Angiopoietin-like Protein 4/ANGPTL4 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

ANGPTL4, also known as PPAR gamma angiopoietin-related protein (PGAR), hepatic fibrinogen/angiopoietin-related protein (HFARP) and fasting-induced adipose factor (FIAF), is a secreted protein that shares structural homology with angiopoietins. It contains an N-terminal coiled-coil region that mediates covalent homo-oligomerization and a C-terminal fibrinogen-like domain. ANGPTL4 undergoes proteolytic processing and releases the C-terminal domain, which circulates as a monomer. At least 2 additional splice isoforms exist. ANGPTL4 is most highly expressed in adipose tissues. Its expression is up-regulated in endothelial cells and cardiomyocytes during hypoxia. ANGPTL4 is involved in the regulation of lipid and glucose metabolism. It has also been associated with angiogenesis. The amino acid sequence of human ANGPTL4 is 81%, 76% and 81% identical to that of porcine, mouse and canine ANGPTL4, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 5 applications: ELISA Capture, ELISA Development, ELISA Development (Capture), ELISA Development (Detection), Western Blot.

Showing Publications 1 - 10 of 15. Show All 15 Publications. Collapse Publications.

Publications using AF3485	Applications	Species
Y Zuo, L Dai, L Li, Y Huang, X Liu, X Liu, X Duan, S Jiang, GM Deng, H Chen ANGPTL4 Regulates Psoriasis via Modulating Hyperproliferation and Inflammation of Keratinocytes Frontiers in Pharmacology, 2022-07-04;13(0):850967. 2022-07-04 [PMID: 35860030] (Western Blot, Human)	Western Blot	Human
Yan Q. Chen, Thomas G. Pottanat, Robert W. Siegel, Mariam Ehsani, Yue-Wei Qian, Eugene Y. Zhen et al. Angiopoietin-like protein 8 differentially regulates ANGPTL3 and ANGPTL4 during postprandial partitioning of fatty acids[S] Journal of Lipid Research 8/1/2020 [PMID: 32487544]
YT Kang, WC Hsu, CC Ou, HC Tai, HT Hsu, KT Yeh, JL Ko Metformin Mitigates Nickel-Elicited Angiopoietin-Like Protein 4 Expression via HIF-1&alpha for Lung Tumorigenesis Int J Mol Sci, 2020-01-17;21(2):. 2020-01-17 [PMID: 31963541] (Western Blot, Human)	Western Blot	Human
BW van der Ko, RG Vink, JWE Jocken, NJT Roumans, GH Goossens, ECM Mariman, MA van Baak, EE Blaak Effect of diet-induced weight loss on angiopoietin-like protein 4 and adipose tissue lipid metabolism in overweight and obese humans Physiol Rep, 2018-07-01;6(13):e13735. 2018-07-01 [PMID: 29998530] (ELISA Development (Capture), Human)	ELISA Development (Capture)	Human
EG Gruppen, S Kersten, RPF Dullaart Plasma angiopoietin-like 4 is related to phospholipid transfer protein activity in diabetic and non-diabetic subjects: role of enhanced low grade inflammation Lipids Health Dis, 2018-03-27;17(1):60. 2018-03-27 [PMID: 29587751] (ELISA Development (Capture), Human)	ELISA Development (Capture)	Human
W Dijk, S Schutte, EO Aarts, IMC Janssen, L Afman, S Kersten Regulation of angiopoietin-like 4 and lipoprotein lipase in human adipose tissue J Clin Lipidol, 2018-02-17;0(0):. 2018-02-17 [PMID: 29555209] (ELISA Capture, Human)	ELISA Capture	Human
Jin-Wu Chen, Ying-Jia Luo, Zheng-Fei Yang, Li-Qiang Wen, Lin Huang Knockdown of angiopoietin-like 4 inhibits the development of human gastric cancer Oncology Reports 2/7/2018 [PMID: 29436683]
L Zhou, Y Huang, H Xie, X Mei Buyang Huanwu Tang improves denervation-dependent muscle atrophy by increasing ANGPTL4, and increases NF-?B and MURF1 levels Mol Med Rep, 2017-12-19;0(0):. 2017-12-19 [PMID: 29257347] (Western Blot, Rat)	Western Blot	Rat
S Izraely, S Ben-Menach, O Sagi-Assif, T Meshel, DM Marzese, S Ohe, I Zubrilov, M Pasmanik-C, DSB Hoon, IP Witz ANGPTL4 promotes the progression of cutaneous melanoma to brain metastasis Oncotarget, 2017-07-05;8(44):75778-75796. 2017-07-05 [PMID: 29100268] (Western Blot, Human)	Western Blot	Human
K Baba, Y Kitajima, S Miyake, J Nakamura, K Wakiyama, H Sato, K Okuyama, H Kitagawa, T Tanaka, M Hiraki, K Yanagihara, H Noshiro Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines Sci Rep, 2017-09-11;7(1):11127. 2017-09-11 [PMID: 28894280] (Western Blot, Human)	Western Blot	Human
Kubo H, Kitajima Y, Kai K et al. Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancer. Oncol Lett 2/1/2016 [PMID: 26893686]
Wieneke Dijk, Markus Heine, Laurent Vergnes, Mariëtte R Boon, Gert Schaart, Matthijs K C Hesselink et al. ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure eLife 10/17/2015 [PMID: 26476336]
Nathanja Tjeerdema, Anastasia Georgiadi, Jacqueline T Jonker, Marjolijn van Glabbeek, Reza Alizadeh Alizadeh Dehnavi, Jouke T Tamsma et al. Inflammation increases plasma angiopoietin-like protein 4 in patients with the metabolic syndrome and type 2 diabetes BMJ Open Diabetes Research & Care 12/3/2014 [PMID: 25512873]
Alex S, Lange K, Amolo T, Grinstead J, Haakonsson A, Szalowska E, Koppen A, Mudde K, Haenen D, Al-Lahham S, Roelofsen H, Houtman R, van der Burg B, Mandrup S, Bonvin A, Kalkhoven E, Muller M, Hooiveld G, Kersten S Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor gamma. Mol Cell Biol, 2013-01-22;33(7):1303-16. 2013-01-22 [PMID: 23339868] (ELISA Development (Detection), Human)	ELISA Development (Detection)	Human
Kersten S, Lichtenstein L, Steenbergen E, Mudde K, Hendriks HF, Hesselink MK, Schrauwen P, Muller M Caloric restriction and exercise increase plasma ANGPTL4 levels in humans via elevated free fatty acids. Arterioscler. Thromb. Vasc. Biol., 2009-04-02;29(6):969-74. 2009-04-02 [PMID: 19342599] (ELISA Development, Human)	ELISA Development	Human
Show All 15 Publications. Collapse Publications.

Array AF3485

• Angiopoietin-like Protein 4/ANGPTL4 Antibodies
• Angiopoietin-like Protein 4/ANGPTL4 ELISA Kits
• Angiopoietin-like Protein 4/ANGPTL4 Lysate
• Angiopoietin-like Protein 4/ANGPTL4 Proteins and Enzymes
• Angiopoietin-like Protein 4/ANGPTL4 ELISA