BACE-1 Antibody (137612)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

BACE-1 (beta‑site APP cleaving enzyme-1) is an aspartic protease and an integral membrane protein (1, 2). It is the major beta secretase, and together with the gamma  secretase, is responsible for generating the amyloid beta peptide (A beta ) from the amyloid precursor protein (APP) (3, 4). Because A beta is a major component of amyloid plaques, BACE-1 has been implicated in the onset and/or progression of Alzheimer's disease. High levels of BACE-1 activity are sufficient to elicit neurodegeneration and neurological decline in vivo, indicating that inhibiting BACE-1 may block not only A beta -dependent but also A beta -independent pathogenic mechanisms (5). In addition to APP, BACE-1 also cleaves APP-like proteins 1 and 2, the cell adhesion protein P-selectin glycoprotein ligand-1 and beta -galactoside alpha 2,6-sialyltransferase, implying that BACE-1 may have additional functions involving the ectodomain shedding of membrane proteins (6‑8).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 5 applications: ELISA Development, IHC, IHC-Fr, Immunoprecipitation, Western Blot.

Showing Publications 1 - 10 of 15. Show All 15 Publications. Collapse Publications.

Publications using MAB931	Applications	Species
Mariko Sawa, Cassia Overk, Ann Becker, Dominique Derse, Ricardo Albay, Kim Weldy et al. Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model Alzheimer's & Dementia 2022-06-01 [PMID: 34757693]
MI Khan, JH Shin, MY Kim, TS Shin, JD Kim Green Tea Seed Isolated Theasaponin E1 Ameliorates AD Promoting Neurotoxic Pathogenesis by Attenuating Abeta Peptide Levels in SweAPP N2a Cells Molecules, 2020-05-16;25(10):. 2020-05-16 [PMID: 32429462] (Western Blot, Mouse)	Western Blot	Mouse
J Wang, A Wuethrich, AA Sina, RE Lane, LL Lin, Y Wang, J Cebon, A Behren, M Trau Tracking extracellular vesicle phenotypic changes enables treatment monitoring in melanoma Sci Adv, 2020-02-26;6(9):eaax3223. 2020-02-26 [PMID: 32133394] (Western Blot, Human)	Western Blot	Human
A Mendsaikha, I Tooyama, JP Bellier, GE Serrano, LI Sue, LF Lue, TG Beach, DG Walker Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer's disease and aged brains: increased levels correlate with neuropathology Acta Neuropathol Commun, 2019-12-21;7(1):215. 2019-12-21 [PMID: 31864418] (IHC-Fr, Western Blot, Human)	IHC-Fr, Western Blot	Human
Yong Shen, Haibo Wang, Qiying Sun, Hailan Yao, Andrew P. Keegan, Mike Mullan et al. Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer’s Disease Dementia in Individuals With Mild Cognitive Impairment Biological Psychiatry 2018-03-01 [PMID: 28359566]
Schnoder L, Hao W, Qin Y, Liu S, Tomic I, Liu X, Fassbender K, Liu Y Deficiency of Neuronal p38alpha MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1. J Biol Chem, 2015-12-09;291(5):2067-79. 2015-12-09 [PMID: 26663083] (IHC, Western Blot, Human)	IHC, Western Blot	Human
Wang Y, Thinakaran G, Kar S Overexpression of the IGF-II/M6P receptor in mouse fibroblast cell lines differentially alters expression profiles of genes involved in Alzheimer's disease-related pathology. PLoS ONE, 2014-05-20;9(5):e98057. 2014-05-20 [PMID: 24846272] (Western Blot, Mouse)	Western Blot	Mouse
Cheng X, He P, Lee T, Yao H, Li R, Shen Y High activities of BACE1 in brains with mild cognitive impairment. Am J Pathol, 2014-01-01;184(1):141-7. 2014-01-01 [PMID: 24332014] (ELISA Development, Western Blot, Human)	ELISA Development, Western Blot	Human
Ping He, Pengtao Li, Qian Hua, Yuan Liu, Matthias Staufenbiel, Rena Li et al. Chronic Administration of Anti-Stroke Herbal Medicine TongLuoJiuNao Reduces Amyloidogenic Processing of Amyloid Precursor Protein in a Mouse Model of Alzheimer’s Disease PLoS ONE 2013-03-05 [PMID: 23472157]
Ping He, Xin Cheng, Matthias Staufenbiel, Rena Li, Yong Shen Long-Term Treatment of Thalidomide Ameliorates Amyloid-Like Pathology through Inhibition of beta -Secretase in a Mouse Model of Alzheimer’s Disease PLoS ONE 2013-02-06 [PMID: 23405115]
Amanda Gonzales, Boris Decourt, Aaron Walker, Rachel Condjella, Hikmet Nural, Marwan N. Sabbagh Development of a specific ELISA to measure BACE1 levels in human tissues Journal of Neuroscience Methods 2011-10-30 [PMID: 21889954]
Yan-Jiang Wang, Xin Wang, Jian-Jun Lu, Qiao-Xin Li, Chang-Yue Gao, Xiao-Hong Liu et al. p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain The Journal of Neuroscience 2011-02-09 [PMID: 21307265]
M. Paul Murphy, Jacqueline Morales, Tina L. Beckett, Giuseppe Astarita, Daniele Piomelli, Adam Weidner et al. Changes in Cognition and Amyloid-beta Processing with Long Term Cholesterol Reduction using Atorvastatin in Aged Dogs Journal of Alzheimer's Disease 2010-09-28 [PMID: 20847439]
Viorela Pop, Elizabeth Head, Nicole C. Berchtold, Charles G. Glabe, Christa M. Studzinski, Adam M. Weidner et al. A beta aggregation profiles and shifts in APP processing favor amyloidogenesis in canines Neurobiology of Aging 2012-01-01 [PMID: 20434811]
Ahmed RR, Holler CJ, Webb RL BACE1 and BACE2 enzymatic activities in Alzheimer's disease. J. Neurochem., 2009-12-04;112(4):1045-53. 2009-12-04 [PMID: 19968762] (ELISA Development, Immunoprecipitation, Western Blot, Human, Rat)	ELISA Development, Immunoprecipitation, Western Blot	Human, Rat
Show All 15 Publications. Collapse Publications.

Array MAB931

• BACE-1 Antibodies
• BACE-1 ELISA Kits
• BACE-1 Lysate
• BACE-1 Protein
• BACE-1 ELISA
• BACE-1 Proteins and Enzymes