Neuroligin 1/NLGN1 Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Neuroligin 1 (neurexin ligand 1; also NL1) is a 116 kDa member of the type-B carboxyesterase/lipase family of proteins. It is postsynaptically expressed on neurons and initiates excitatory presynapse maturation through binding to a select isoform of beta -neurexin. Mature rat NL1 is 798 amino acids (aa) in length. It is expressed as a type I transmembrane glycoprotein that contains a 652 aa extracellular domain (ECD) (aa 46‑697) and a 125 aa cytoplasmic tail. The ECD possesses a nonfunctional esterase homology domain (aa 54‑612). Rat NL1 has at least three alternate splice forms. One shows a deletion of aa 165‑184 plus aa 298‑306, while the remaining two show deletions of either aa 165‑184, or aa 298‑306, respectively. Rat ECD shares 97% and 93% aa identity with mouse and human NL1 CED, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 2 of 2.

Publications using AF4340	Applications	Species
Ramirez M, Ninoyu Y, Miller C et al. Cochlear ribbon synapse maturation requires Nlgn1 and Nlgn3 iScience 7/1/2022 [PMID: 35992071]
Junlin Ouyang, Xiaping Chen, Shanchun Su, Xiaohui Li, Xueqin Xu, Xinhua Yu et al. Neuroligin1 Contributes to Neuropathic Pain by Promoting Phosphorylation of Cofilin in Excitatory Neurons Frontiers in Molecular Neuroscience 2021-02-25 [PMID: 33716669]

Array AF4340

• Neuroligin 1/NLGN1 Antibodies
• Neuroligin 1/NLGN1 Lysate
• Neuroligin 1/NLGN1 Protein
• Neuroligin 1/NLGN1 Proteins and Enzymes