Glut2 Products

Description

Glucose transporters are integral membrane glycoproteins involved in transporting glucose into most cells. Seven types of glucose transport carrier proteins, designated as Glut 1 to 7, facilitate glucose transport across the cell membrane. Molecular cloning of glucose transporters have identified a family of closely related genes that encode at least 7 proteins exhibiting high degree of amino acid homology (45% to 65%), all in the molecular weight range of 40 to 60 kDa. Individual members of the Glut family have predicted secondary structure characteristic of 12 membrane spanning domains of other transport carriers. The majority of differences in sequence homology in Glut proteins occur at 4 hydrophilic domains that may play a role in distinct tissue specific pattern of expression and targeting. All Glut proteins are glycosylated at or near the C terminus and are present on either cell surface or in intracellular sites. Some transporters exhibit dynamic trafficking between intracellular storage sites and plasma membranes in response to various stimuli. In some tissues Glut proteins are asymmetrically distributed between apical and basolateral membranes as in blood brain barrier and blood testis barriers.

Bioinformatics

Entrez	25351 Rat 6514 Human
Uniprot	AAH60041.1 Human NP_000331 Human NP_000331.1 Human P11168 Human P12336 Rat
Product By Gene ID	6514
Alternate Names	GLUT2 Glucose transporter type 2, liver GLUT-2 SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 solute carrier family 2, facilitated glucose transporter member 2

Related Glut2 Blog Posts

Check out the latest blog posts on Glut2.

Deficiency of GluT1 leads to neurological problems while excess is involved in cancers By Jamshed Arslan, Pharm. D., PhD. What Are GluTs?Mammalian cell metabolism is incomplete without glucose   . Glucose is a monosaccharide that is transported to the cells through facilitative diffusion, a ...    Read more.

Read more Glut2 related blogs.