PDGFR alpha Products

Description

Platelet-derived growth factor receptors exhibit tyrosine-protein kinase activity and have been implicated in the control of cell proliferation, survival and migration. PDGF receptors, PDGFR-alpha and PDGFR-beta, have 5 extracellular immunoglobulin-like domains and an intracellular tyrosine kinase domain. Upon binding a PDGF, the receptors form homo-and heterodimers. Dimerization of the receptors results in phosphorylation in the complex. More than 10 different SH2-domain-containing molecules have been shown to bind to different autophosphorylation sites in the PDGF-alpha and beta receptors. PDGF alpha receptors are expressed in oligodendrocyte progenitor cells and PDGF beta receptors are expressed on neurons.

Bioinformatics

Uniprot	AAH15186 Human ENSP00000257290 Human NM_006206 Human NP_006197 Human P16234 Human P26618 Mouse
Product By Gene ID	5156
Alternate Names	alpha-type platelet-derived growth factor receptor CD140 antigen-like family member A CD140a antigen CD140A CD140a EC 2.7.10 EC 2.7.10.1 MGC74795 PDGFR2 PDGFRA/BCR fusion PDGF-R-alpha platelet-derived growth factor receptor, alpha polypeptide rearranged-in-hypereosinophilia-platelet derived growth factor receptor alphafusion protein RHEPDGFRA

Research Areas for PDGFR alpha

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase