09-15 (IHC, Mouse)	IHC	Mouse
Grigorash BB, van Essen D, Liang G et al. p16High senescence restricts cellular plasticity during somatic cell reprogramming Nature cell biology 2023-09-01 [PMID: 37652981] (IHC-P, Mouse) Details: 1:1000 IHC-P dilution	IHC-P	Mouse
Williams EP, Xue Y, Lee J et al. Deep spatial profiling of Venezuelan equine encephalitis virus reveals increased genetic diversity amidst neuroinflammation and cell death during brain infection Journal of Virology 2023-08-31 [PMID: 37560924]
Poelaert KCK, van Kleef RGDM, Liu M et al. Enterovirus D-68 Infection of Primary Rat Cortical Neurons: Entry, Replication, and Functional Consequences mBio 2023-03-06 [PMID: 36877033] (ICC/IF, Rat)	ICC/IF	Rat
Pawlik K, Ciapa?a K, Ciechanowska A et al. Pharmacological Evidence of the Important Roles of CCR1 and CCR3 and Their Endogenous Ligands CCL2/7/8 in Hypersensitivity Based on a Murine Model of Neuropathic Pain Cells 2022-12-26 [PMID: 36611891]
Chen P, Liu X, Lin M et al. NeuroD1 administration ameliorated neuroinflammation and boosted neurogenesis in a mouse model of subarachnoid hemorrhage Research Square 2023-06-30 (IHC-Fr, Mouse)	IHC-Fr	Mouse
Ciechanowska A, Rojewska E, Piotrowska A et al. New insights into the analgesic properties of the XCL1/XCR1 and XCL1/ITGA9 axes modulation under neuropathic pain conditions - evidence from animal studies Frontiers in immunology 2022-12-22 [PMID: 36618360] (WB, Mouse)	WB	Mouse
Mona K, Marnick C, Sumin C et al. Anatomical barriers against SARS-CoV-2 neuroinvasion at vulnerable interfaces visualized in deceased COVID-19 patients Neuron 2022-11-01 [PMID: 36446381] (IF/IHC, Human)	IF/IHC	Human
Kong W, Montano M, Corley MJ et al. Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of Neurons mBio 2022-10-31 [PMID: 36314791] (IHC-Fr, Human)	IHC-Fr	Human
Schr�ter M, Wang C, Terrigno M et al. Functional imaging of brain organoids using high-density microelectrode arrays MRS Bulletin 2022-06-30 [PMID: 36120104]
Kanaya A, Yang M, Emala C, Mikami M. Chronic allergic lung inflammation negatively influences neurobehavioral outcomes in mice Journal of Neuroinflammation 2022-08-31 [PMID: 36045388] (B/N, WB)	B/N, WB
Gong J, Liu Y, Chung TH et al. Intracerebral lentiviral ABCD1 gene therapy in an early disease onset ALD mouse model Gene therapy 2022-07-06 [PMID: 35790794]
Benton KC, Wheeler DS, Kurtoglu B et al. Norepinephrine activates ?(1) -adrenergic receptors at the inner nuclear membrane in astrocytes Glia 2022-09-01 [PMID: 35589612] (WB, ICC/IF, B/N)	WB, ICC/IF, B/N
Killoy, KM;Harlan, BA;Pehar, M;Vargas, MR; NR1D1 downregulation in astrocytes induces a phenotype that is detrimental to cocultured motor neurons FASEB journal : official publication of the Federation of American Societies for Experimental Biology [PMID: 35319791] (ICC/IF, Mouse)	ICC/IF	Mouse
Barut J, Rafa-Zablocka K, Jurga AM et al. Genetic lesions of the noradrenergic system trigger induction of oxidative stress and inflammation in the ventral midbrain Neurochemistry international 2022-02-09 [PMID: 35150790] (WB, Mouse)	WB	Mouse
MendonCa IP, Paiva IHR, Duarte-Silva EP et al. Metformin and fluoxetine improve depressive-like behavior in a murine model of Parkinsons disease through the modulation of neuroinflammation, neurogenesis and neuroplasticity International immunopharmacology 2022-01-01 [PMID: 34890997] (IF/IHC, Mouse)	IF/IHC	Mouse
Jin L, Xiao L, Ding M Et al. Heterogeneous macrophages contribute to the pathology of disc herniation induced radiculopathy The spine journal : official journal of the North American Spine Society 2021-10-27 [PMID: 34718176] (IF/IHC, Human)	IF/IHC	Human
Kirschner A, Strat AN, Yablonski J Et al. Mechanosensitive channel inhibition attenuates TGF beta 2-induced actin cytoskeletal remodeling and reactivity in mouse optic nerve head astrocytes Exp Eye Res 2021-10-17 [PMID: 34656548] (IF/IHC, WB, Rat, Mouse)	IF/IHC, WB	Rat, Mouse
Wang Z, Wang H, Becker R et al. Acoustofluidic separation enables early diagnosis of traumatic brain injury based on circulating exosomes Microsyst Nanoeng 2021-09-27 [PMID: 34567734]
Kilic U, Elibol B, Beker M et al. Inflammatory Cytokines are in Action: Brain Plasticity and Recovery after Brain Ischemia Due to Delayed Melatonin Administration Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2021-09-18 [PMID: 34547676] (IF/IHC, Mouse)	IF/IHC	Mouse
Jeon H, Kim M, Park W et al. Upregulation of AQP4 Improves Blood-Brain Barrier Integrity and Perihematomal Edema Following Intracerebral Hemorrhage Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2021-09-20 [PMID: 34545550] (IF/IHC, Mouse)	IF/IHC	Mouse
Serpe C, Monaco L, Relucenti M Et al. Microglia-Derived Small Extracellular Vesicles Reduce Glioma Growth by Modifying Tumor Cell Metabolism and Enhancing Glutamate Clearance through miR-124 Cells 2021-08-12 [PMID: 34440835] (IF/IHC, Mouse)	IF/IHC	Mouse
Parvin S, Williams CR, Jarrett SA, Garraway SM Spinal Cord Injury Increases Pro-inflammatory Cytokine Expression in Kidney at Acute and Sub-chronic Stages Inflammation 2021-08-21 [PMID: 34417952] (WB, Mouse)	WB	Mouse
Cocozza G, Garofalo S, Morotti M Et al. The feeding behaviour of ALS mouse models is modulated by the Ca2+ -activated KCa3.1 channels British journal of pharmacology 2021-08-19 [PMID: 34411281] (Mouse)		Mouse
Di Martino R, Sisalli MJ, Sirabella R et al. Ncx3-Induced Mitochondrial Dysfunction in Midbrain Leads to Neuroinflammation in Striatum of A53t-?-Synuclein Transgenic Old Mice International Journal of Molecular Sciences 2021-07-30 [PMID: 34360942] (WB)	WB
Teng Y, Liu Z, Chen X et al. Conditional deficiency of m6A methyltransferase Mettl14 in substantia nigra alters dopaminergic neuron function Journal of Cellular and Molecular Medicine 2021-09-01 [PMID: 34288397] (WB)	WB
Oliveira WH, Braga CF, LOs DB et al. Metformin prevents p-tau and amyloid plaque deposition and memory impairment in diabetic mice Experimental brain research 2021-07-20 [PMID: 34283253]
Wang M, Feng L, Li Z et al. Thymosin beta-4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-kappa B signaling axis in APP/PS1 mice Journal of Neuroinflammation 2021-12-01 [PMID: 34183019] (IF/IHC, Mouse)	IF/IHC	Mouse
Maimon R, Chillon-Marinas C, Snethlage CE et al. Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB Nature neuroscience 2021-06-03 [PMID: 34083786] (IF/IHC, Mouse)	IF/IHC	Mouse
Vegh C, Wear D, Okaj I et al. Combined Ubisol-Q10 and Ashwagandha Root Extract Target Multiple Biochemical Mechanisms and Reduces Neurodegeneration in a Paraquat-Induced Rat Model of Parkinsons Disease Antioxidants 2021-04-06 [PMID: 33917328] (IF/IHC, Rat)	IF/IHC	Rat
Sun Z, Cheng Z, Gong N et al. Neural presbycusis at ultra-high frequency in aged common marmosets and rhesus monkeys Aging (Albany NY) 2021-05-15 [PMID: 33909598] (B/N)	B/N
Presa M, Bailey RM, Davis C et al. AAV9-mediated FIG4 delivery prolongs life span in Charcot Marie Tooth disease type 4J mouse model The Journal of clinical investigation 2021-04-20 [PMID: 33878035] (WB, Mouse)	WB	Mouse
Derbis M, Kul E, Niewiadomska D et al. Short antisense oligonucleotides alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats Nature communications 2021-02-24 [PMID: 33627639] (WB, Human)	WB	Human
Lee H, Koh JY Roles for H+ /K+ -ATPase and zinc transportor 3 in cAMP-mediated lysosomal acidification in bafilomycin A1-treated astrocytes Glia 2020-12-14 [PMID: 33314298]
Kikuoka R, Miyazaki I, Kubota N et al. Mirtazapine exerts astrocyte-mediated dopaminergic neuroprotection Sci Rep 2020-11-26 [PMID: 33244123] (IF/IHC, Rat) Details: Immunohistochemical analysis of rat neurons and astrocytes.	IF/IHC	Rat
Rimola, V, Hahnefeld, L Et al. Lysophospholipids Contribute to Oxaliplatin-Induced Acute Peripheral Pain. J Neurosci 2020-12-02 [PMID: 33158961] (WB, ICC/IF, Human)	WB, ICC/IF	Human
Zeltser N, Meyer I, Hernandez GV et al. Neurodegeneration in juvenile Iberian pigs with diet-induced nonalcoholic fatty liver disease Am. J. Physiol. Endocrinol. Metab. 2020-09-01 [PMID: 32744096]
Zajaczkowska R, Kwiatkowski K, Pawlik K et al. Metamizole relieves pain by influencing cytokine levels in dorsal root ganglia in a rat model of neuropathic pain Pharmacol Rep 2020-07-20 [PMID: 32691345] (WB, Rat)	WB	Rat
Hernandez-Rodriguez M, Arciniega-Martinez IM, Garcia-Marin ID et al. Chronic Administration of Scopolamine Increased GSK3betaP9, Beta Secretase, Amyloid Beta, and Oxidative Stress in the Hippocampus of Wistar Rats Mol. Neurobiol. 2020-07-07 [PMID: 32638218] Details: Citation using the HRP format of this antibody.
Lavi E, Cong L Type I Astrocytes and Microglia Induce a Cytokine Response in an Encephalitic Murine Coronavirus Infection Exp Mol Pathol. 2020-05-23 [PMID: 32454103] (ICC/IF, Mouse)	ICC/IF	Mouse
Wang M, Zong Hf, Chang Kw et Al. 5-HT1AR alleviates A beta-induced cognitive decline and neuroinflammation through crosstalk with NF-kappa B pathway in mice Int. Immunopharmacol. 2020-01-01 [PMID: 32143008] (IF/IHC, Mouse)	IF/IHC	Mouse
Chang CY, Liang MZ, Wu CC et al. WNT3A Promotes Neuronal Regeneration upon Traumatic Brain Injury Int J Mol Sci 2020-02-21 [PMID: 32098078] (IHC-P, Rat)	IHC-P	Rat
Ciechanowska A, Popiolek-Barczyk K, Pawlik K et al. Changes in macrophage inflammatory protein-1 (MIP-1) family members expression induced by traumatic brain injury in mice Immunobiology 2020-02-01 [PMID: 32059938] (WB, Mouse)	WB	Mouse
Tanaka T, Murata H, Miyazaki R, et al. Human recombinant erythropoietin improves motor function in rats with spinal cord compression-induced cervical myelopathy PLoS ONE 2019-12-10 [PMID: 31821342] (IF/IHC, Rat)	IF/IHC	Rat
Murtaj V, Belloli S, Di Grigoli G et al. Age and Sex Influence the Neuro-inflammatory Response to a Peripheral Acute LPS Challenge Front Aging Neurosci 2019-11-05 [PMID: 31749696] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Mazur C, Powers B, Zasadny K et al. Brain pharmacology of intrathecal antisense oligonucleotides revealed through multimodal imaging JCI Insight 2019-10-17 [PMID: 31619586] (IHC-Fr, Rat)	IHC-Fr	Rat
Piotrowska A, Rojewska E, Pawlik K et al. Pharmacological Blockade of Spinal CXCL3/CXCR2 Signaling by NVP CXCR2 20, a Selective CXCR2 Antagonist, Reduces Neuropathic Pain Following Peripheral Nerve Injury Front Immunol 2019-09-26 [PMID: 31616413] (WB, Mouse, Rat)	WB	Mouse, Rat
McAvoy KM, Rajamohamed Sait H, Marsh G et al. Cell-autonomous and non-cell autonomous effects of neuronal BIN1 loss in vivo PLoS ONE 2019-08-13 [PMID: 31408457] (ICC/IF, Mouse, Rat)	ICC/IF	Mouse, Rat
de Carvalho T, Peixoto C, de Paiva I et al. Does physical exercise influence in the development of Neuroeschistosomiasis? Brain Research Bulletin 2019-08-01 [PMID: 31377443] (IF/IHC, Mouse)	IF/IHC	Mouse
FranCa MER, Ramos RKLG, Oliveira WH et al. Tadalafil restores long-term memory and synaptic plasticity in mice with hepatic encephalopathy Toxicol. Appl. Pharmacol. 2019-07-16 [PMID: 31323263] (IHC-P, Mouse)	IHC-P	Mouse
Crotti A, Sait HR, McAvoy KM et al. BIN1 favors the spreading of Tau via extracellular vesicles Sci Rep 2019-07-01 [PMID: 31263146] (IF/IHC, Mouse)	IF/IHC	Mouse
Schober ME, Requena DF, Casper TC Et al. Docosahexaenoic acid decreased neuroinflammation in rat pups after controlled cortical impact Exp Neurol 2019-06-28 [PMID: 31247195] (WB, Human)	WB	Human
Epperly M W, Fisher R et al. Amelioration of Amyotrophic Lateral Sclerosis in SOD1G93A Mice by M2 Microglia from Transplanted Marrow. In Vivo 2019-04-28 [PMID: 31028184] (ICC/IF, Mouse)	ICC/IF	Mouse
Gimenes AD, Andrade BFD, Pinotti JVP et al. Annexin A1-derived peptide Ac2-26 in a pilocarpine-induced status epilepticus model: anti-inflammatory and neuroprotective effects J Neuroinflammation. 2019-02-11 [PMID: 30755225] (WB, Rat)	WB	Rat
Sankar SB, Pybus AF, Liew A et al. Low cerebral blood flow is a non-invasive biomarker of neuroinflammation after repetitive mild traumatic brain injury Neurobiol. Dis. 2018-12-25 [PMID: 30592976] (WB, Mouse)	WB	Mouse
Lepore F, D'Alessandro G, Antonangeli F et al. CXCL16/CXCR6 Axis Drives Microglia/Macrophages Phenotype in Physiological Conditions and Plays a Crucial Role in Glioma Front Immunol 2018-11-27 [PMID: 30542347] (IF/IHC, Mouse)	IF/IHC	Mouse
Cocozza G, di Castro MA, Carbonari L et al. Ca2+-activated k+ channels modulate microglia affecting motor neuron survival in hSOD1G93A mice. Brain Behav. Immun. 2018-07-03 [PMID: 29981425] (ICC/IF, Mouse)	ICC/IF	Mouse
Grimaldi A, Brighi C, Peruzzi G et al. Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer's disease in the 3xTg-AD mouse model Cell Death Dis 2018-06-07 [PMID: 29880901] (ICC/IF, Mouse)	ICC/IF	Mouse
Grimaldi A, D'Alessandro G, Di Castro MA et al. Kv1.3 activity perturbs the homeostatic properties of astrocytes in glioma Sci Rep. 2018-05-15 [PMID: 29769580] (IF/IHC, Mouse)	IF/IHC	Mouse
Jurga AM, Piotrowska A, Makuch W et al. Blockade of P2X4 Receptors Inhibits Neuropathic Pain-Related Behavior by Preventing MMP-9 Activation and, Consequently, Pronociceptive Interleukin Release in a Rat Model. Front Pharmacol. 2017-03-09 [PMID: 28275350] (WB, Rat)	WB	Rat
Klemis V, Ghura H et al. Circulating fibronectin contributes to mesangial expansion in a murine model of type 1 diabetes. Kidney Int 2017-01-06 [PMID: 28159318] (IF/IHC, Mouse)	IF/IHC	Mouse
Fil D, DeLoach A, Yadav S et al. Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease Hum. Mol. Genet 2016-12-30 [PMID: 28040732] (IHC-Fr, Human)	IHC-Fr	Human
Zychowska M, Rojewska E, Makuch W et al. Participation of pro- and anti-nociceptive interleukins in botulinum toxin A-induced analgesia in a rat model of neuropathic pain. Eur. J. Pharmacol. 2016-09-09 [PMID: 27619001]
Kenig S, Faoro V, Bourkoula E et al. Topoisomerase IIbeta mediates the resistance of glioblastoma stem cells to replication stress-inducing drugs Cancer Cell Int. 2016-07-27 [PMID: 27462186] (WB)	WB
Piotrowska A, Kwiatkowski K, Rojewska E. Direct and indirect pharmacological modulation of CCL2/CCR2 pathway results in attenuation of neuropathic pain-In vivo and in vitro evidence. J Neuroimmunol. 2016-08-15 [PMID: 27397071] (WB, Rat)	WB	Rat
Pilat D, Piotrowska A, Rojewska E et al. Blockade of IL-18 signaling diminished neuropathic pain and enhanced the efficacy of morphine and buprenorphine. Mol. Cell. Neurosci. 2016-01-05 [PMID: 26763728] (WB, Rat)	WB	Rat
Anzilotti S, Tornincasa M, Gerlini R et al. Genetic ablation of homeodomain-interacting protein kinase 2 selectively induces apoptosis of cerebellar Purkinje cells during adulthood and generates an ataxic-like phenotype. Cell Death Dis. 2015-12-04 [PMID: 26633710] (IHC-Fr, WB, Mouse)	IHC-Fr, WB	Mouse
Kwon JJ, Nabinger SC, Vega Z et al. Pathophysiological role of microRNA-29 in pancreatic cancer stroma. Sci Rep 2015-01-01 [PMID: 26095125] (ICC/IF)	ICC/IF
Popiolek-Barczyk K, Kolosowska N. Parthenolide Relieves Pain and Promotes M2 Microglia/Macrophage Polarization in Rat Model of Neuropathy. Neural Plasticity. 2015-01-01 [PMID: 26090236] (WB, Rat)	WB	Rat
Northcott PA, Lee C, Zichner T et al. Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. Nature 2014-07-24 [PMID: 25043047]
Ghods AJ, Glick R, Braun D, Feinstein D. Beneficial actions of the anti-inflammatory dimethyl fumarate in glioblastomas. Surg Neurol Int 2013-12-24 [PMID: 24404403] (ICC/IF, Mouse, Human)	ICC/IF	Mouse, Human
Adhi M, Cashman SM, Kumar-Singh R. Adeno-Associated Virus Mediated Delivery of a Non-Membrane Targeted Human Soluble CD59 Attenuates Some Aspects of Diabetic Retinopathy in Mice. PLoS One. 2013-10-22 [PMID: 24167638] (IF/IHC, ICC/IF, Mouse)	IF/IHC, ICC/IF	Mouse
D'Alessandro G, Catalano M, Sciaccaluga M et al. KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo. Cell Death Dis. 2013-08-15 [PMID: 23949222] (ICC/IF, Human, Mouse)	ICC/IF	Human, Mouse
Xia G, Santostefano KE, Goodwin M et al. Generation of Neural Cells from DM1 Induced Pluripotent Stem Cells As Cellular Model for the Study of Central Nervous System Neuropathogenesis Cell Reprogram 2013-04-01 [PMID: 23550732]
Xia G, Santostefano K, Hamazaki T et al. Generation of Human-Induced Pluripotent Stem Cells to Model Spinocerebellar Ataxia Type 2 In vitro J Mol Neurosci 2012-12-09 [PMID: 23224816] (ICC/IF, Human)	ICC/IF	Human
Gomme EA, Wirblich C, Addya S et al. Immune Clearance of Attenuated Rabies Virus Results in Neuronal Survival with Altered Gene Expression PLoS Pathog 2012-10-01 [PMID: 23071441] (ICC/IF, IHC-Fr, Mouse)	ICC/IF, IHC-Fr	Mouse
Gatzioufas Z, Stupp T, Moschos MM et al. Effect of botulinum toxin A on the intraocular pressure and the retina in an animal model Cutan Ocul Toxicol 2012-08-24 [PMID: 22917001] (ICC/IF, IF/IHC, Rat)	ICC/IF, IF/IHC	Rat
O'Donnell LA, Conway S, Rose RW, Nicolas E, Slifker M, Balachandran S, Rall GF. STAT1-Independent Control of a Neurotropic Measles Virus Challenge in Primary Neurons and Infected Mice. J Immunol;188(4):1915-23. 2012-02-15 [PMID: 22246627] (ICC/IF, Mouse)	ICC/IF	Mouse
Sims B, Clarke M, Francillion L et al. Hypoxic preconditioning involves system Xc(-) regulation in mouse neural stem cells. Stem Cell Research. 2011-09-28 [PMID: 22056639] (ICC/IF, Mouse)	ICC/IF	Mouse
Wu K, Li S, Bodhinathan K et al. Enhanced expression of Pctk1, Tcf12 and Ccnd1 in hippocampus of rats: Impact on cognitive function, synaptic plasticity and pathology. Neurobiology of Learning and Memory. 2011-09-25 [PMID: 21982980] (IHC-Fr, Rat)	IHC-Fr	Rat
Traudt CM, Tkac I, Ennis KM, Sutton LM, Mammel DM, Rao R. Postnatal morphine administration alters hippocampal development in rats. J Neurosci Res;90(1):307-14. 2012-01-01 [PMID: 21971612] (ICC/IF, IF/IHC, Rat)	ICC/IF, IF/IHC	Rat
Obara I, Tochiki KK, Geranton SM et al. Systemic inhibition of the mammalian target of rapamycin (mTOR) pathway reduces neuropathic pain in mice. Pain. 2011-09-12 [PMID: 21917376] (WB, Mouse)	WB	Mouse
Alexanian AR, Fehlings MG, Zhang Z, Maiman DJ. Transplanted Neurally Modified Bone Marrow-Derived Mesenchymal Stem Cells Promote Tissue Protection and Locomotor Recovery in Spinal Cord Injured Rats. Neurorehabil Neural Repair. 2011-08-15 [PMID: 21844281] (ICC/IF, Rat)	ICC/IF	Rat
Poole DP, Pelayo JC, Cattaruzza F et al. Transient receptor potential ankyrin 1 is expressed by inhibitory motoneurons of the mouse intestine Gastroenterology 2011-08-01 [PMID: 21689654] (IF/IHC, ICC/IF, Mouse)	IF/IHC, ICC/IF	Mouse
Marroquin Belaunzaran O, Cordero M et al. Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool PLoS One 2011-04-20 [PMID: 21533130] (ICC/IF, IF/IHC, Mouse)	ICC/IF, IF/IHC	Mouse
Chen W-S, Yueh C-Y, Huang Y-A, Hwang E. An inverted method for culturing dissociated mouse hippocampal neurons. Neurosci Res. 2011-01-01 [PMID: 21241744] (ICC/IF, Mouse)	ICC/IF	Mouse
Uthaiah RC, Hudspeth AJ. Molecular anatomy of the hair cell's ribbon synapse. J Neurosci 2010-09-15 [PMID: 20844134] (WB, Mouse, Chicken)	WB	Mouse, Chicken
Wu Q, Howell MP, Palmiter RD. Ablation of Neurons Expressing Agouti-Related Protein Activates Fos Gliosis in Postsynaptic Target Regions. J Neurosci;28(37):9218-9226. 2008-01-01 [PMID: 18784302] (IF/IHC, Mouse)	IF/IHC	Mouse
Maezawa Izumi, Maeda Nobuyo, Montine Thomas J et al. Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice. Journal of Neuroinflammation 2006-01-01 [PMID: 16603079] (WB, Mouse)	WB	Mouse
Maezawa, I et al. Neurotoxicity from innate immune response is greatest with targeted replcament of e4 allele of apolipoprotein E gene is mediated by microglial p38MAPK. FASEB J. 2006-01-01 [PMID: 16481366] (IF/IHC, Mouse)	IF/IHC	Mouse
Li Y, Fu L, Gonzales DM et al. Coronavirus neurovirulence correlates with the ability of the virus to induce proinflammatory cytokine signals from astrocytes and microglia. J Virol 2004-04-01 [PMID: 15016862] (ICC/IF, Mouse)	ICC/IF	Mouse
Henion, T et al. Expression of dystroglycan, fukutin POMGnT1 during mouse cerebellar development. Molecular Brain Research 112:177-181. 2003-01-01 [PMID: 12670716] (ICC/IF, Mouse)	ICC/IF	Mouse
Bignami A, Eng LF, Dahl D, Uyeda CT. Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence. Brain Res 43:429-35. 1972-01-01 [PMID: 4559710] (ICC/IF, Rabbit, Rat, Guinea Pig, Human)	ICC/IF	Rabbit, Rat, Guinea Pig, Human
Show All 102 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	WB	Bovine	07/28/2020	View Summary Application Western Blot Sample Tested retina Species Bovine Lot 179040517
Enlarge	5 reviewed by: Verified Customer	WB	Goat	07/28/2020	View Summary Application Western Blot Sample Tested 30ug,retina Species Goat Lot 179040517
Enlarge	5 reviewed by: Verified Customer	WB	Pig	07/28/2020	View Summary Application Western Blot Sample Tested retina Species Pig Lot 179040517 Comments Comments use at 1:500
Enlarge	5 reviewed by: Verified Customer	WB	Human	07/28/2020	View Summary Application Western Blot Sample Tested retina Species Human Lot 179040517
Enlarge	5 reviewed by: Verified Customer	WB	Mouse	07/28/2020	View Summary Application Western Blot Sample Tested retina Species Mouse Lot 179040517
Enlarge	5 reviewed by: Verified Customer	WB	Rat	07/28/2020	View Summary Application Western Blot Sample Tested retina Species Rat Lot 179-040517
Enlarge	5 reviewed by: Verified Customer	ICC	Human	06/23/2020	View Summary Application Immunocytochemistry Sample Tested mixed neuronal primary culture Species Human Lot 179040517
Enlarge	5 reviewed by: Verified Customer	IHC-P	Mouse	06/07/2019	View Summary Application Immunohistochemistry-Paraffin Sample Tested Mouse brain Species Mouse Lot 121712 Comments Comments Proteinasi K treatment; Primary Ab 1:1000. Detection with Polymer-HRP.
Enlarge	4 reviewed by: Verified Customer	IHC	Mouse	06/29/2017	View Summary Application Immunohistochemistry Sample Tested PFA Fixed Frozen Section of Mouse Brain Species Mouse Comments Comments WD [1:K]; Secondary ab RTU Polymer-HRP
	3 reviewed by: Verified Customer	ICC	Mouse	04/18/2017	View Summary Application Immunocytochemistry Sample Tested Primary mouse cortical astrocytes Species Mouse
Enlarge	5 reviewed by: Janosch Heller	ICC	Rat	03/27/2017	View Summary Application Immunocytochemistry Sample Tested Primary rat cortical neurons Species Rat Comments Comments Fixation: 4% paraformaldehyde (TAAB) in PBS, 15 minutes RT Blocking: 10% donkey serum and 1% BSA in PBS with 0.1% saponin, 1 hour RT Permeabilization: 0.1% saponin Primary Antibody: 1:1000 in PBS with 0.1% saponin, overnight, 4°C Wash: three times wash with PBS with 0.1% saponin, 10 min each Secondary Antibody: Invitrogen goat anti-rabbit Alexa647, 1:500 in PBS with 0.1% saponin, 2 hours, RT Wash: two washes with PBS with 0.1% saponin, 10 min each and three washes with PBS, 10 min each Microscope: Burker Vutara 350 The antibody labels intermediate filaments in cultured astrocytes.
Enlarge	5 reviewed by: Verified Customer	IF	Mouse	01/17/2014	View Summary Application Immunofluorescence Species Mouse

Array NB300-141

• GFAP Antibodies
• GFAP ELISA Kits
• GFAP Lysate
• GFAP Proteins
• GFAP ELISA