Brg1 Antibody

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Alternatively spliced transcripts have been found for this gene, but their full-length natures have not been determined.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: Chemotaxis, IP, WB.

Showing Publications 1 - 6 of 6.

Publications using NB100-2594	Applications	Species
Quillien A, Gilbert G, Boulet M et al. Prmt5 promotes vascular morphogenesis independently of its methyltransferase activity PLOS Genetics 2021-06-21 [PMID: 34153034]
Singh AP, Foley JF, Rubino M et al. Brg1 enables rapid growth of the early embryo by suppressing genes that regulate apoptosis and cell growth arrest. Mol. Cell. Biol. 2016-05-16 [PMID: 27185875] (Chemotaxis, IP, WB, Mouse)	Chemotaxis, IP, WB	Mouse
Hoffman J, Muse G, Langer L et al. BRG1 establishes the neuroectodermal chromatin landscape to restrict dorsal cell fates bioRxiv 2023-06-25 (Human)		Human
Singh AP, Archer TK. Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation. Nucleic Acids Res 2014-03-01 [PMID: 24335282] (IP, Chemotaxis, Mouse)	IP, Chemotaxis	Mouse
Miyamoto K, Pasque V, Jullien J et al. Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes. Genes Dev 2011-05-01 [PMID: 21536734]
Goldman JA, Garlick JD, Kingston RE. Chromatin remodeling by imitation switch (ISWI) class ATP-dependent remodelers is stimulated by histone variant H2A.Z. J Biol Chem 2010-02-12 [PMID: 19940112]

Array NB100-2594

• Brg1 Antibodies
• Brg1 Protein