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APH1A Antibody

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Western Blot: APH1A Antibody [NB100-74360] - Analysis of mouse brain and kidney extracts.
Western Blot: APH1A Antibody [NB100-74360] - Analysis of mouse brain and kidney extracts.
Immunocytochemistry/ Immunofluorescence: APH1A Antibody [NB100-74360] - Staining of APH-1 in human KNS-42 glioma cells.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ICC/IF, IHC, IP, ChIP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.69 mg/ml

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APH1A Antibody Summary

Immunogen
Synthetic peptide, KLH conjugated, corresponding to residues C (245) R R Q E D S R V M V Y S A L R I P P E D (265) of human APH-1aL/CT.
Specificity
APH-1
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
APH1A
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Chromatin Immunoprecipitation (ChIP) 1:10-1:500
  • Immunocytochemistry/ Immunofluorescence 1:100
  • Immunohistochemistry 1:10 - 1:500
  • Immunohistochemistry-Frozen 1:10 - 1:500
  • Immunohistochemistry-Paraffin 1:10 - 1:500
  • Immunoprecipitation 1:10 - 1:500
  • Western Blot 1:1000
Application Notes
WB: Detects an approx. 18 kDa protein representing APH-1 in mouse brain and kidney extracts. ChIP usage was reported in the scientific literature (PMID: 20145246).
Publications
Read Publications using NB100-74360.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS with 1 mg/ml BSA
Preservative
0.005% Sodium Azide
Concentration
0.69 mg/ml
Purity
Immunogen affinity purified

Alternate Names for APH1A Antibody

  • 6530402N02Rik
  • anterior pharynx defective 1 homolog A (C. elegans)
  • APH-1
  • APH1A
  • APH-1A
  • aph-1alpha
  • CGI-78
  • gamma-secretase subunit APH-1A
  • Presenilin-stabilization factor
  • PSF

Background

Anterior Pharynx Defective 1 (APH1a) is an integral transmembrane protein forming a component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for APH1A Antibody (NB100-74360)(2)


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Product General Protocols

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Bioinformatics

Gene Symbol APH1A
Entrez
Uniprot