hnRNP L Antibody (4D11) - BSA Free

Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (HNRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with HNRNP complexes and along with other HNRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of HNRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions.Strucutrally, hnRPL contains 2 segments of approximately 80 amino acids each which are weakly related to each other and to the ribonucleoprotein consensus sequence-type RNA-binding domains of other HNRNP and snRNP proteins.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: ICC/IF, IP, WB.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using NB120-6106	Applications	Species
Yao P, Wu J, Lindner D, Fox PL. Interplay between miR-574-3p and hnRNP L regulates VEGFA mRNA translation and tumorigenesis. Nucleic Acids Res. 2017-05-17 [PMID: 28520992] (IP, Mouse)	IP	Mouse
Li Y, Collins M, An J et al. Immunoprecipitation and mass spectrometry defines an extensive RBM45 protein-protein interaction network Brain Res. 2016-03-12 [PMID: 26979993] (ICC/IF, WB, IP, Human)	ICC/IF, WB, IP	Human
Yao P, Potdar AA, Ray PS et al. The HILDA Complex Coordinates a Conditional Switch in the 3'-Untranslated Region of the VEGFA mRNA. PLoS Biol. 2013-08-01 [PMID: 23976881] (WB, Human)	WB	Human
Halbert D, Domenyuk V, Spetzler D et al. Aptamers and uses thereof United States Patent Application US 9958448 B2 2018-01-01
Sun C, Liu M, Chang J et Al. hnRNP L negatively regulates foot-and-mouth disease virus replication through inhibiting viral RNA synthesis by interacting with IRES in 5' untranslated region J. Virol. 2020-03-11 [PMID: 32161169]
Hung LH, Heiner M, Hui J et al. Diverse roles of hnRNP L in mammalian mRNA processing: a combined microarray and RNAi analysis. RNA. 2008-02-01 [PMID: 18073345] (WB, Human)	WB	Human
Hui J, Stangl K, Lane WS, Bindereif A. HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats. Nat Struct Biol. 2003-01-01 [PMID: 12447348] (WB, Human)	WB	Human
Soderberg M, Raffalli-Mathieu F, Lang MA. Inflammation modulates the interaction of heterogeneous nuclear ribonucleoprotein (hnRNP) I/polypyrimidine tract binding protein and hnRNP L with the 3'untranslated region of the murine inducible nitric-oxide synthase mRNA. Mol Pharmacol. 2002-08-01 [PMID: 12130696] (IP, Mouse)	IP	Mouse
Shih SC, Claffey KP. Regulation of human vascular endothelial growth factor mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein L. J Biol Chem. 1999-01-15 [PMID: 9880507] (IP, WB, Human)	IP, WB	Human
Hahm B, Kim YK, Kim JH et al. Heterogeneous nuclear ribonucleoprotein L interacts with the 3' border of the internal ribosomal entry site of hepatitis C virus. J Virol. 1998-11-01 [PMID: 9765422] (WB, Human)	WB	Human
Liu X, Mertz JE. HnRNP L binds a cis-acting RNA sequence element that enables intron-dependent gene expression. Genes Dev. 1995-07-15 [PMID: 7542615] (IP, Human)	IP	Human
Show All 11 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	IF	Rat	10/22/2015	View Summary Application Immunofluorescence Sample Tested Rat Primary Motor Neurons Species Rat
Enlarge	5 reviewed by: Verified Customer	WB	Human	11/14/2014	View Summary Application Western Blot Sample Tested HEK whole cell lysates Species Human
	4 reviewed by: Nadine Bakkar	WB	Human	08/19/2014	View Summary Application Western Blot Sample Tested HEK nuclear lysate Species Human

Array NB120-6106

• hnRNP L Antibodies
• hnRNP L Lysates
• hnRNP L Proteins