FKBP51/FKBP5 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

FK506 binding protein, 51 kDa molecular weight (FKBP51) is a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans- proline residues critical for proper folding of proteins. The macrolide immunosuppressants FK506 and Rapamycin are FKBP51 inhibitors. FKBP51 levels are induced by glucocorticoids. It associates with HSP90 complexes that are critical for the proper folding of steroid receptors. Single nucleotide polymorphisms in FKBP51 have been associated with major depression and hyper-responsiveness to antidepressants.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: IHC-Fr, IHC-P, In Situ PLA, Western Blot.

Showing Publications 1 - 9 of 9.

Publications using AF4094	Applications	Species
O Guzeloglu-, N Semerci, X Guo, K Larsen, A Ozmen, S Arlier, D Mutluay, C Nwabuobi, B Sipe, I Buhimschi, C Buhimschi, F Schatz, UA Kayisli, CJ Lockwood Decidual cell FKBP51-progesterone receptor binding mediates maternal stress-induced preterm birth Proceedings of the National Academy of Sciences of the United States of America, 2021-03-16;118(11):. 2021-03-16 [PMID: 33836562] (In Situ PLA, Mouse)	In Situ PLA	Mouse
Williamson M, Garg R, Wells C et al. PlexinB1 Promotes Nuclear Translocation of the Glucocorticoid Receptor. Cells. 12/18/2019 [PMID: 31861264]
Williamson M, Garg R, Wells C et al. PlexinB1 Promotes Nuclear Translocation of the Glucocorticoid Receptor. Cells. 2019-12-18 [PMID: 31861264]
L Janeckova, K Kostovciko, J Svec, M Stastna, H Strnad, M Kolar, T Hudcovic, J Stancikova, J Tureckova, N Baloghova, E Sloncova, K Galuskova, H Tlaskalova, V Korinek Unique Gene Expression Signatures in the Intestinal Mucosa and Organoids Derived from Germ-Free and Monoassociated Mice Int J Mol Sci, 2019-03-29;20(7):. 2019-03-29 [PMID: 30934845] (IHC-P, Mouse)	IHC-P	Mouse
Dieuwertje C E Spaanderman, Mark Nixon, Jacobus C Buurstede, Hetty H C M Sips, Maaike Schilperoort, Eline N Kuipers et al. Androgens modulate glucocorticoid receptor activity in adipose tissue and liver Journal of Endocrinology 1/1/2019 [PMID: 30400038]
Ozlem Guzeloglu Kayisli, Umit A. Kayisli, Murat Basar, Nihan Semerci, Frederick Schatz, Charles J. Lockwood Progestins Upregulate FKBP51 Expression in Human Endometrial Stromal Cells to Induce Functional Progesterone and Glucocorticoid Withdrawal: Implications for Contraceptive- Associated Abnormal Uterine Bleeding PLOS ONE 10/5/2015 [PMID: 26436918]
Michael G. Doran, Philip A. Watson, Sarah M. Cheal, Daniel E. Spratt, John Wongvipat, Jeffrey M. Steckler et al. Annotating STEAP1 Regulation in Prostate Cancer with 89Zr Immuno-PET Journal of Nuclear Medicine 12/3/2014 [PMID: 25453051]
Tannour-Louet M, Han S, Louet JF et al. Increased gene copy number of the vesicle SNARE VAMP7 disrupts human male urogenital development through altered estrogen action. Nat Med 7/1/2014 [PMID: 24880616]
Caldwell JM, Blanchard C, Collins MH, Putnam PE, Kaul A, Aceves SS, Bouska CA, Rothenberg ME Glucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51. J. Allergy Clin. Immunol., 2010-04-01;125(4):879-888. 2010-04-01 [PMID: 20371398] (IHC-Fr, Western Blot, Human)	IHC-Fr, Western Blot	Human

Array AF4094

• FKBP51/FKBP5 Antibodies
• FKBP51/FKBP5 ELISA Kits
• FKBP51/FKBP5 Lysates
• FKBP51/FKBP5 Proteins