ATRX Antibody

ATRX is encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 5 applications: IF/IHC, IHC, IHC-P, Immunohistochemistry-Paraffin, WB.

Showing Publications 1 - 10 of 26. Show All 26 Publications. Collapse Publications.

Publications using NBP1-83077	Applications	Species
Familiari P, Relucenti M, Lapolla P et al. Adult IDH Wild-Type Glioblastoma Ultrastructural Investigation Suggests a Possible Correlation between Morphological Biomarkers and Ki-67 Index Biomedicines 2023-07-12 [PMID: 37509607] (IHC, Human)	IHC	Human
Familiari P, Lapolla P, Picotti V et al. Role of 1p/19q Codeletion in Diffuse Low-grade Glioma Tumour Prognosis Anticancer research 2023-06-01 [PMID: 37247932] (Immunohistochemistry-Paraffin, Human)	Immunohistochemistry-Paraffin	Human
ssa Francesca DSMP, Buttarelli R. Biomolecular characterization of metastatic medulloblastoma and study of telomere lengthening control Thesis 2017-01-01 (IHC-P, Human)	IHC-P	Human
Minniti G, Paolini S, Antonelli M et al. Long-term treatment outcomes of temozolomide-based chemoradiation in patients with adult-type diffuse IDH-mutant grade 2 astrocytoma J Neurooncol 2023-09-04 [PMID: 37665475]
Zhang PP, He ZC, Yao XH et al. COVID-19-associated monocytic encephalitis (CAME): histological and proteomic evidence from autopsy Signal transduction and targeted therapy 2023-01-06 [PMID: 36609561] (IHC-P, Human) Details: COVID-19 Brain sections, dilution used 1:1000	IHC-P	Human
Alzoubi H, Minasi S, Gianno F et al. Alternative Lengthening of Telomeres (ALT) and Telomerase Reverse Transcriptase Promoter Methylation in Recurrent Adult and Primary Pediatric Pituitary Neuroendocrine Tumors Endocrine pathology 2022-01-06 [PMID: 34993885] (IF/IHC)	IF/IHC
Gianno F, Antonelli M, Di Dio T, et al. Correlation Between Immunohistochemistry and Sequencing in H3G34-Mutant Gliomas The American journal of surgical pathology 2021-02-01 [PMID: 33428336]
Minasi S, Baldi C, Gianno F et al. Alternative lengthening of telomeres in molecular subgroups of paediatric high-grade glioma Childs Nerv Syst 2020-10-31 [PMID: 33128602] (IF/IHC, Human)	IF/IHC	Human
Minasi S, Baldi C, Pietsch T et al. Telomere elongation via alternative lengthening of telomeres (ALT) and telomerase activation in primary metastatic medulloblastoma of childhood J. Neurooncol. 2019-03-04 [PMID: 30830680] (IF/IHC, Human)	IF/IHC	Human
Li X, Oh S, Song H et al. A potential common role of the Jumonji C domain containing 1A histone demethylase and chromatin remodeler ATRX in promoting colon cancer. Oncol Lett 2018-09-24 [PMID: 30405805] (WB, Human)	WB	Human
Masayuki Yoshida, Reiko Ogawa, Hiroshi Yoshida et al. TERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast. British Journal of Cancer 2015-09-10 [PMID: 26355235] (IF/IHC, Human)	IF/IHC	Human
Napier CE, Huschtscha LI, Harvey A et al. ATRX represses alternative lengthening of telomeres. Oncotarget 2015-06-30 [PMID: 26001292] (WB, Human)	WB	Human
Hayashi S, Sasaki H, Kimura T et al. Molecular-genetic and clinical characteristics of gliomas with astrocytic appearance and total 1p19q loss in a single institutional consecutive cohort. Oncotarget 2015-06-30 [PMID: 25991674] (IF/IHC, Human)	IF/IHC	Human
Fishbein L, Khare S, Wubbenhorst B et al. Whole exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas. Nat Commun 2015-01-21 [PMID: 25608029] (IF/IHC, Human)	IF/IHC	Human
Cryan JB, Haidar S, Ramkissoon LA et al. Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas. Oncotarget 2014-09-30 [PMID: 25257301] (IF/IHC, Human)	IF/IHC	Human
Barszczyk M, Buczkowicz P, Castelo-Branco P et al. Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells. Acta Neuropathol 2014-12-01 [PMID: 25120190] (IF/IHC, Human)	IF/IHC	Human
Haberler C, Wohrer A. Clinical Neuropathology practice news 2-2014: ATRX, a new candidate biomarker in gliomas. Clin Neuropathol 2014-03-01 [PMID: 24559763]
Cairncross JG, Wang M, Jenkins RB et al. Benefit From Procarbazine, Lomustine, and Vincristine in Oligodendroglial Tumors Is Associated With Mutation of IDH. J Clin Oncol 2014-03-10 [PMID: 24516018] (IF/IHC, Human)	IF/IHC	Human
Abedalthagafi M, Phillips JJ, Kim GE et al. The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas. Mod Pathol 2013-11-01 [PMID: 23765250]
Nguyen DN, Heaphy CM, de Wilde RF et al. Molecular and morphologic correlates of the alternative lengthening of telomeres phenotype in high-grade astrocytomas. Brain Pathol 2013-05-01 [PMID: 22928601]
Jiao Y, Killela PJ, Reitman ZJ et al. Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. Oncotarget 2012-07-01 [PMID: 22869205] (IF/IHC, Human)	IF/IHC	Human
Lovejoy CA, Li W, Reisenweber S et al. Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway. PLoS Genet 2012-01-01 [PMID: 22829774]
de Wilde RF, Heaphy CM, Maitra A et al. Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors. Mod Pathol 2012-07-01 [PMID: 22575867]
Schwartzentruber J, Korshunov A, Liu XY et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature 2012-01-29 [PMID: 22286061]
Heaphy CM, de Wilde RF, Jiao Y et al. Altered telomeres in tumors with ATRX and DAXX mutations. Science 2011-07-22 [PMID: 21719641]
Bolander A, Agnarsdottir M, Stromberg S et al. The protein expression of TRP-1 and galectin-1 in cutaneous malignant melanomas. Cancer Genomics Proteomics 2008-11-01 [PMID: 19287070]
Show All 26 Publications. Collapse Publications.

Array NBP1-83077

• ATRX Antibodies
• ATRX Lysate
• ATRX Proteins