Glut2 Antibody - BSA Free

SLC2A2 (Solute Carrier Family 2), also known as Glucose Transporter GLUT2, is an integral plasma membrane glycoprotein found in the liver, islet beta cells, intestine, and kidney epithelium. This isoform of the glucose transporter mediates the two way transfer of glucose across the plasma membrane and is responsible for the uptake of glucose in beta cells. Mutations in SLC2A2 lead to Fanconi-Bickel syndrome (FBS), which results in hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose. Recent studies have shown that mutations in SLC2A2 can cause neonatal diabetes, and therefore may contribute to human insulin secretion (PMID: 22660720). Novel SLC2A2 mutations have also been discovered and are being investigated to determine their roles in FBS as well (PMID: 22145468).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: IF/IHC, IHC-Fr, IHC-FrFl, IHC-P, WB.

Showing Publications 1 - 10 of 15. Show All 15 Publications. Collapse Publications.

Publications using NBP2-22218	Applications	Species
Juras J, Webb M, Young L et al. In situ microwave fixation provides an instantaneous snapshot of the brain metabolome Cell Reports Methods 2023-04-01 [PMID: 37159672] (IHC-FrFl, Mouse)	IHC-FrFl	Mouse
Shiraki A, Oyama JI, Shimizu T, Node K Linagliptin exacerbates heart failure due to energy deficiency via downregulation of glucose utilization and absorption in a mouse model European journal of pharmacology 2023-03-23 [PMID: 36965743]
Yang K, Sun J, Zhang Z et al. Reduction of mRNA m6A associates with glucose metabolism via YTHDC1 in human and mice Diabetes research and clinical practice 2023-03-04 [PMID: 36878322] (WB, Mouse)	WB	Mouse
Cornell D, Miwa S, Georgiou M et al. Pseudoislet Aggregation of Pancreatic beta-Cells Improves Glucose Stimulated Insulin Secretion by Altering Glucose Metabolism and Increasing ATP Production Cells 2022-07-29 [PMID: 35954174] (WB, Mouse)	WB	Mouse
Liu R, Liu C, He X et al. MicroRNA-21 promotes pancreatic beta cell function through modulating glucose uptake Nature communications 2022-06-21 [PMID: 35729232] (WB, Mouse)	WB	Mouse
Visavadiya NP, Rossiter HB, Khamoui AV. Distinct glycolytic pathway regulation in liver, tumour and skeletal muscle of mice with cancer cachexia Cell Biochemistry and Function 2021-08-01 [PMID: 34129243]
Shriwas P, Roberts D, Li Y et al. A small-molecule pan-class I glucose transporter inhibitor reduces cancer cell proliferation in vitro and tumor growth in vivo by targeting glucose-based metabolism Cancer & metabolism 2021-03-26 [PMID: 33771231] (IF/IHC)	IF/IHC
Bernard H, Teijeiro A, Chaves-Perez A et al. Coxsackievirus B Type 4 Infection in beta Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing Cell Reports Medicine 2020-10-01 [PMID: 33205075] (WB, Mouse)	WB	Mouse
Lei Y, Hu Q, Gu J Expressions of Carbohydrate Response Element Binding Protein and Glucose Transporters in Liver Cancer and Clinical Significance Pathol. Oncol. Res. 2019-08-12 [PMID: 31407220] (IHC-P, Human)	IHC-P	Human
Nakagawa, K;Fujiwara, K;Nishimura, A;Murakami, C;Kawamoto, K;Ichinose, C;Kunitou, Y;Suhara, Y;Okano, T;Hasegawa, H; UBIAD1 Plays an Essential Role in the Survival of Pancreatic Acinar Cells Int J Mol Sci 2019-04-22 [PMID: 31013667] (IF/IHC, Mouse)	IF/IHC	Mouse
Du J, Hu C, Bai J et al. Intestinal Glucose Absorption Was Reduced by Vertical Sleeve Gastrectomy via Decreased Gastric Leptin Secretion Obes Surg 2018-06-18 [PMID: 29915972] (Mouse)		Mouse
Hassani-Nezhad-Gashti F, Rysa J, Kummu O et al. Activation of nuclear receptor PXR impairs glucose tolerance and dysregulates GLUT2 expression and subcellular localization in liver Biochem. Pharmacol. 2018-01-05 [PMID: 29309761] (Mouse)		Mouse
Kim DS, Song L, Wang J et al. GRP94 is an Essential Regulator of Pancreatic B Cell Development, Mass and Function in Male Mice. Endocrinology 2017-12-20 [PMID: 29272356] (Mouse)		Mouse
Micucci C, Orciari S, Catalano A. Hyperglycemia Promotes K-Ras-Induced Lung Tumorigenesis through BASCs Amplification PLoS ONE 2014-08-22 [PMID: 25144301]
Juras JA PERIPHERAL AND CENTRAL GLUCOSE FLUX IN TYPE I DIABETES Thesis 2022-01-01 (IHC-Fr, Mouse)	IHC-Fr	Mouse
Show All 15 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Zeyuan Zhang	WB	Mouse	07/31/2023	View Summary Application Western Blot Sample Tested mouse hepatocytes and HepG2 cells Species Mouse Lot B-5
Enlarge	4 reviewed by: Verified Customer	WB	Human	01/13/2020	View Summary Application Western Blot Sample Tested Cultured cancer cell lysates Species Human Lot B-1
Enlarge	4 reviewed by: Kohsuke Kataoka	WB	Mouse	02/07/2018	View Summary Application Western Blot Sample Tested Min6 mouse insulinoma whole cell lysate Species Mouse Lot A-2

Array NBP2-22218

• Glut2 Antibodies
• Glut2 ELISA Kits
• Glut2 Proteins