NONO Antibody

Non-POU-domain-containing octamer binding protein (NONO) is a member of the DBHS (drosophila behavior, human splicing) domain-containing family and is an RNA- and DNA- binding protein. NONO and other DBHS domain-containing proteins are multifunctional and are reported to be involved in transcriptional regulation, mRNA processing, and DNA non-homologous end joining (NHEJ). NONO functions as a coregulator of the androgen receptor (AR) and also regulates cAMP transcriptional activity by interacting with gene promoter elements. NONO is also involved in pre-mRNA splicing through an interaction with U5 snRNA and can stimulate DNA nonhomologous end joining (NHEJ) through the interaction with ku70/G22p and ku80/XRCC5 dimers. Alternate names for NONO include 54 kDa nuclear RNA- and DNA-binding protein, p54 (nrb), 55 kDa nuclear protein, NMT55, DNA-binding p52/p100 complex, NRB54, P54, and P54NRB.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 5 of 5.

Publications using NB100-1556	Applications	Species
Wang IX, Grunseich C, Fox J et al. Human proteins that interact with RNA/DNA hybrids Genome Res. 2018-08-14 [PMID: 30108179] (WB, Human)	WB	Human
Hashiramoto Akira, Konishi Yoshitake, Murayama Koichi et al. A variant of death-receptor 3 associated with rheumatoid arthritis interferes with apoptosis-induction of T cell. J Biol Chem 2018-01-01 [PMID: 29180447] (WB, Mouse)	WB	Mouse
Krietsch J, Caron MC, Gagne JP et al. PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks. Nucleic Acids Res 2012-11-01 [PMID: 22941645]
Isabelle M, Gagne JP, Gallouzi IE et al. Quantitative proteomics and dynamic imaging reveal that G3BP-mediated stress granule assembly is poly(ADP-ribose)-dependent following exposure to MNNG-induced DNA alkylation. J Cell Sci 2012-10-01 [PMID: 22767504]
Zhang C, Zhang MX, Shen YH et al. TNF-alpha suppresses prolyl-4-hydroxylase alpha1 expression via the ASK1-JNK-NonO pathway. Arterioscler Thromb Vasc Biol 2007-08-01 [PMID: 17478756]

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	WB	Human	03/09/2018	View Summary Application Western Blot Sample Tested B-cell whole cell lysate 40ug Species Human Lot A1 Comments Comments BIOSCARF
Enlarge	5 reviewed by: Verified Customer	ICC	Human	01/11/2018	View Summary Application Immunocytochemistry Sample Tested fibroblasts Species Human Lot A1 Comments Comments 1:200 in 1X PBS/1% BSA/0.3% Triton X-100, 16 hours 4C.

Array NB100-1556

• NONO Antibodies
• NONO ELISA Kits
• NONO Lysates
• NONO Proteins