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IGSF4A/SynCAM1/CADM1 Antibody

 (2 Publications)
 
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Western Blot: IGSF4A/SynCAM1/CADM1 Antibody [NB300-186] - Cells were transfected with the pCMV6-ENTRY control or pCMV6-ENTRY CADM1 cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SynCAM/CADM1.
Western Blot: IGSF4A/SynCAM1/CADM1 Antibody [NB300-186] - Cells were transfected with the pCMV6-ENTRY control or pCMV6-ENTRY CADM1 cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were ...read more
Immunocytochemistry/ Immunofluorescence: IGSF4A/SynCAM1/CADM1 Antibody [NB300-186] - SynCAM/CADM1 antibody was tested in SH-SY-5Y cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI ...read more
Western Blot: IGSF4A/SynCAM1/CADM1 Antibody [NB300-186] - Rat brain and HEK cell lysates showing different glycosylation patterns. Brain fractions give banding patterns of a core glycosylation population around 50kDa ...read more
Simple Western: IGSF4A/SynCAM1/CADM1 Antibody [NB300-186] - Simple Western lane view shows a specific band for SynCAM in 0.5 mg/ml of Human Brain lysate. This experiment was performed under reducing conditions using ...read more

Product Details

Summary
Reactivity Hu, RtSpecies Glossary
Applications WB, Simple Western, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

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IGSF4A/SynCAM1/CADM1 Antibody Summary

Immunogen
A synthetic peptide corresponding to the C-terminal region of rat SynCAM/CADM1.
Localization
Growth cone
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CADM1
Purity
Unpurified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence 1:2000
  • Simple Western 1:1000
  • Western Blot 1:1000
Application Notes
This SynCAM/CADM1 antibody can be used for Western blot and Immunocytochemistry/Immunofluorescence. Brain fractions give banding patterns of a core glycosylation population around 50kDa and a slightly higher glycosylated population around 65 kDa. Heterologous cell lysates give a single band around 107kDa. In ICC/IF, membrane staining was observed in SH-SY-5Y cells.

In Simple Western only 10 - 15 uL of the recommended dilution is used per data point. Separated by Size-Wes, Sally Sue/Peggy Sue.
Control Peptide
IGSF4A/SynCAM1/CADM1 Peptide (NB300-186PEP)
Publications
Read Publications using
NB300-186 in the following applications:

  • WB
    1 publication

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Whole antisera
Preservative
0.02% Sodium Azide
Purity
Unpurified

Alternate Names for IGSF4A/SynCAM1/CADM1 Antibody

  • BL2
  • Cadm1
  • cell adhesion molecule 1
  • IgSF4
  • IGSF4A
  • IGSF4ADKFZp686F1789
  • IGSF4immunoglobulin superfamily, member 4D variant 2
  • Immunoglobulin superfamily member 4
  • immunoglobulin superfamily, member 4
  • Necl-2
  • NECL2MGC149785
  • nectin-like 2
  • Nectin-like protein 2
  • RA175
  • sgIGSF
  • Spermatogenic immunoglobulin superfamily
  • ST17
  • sTSLC-1
  • Synaptic cell adhesion molecule
  • SynCAM
  • SynCAM1
  • SYNCAMMGC51880
  • TSLC1
  • TSLC-1
  • TSLC1/Nectin-like 2/IGSF4
  • Tumor suppressor in lung cancer 1SYNCAM1

Background

CADM1 (cell adhesion molecule 1; SynCAM1) is an intercellular cell adhesion receptor which belongs to immunoglobulin superfamily and is expressed by diverse cell types which includes lung alveolar cells, biliary epithelial cells, pancreatic islet cells, ameloblasts, neurons, and mast cells. Human CADM1 was originally discovered as a tumour suppressor of lung cancer 1, and modulation of its expression, SNPs or mutations in CADM1 are now known to implicate in several diseases including cancer, autism spectrum disorder and venous thrombosis. The expression of CADM1 is significantly reduced in neuroblastoma and cancers of the lung, oesophagus and skin; wherein it is inversely correlated with carcinogenic progression. Its expression is reduced in endothelial cells in venous thrombosis, however, it gets upregulated in adult T-cell leukaemia/lymphoma as well as acute T-cell leukaemia wherein it facilitates tissue infiltration. CADM1 is involved in adhesion via homophilic and heterophilic interactions with other cell's counter-receptors that belongs to same family (CADM1 itself, CADM2, CADM3, nectin3 and CRTAM). CADM1 expression is also increased in neuro-developmental disorder Rett syndrome.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IGSF4A/SynCAM1/CADM1 Antibody (NB300-186)(2)

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 1 application: WB.


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Bioinformatics

Gene Symbol CADM1
Entrez
Uniprot