Daxx Antibody

DAXX (death-domain-associated protein) was originally identified as a cytoplasmic protein that binds to the death domain of the transmembrane death receptor Fas. It is now that known that the a large proportion of DAXX molecules are nuclear and associate with the promyelocytic leukemia nuclear body (PML-NB) and other subnuclear domains (reviewed in Salomoni and Khelifi). The promyelocytic leukemia protein PML is an essential component of the PML-NB. Data suggests that certain stimuli including Fas stimulation, causes DAXX to be translocated from the nucleus to the cytoplasm. DAXX is ubiquitously expressed, and particularly high levels of DAXX have been reported in the thymus and testes. At the cellular level DAXX may be found in cytoplasm and within heterochromatic regions of the nucleus. DAXX has been reported to interact and co-localize with PML in the nucleus of tumor cell lines and primary cells. PML is necessary for Fas-induced cell death and DAXX pro-apoptotic functions. DAXX is thought to have both pro- and anti-apoptotic functions depending on the stimulus and the cell type. DAXX pro-apoptotic functions appear to occur in both the cytoplasm and nucleus. Although the mechanisms remain to be fully elucidated, research indicates that DAXX plays a role in the pathology of human diseases including cancer and neurodegenerative disorders. Human DAXX is a 740 amino acid protein (GenBank no. gi/62898369).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NB100-56136	Applications	Species
Yang R, Hu K, Chen J et al. Necrostatin-1 protects hippocampal neurons against ischemia/reperfusion injury via the RIP3/DAXX signaling pathway in rats. Neurosci. Lett. Jun 9 2017 [PMID: 28501693]

Array NB100-56136

• Daxx Antibodies
• Daxx Lysates
• Daxx Proteins