Desmin Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Desmin is a 53 kDa, muscle-specific molecule that belongs to the intermediate filament superfamily of cytoskeletal proteins. Cytoplasmic Desmin homopolymers form stable filamentous networks that stabilize lateral alignments of myofibrils. Human Desmin is 470 amino acid (aa) peptide. It contains an N-terminal head segment (aa 1-84), multiple coiled regions (aa 109-412), and a tail region (aa 413-470). Single amino acid substitutions and three-amino acid deletions are associated with cardio‑skeletal myopathies. Most mutations affect filament assembly. Desmin is a highly conserved protein. Over the region used as immunogen, human Desmin is 99% identical to the corresponding mouse, canine, and porcine protein sequences.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Transgenic Mouse.

We have publications tested in 7 applications: Bioassay, ICC, IHC, IHC-Fr, IHC-P, Immunohistochemistry, Western Blot.

Showing Publications 1 - 10 of 34. Show All 34 Publications. Collapse Publications.

Publications using AF3844	Applications	Species
Quach, H;Farrell, S;Wu, MJM;Kanagarajah, K;Leung, JW;Xu, X;Kallurkar, P;Turinsky, AL;Bear, CE;Ratjen, F;Kalish, B;Goyal, S;Moraes, TJ;Wong, AP; Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticity Nature communications 2024-07-13 [PMID: 39003323] (Immunohistochemistry, Human)	Immunohistochemistry	Human
Khanal, S;Liu, Y;Bamidele, AO;Wixom, AQ;Washington, AM;Jalan-Sakrikar, N;Cooper, SA;Vuckovic, I;Zhang, S;Zhong, J;Johnson, KL;Charlesworth, MC;Kim, I;Yeon, Y;Yoon, S;Noh, YK;Meroueh, C;Timbilla, AA;Yaqoob, U;Gao, J;Kim, Y;Lucien, F;Huebert, RC;Hay, N;Simons, M;Shah, VH;Kostallari, E; Glycolysis in hepatic stellate cells coordinates fibrogenic extracellular vesicle release spatially to amplify liver fibrosis Science advances 2024-06-28 [PMID: 38941469] (Immunohistochemistry, Mouse)	Immunohistochemistry	Mouse
Barbeau, S;Semprez, F;Dobbertin, A;Merriadec, L;Roussange, F;Eymard, B;Sternberg, D;Fournier, E;Karasoy, H;Martinat, C;Legay, C; Molecular Analysis of a Congenital Myasthenic Syndrome Due to a Pathogenic Variant Affecting the C-Terminus of ColQ International journal of molecular sciences 2023-11-11 [PMID: 38003406] (Bioassay, Human)	Bioassay	Human
He, S;Guo, Z;Zhou, M;Wang, H;Zhang, Z;Shi, M;Li, X;Yang, X;He, L; Spatial-temporal proliferation of hepatocytes during pregnancy revealed by genetic lineage tracing Cell stem cell 2023-09-27 [PMID: 37794588] (IHC, Transgenic Mouse)	IHC	Transgenic Mouse
Lingfei Li, Yanhai Feng, Junhui Zhang, Qiong Zhang, Jun Ren, Cheng Sun et al. Microtubule associated protein 4 phosphorylation-induced epithelial-to-mesenchymal transition of podocyte leads to proteinuria in diabetic nephropathy Cell Communication and Signaling 12/1/2022 [PMID: 35902952]
Ludovica Ceci, Lixian Chen, Leonardo Baiocchi, Nan Wu, Lindsey Kennedy, Guido Carpino et al. Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model Cellular and Molecular Gastroenterology and Hepatology 7/19/2022 [PMID: 35863741]
Olmsted ZT, Paluh JL. A combined human gastruloid model of cardiogenesis and neurogenesis iScience 6/17/2022 [PMID: 35721464]
Olmsted ZT, Paluh JL. A combined human gastruloid model of cardiogenesis and neurogenesis iScience 2022-06-17 [PMID: 35721464]
Difang Sun, Zongyi Zhan, Rui Zeng, Xiaolin Liu, Bin Wang, Fan Yang et al. Long-term and potent IOP-lowering effect of I kappa B alpha -siRNA in a nonhuman primate model of chronic ocular hypertension iScience 4/15/2022 [PMID: 35445186]
A Brodehl, C Hain, F Flottmann, S Ratnavadiv, A Gaertner, B Klauke, J Kalinowski, H Körperich, J Gummert, L Paluszkiew, MA Deutsch, H Milting The Desmin Mutation DES-c.735G>C Causes Severe Restrictive Cardiomyopathy by Inducing In-Frame Skipping of Exon-3 Biomedicines, 2021-10-05;9(10):. 2021-10-05 [PMID: 34680517] (IHC, Human)	IHC	Human
Yu-Kai Su, Oluwaseun Adebayo Bamodu, I-Chang Su, Narpati Wesa Pikatan, Iat-Hang Fong, Wei-Hwa Lee et al. Combined Treatment with Acalabrutinib and Rapamycin Inhibits Glioma Stem Cells and Promotes Vascular Normalization by Downregulating BTK/mTOR/VEGF Signaling Pharmaceuticals (Basel) 8/29/2021 [PMID: 34577576]
Cyrine Ben Dhaou, Kamel Mandi, Mickaël Frye, Angela Acheampong, Ayoub Radi, Benjamin De Becker et al. Chemerin regulates normal angiogenesis and hypoxia-driven neovascularization Angiogenesis 5/1/2022 [PMID: 34524600]
LE Bruijn, BEWM van den Ak, CM van Rhijn, JF Hamming, JHN Lindeman Extreme Diversity of the Human Vascular Mesenchymal Cell Landscape J Am Heart Assoc, 2020-11-16;9(23):e017094. 2020-11-16 [PMID: 33190596] (IHC, Human)	IHC	Human
M Hara-Chiku, M Tanaka, AS Verkman, M Yasui Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury Nat Commun, 2020-11-09;11(1):5666. 2020-11-09 [PMID: 33168815] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Yeojin Lee, Juliana Leslie, Ying Yang, Lei Ding Hepatic stellate and endothelial cells maintain hematopoietic stem cells in the developing liver Journal of Experimental Medicine 3/1/2021 [PMID: 33151261]
M Deng, L Xu, X Xie, X Sheng, Z Zou, M Yao Downregulation of syndecan?1 expression induces activation of hepatic stellate cells via the TGF??1/Smad3 signaling pathway Mol Med Rep, 2019-05-09;0(0):. 5/9/2019 [PMID: 31115505]
Elisabeth J. M. Huijbers, Inge M. van der Werf, Lisette D. Faber, Lena D. Sialino, Pia van der Laan, Hanna A. Holland et al. Targeting Tumor Vascular CD99 Inhibits Tumor Growth Frontiers in Immunology 4/2/2019 [PMID: 31001265]
X Han, Y Wang, W Pu, X Huang, L Qiu, Y Li, W Yu, H Zhao, X Liu, L He, L Zhang, Y Ji, J Lu, KO Lui, B Zhou Lineage Tracing Reveals the Bipotency of SOX9+ Hepatocytes during Liver Regeneration Stem Cell Reports, 2019-02-14;12(3):624-638. 2019-02-14 [PMID: 30773487] (IHC, Mouse)	IHC	Mouse
Niu F, Liao K, Hu G et al. Cocaine-induced release of CXCL10 from pericytes regulates monocyte transmigration into the CNS. J. Cell Biol. 1/9/2019 [PMID: 30626719]
A Dubrac, SE Künzel, SH Künzel, J Li, RR Chandran, K Martin, DM Greif, RH Adams, A Eichmann NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy Nat Commun, 2018-08-27;9(1):3463. 2018-08-27 [PMID: 30150707] (IHC, Mouse)	IHC	Mouse
C Szot, S Saha, XM Zhang, Z Zhu, MB Hilton, K Morris, S Seaman, JM Dunleavey, KS Hsu, GJ Yu, H Morris, DA Swing, DC Haines, Y Wang, J Hwang, Y Feng, D Welsch, G DeCrescenz, A Chaudhary, E Zudaire, DS Dimitrov, B St Croix Tumor stroma-targeted antibody-drug conjugate triggers localized anticancer drug release J. Clin. Invest., 2018-06-04;0(0):. 2018-06-04 [PMID: 29863500] (IHC-P, Human)	IHC-P	Human
Lauren B. Rodda, Erick Lu, Mariko L. Bennett, Caroline L. Sokol, Xiaoming Wang, Sanjiv A. Luther et al. Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity Immunity 5/1/2018 [PMID: 29752062]
HS Lee, J Choi, T Son, HJ Wee, SJ Bae, JH Seo, JH Park, SH Ryu, D Lee, MK Jang, E Yu, YH Chung, KW Kim Altered AKAP12 expression in portal fibroblasts and liver sinusoids mediates transition from hepatic fibrogenesis to fibrosis resolution Exp. Mol. Med., 2018-04-27;50(4):48. 2018-04-27 [PMID: 29700280] (IHC, Human)	IHC	Human
Stephen E. McGowan, Diann M. McCoy Neuropilin-1 and platelet-derived growth factor receptors cooperatively regulate intermediate filaments and mesenchymal cell migration during alveolar septation American Journal of Physiology-Lung Cellular and Molecular Physiology 7/1/2018 [PMID: 29543041]
CA Lyon, H Williams, R Bianco, SJ Simmonds, BA Brown, KS Wadey, FCT Smith, JL Johnson, SJ George Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression Sci Rep, 2017-12-11;7(1):17342. 2017-12-11 [PMID: 29229950] (ICC, Mouse)	ICC	Mouse
Anitha K. Shenoy, Yue Jin, Huacheng Luo, Ming Tang, Christine Pampo, Rong Shao et al. Epithelial-to-mesenchymal transition confers pericyte properties on cancer cells Journal of Clinical Investigation 10/10/2016 [PMID: 27721239]
J Kloepper, L Riedemann, Z Amoozgar, G Seano, K Susek, V Yu, N Dalvie, RL Amelung, M Datta, JW Song, V Askoxylaki, JW Taylor, C Lu-Emerson, A Batista, ND Kirkpatric, K Jung, M Snuderl, A Muzikansky, KG Stubenrauc, O Krieter, H Wakimoto, L Xu, LL Munn Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival Proc Natl Acad Sci USA, 2016-04-04;113(16):4476-81. 2016-04-04 [PMID: 27044098] (IHC-P, Mouse)	IHC-P	Mouse
TE Peterson, ND Kirkpatric, Y Huang, CT Farrar, KA Marijt, J Kloepper, M Datta, Z Amoozgar, G Seano, K Jung, WS Kamoun, T Vardam, M Snuderl, J Goveia, S Chatterjee, A Batista, A Muzikansky, CC Leow, L Xu, TT Batchelor, DG Duda, D Fukumura, RK Jain Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages Proc Natl Acad Sci USA, 2016-04-04;113(16):4470-5. 2016-04-04 [PMID: 27044097] (IHC-P, Mouse)	IHC-P	Mouse
Liu Q, Yang R, Huang X, Zhang H, He L, Zhang L, Tian X, Nie Y, Hu S, Yan Y, Zhang L, Qiao Z, Wang Q, Lui K, Zhou B Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes. Cell Res, 2015-12-04;26(1):119-30. 2015-12-04 [PMID: 26634606] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Riordan D, Varma S, West R, Brown P Automated Analysis and Classification of Histological Tissue Features by Multi-Dimensional Microscopic Molecular Profiling. PLoS ONE, 2015-07-15;10(7):e0128975. 2015-07-15 [PMID: 26176839] (IHC-P, Human)	IHC-P	Human
Maury Y, Come J, Piskorowski R, Salah-Mohellibi N, Chevaleyre V, Peschanski M, Martinat C, Nedelec S Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes. Nat Biotechnol, 2014-11-10;33(1):89-96. 2014-11-10 [PMID: 25383599] (IHC, Human)	IHC	Human
Durruthy-Durruthy , Jens, Briggs , Sharon F, Awe , Jason, Ramathal , Cyril Y, Karumbayaram , Saravana, Lee , Patrick, Heidmann , Julia D, Clark , Amander, Karakikes , Ioannis, Loh , Kyle M, Wu , Joseph C, Hoffman , Andrew R, Byrne , James, Reijo Pera , Renee A, Sebastiano , Vittorio Rapid and efficient conversion of integration-free human induced pluripotent stem cells to GMP-grade culture conditions. PLoS ONE, 2014-04-09;9(4):e94231. 2014-04-09 [PMID: 24718618] (ICC, Human)	ICC	Human
Brodehl A, Dieding M, Klauke B, Dec E, Madaan S, Huang T, Gargus J, Fatima A, Saric T, Cakar H, Walhorn V, Tonsing K, Skrzipczyk T, Cebulla R, Gerdes D, Schulz U, Gummert J, Svendsen J, Olesen M, Anselmetti D, Christensen A, Kimonis V, Milting H The novel desmin mutant p.A120D impairs filament formation, prevents intercalated disk localization, and causes sudden cardiac death. Circ Cardiovasc Genet, 2013-11-07;6(6):615-23. 2013-11-07 [PMID: 24200904] (IHC-Fr, Human)	IHC-Fr	Human
Brodehl A, Hedde PN, Dieding M, Fatima A, Walhorn V, Gayda S, Šarić T, Klauke B, Gummert J, Anselmetti D, Heilemann M, Nienhaus GU, Milting H Dual color photoactivation localization microscopy of cardiomyopathy-associated desmin mutants. J. Biol. Chem., 2012-03-08;287(19):16047-57. 2012-03-08 [PMID: 22403400] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Show All 34 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Wan-Ching Cheng	WB	Cat	10/27/2018	View Summary Application Western Blot Sample Tested Heart tissue Species Cat Lot YIL0618061 Comments Comments 1:1000 in 1%milk/TBST overnight at 4C; washed 10 min for 3 times and incubate with mouse-anti-goat-HRP monoclonal antibody for 1 hour; washed for another 5 min 3 times. Developed with ECL.
	5 reviewed by: Verified Customer	IHC-P	Human	01/08/2015	View Summary Application Immunohistochemistry-Paraffin Sample Tested See PMID 24200904 Species Human

Array AF3844

• Desmin Antibodies
• Desmin ELISA Kits
• Desmin Lysate
• Desmin Proteins