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Olig2 Antibody [Unconjugated]

Name: Olig2 Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF2418
Rating: 4.5 (2 reviews)

(198 Publications)

(2 Reviews)

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Olig2 and Oligodendrocyte Marker O4 were detected in 7 day differentiated rat cortical stem cells using 10 µg/mL Goat Anti-Human/Mouse/Rat Olig2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2418) and 10 ...read more

A172 human glioblastoma cell line were fixed using formaldehyde, resuspended in lysis buffer, and sonicated to shear chromatin. Olig2/DNA complexes were immunoprecipitated using 5 μg Goat Anti-Human/Mouse/Rat Olig2 ...read more

Olig2 was detected in immersion fixed frozen sections of mouse embryo (13 d.p.c.) using Goat Anti-Human/Mouse/Rat Olig2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2418) at 8 µg/mL overnight at 4 °C. ...read more

Olig2 was detected in immersion fixed paraffin-embedded sections of human brain (cortex) using Goat Anti-Human/Mouse/Rat Olig2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2418) at 10 µg/mL for ...read more

Olig2 was detected in immersion fixed paraffin-embedded sections of rat midbrain using Goat Anti-Human/Mouse/Rat Olig2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2418) at 10 µg/mL for 1 hour ...read more

Pathological analysis of l2hgdh-/- mice.The figure compares the histological and ultrastructural appearance of the brain of l2hgdh+/+ (left panels: A, B, E, G, H, K, L) and l2hgdh-/- mice (right panels: C, D, F, I, J, ...read more

alpha -Syn PFF exposure to immature OLGs during differentiation-induced abnormal oligodendrogenesis. a Confocal images of oligodendroglial cells on day 4 after differentiation induction showing the colocalization of ...read more

Product Details

Summary

Reactivity	Hu, Mu, RtSpecies Glossary
Applications	WB, IHC, ChIP, Dual ISH-IHC, ICC/IF
Clonality	Polyclonal
Host	Goat
Conjugate	Unconjugated
Concentration	LYOPH

Order Details

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Catalog# & Conjugate	Size	Price
Biotin BAF2418

View Available Formulations

Catalog# & Formulation	Size	Price
Carrier Free AF2418-SP

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Conjugate	Catalog #	Availability	Size	Price
Biotin	BAF2418

Olig2 Antibody [Unconjugated] Summary

Immunogen	E. coli-derived recombinant human Olig2 Met1-Lys323 Accession # Q13516
Specificity	Detects human Olig2 in direct ELISAs and Western blots.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Goat
Gene	OLIG2
Purity Statement	Antigen Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Applications/Dilutions

Dilutions

Chromatin Immunoprecipitation (ChIP) 5 ug/5 x 10^6 cells
Dual RNAscope ISH-IHC 5-15 ug/mL
Immunocytochemistry 5-15 ug/mL
Immunohistochemistry 5-15 ug/mL
Western Blot 0.1 ug/mL

Reviewed Applications

Read 2 Reviews rated 4.5

using
AF2418 in the following applications:

Immunohistochemistry-Frozen
Immunocytochemistry

Publications

Read Publications using
AF2418 in the following applications:

Bioassay
2 publications
ChIP
1 publication
Co-Immunoprecipitation
1 publication
FISH
1 publication
Flow Cytometry
2 publications
ICC
22 publications
IHC
68 publications
IHC-Fr
7 publications
IHC-P
2 publications
IHC/IF
1 publication
Immunocytochemistry
2 publications
Immunohistochemistry
7 publications
Western Blot
9 publications

Packaging, Storage & Formulations

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Olig2 Antibody [Unconjugated]

BHLHB1
BHLHE19
Class B basic helix-loop-helix protein 1
Class E basic helix-loop-helix protein 19
human protein kinase C-binding protein RACK17
Olig2
OLIGO2
oligodendrocyte lineage transcription factor 2
oligodendrocyte transcription factor 2
oligodendrocyte-specific bHLH transcription factor 2
PRKCBP2
protein kinase C binding protein 2
Protein kinase C-binding protein 2
Protein kinase C-binding protein RACK17
RACK17
RACK17helix-loop-helix protein, class B, 1

Background

Olig1 and Olig2 are basic-helix-loop-helix (bHLH) transcription factors expressed in the motor neuron progenitor (pMN) domain of the spinal cord that generates motor neurons and oligodendrocytes. Olig1 is involved in the development and maturation of oligodendrocytes. Olig2 is required for oligodendrocyte and motor neuron specification in the spinal cord.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Olig2 Antibody (AF2418)(198)

We have publications tested in 8 confirmed species: Human, Mouse, Rat, Chicken, Ferret, Hamster - Mesocricetus auratus (Golden Hamster), Transgenic Mouse, Xenograft.

We have publications tested in 13 applications: Bioassay, ChIP, Co-Immunoprecipitation, FISH, Flow Cytometry, ICC, IHC, IHC-Fr, IHC-P, IHC/IF, Immunocytochemistry, Immunohistochemistry, Western Blot.

Showing Publications 1 - 10 of 198. Show All 198 Publications.

Publications using AF2418	Applications	Species
MacArthur, IC;Ma, L;Huang, CY;Bhavsar, H;Suzuki, M;Dawlaty, MM; Developmental DNA demethylation is a determinant of neural stem cell identity and gliogenic competence Science advances 2024-08-30 [PMID: 39196941] (Immunohistochemistry, Transgenic Mouse)	Immunohistochemistry	Transgenic Mouse

Jansen, MI;Musumeci, G;Castorina, A; Differential Expression of PACAP/VIP Receptors in the Post-Mortem CNS White Matter of Multiple Sclerosis Donors International journal of molecular sciences 2024-08-14 [PMID: 39201536] (Immunohistochemistry, Human)	Immunohistochemistry	Human
Rosberg, R;Smolag, KI;Sjölund, J;Johansson, E;Bergelin, C;Wahldén, J;Pantazopoulou, V;Ceberg, C;Pietras, K;Blom, AM;Pietras, A; Hypoxia-induced complement component 3 promotes aggressive tumor growth in the glioblastoma microenvironment JCI insight 2024-08-22 [PMID: 39172519] (Immunohistochemistry, Mouse)	Immunohistochemistry	Mouse
Park, H;Song, J;Jeong, HW;Grönloh, MLB;Koh, BI;Bovay, E;Kim, KP;Klotz, L;Thistlethwaite, PA;van Buul, JD;Sorokin, L;Adams, RH; Apelin modulates inflammation and leukocyte recruitment in experimental autoimmune encephalomyelitis Nature communications 2024-07-25 [PMID: 39060233] (Immunohistochemistry, Mouse)	Immunohistochemistry	Mouse
Hawkins, S;Mondaini, A;Namboori, SC;Nguyen, GG;Yeo, GW;Javed, A;Bhinge, A; ePRINT: exonuclease assisted mapping of protein-RNA interactions Genome biology 2024-05-28 [PMID: 38807229] (Immunocytochemistry, Human)	Immunocytochemistry	Human
Ozkan, A;Padmanabhan, HK;Shipman, SL;Azim, E;Kumar, P;Sadegh, C;Basak, AN;Macklis, JD; Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors bioRxiv : the preprint server for biology 2024-04-23 [PMID: 38712174] (Immunocytochemistry, Transgenic Mouse)	Immunocytochemistry	Transgenic Mouse
Bachmann, H;Vandemoortele, B;Vermeirssen, V;Carrette, E;Vonck, K;Boon, P;Raedt, R;Laureys, G; Vagus Nerve Stimulation enhances remyelination and decreases innate neuroinflammation in lysolecithin-induced demyelination Brain stimulation 2024-04-20 [PMID: 38648972] (Immunohistochemistry, Rat)	Immunohistochemistry	Rat
Yang, TT;Liu, PJ;Sun, QY;Wang, ZY;Yuan, GB;Fan, ZX;Ma, L;Lu, JF;Yuan, BY;Zou, WL;Zhao, LM;Li, Q;Liu, GZ; CD4+CD25+ regulatory T cells ex vivo generated from autologous naïve CD4+ T cells suppress EAE progression Scientific reports 2024-03-15 [PMID: 38491084] (Immunohistochemistry, Mouse)	Immunohistochemistry	Mouse
Huuki-Myers, LA;Montgomery, KD;Kwon, SH;Cinquemani, S;Maden, SK;Eagles, NJ;Kleinman, JE;Hyde, TM;Hicks, SC;Maynard, KR;Collado-Torres, L; Benchmark of cellular deconvolution methods using a multi-assay reference dataset from postmortem human prefrontal cortex bioRxiv : the preprint server for biology 2024-02-12 [PMID: 38405805] (IHC, Human)	IHC	Human
Zhu, Q;Liang, P;Meng, H;Li, F;Miao, W;Chu, C;Wang, W;Li, D;Chen, C;Shi, Y;Yu, X;Ping, Y;Niu, C;Wu, HB;Zhang, A;Bian, XW;Zhou, W; Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells Nature communications 2024-01-02 [PMID: 38167292] (Immunohistochemistry, Human, Xenograft)	Immunohistochemistry	Human, Xenograft
Álvarez, I;Tirado-Herranz, A;Alvarez-Palomo, B;Osete, JR;Edel, MJ; Proteomic Analysis of Human iPSC-Derived Neural Stem Cells and Motor Neurons Identifies Proteasome Structural Alterations Cells 2023-12-08 [PMID: 38132120] (ICC, Human)	ICC	Human
Bilgic, M;Wu, Q;Suetsugu, T;Shitamukai, A;Tsunekawa, Y;Shimogori, T;Kadota, M;Nishimura, O;Kuraku, S;Kiyonari, H;Matsuzaki, F; Truncated radial glia as a common precursor in the late corticogenesis of gyrencephalic mammals eLife 2023-11-21 [PMID: 37988289] (IHC, Ferret)	IHC	Ferret
Garza, R;Sharma, Y;Atacho, DAM;Thiruvalluvan, A;Abu Hamdeh, S;Jönsson, ME;Horvath, V;Adami, A;Ingelsson, M;Jern, P;Hammell, MG;Englund, E;Kirkeby, A;Jakobsson, J;Marklund, N; Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia Cell reports 2023-11-28 [PMID: 37967557] (Bioassay, Human)	Bioassay	Human
Muttathukunnel, P;Wälti, M;Aboouf, MA;Köster-Hegmann, C;Haenggi, T;Gassmann, M;Pannzanelli, P;Fritschy, JM;Schneider Gasser, EM; Erythropoietin regulates developmental myelination in the brain stimulating postnatal oligodendrocyte maturation Scientific reports 2023-11-09 [PMID: 37945644] (IHC, Mouse)	IHC	Mouse
Davaanyam, D;Lee, H;Seol, SI;Oh, SA;Kim, SW;Lee, JK; HMGB1 induces hepcidin upregulation in astrocytes and causes an acute iron surge and subsequent ferroptosis in the postischemic brain Experimental & molecular medicine 2023-11-01 [PMID: 37907744] (IHC, Rat)	IHC	Rat
Seo, JS;Lee, SH;Won, HS;Yang, M;Nahm, SS;Nam, SM; Effects of Gestational and Lactational Lead Exposure and High Fat Diet Feeding on Cerebellar Development of Postnatal Rat Offspring Nutrients 2023-10-10 [PMID: 37892401] (IHC, Rat)	IHC	Rat
Abdel Fattah, AR;Kolaitis, N;Van Daele, K;Daza, B;Rustandi, AG;Ranga, A; Targeted mechanical stimulation via magnetic nanoparticles guides in vitro tissue development Nature communications 2023-08-30 [PMID: 37644160] (IHC, Mouse)	IHC	Mouse
Walter, J;Mende, J;Hutagalung, S;Alhalabi, OT;Grutza, M;Zheng, G;Skutella, T;Unterberg, A;Zweckberger, K;Younsi, A; The Single-Dose Application of Interleukin-4 Ameliorates Secondary Brain Damage in the Early Phase after Moderate Experimental Traumatic Brain Injury in Mice International journal of molecular sciences 2023-08-14 [PMID: 37628939] (IHC, Mouse)	IHC	Mouse
Judith Niesen, Irm Hermans-Borgmeyer, Christina Krüger, Melanie Schoof, Franziska Modemann, Ulrich Schüller hGFAP-mediated GLI2 overexpression leads to early death and severe cerebellar malformations with rare tumor formation iScience 2023-09-15 [PMID: 37608807]
Nilsson G, Mottahedin A, Zelco A et al. Two different isoforms of osteopontin modulate myelination and axonal integrity FASEB BioAdvances 2023-06-17 [PMID: 37554545]
Baeza-Kallee, N;Bergès, R;Hein, V;Cabaret, S;Garcia, J;Gros, A;Tabouret, E;Tchoghandjian, A;Colin, C;Figarella-Branger, D; Deciphering the Action of Neuraminidase in Glioblastoma Models International journal of molecular sciences 2023-07-19 [PMID: 37511403] (ICC, Mouse)	ICC	Mouse
Mätlik, K;Baffuto, M;Kus, L;Deshmukh, AL;Davis, DA;Paul, MR;Carroll, TS;Caron, MC;Masson, JY;Pearson, CE;Heintz, N; Cell Type Specific CAG Repeat Expansions and Toxicity of Mutant Huntingtin in Human Striatum and Cerebellum bioRxiv : the preprint server for biology 2023-06-08 [PMID: 37333326] (Flow Cytometry, Western Blot, Human)	Flow Cytometry, Western Blot	Human
Ryann M. Fame, Huixin Xu, Aja Pragana, Maria Lehtinen Age-appropriate potassium clearance from perinatal cerebrospinal fluid depends on choroid plexus NKCC1 Fluids and Barriers of the CNS 2023-06-16 [PMID: 37328833]
Maruyama, T;Tanabe, S;Uyeda, A;Suzuki, T;Muramatsu, R; Free fatty acids support oligodendrocyte survival in a mouse model of amyotrophic lateral sclerosis Frontiers in cellular neuroscience 2023-05-12 [PMID: 37252191] (IHC, Mouse)	IHC	Mouse
Seeker, LA;Bestard-Cuche, N;J�kel, S;Kazakou, NL;B�strand, SMK;Wagstaff, LJ;Cholewa-Waclaw, J;Kilpatrick, AM;Van Bruggen, D;Kabbe, M;Baldivia Pohl, F;Moslehi, Z;Henderson, NC;Vallejos, CA;La Manno, G;Castelo-Branco, G;Williams, A; Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and�CNS function Acta neuropathologica communications 2023-05-22 [PMID: 37217978] (IHC, Human)	IHC	Human
Pressl, C;M�tlik, K;Kus, L;Darnell, P;Luo, JD;Weiss, AR;Liguore, W;Carroll, TS;Davis, DA;McBride, J;Heintz, N; Layer 5a Corticostriatal Projection Neurons are Selectively Vulnerable in Huntington's Disease bioRxiv : the preprint server for biology 2023-04-24 [PMID: 37162977] (ICC, Human)	ICC	Human
Zhang, T;Pang, W;Feng, T;Guo, J;Wu, K;Nunez Santos, M;Arthanarisami, A;Nana, AL;Nguyen, Q;Kim, PJ;Jankowsky, JL;Seeley, WW;Hu, F; TMEM106B regulates microglial proliferation and survival in response to demyelination Science advances 2023-05-05 [PMID: 37146150] (IHC, Mouse)	IHC	Mouse
Zhang T, Feng T, Wu K et al. Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination Acta Neuropathologica 2023-07-01 [PMID: 37120788]
Y Wang, D Sadike, B Huang, P Li, Q Wu, N Jiang, Y Fang, G Song, L Xu, W Wang, M Xie Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4/MyD88/NF-kappaB pathway in LPC-induced demyelination Journal of Neuroinflammation, 2023-02-18;20(1):41. 2023-02-18 [PMID: 36803990] (IHC, Mouse)	IHC	Mouse
B Rocamonde, S Alais, R Pelissier, V Moulin, B Rimbaud, R Lacoste, N Aurine, C Baquerre, B Pain, Y Tanaka, C Mathieu, H Dutartre STLV-1 Commonly Targets Neurons in the Brain of Asymptomatic Non-Human Primates MBio, 2023-02-21;0(0):e0352622. 2/21/2023 [PMID: 36802226]
Wang J, Xu L, Peng D et al. IFN-?-STAT1-mediated CD8+ T-cell-neural stem cell cross talk controls astrogliogenesis after spinal cord injury Inflammation and regeneration 2023-02-13 [PMID: 36782279]
H Park, B Cho, H Kim, T Saito, TC Saido, KJ Won, J Kim Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice Nature Communications, 2023-02-13;14(1):802. 2023-02-13 [PMID: 36781874] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
M Ferren, A Lalande, M Iampietro, L Canus, D Decimo, D Gerlier, M Porotto, C Mathieu Early Permissiveness of Central Nervous System Cells to Measles Virus Infection Is Determined by Hyperfusogenicity and Interferon Pressure Viruses, 2023-01-13;15(1):. 2023-01-13 [PMID: 36680268] (Bioassay, Hamster - Mesocricetus auratus (Golden Hamster))	Bioassay	Hamster - Mesocricetus auratus (Golden Hamster)
Marie Gavid, Louise Coulomb, Justin Thomas, Inès Aouimeur, Paul Verhoeven, Marielle Mentek et al. Technique of flat-mount immunostaining for mapping the olfactory epithelium and counting the olfactory sensory neurons PLOS ONE 2023-01-17 [PMID: 36649285]
Qing Zhao, Yanjing Zhu, Yilong Ren, Shuai Yin, Liqun Yu, Ruiqi Huang et al. Neurogenesis potential of oligodendrocyte precursor cells from oligospheres and injured spinal cord Frontiers in Cellular Neuroscience 2022-12-22 [PMID: 36619671]
Samu N Kurki, Pavel Uvarov, Alexey S Pospelov, Kalevi Trontti, Antje K Hübner, Rakenduvadhana Srinivasan et al. Expression patterns of NKCC1 in neurons and non-neuronal cells during cortico-hippocampal development Cerebral Cortex 2023-05-09 [PMID: 36573432]
S Chen, Y Chang, L Li, D Acosta, Y Li, Q Guo, C Wang, E Turkes, C Morrison, D Julian, ME Hester, DW Scharre, C Santiskulv, SX Song, JT Plummer, GE Serrano, TG Beach, KE Duff, Q Ma, H Fu Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease Acta neuropathologica communications, 2022-12-21;10(1):188. 2022-12-21 [PMID: 36544231] (IHC, Human)	IHC	Human
SI Ramos, ZM Mussa, EN Falk, B Pai, B Giotti, K Allette, P Cai, F Dekio, R Sebra, KG Beaumont, AM Tsankov, NM Tsankova An atlas of late prenatal human neurodevelopment resolved by single-nucleus transcriptomics Nature Communications, 2022-12-12;13(1):7671. 2022-12-12 [PMID: 36509746] (IHC/IF, Human)	IHC/IF	Human
I Berglar, S Hehlgans, A Wehle, C Roth, C Herold-Men, F Rödel, D Kögel, B Linder CHRDL1 Regulates Stemness in Glioma Stem-like Cells Cells, 2022-12-03;11(23):. 2022-12-03 [PMID: 36497175] (Western Blot, Human)	Western Blot	Human
Arpan G. Mazumder, Amélie M. Julé, Paul F. Cullen, Daniel Sun Astrocyte heterogeneity within white matter tracts and a unique subpopulation of optic nerve head astrocytes iScience 2022-12-22 [PMID: 36465110]
T Dierckx, S Vanherle, M Haidar, E Grajchen, F Mingneau, P Gervois, E Wolfs, D Bylemans, A Voet, T Nguyen, I Hamad, M Kleinewiet, JFJ Bogie, JJA Hendriks Phloretin enhances remyelination by stimulating oligodendrocyte precursor cell differentiation Proceedings of the National Academy of Sciences of the United States of America, 2022-11-07;119(46):e2120393119. 2022-11-07 [PMID: 36343243] (IHC, Mouse)	IHC	Mouse
Y Su, Y Zhou, ML Bennett, S Li, M Carceles-C, L Lu, S Huh, D Jimenez-Cy, BC Kennedy, SK Kessler, AN Viaene, I Helbig, X Gu, JE Kleinman, TM Hyde, DR Weinberger, DW Nauen, H Song, GL Ming A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan Cell Stem Cell, 2022-11-03;29(11):1594-1610.e8. 2022-11-03 [PMID: 36332572] (IHC, Human)	IHC	Human
T Zhou, Y Li, X Li, F Zeng, Y Rao, Y He, Y Wang, M Liu, D Li, Z Xu, X Zhou, S Du, F Niu, J Peng, X Mei, SJ Ji, Y Shu, W Lu, F Guo, T Wu, TF Yuan, Y Mao, B Peng Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice Nature Communications, 2022-10-24;13(1):6233. 2022-10-24 [PMID: 36280666] (IHC, Human)	IHC	Human
B Pai, J Tome-Garci, WS Cheng, G Nudelman, KG Beaumont, S Ghatan, F Panov, E Caballero, K Sarpong, L Marcuse, J Yoo, Y Jiang, A Schaefer, S Akbarian, R Sebra, D Pinto, E Zaslavsky, NM Tsankova High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy Acta neuropathologica communications, 2022-10-23;10(1):149. 2022-10-23 [PMID: 36274170] (IHC, Human)	IHC	Human
N Vilallongu, J Schaeffer, AM Hesse, C Delpech, B Blot, A Paccard, E Plissonnie, B Excoffier, Y Couté, S Belin, H Nawabi Guidance landscapes unveiled by quantitative proteomics to control reinnervation in adult visual system Nature Communications, 2022-10-13;13(1):6040. 2022-10-13 [PMID: 36229455] (IHC, Mouse)	IHC	Mouse
Hyun-Woo Jeong, Rodrigo Diéguez-Hurtado, Hendrik Arf, Jian Song, Hongryeol Park, Kai Kruse et al. Single-cell transcriptomics reveals functionally specialized vascular endothelium in brain eLife 2022-10-05 [PMID: 36197007]
Bretheau F, Castellanos-Molina A, B�langer D et al. The alarmin interleukin-1? triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury Nature Communications 2022-10-02 [PMID: 36184639]
A Benraiss, JN Mariani, A Tate, PM Madsen, KM Clark, KA Welle, R Solly, L Capellano, K Bentley, D Chandler-M, SA Goldman A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice Cell Reports, 2022-08-30;40(9):111291. 2022-08-30 [PMID: 36044851] (IHC, Mouse)	IHC	Mouse
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Y Hayashi, S Mikawa, C Ogawa, K Masumoto, F Katou, K Sato BMP6 expression in the adult rat central nervous system J. Chem. Neuroanat., 2019-03-27;0(0):. 2019-03-27 [PMID: 30928603] (IHC-Fr, Rat)	IHC-Fr	Rat
Linder B, Wehle A, Hehlgans S et al. Arsenic Trioxide and (-)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling Cancers (Basel) 3/12/2019 [PMID: 30871073]
Roey Baror, Björn Neumann, Michael Segel, Kevin J. Chalut, Stephen P. J. Fancy, Dorothy P. Schafer et al. Transforming growth factor‐beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors Glia 2019-07-01 [PMID: 30861188]
Sarah Jäkel, Eneritz Agirre, Ana Mendanha Mendanha Falcão, David van Bruggen, Ka Wai Lee, Irene Knuesel et al. Altered human oligodendrocyte heterogeneity in multiple sclerosis Nature 2019-02-01 [PMID: 30747918]
V Bellver-La, F Bretheau, B Mailhot, N Vallières, M Lessard, ME Janelle, N Vernoux, MÈ Tremblay, T Fuehrmann, MS Shoichet, S Lacroix Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury Nat Commun, 2019-01-31;10(1):518. 2019-01-31 [PMID: 30705270] (IHC, Mouse)	IHC	Mouse
Sylvie Berthier, Louis Larrouquère, Pierre Champelovier, Edwige Col, Christine Lefebvre, Cécile Cottet-Rouselle et al. A New Patient-Derived Metastatic Glioblastoma Cell Line: Characterisation and Response to Sodium Selenite Anticancer Agent Cancers (Basel) 2018-12-21 [PMID: 30583471]
M Osipovitch, A Asenjo Mar, JN Mariani, A Cornwell, S Dhaliwal, L Zou, D Chandler-M, S Wang, X Li, SJ Benraiss, R Agate, A Lampp, A Benraiss, MS Windrem, SA Goldman Human ESC-Derived Chimeric Mouse Models of Huntington's Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation Cell Stem Cell, 2018-12-13;0(0):. 2018-12-13 [PMID: 30554964] (IHC, Human)	IHC	Human
AM Falcão, D van Brugge, S Marques, M Meijer, S Jäkel, E Agirre, Samudyata, EM Floriddia, DP Vanichkina, C Ffrench-Co, A Williams, AO Guerreiro-, G Castelo-Br Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis Nat. Med., 2018-11-12;0(0):. 2018-11-12 [PMID: 30420755] (IHC-Fr, Mouse)	IHC-Fr	Mouse
LM Ruiz-Perer, L Schneider, BA Windmöller, J Müller, JFW Greiner, C Kaltschmid, B Kaltschmid NF-?B p65 directs sex-specific neuroprotection in human neurons Sci Rep, 2018-10-30;8(1):16012. 2018-10-30 [PMID: 30375448] (ICC, Human)	ICC	Human
Y Hayashi, S Mikawa, C Ogawa, K Masumoto, F Katou, K Sato Myostatin expression in the adult rat central nervous system J. Chem. Neuroanat., 2018-10-24;0(0):. 2018-10-24 [PMID: 30366029] (IHC, Rat)	IHC	Rat
Ghaffari S, Naderi Nabi F et al. Estrogen Inhibits LDL (Low-Density Lipoprotein) Transcytosis by Human Coronary Artery Endothelial Cells via GPER (G-Protein-Coupled Estrogen Receptor) and SR-BI (Scavenger Receptor Class B Type 1). Arterioscler Thromb Vasc Biol 1/10/2018 [PMID: 30354216]
Xiao Xu, Elitsa I Stoyanova, Agata E Lemiesz, Jie Xing, Deborah C Mash, Nathaniel Heintz Species and cell-type properties of classically defined human and rodent neurons and glia eLife 2018-10-15 [PMID: 30320555]
Q Chen, J Wu, Q Ye, F Ma, Q Zhu, Y Wu, C Shan, X Xie, D Li, X Zhan, C Li, XF Li, X Qin, T Zhao, H Wu, PY Shi, J Man, CF Qin Treatment of Human Glioblastoma with a Live Attenuated Zika Virus Vaccine Candidate MBio, 2018-09-18;9(5):. 2018-09-18 [PMID: 30228241] (IHC, Mouse)	IHC	Mouse
Lucas Schirmer, Wiebke Möbius, Chao Zhao, Andrés Cruz-Herranz, Lucile Ben Haim, Christian Cordano et al. Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity eLife 2018-09-11 [PMID: 30204081]
MK Giacci, CA Bartlett, NM Smith, KS Iyer, LM Toomey, H Jiang, P Guagliardo, MR Kilburn, M Fitzgerald Oligodendroglia are particularly vulnerable to oxidative damage after neurotrauma in vivo J. Neurosci., 2018-06-18;0(0):. 6/18/2018 [PMID: 29915135]
T Srivastava, P Diba, JM Dean, F Banine, D Shaver, M Hagen, X Gong, W Su, B Emery, DL Marks, EN Harris, B Baggenstos, PH Weigel, LS Sherman, SA Back A TLR/AKT/FoxO3 immune tolerance-like pathway disrupts the repair capacity of oligodendrocyte progenitors J. Clin. Invest., 2018-04-16;0(0):. 2018-04-16 [PMID: 29664021] (IHC, Rat)	IHC	Rat
Zhang S, RaSai A, Wang Y et al. The Stem Cell Factor Sox2 Is a Positive Timer of Oligodendrocyte Development in the Postnatal Murine Spinal Cord. Mol. Neurobiol. 4/5/2018 [PMID: 29623612]
F Cathomas, D Azzinnari, G Bergamini, H Sigrist, M Buerge, V Hoop, B Wicki, L Goetze, S Soares, D Kukelova, E Seifritz, S Goebbels, KA Nave, M Said Ghand, C Seoighe, T Hildebrand, G Leparc, H Klein, E Stupka, B Hengerer, CR Pryce Oligodendrocyte gene expression is reduced by and influences effects of chronic social stress in mice Genes Brain Behav., 2018-04-17;0(0):e12475. 2018-04-17 [PMID: 29566304] (IHC-Fr, Mouse)	IHC-Fr	Mouse
M Datta, O Staszewski, E Raschi, M Frosch, N Hagemeyer, TL Tay, T Blank, M Kreutzfeld, D Merkler, S Ziegler-Wa, P Matthias, M Meyer-Lueh, M Prinz Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner Immunity, 2018-03-13;0(0):. 2018-03-13 [PMID: 29548672] (IHC-Fr, Mouse)	IHC-Fr	Mouse
S Zhang, X Zhu, X Gui, C Croteau, L Song, J Xu, A Wang, P Bannerman, F Guo Sox2 is essential for oligodendroglial proliferation and differentiation during postnatal brain myelination and CNS remyelination J. Neurosci., 2018-01-15;0(0):. 1/15/2018 [PMID: 29335358]
W Zhou, C Chen, Y Shi, Q Wu, RC Gimple, X Fang, Z Huang, K Zhai, SQ Ke, YF Ping, H Feng, JN Rich, JS Yu, S Bao, XW Bian Targeting Glioma Stem Cell-Derived Pericytes Disrupts the Blood-Tumor Barrier and Improves Chemotherapeutic Efficacy Cell Stem Cell, 2017-11-02;21(5):591-603.e4. 2017-11-02 [PMID: 29100012] (IHC, Human)	IHC	Human
Xun Jin, Leo J. Y. Kim, Qiulian Wu, Lisa C. Wallace, Briana C. Prager, Tanwarat Sanvoranart et al. Targeting glioma stem cells through combined BMI1 and EZH2 inhibition Nature Medicine 2017-11-01 [PMID: 29035367]
Ryan L. O’Hare Doig, Wissam Chiha, Marcus K. Giacci, Nathanael J. Yates, Carole A. Bartlett, Nicole M. Smith et al. Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma BMC Neuroscience 2017-12-01 [PMID: 28806920]
FI Young, M Keruzore, X Nan, N Gennet, EJ Bellefroid, M Li The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1 Proc. Natl. Acad. Sci. U.S.A., 2017-06-27;0(0):. 2017-06-27 [PMID: 28655839] (ICC, Mouse)	ICC	Mouse
NJ Yates, MK Giacci, RL O'Hare Doi, W Chiha, BE Ashworth, J Kenna, CA Bartlett, M Fitzgerald Delayed treatment of secondary degeneration following acute optic nerve transection using a combination of ion channel inhibitors Neural Regen Res, 2017-02-01;12(2):307-316. 2017-02-01 [PMID: 28400815] (IHC, Rat)	IHC	Rat
Breton Q, Plouhinec H, Prunier-Mirebeau D et al. BRAF-V600E immunohistochemistry in a large series of glial and glial-neuronal tumors. Brain Behav. 3/1/2017 [PMID: 28293477]
Diego Pignataro, Diego Sucunza, Lucia Vanrell, Esperanza Lopez-Franco, Iria G. Dopeso-Reyes, Africa Vales et al. Adeno-Associated Viral Vectors Serotype 8 for Cell-Specific Delivery of Therapeutic Genes in the Central Nervous System Frontiers in Neuroanatomy 2017-02-10 [PMID: 28239341]
Brain tissue banking for stem cells for our future Sci Rep, 2016-12-19;6(0):39394. 2016-12-19 [PMID: 27991551] (IHC, Human)	IHC	Human
Majistor Raj Luxman Maglo Renkilaraj The intellectual disability protein PAK3 regulates oligodendrocyte precursor cell differentiation Neurobiol. Dis, 2016-12-06;0(0):. 2016-12-06 [PMID: 27940202] (ICC, Mouse)	ICC	Mouse
A cord blood monocyte-derived cell therapy product accelerates brain remyelination JCI Insight, 2016-08-18;1(13):e86667. 2016-08-18 [PMID: 27699230] (IHC, Mouse)	IHC	Mouse
Patched1 and Patched2 inhibit Smoothened non-cell autonomously Elife, 2016-08-23;5(0):. 2016-08-23 [PMID: 27552050] (ICC, Mouse)	ICC	Mouse
Naoya Murao, Taito Matsuda, Hirofumi Noguchi, Haruhiko Koseki, Masakazu Namihira, Kinichi Nakashima Characterization of Np95 expression in mouse brain from embryo to adult: A novel marker for proliferating neural stem/precursor cells Neurogenesis (Austin) 2014-11-17 [PMID: 27504471]
Qi Xie RBPJ maintains brain tumor-initiating cells through CDK9-mediated transcriptional elongation J Clin Invest, 2016-06-20;126(7):2757-2772. 2016-06-20 [PMID: 27322055] (Western Blot, Human)	Western Blot	Human
Olig2 is expressed late in human eosinophil development and controls Siglec-8 expression J Leukoc Biol, 2016-05-06;0(0):. 2016-05-06 [PMID: 27154355] (ChIP, Human)	ChIP	Human
SH Choi, SH Kim, KW Shim, JW Han, J Choi, DS Kim, CJ Lyu, JW Kim, CO Suh, J Cho Treatment Outcome and Prognostic Molecular Markers of Supratentorial Primitive Neuroectodermal Tumors PLoS ONE, 2016-04-13;11(4):e0153443. 2016-04-13 [PMID: 27074032] (IHC-P, Human)	IHC-P	Human
Saverio Tardito, Anaïs Oudin, Shafiq U. Ahmed, Fred Fack, Olivier Keunen, Liang Zheng et al. Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma Nature Cell Biology 2015-12-01 [PMID: 26595383]
Julia Marschallinger, Iris Schäffner, Barbara Klein, Renate Gelfert, Francisco J. Rivera, Sebastian Illes et al. Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug Nature Communications 2015-10-27 [PMID: 26506265]
Hélène O. B. Gautier, Kimberley A. Evans, Katrin Volbracht, Rachel James, Sergey Sitnikov, Iben Lundgaard et al. Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors Nature Communications 2015-10-06 [PMID: 26439639]
Mendes F, Coelho Aguiar J, Kahn S, Reis A, Dubois L, Romao L, Ferreira L, Chneiweiss H, Moura Neto V, Abreu J Connective-Tissue Growth Factor (CTGF/CCN2) Induces Astrogenesis and Fibronectin Expression of Embryonic Neural Cells In Vitro. PLoS ONE, 2015-08-04;10(8):e0133689. 2015-08-04 [PMID: 26241738] (Human)		Human
Rzem R, Achouri Y, Marbaix E, Schakman O, Wiame E, Marie S, Gailly P, Vincent M, Veiga-da-Cunha M, Van Schaftingen E A mouse model of L-2-hydroxyglutaric aciduria, a disorder of metabolite repair. PLoS ONE, 2015-03-12;10(3):e0119540. 2015-03-12 [PMID: 25763823] (IHC, Mouse)	IHC	Mouse
Xie Q, Wu Q, Horbinski C, Flavahan W, Yang K, Zhou W, Dombrowski S, Huang Z, Fang X, Shi Y, Ferguson A, Kashatus D, Bao S, Rich J Mitochondrial control by DRP1 in brain tumor initiating cells. Nat Neurosci, 2015-03-02;18(4):501-10. 2015-03-02 [PMID: 25730670] (IHC, Western Blot, Human)	IHC, Western Blot	Human
Wenchao Zhou, Susan Q. Ke, Zhi Huang, William Flavahan, Xiaoguang Fang, Jeremy Paul et al. Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth Nature Cell Biology 2015-02-01 [PMID: 25580734]
Ben-Shushan E, Feldman E, Reubinoff B Notch signaling regulates motor neuron differentiation of human embryonic stem cells. Stem Cells, 2015-02-01;33(2):403-15. 2015-02-01 [PMID: 25335858] (ICC, Human)	ICC	Human
Daniel L. Haus, Hal X. Nguyen, Eric M. Gold, Noriko Kamei, Harvey Perez, Harry D. Moore et al. CD133-enriched Xeno-Free human embryonic-derived neural stem cells expand rapidly in culture and do not form teratomas in immunodeficient mice Stem Cell Research 2014-09-01 [PMID: 25082219]
Aminata P. Coulibaly, Matthew R. Deer, Lori G. Isaacson Distribution and phenotype of TrkB oligodendrocyte lineage cells in the adult rat spinal cord Brain Research 2014-09-25 [PMID: 25072185]
Liu , J K, Lubelski , D, Schonberg , D L, Wu , Q, Hale , J S, Flavahan , W A, Mulkearns-Hubert , E E, Man , J, Hjelmeland , A B, Yu , J, Lathia , J D, Rich , J N Phage display discovery of novel molecular targets in glioblastoma-initiating cells. Cell Death Differ, 2014-05-16;21(8):1325-39. 2014-05-16 [PMID: 24832468] (ICC, IHC, Western Blot, Human)	ICC, IHC, Western Blot	Human
Bergsland M, Covacu R, Perez Estrada C, Svensson M, Brundin L Nitric oxide-induced neuronal to glial lineage fate-change depends on NRSF/REST function in neural progenitor cells. Stem Cells, 2014-09-01;32(9):2539-49. 2014-09-01 [PMID: 24807147] (IHC, Rat)	IHC	Rat
Yan K, Wu Q, Yan D, Lee C, Rahim N, Tritschler I, DeVecchio J, Kalady M, Hjelmeland A, Rich J Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy. Genes Dev, 2014-05-01;28(10):1085-100. 2014-05-01 [PMID: 24788093] (IHC, Human)	IHC	Human
Sahar Rosenblum, Tenille N. Smith, Nancy Wang, Joshua Y. Chua, Erick Westbroek, Kendrick Wang et al. BDNF Pretreatment of Human Embryonic-Derived Neural Stem Cells Improves Cell Survival and Functional Recovery after Transplantation in Hypoxic–Ischemic Stroke Cell Transplantation 2015-12-01 [PMID: 24594369]
Seto Y, Nakatani T, Masuyama N, Taya S, Kumai M, Minaki Y, Hamaguchi A, Inoue Y, Inoue T, Miyashita S, Fujiyama T, Yamada M, Chapman H, Campbell K, Magnuson M, Wright C, Kawaguchi Y, Ikenaka K, Takebayashi H, Ishiwata S, Ono Y, Hoshino M Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum. Nat Commun, 2014-01-01;5(0):3337. 2014-01-01 [PMID: 24535035] (IHC, Mouse)	IHC	Mouse
Srikanth , Maya, Kim , Juno, Das , Sunit, Kessler , John A BMP signaling induces astrocytic differentiation of clinically derived oligodendroglioma propagating cells. Mol Cancer Res, 2013-11-22;12(2):283-94. 2013-11-22 [PMID: 24269952] (IHC-Fr, Human)	IHC-Fr	Human
Piltti K, Salazar D, Uchida N, Cummings B, Anderson A Safety of epicenter versus intact parenchyma as a transplantation site for human neural stem cells for spinal cord injury therapy. Stem Cells Transl Med, 2013-02-14;2(3):204-16. 2013-02-14 [PMID: 23413374] (ICC, Human)	ICC	Human
Kuboyama , Kazuya, Fujikawa , Akihiro, Masumura , Makoto, Suzuki , Ryoko, Matsumoto , Masahito, Noda , Masaharu Protein tyrosine phosphatase receptor type z negatively regulates oligodendrocyte differentiation and myelination. PLoS ONE, 2012-11-07;7(11):e48797. 2012-11-07 [PMID: 23144976] (ICC, Mouse)	ICC	Mouse
Zelinka C, Scott M, Volkov L, Fischer A The reactivity, distribution and abundance of Non-astrocytic Inner Retinal Glial (NIRG) cells are regulated by microglia, acute damage, and IGF1. PLoS ONE, 2012-09-04;7(9):e44477. 2012-09-04 [PMID: 22973454] (IHC, Chicken)	IHC	Chicken
Martinez-Cerdeno V, Lemen JM, Chan V, Wey A, Lin W, Dent SR, Knoepfler PS N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells. PLoS ONE, 2012-06-26;7(6):e39456. 2012-06-26 [PMID: 22745758] (IHC-P, Mouse)	IHC-P	Mouse
Sahar Rosenblum, Nancy Wang, Tenille N. Smith, Arjun V. Pendharkar, Joshua Y. Chua, Harjus Birk et al. Timing of Intra-Arterial Neural Stem Cell Transplantation After Hypoxia–Ischemia Influences Cell Engraftment, Survival, and Differentiation Stroke 2012-06-01 [PMID: 22535265]
M Fareh, L Turchi, V Virolle, D Debruyne, F Almairac, S de-la-Forest Divonne et al. The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network Cell Death & Differentiation 2012-02-01 [PMID: 21720384]
Stridh L, Smith PL, Naylor AS et al. Regulation of toll-like receptor 1 and -2 in neonatal mice brains after hypoxia-ischemia. J Neuroinflammation. 5/10/2011 [PMID: 21569241]
Salazar DL, Uchida N, Hamers FP, Cummings BJ, Anderson AJ Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model. PLoS ONE, 2010-08-18;5(8):e12272. 2010-08-18 [PMID: 20806064] (ICC, Human)	ICC	Human
Vue TY, Aaker J, Taniguchi A Characterization of progenitor domains in the developing mouse thalamus. J. Comp. Neurol., 2007-11-01;505(1):73-91. 2007-11-01 [PMID: 17729296] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Widestrand A, Faijerson J, Wilhelmsson U, Smith PL, Li L, Sihlbom C, Eriksson PS, Pekny M Increased neurogenesis and astrogenesis from neural progenitor cells grafted in the hippocampus of GFAP-/- Vim-/- mice. Stem Cells, 2007-07-12;25(10):2619-27. 2007-07-12 [PMID: 17628017] (ICC, Rat)	ICC	Rat
Bauer S, Patterson PH Leukemia inhibitory factor promotes neural stem cell self-renewal in the adult brain. J. Neurosci., 2006-11-15;26(46):12089-99. 2006-11-15 [PMID: 17108182] (IHC-Fr, Mouse)	IHC-Fr	Mouse
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Reviews for Olig2 Antibody (AF2418) (2) 4.52

Average Rating: 4.5

(Based on 2 reviews)

We have 2 reviews tested in 1 species: Mouse.

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Immunohistochemistry-Frozen Olig2 AF2418

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Xuecheng Qiu

IHC-Fr

Mouse

05/12/2019

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Application	Immunohistochemistry-Frozen
Sample Tested	Mouse brain
Species	Mouse
Lot	UPA0617051

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Mouse

01/06/2015

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Application	Immunocytochemistry
Sample Tested	See PMID 22504067
Species	Mouse

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SH-SY5Y human neuroblastoma cell line was stained with Goat Anti-Human/Mouse/RatEphrin-B2 Antigen Affinity-purified Polyclonal Antibody (Catalog #AF496,filled histogram) or Normal Goat IgG Isotype Control Antibody(Catalog # AB-108-C, open histogram), followed by Phycoerythrin-conjugatedAnti-Goat IgG Secondary Antibody (Catalog #F0107).

Goat IgG Isotype Control [Unconjugated]
AB-108-C

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	Xuecheng Qiu 05/12/2019
Application:	IHC-Fr
Species:	Mouse

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	Verified Customer 01/06/2015
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Bioinformatics

Gene Symbol	OLIG2
Uniprot	Q13516()

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Olig2 Antibody [Unconjugated]

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Publications for Olig2 Antibody (AF2418)(198)

Reviews for Olig2 Antibody (AF2418) (2) 4.52

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