CCR8 Antibody (191704) [Allophycocyanin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CCR8 (C-C chemokine receptor 8; previously called CKR-L1 or TER1 and designated CD198) is a 41-43 kDa member of the GPCR 1 family of transmembrane proteins.  CCR8 is expressed on vascular smooth muscle cells, monocytes, eosinophils, peritoneal macrophages, thymocytes, CD8⁺ T cells, Langerhans cells and neurons.  CCL1/TCA3 and vMIP-1 are known agonists for CCR8.  Human CCR8 is a 7-transmembrane protein that is 355 amino acids (aa) in length.  It contains a 35 aa N-terminal extracellular domain plus a 51 aa C-terminal cytoplasmic tail. Over aa sequences 1-33 and 92-105 collectively, human and mouse CCR8 share 64% aa sequence identity.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Flow Cytometry, ICC.

Showing Publications 1 - 6 of 6.

Publications using FAB1429A	Applications	Species
S Su, J Liao, J Liu, D Huang, C He, F Chen, L Yang, W Wu, J Chen, L Lin, Y Zeng, N Ouyang, X Cui, H Yao, F Su, JD Huang, J Lieberman, Q Liu, E Song Blocking the recruitment of naive CD4(+) T cells reverses immunosuppression in breast cancer Cell Res, 2017-03-14;0(0):. 2017-03-14 [PMID: 28290464] (Flow Cytometry, Human)	Flow Cytometry	Human
Jared Klarquist, Kristen Tobin, Peyman Farhangi Farhangi Oskuei, Steven W. Henning, Manuel F. Fernandez, Emilia R. Dellacecca et al. Ccl22 Diverts T Regulatory Cells and Controls the Growth of Melanoma Cancer Research 2016-11-01 [PMID: 27634754]
Morandi , Fabio, Di Carlo , Emma, Ferrone , Soldano, Petretto , Andrea, Pistoia , Vito, Airoldi , Irma IL-27 in human secondary lymphoid organs attracts myeloid dendritic cells and impairs HLA class I-restricted antigen presentation. J Immunol, 2014-02-19;192(6):2634-42. 2014-02-19 [PMID: 24554774] (Flow Cytometry, Human)	Flow Cytometry	Human
Jared Klarquist, Cecele J Denman, Claudia Hernandez, Derek A Wainwright, Derek J Wainwright, Faith M Strickland et al. Reduced skin homing by functional Treg in vitiligo Pigment Cell & Melanoma Research 2010-04-01 [PMID: 20175879]
Ahern D, Lloyd CM, Robinson DS Chemokine responsiveness of CD4+ CD25+ regulatory and CD4+ CD25- T cells from atopic and nonatopic donors. Allergy, 2009-02-07;64(8):1121-9. 2009-02-07 [PMID: 19208087] (Flow Cytometry, Human)	Flow Cytometry	Human
Bayry J, Triebel F, Kaveri SV, Tough DF Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells. J. Immunol., 2007-04-01;178(7):4184-93. 2007-04-01 [PMID: 17371975] (ICC, Human)	ICC	Human

Array FAB1429A

• CCR8 Antibodies
• CCR8 ELISA Kits