NKX2.2 Antibody

Nkx2.2, or Homeobox protein Nkx-2.2, consists of a 273 amino acid isoform that is 30 kDa, and is involved in controlling and maintaining the expression of genes within pancreatic endocrine cells and axons. Current research is being conducted on the relationship between Nkx2.2 and a variety of diseases and disorders, including glioma, neuronitis, maturity-onset diabetes, pancreatitis, Partington syndrome, sarcoma, gastrointestinal neuroendocrine tumor, acute lymphoblastic leukemia, multiple sclerosis, and carcinoid tumors. The protein has been linked to the Wnt, Hedgehog, and notch pathways, as well as regulation of beta-cell development and gene expression. NKx2.2 interacts with several other proteins, including OLIG2, HDAC1, SIN3A, FOXA2, and FOXO1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: IF/IHC, IHC-P, KO.

Showing Publications 1 - 6 of 6.

Publications using NBP1-82554	Applications	Species
Hall ET, Dillard ME, Cleverdon ER, Zhang Y et Al. Cytoneme signaling provides essential contributions to mammalian tissue patterning Cell 2024-01-03 [PMID: 38171360]
Pasquali L, Gaulton KJ, Rodriguez-Segui SA et al. Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants. Nat Genet 2014-02-01 [PMID: 24413736]
Fiori JL, Shin YK, Kim W et al. Resveratrol Prevents beta-cell Dedifferentiation in Non-Human Primates Given a High Fat/ High Sugar Diet. Diabetes 2013-07-24 [PMID: 23884882]
Lawson MH, Cummings NM, Rassl DM et al Two novel determinants of EPE resistance in small cell lung cancer Cancer Res 2011-07-01 [PMID: 21642373]
Hall ET, Stewart DP, Dillard M et al. Myosin 10 and a Cytoneme-Localized Ligand Complex Promote Morphogen Transport bioRxiv 2020-01-01 (KO, IF/IHC, Mouse)	KO, IF/IHC	Mouse
Fujikawa T, Uemura S, Yoshida M et al. Spindle cell sarcoma with KIAA1549 BRAF resembling infantile fibrosarcoma morphologically: A case report and literature review Oncology Letters 2022-11-01 [PMID: 36380878] (IHC-P, Human)	IHC-P	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	3 reviewed by: Verified Customer	ICC	Feline	06/23/2017	View Summary Application Immunocytochemistry Sample Tested Optic nerve Species Feline Lot B81867 Comments Comments 4%PFA fixed tissue
Enlarge	5 reviewed by: Jason Spaeth	IHC-Fr	Mouse	11/09/2016	View Summary Application Immunohistochemistry-Frozen Sample Tested Mouse pancreas in OCT Species Mouse

Array NBP1-82554

• NKX2.2 Antibodies
• NKX2.2 Lysate
• NKX2.2 Protein