Human Phospho-PDGF R alpha DuoSet IC ELISA, 2 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

PDGF R alpha (Platelet-Derived Growth Factor Receptor alpha) is a transmembrane receptor tyrosine kinase that can form homodimers or heterodimers with PDGF R beta when engaged by dimers of the PDGF ligands. PDGF R alpha binds to PDGF-AA, PDGF-AB, and PDGF-CC. It is strongly expressed in oligodendrocyte, lung, skin, and intestinal progenitor cells, at low levels in most mesenchymal cells, and can be induced by inflammation. PDGF R alpha function is important during formation of the cranial and cardiac neural crest, retina, gonads, lung alveoli, intestinal villi, skin, hair follicles, skeleton, teeth, palate, and interstitial kidney mesenchyme. Dysregulated PDGF R alpha signaling can result in spina bifida or cleft palate-type malformations. Postnatally, PDGF R alpha is implicated in gliomas and fibrotic disorders of lung, heart, and skin (scleroderma).

We have publications tested in 2 confirmed species: Human, Porcine.

Showing Publications 1 - 7 of 7.

Publications using DYC2114-2	Applications	Species
Uezumi A, Fukada S, Yamamoto N, Ikemoto-Uezumi M, Nakatani M, Morita M, Yamaguchi A, Yamada H, Nishino I, Hamada Y, Tsuchida K Identification and characterization of PDGFRalpha+ mesenchymal progenitors in human skeletal muscle. Cell Death Dis, 2014-04-17;5(0):e1186. 2014-04-17 [PMID: 24743741] (Human)		Human
Wollin L, Maillet I, Quesniaux V, Holweg A, Ryffel B Antifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis. J Pharmacol Exp Ther, 2014-02-20;349(2):209-20. 2014-02-20 [PMID: 24556663] (Human)		Human
Pellet-Many C, Frankel P, Evans IM, Herzog B, Junemann-Ramirez M, Zachary IC Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas. Biochem. J., 2011-05-01;435(3):609-18. 2011-05-01 [PMID: 21306301] (Human)		Human
Schultz JD, Rotunno S, Riedel F, Anders C, Erben P, Hofheinz RD, Faber A, Thorn C, Sommer JU, Hormann K, Sauter A Synergistic effects of imatinib and carboplatin on VEGF, PDGF and PDGF-Ralpha/beta expression in squamous cell carcinoma of the head and neck in vitro. Int. J. Oncol., 2011-01-18;38(4):1001-12. 2011-01-18 [PMID: 21249316] (Human)		Human
Loizos N, Lariccia L, Weiner J, Griffith H, Boin F, Hummers L, Wigley F, Kussie P Lack of detection of agonist activity by antibodies to platelet-derived growth factor receptor alpha in a subset of normal and systemic sclerosis patient sera. Arthritis Rheum., 2009-04-01;60(4):1145-51. 2009-04-01 [PMID: 19333919] (Porcine)		Porcine
Soroceanu L, Akhavan A, Cobbs CS Platelet-derived growth factor-alpha receptor activation is required for human cytomegalovirus infection. Nature, 2008-08-13;455(7211):391-5. 2008-08-13 [PMID: 18701889] (Human)		Human
Ball SG, Shuttleworth CA, Kielty CM Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. J. Cell Biol., 2007-04-30;177(3):489-500. 2007-04-30 [PMID: 17470632] (Human)		Human

Array DYC2114-2

• PDGFR alpha Antibodies
• PDGFR alpha Antibody Pair
• PDGFR alpha Lysate
• PDGFR alpha Protein
• PDGFR alpha ELISAs
• PDGFR alpha Proteins and Enzymes